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Ed."},{"issue":"4","key":"10.1016\/j.bcp.2018.12.003_b0385","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/nano8040239","article-title":"Implementation of safe-by-design for nanomaterial development and safe innovation: why we need a comprehensive approach","volume":"8","author":"Kraegeloh","year":"2018","journal-title":"Nanomaterials"},{"key":"10.1016\/j.bcp.2018.12.003_b0390","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmat2398","article-title":"Biodegradable luminescent porous silicon nanoparticles for in vivo applications","volume":"8","author":"Park","year":"2009","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bcp.2018.12.003_b0395","first-page":"(2)","article-title":"Biodegradable and renal clearable inorganic nanoparticles","volume":"3","author":"Ehlerding","year":"2016","journal-title":"Adv. Sci. 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