{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:55:06Z","timestamp":1789379706189,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_156270\/1"],"award-info":[{"award-number":["31003A_156270\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_160206"],"award-info":[{"award-number":["31003A_160206"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bcp.2019.01.011","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T16:08:15Z","timestamp":1547482095000},"page":"345-356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells"],"prefix":"10.1016","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-9732","authenticated-orcid":false,"given":"Deborah","family":"Rudin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Lanzilotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Housecroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin C.","family":"Constable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Drewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Haschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-4145","authenticated-orcid":false,"given":"Stephan","family":"Kr\u00e4henb\u00fchl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2019.01.011_b0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00228-014-1781-z","article-title":"Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports","volume":"71","author":"Blaser","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2019.01.011_b0010","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1023\/A:1021077810548","article-title":"Gastrointestinal tolerability of metamizol, acetaminophen, and diclofenac in subchronic treatment in rats","volume":"47","author":"S\u00e1nchez","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bcp.2019.01.011_b0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejps.2018.05.003","article-title":"N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole","volume":"120","author":"Bachmann","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2019.01.011_b0020","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF00315516","article-title":"The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction","volume":"45","author":"Heinemeyer","year":"1993","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bcp.2014.09.005","article-title":"Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole","volume":"92","author":"Martinez","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2019.01.011_b0030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/00498259509061862","article-title":"Metabolism of aminopyrine and derivatives in man: in vivo study of monomorphic and polymorphic metabolic pathways","volume":"25","author":"Agundez","year":"1995","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bcp.2019.01.011_b0035","doi-asserted-by":"crossref","unstructured":"L. Blaser, H. Hassna, S. Hofmann, A. Holbro, M. Haschke, A. Ratz Bravo, et al., Leucopenia associated with metamizole: a case-control study Swiss medical weekly, 2017, 147, w14438.","DOI":"10.4414\/smw.2017.14438"},{"issue":"4","key":"10.1016\/j.bcp.2019.01.011_b0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF00549594","article-title":"Plasma kinetics of dipyrone metabolites in rapid and slow acetylators","volume":"27","author":"Levy","year":"1984","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2019.01.011_b0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/MOH.0b013e3282f15fb9","article-title":"Idiosyncratic drug-induced agranulocytosis or acute neutropenia","volume":"15","author":"Andres","year":"2008","journal-title":"Curr. Opin. Hematol."},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0050","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1517\/14740338.6.3.323","article-title":"Non-chemotherapy drug-induced agranulocytosis","volume":"6","author":"Garbe","year":"2007","journal-title":"Expert Opin. Drug Saf."},{"issue":"45","key":"10.1016\/j.bcp.2019.01.011_b0055","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1024\/1661-8157.95.45.1743","article-title":"Agranulocytosis in a patient treated with metamizole and clopidogrel","volume":"95","author":"Kummer","year":"2006","journal-title":"Praxis (Bern 1994)"},{"issue":"1","key":"10.1016\/j.bcp.2019.01.011_b0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00008571-199602000-00005","article-title":"Genetic factors and risk of agranulocytosis from metamizol","volume":"6","author":"Vlahov","year":"1996","journal-title":"Pharmacogenetics"},{"issue":"2","key":"10.1016\/j.bcp.2019.01.011_b0065","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1021\/tx00044a007","article-title":"Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis","volume":"8","author":"Uetrecht","year":"1995","journal-title":"Chem. Res. Toxicol."},{"issue":"3-4","key":"10.1016\/j.bcp.2019.01.011_b0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/10428199909167386","article-title":"Myeloperoxidase gene expression and regulation by myeloid cell growth factors in normal and leukemic cells","volume":"32","author":"Tsuruta","year":"1999","journal-title":". Leuk. Lymphoma"},{"issue":"2\u20133","key":"10.1016\/j.bcp.2019.01.011_b0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tox.2012.05.017","article-title":"Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites","volume":"299","author":"Maseneni","year":"2012","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.bcp.2019.01.011_b0080","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1021\/bi00507a018","article-title":"Purification and characterization of small molecular weight myeloperoxidase from human promyelocytic leukemia HL-60 cells","volume":"20","author":"Yamada","year":"1981","journal-title":"Biochemistry"},{"issue":"12","key":"10.1016\/j.bcp.2019.01.011_b0085","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0145-2126(93)90160-M","article-title":"The effects of GM-CSF on myeloperoxidase release in normal and myelodysplastic neutrophils","volume":"17","author":"Dang","year":"1993","journal-title":"Leuk. Res."},{"issue":"11","key":"10.1016\/j.bcp.2019.01.011_b0090","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1089\/ars.2009.2538","article-title":"Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease","volume":"11","author":"van der Veen","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.bcp.2019.01.011_b0095","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1582-4934.2009.00897.x","article-title":"Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems","volume":"14","author":"L\u00fc","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2019.01.011_b0100","first-page":"181","article-title":"Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid","author":"Winterbourn","year":"2002","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.bcp.2019.01.011_b0105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-5793(86)80626-3","article-title":"Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides","volume":"201","author":"Gutteridge","year":"1986","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2019.01.011_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/0378-4274(95)03532-X","article-title":"Toxicity of iron and hydrogen peroxide: the Fenton reaction","volume":"82-83","author":"Winterbourn","year":"1995","journal-title":"Toxicol. Lett."