{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:36Z","timestamp":1786985076262,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bcp.2019.03.002","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T10:35:17Z","timestamp":1551522917000},"page":"335-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques"],"prefix":"10.1016","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-7849","authenticated-orcid":false,"given":"Yasuhiro","family":"Uno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Takahira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Onozeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ikenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Ikushiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-4261","authenticated-orcid":false,"given":"Hiroshi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2019.03.002_b0005","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3109\/03602532.2010.549492","article-title":"Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function","volume":"43","author":"Uno","year":"2011","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bcp.2019.03.002_b0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/dmd.114.061275","article-title":"Evaluation of 89 compounds for identification of substrates for cynomolgus monkey CYP2C76, a new bupropion\/nifedipine oxidase","volume":"43","author":"Hosaka","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1124\/dmd.115.063925","article-title":"Comprehensive evaluation for substrate selectivity of cynomolgus monkey cytochrome P450 2C9, a new efavirenz oxidase","volume":"43","author":"Hosaka","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","article-title":"Human UDP-glucuronosyltransferases: metabolism, expression, and disease","volume":"40","author":"Tukey","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2019.03.002_b0025","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0009-2797(00)00198-8","article-title":"Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions","volume":"129","author":"Ritter","year":"2000","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bcp.2019.03.002_b0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/01.fpc.0000173483.13689.56","article-title":"Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily","volume":"15","author":"Mackenzie","year":"2005","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0035","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3109\/00498254.2011.618954","article-title":"Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues","volume":"42","author":"Court","year":"2012","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bcp.2019.03.002_b0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1124\/dmd.108.023598","article-title":"Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction","volume":"37","author":"Ohno","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0045","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.bcp.2010.04.034","article-title":"Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): mechanisms responsible for interindividual variation of UGT levels","volume":"80","author":"Bock","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.002_b0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.dmpk.2014.12.001","article-title":"A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development","volume":"30","author":"Oda","year":"2015","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.bcp.2019.03.002_b0055","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/bj3370567","article-title":"Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein","volume":"337","author":"Barbier","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2019.03.002_b0060","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1210\/endo.141.7.7583","article-title":"Distribution of uridine diphosphate-glucuronosyltransferase (UGT) expression and activity in cynomolgus monkey tissues: evidence for differential expression of steroid-conjugating UGT enzymes in steroid target tissues","volume":"141","author":"Albert","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2019.03.002_b0065","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1210\/endo.140.12.7192","article-title":"UGT2B23, a novel uridine diphosphate-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites","volume":"140","author":"Barbier","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2019.03.002_b0070","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1006\/jmbi.1997.1486","article-title":"Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens","volume":"275","author":"Beaulieu","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bcp.2019.03.002_b0075","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1046\/j.1432-1327.1999.00197.x","article-title":"Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone","volume":"260","author":"B\u00e9langer","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2019.03.002_b0080","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1089\/dna.1997.16.1195","article-title":"Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey","volume":"16","author":"B\u00e9langer","year":"1997","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bcp.2019.03.002_b0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/bj20011594","article-title":"Isolation and characterization of the monkey UGT2B30 gene that encodes a uridine diphosphate-glucuronosyltransferase enzyme active on mineralocorticoid, glucocorticoid, androgen and oestrogen hormones","volume":"365","author":"Girard","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2019.03.002_b0090","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.106.022673","article-title":"CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone","volume":"70","author":"Uno","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.002_b0095","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1124\/jpet.111.185009","article-title":"Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys","volume":"339","author":"Uehara","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2019.03.002_b0100","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.febslet.2007.12.031","article-title":"Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: a systematic identification of drug-metabolizing enzymes","volume":"582","author":"Uno","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2019.03.002_b0105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbagen.2004.02.012","article-title":"Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes","volume":"1672","author":"Ikushiro","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2019.03.002_b0110","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/dna.1985.4.203","article-title":"Expression of rat liver cytochrome P-450MC cDNA in Saccharomyces cerevisiae","volume":"4","author":"Oeda","year":"1985","journal-title":"DNA (Mary Ann Liebert, Inc)"},{"key":"10.1016\/j.bcp.2019.03.002_b0115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bcp.2018.06.027","article-title":"Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques","volume":"155","author":"Uno","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.002_b0120","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/0049825021000022348","article-title":"Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes","volume":"33","author":"Takemoto","year":"2003","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bcp.2019.03.002_b0125","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/dmd.112.049171","article-title":"Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco carcinogen metabolism","volume":"41","author":"Bushey","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0130","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/jpet.112.198770","article-title":"Identification and functional characterization of a novel UDP-glucuronosyltransferase 2A1 splice variant: potential importance in tobacco-related cancer susceptibility","volume":"343","author":"Bushey","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2019.03.002_b0135","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/FPC.0b013e3282f1f118","article-title":"Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity","volume":"17","author":"Girard","year":"2007","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.21464","article-title":"Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus","volume":"45","author":"L\u00e9vesque","year":"2007","journal-title":"Hepatol. (Baltimore, MD)"},{"key":"10.1016\/j.bcp.2019.03.002_b0145","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1074\/jbc.M109.083139","article-title":"Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions","volume":"285","author":"Bellemare","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2019.03.002_b0150","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/FPC.0b013e3283498147","article-title":"Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants","volume":"21","author":"M\u00e9nard","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0155","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/FPC.0b013e328336ef1c","article-title":"Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation","volume":"20","author":"L\u00e9vesque","year":"2010","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/FPC.0b013e328341db05","article-title":"Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis","volume":"21","author":"Bushey","year":"2011","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0165","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/FPC.0b013e3283330767","article-title":"Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3","volume":"19","author":"Sneitz","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0170","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1124\/mol.108.045500","article-title":"Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction","volume":"74","author":"Court","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.002_b0175","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/03602530903209049","article-title":"The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families","volume":"42","author":"Radominska-Pandya","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bcp.2019.03.002_b0180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/sj.tpj.6500171","article-title":"Pharmacogenomics of human UDP-glucuronosyltransferase enzymes","volume":"3","author":"Guillemette","year":"2003","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.bcp.2019.03.002_b0185","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pharmthera.2013.09.002","article-title":"Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review","volume":"141","author":"Stingl","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2019.03.002_b0190","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2217\/pgs.11.105","article-title":"Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes","volume":"12","author":"Zhou","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.bcp.2019.03.002_b0195","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1124\/dmd.108.021428","article-title":"Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines","volume":"36","author":"Nakamura","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0200","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1124\/dmd.109.030635","article-title":"Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine","volume":"38","author":"Abildskov","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030067","article-title":"Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates","volume":"3","author":"Thomas","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcp.2019.03.002_b0210","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1124\/mol.118.111773","article-title":"Intergenic splicing between four adjacent UGT genes (2B15, 2B29P2, 2B17, 2B29P1) gives rise to variant UGT proteins that inhibit glucuronidation via protein-protein interactions","volume":"94","author":"Hu","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.002_b0215","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/bcr936","article-title":"Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview","volume":"6","author":"Guillemette","year":"2004","journal-title":"Breast Cancer Res.: BCR"},{"key":"10.1016\/j.bcp.2019.03.002_b0220","first-page":"1","article-title":"Human UGT2B7 catalyzes morphine glucuronidation","volume":"25","author":"Coffman","year":"1997","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0225","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1124\/dmd.31.9.1125","article-title":"Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism","volume":"31","author":"Court","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2019.03.002_b0230","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3109\/00498254.2011.563327","article-title":"N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases","volume":"41","author":"Kaivosaari","year":"2011","journal-title":"Xenobiotica"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219300887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219300887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:08:09Z","timestamp":1757768889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295219300887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":46,"alternative-id":["S0006295219300887"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2019.03.002","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2019.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}