},{"issue":"9","key":"10.1016\/j.bcp.2019.01.011_b0115","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood.V95.9.2960.009k13_2960_2966","article-title":"Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H(2)O(2)","volume":"95","author":"Lipinski","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcp.2019.01.011_b0120","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sj.bjp.0707239","article-title":"Inhibition of cyclooxygenases by dipyrone","volume":"151","author":"Pierre","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2019.01.011_b0125","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1182\/blood.V80.1.225.225","article-title":"Effects of gamma-interferon on human neutrophils: protection from deterioration on storage","volume":"80","author":"Klebanoff","year":"1992","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0130","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1124\/jpet.106.108993","article-title":"Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives","volume":"319","author":"Waldhauser","year":"2006","journal-title":"J. Pharmacol. Experimental Therapeutics"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2019.01.011_b0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/bj3120107","article-title":"Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis","volume":"312","author":"van Berkel","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2019.01.011_b0140","doi-asserted-by":"crossref","unstructured":"S. Hashizume, K. Kuroda, H. Murakami, Cell culture assay of biological activity of lactoferrin and transferrin, in: D. Barnes, D.A. Sirbasku, (Eds.), Methods in Enzymology, 147: Academic Press, 1987, pp. 302\u2013314.","DOI":"10.1016\/0076-6879(87)47120-6"},{"issue":"6","key":"10.1016\/j.bcp.2019.01.011_b0145","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1177\/1091581816659661","article-title":"Cytotoxicity of manganese (III) complex in human breast adenocarcinoma cell line is mediated by the generation of reactive oxygen species followed by mitochondrial damage","volume":"35","author":"Al-Anbaky","year":"2016","journal-title":"Int. J. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2019.01.011_b0150","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1124\/jpet.114.221788","article-title":"PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis","volume":"353","author":"Zheng","year":"2015","journal-title":"J. Pharmacol. Experimental Therapeutics"},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030501","article-title":"Lactoferrin: balancing ups and downs of inflammation due to microbial infections","volume":"18","author":"Drago-Serrano","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2019.01.011_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1002817226110","article-title":"Lactoferrin and its biological functions","volume":"66","author":"Kanyshkova","year":"2001","journal-title":"Biochem. Biokhimiia"},{"issue":"2","key":"10.1016\/j.bcp.2019.01.011_b0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0609.1977.tb02080.x","article-title":"Myeloperoxidase and lactoferrin of blood neutrophils and plasma in chronic granulocytic leukaemia","volume":"18","author":"Olofsson","year":"1977","journal-title":"Scandinavian J. Haematol."},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/08998280.2006.11928171","article-title":"Structure-function relations of human hemoglobins","volume":"19","author":"Marengo-Rowe","year":"2006","journal-title":"Proceedings (Baylor University Medical Center)"},{"issue":"6","key":"10.1016\/j.bcp.2019.01.011_b0175","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1084\/jem.133.6.1264","article-title":"The enzymatic degradation of hemoglobin to bile pigments by macrophages","volume":"133","author":"Pimstone","year":"1971","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.toxlet.2005.03.004","article-title":"Free heme toxicity and its detoxification systems in human","volume":"157","author":"Kumar","year":"2005","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0185","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/00032719.2010.500777","article-title":"Flow injection spectrophotometric determination of dipyrone in pharmaceutical formulations using Fe(III) as reagent","volume":"44","author":"Suarez","year":"2011","journal-title":"Anal. Lett."},{"issue":"3","key":"10.1016\/j.bcp.2019.01.011_b0190","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0026-265X(90)90141-Q","article-title":"Some observations on a simple method for the determination of novalgin in drug formulations with iron(III)-1,10-phenanthroline","volume":"41","author":"Qureshi","year":"1990","journal-title":"Microchem. J."},{"key":"10.1016\/j.bcp.2019.01.011_b0195","unstructured":"Documed. \u2018Arzneimittel-Kompendium Der Schweiz: Fachinformation Novalgin\u00ae\u2019. 2016."},{"issue":"5","key":"10.1016\/j.bcp.2019.01.011_b0200","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0953-6205(02)00085-7","article-title":"Modern management of non-chemotherapy drug-induced agranulocytosis: a monocentric cohort study of 90 cases and review of the literature","volume":"13","author":"Andres","year":"2002","journal-title":"Eur. J. Intern. Med."},{"issue":"5","key":"10.1016\/j.bcp.2019.01.011_b0205","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/01.HYP.36.5.878","article-title":"Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity","volume":"36","author":"Lacy","year":"2000","journal-title":"Hypertension (Dallas, Tex: 1979)"},{"key":"10.1016\/j.bcp.2019.01.011_b0210","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.abb.2016.05.005","article-title":"What is the concentration of hydrogen peroxide in blood and plasma?","volume":"603","author":"Forman","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bcp.2019.01.011_b0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2019.01.011_b0220","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.chemosphere.2015.02.010","article-title":"Decomposition of drug mixture in Fenton and photo-Fenton processes: comparison to singly treatment, evolution of inorganic ions and toxicity assay","volume":"127","author":"Giri","year":"2015","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.bcp.2019.01.011_b0225","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1179\/135100009X12525712409931","article-title":"Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke","volume":"14","author":"Robinson","year":"2009","journal-title":"Redox Report"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219300176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219300176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:59:10Z","timestamp":1777377550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295219300176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":45,"alternative-id":["S0006295219300176"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2019.01.011","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2019.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}