{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:45:54Z","timestamp":1788792354423,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1127"],"award-info":[{"award-number":["SFB1127"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1278"],"award-info":[{"award-number":["SFB1278"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004505","name":"University of Catania","doi-asserted-by":"publisher","award":["2016-2018"],"award-info":[{"award-number":["2016-2018"]}],"id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.bcp.2019.03.003","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T10:35:30Z","timestamp":1551522930000},"page":"263-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy"],"prefix":"10.1016","volume":"165","author":[{"given":"Jana","family":"Gerstmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kretzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Di Micco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Miek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Butschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Cantone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Bilancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Troisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Cardullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tringali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Ialenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5170","authenticated-orcid":false,"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-4379","authenticated-orcid":false,"given":"Oliver","family":"Werz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2019.03.003_b0005","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1126\/science.1230720","article-title":"Anti-inflammatory therapy in chronic disease: challenges and opportunities","volume":"339","author":"Tabas","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bcp.2019.03.003_b0010","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(09)60008-8","article-title":"Rheumatoid arthritis","volume":"373","author":"Klareskog","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2019.03.003_b0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.advms.2017.06.004","article-title":"A systematic review on the role of eicosanoid pathways in rheumatoid arthritis","volume":"63","author":"Hoxha","year":"2018","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.bcp.2019.03.003_b0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00281-012-0342-8","article-title":"Multifaceted roles of PGE2 in inflammation and cancer","volume":"35","author":"Nakanishi","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bcp.2019.03.003_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.06.022","article-title":"Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders","volume":"98","author":"Koeberle","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.003_b0030","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1172\/JCI97945","article-title":"Leukotriene biosynthetic enzymes as therapeutic targets","volume":"128","author":"Haeggstrom","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2019.03.003_b0035","first-page":"331","article-title":"5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease","volume":"2015","author":"Radmark","year":"1851","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2019.03.003_b0040","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.1144346","article-title":"Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein","volume":"317","author":"Ferguson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bcp.2019.03.003_b0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1096\/fj.15-278010","article-title":"Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase\/5-lipoxygenase-activating protein complex in blood leukocytes","volume":"30","author":"Gerstmeier","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2019.03.003_b0050","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-5","article-title":"Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily","volume":"161","author":"Jakobsson","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bcp.2019.03.003_b0055","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/13543776.2017.1276568","article-title":"Novel leukotriene biosynthesis inhibitors (2012\u20132016) as anti-inflammatory agents","volume":"27","author":"Werz","year":"2017","journal-title":"Expert. Opin. Ther. Pat."},{"key":"10.1016\/j.bcp.2019.03.003_b0060","doi-asserted-by":"crossref","unstructured":"K.D. Rainsford, Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage, Agents Actions 39 Spec No (1993) C24-26.","DOI":"10.1007\/BF01972709"},{"key":"10.1016\/j.bcp.2019.03.003_b0065","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.biotechadv.2018.02.010","article-title":"Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis","volume":"36","author":"Koeberle","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.bcp.2019.03.003_b0070","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2019.03.003_b0075","article-title":"Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology","author":"Dalli","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.003_b0080","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1039\/C0OB00480D","article-title":"Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans","volume":"9","author":"Di Micco","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0085","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1039\/c3ob42521e","article-title":"Bio-inspired benzo[k, l]xanthene lignans: synthesis, DNA-interaction and antiproliferative properties","volume":"12","author":"Spatafora","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/acs.jctc.5b00864","article-title":"OPLS3: a force field providing broad coverage of drug-like small molecules and proteins","volume":"12","author":"Harder","year":"2016","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.bcp.2019.03.003_b0095","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1021\/ja00172a038","article-title":"Semianalytical treatment of solvation for molecular mechanics and dynamics","volume":"112","author":"Still","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2019.03.003_b0100","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.ejmech.2017.10.039","article-title":"Discovery of new potent molecular entities able to inhibit mPGES-1","volume":"143","author":"Di Micco","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J. Comput. Aid. Mol. Des."},{"key":"10.1016\/j.bcp.2019.03.003_b0110","first-page":"6289","article-title":"Biomimetic synthesis of natural and \u201cunnatural\u201d lignans by oxidative coupling of caffeic esters","author":"Daquino","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41467-017-02538-5","article-title":"Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity","volume":"9","author":"Werz","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2019.03.003_b0120","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201802509R","article-title":"Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome","author":"Werner","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2019.03.003_b0125","first-page":"2961","article-title":"An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis","volume":"2014","author":"Gerstmeier","year":"1840","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2019.03.003_b0130","doi-asserted-by":"crossref","first-page":"16520","DOI":"10.1074\/jbc.M011205200","article-title":"5-Lipoxygenase interacts with coactosin-like protein","volume":"276","author":"Provost","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0135","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1432-1033.1995.0401h.x","article-title":"Mutations at the C-terminal isoleucine and other potential iron ligands of 5-lipoxygenase","volume":"230","author":"Hammarberg","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2019.03.003_b0140","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1096\/fj.02-0815fje","article-title":"Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors","volume":"17","author":"Fischer","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2019.03.003_b0145","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1016\/j.bmc.2012.04.048","article-title":"Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)","volume":"20","author":"Banoglu","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0150","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.plefa.2013.06.004","article-title":"High capacity for leukotriene biosynthesis in peripheral blood during pregnancy","volume":"89","author":"Schaible","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.bcp.2019.03.003_b0155","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1124\/jpet.108.139444","article-title":"Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1","volume":"326","author":"Koeberle","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2019.03.003_b0160","first-page":"1605","article-title":"Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors","volume":"2016","author":"Liening","year":"1861","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2019.03.003_b0165","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0006-2952(02)01387-4","article-title":"Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase","volume":"64","author":"Albert","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.003_b0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.plefa.2017.01.004","article-title":"Identification and profiling of specialized pro-resolving mediators in human tears by lipid mediator metabolomics","volume":"117","author":"English","year":"2017","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.bcp.2019.03.003_b0175","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2019.03.003_b0180","doi-asserted-by":"crossref","first-page":"9398","DOI":"10.1038\/s41598-017-09795-w","article-title":"Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase","volume":"7","author":"Garscha","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2019.03.003_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2014.05.011","article-title":"In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis","volume":"87","author":"Rossi","year":"2014","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2019.03.003_b0190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bcp.2016.08.023","article-title":"BRP-187: a potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase\/5-lipoxygenase-activating protein (FLAP) complex assembly","volume":"119","author":"Garscha","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.003_b0195","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.bmc.2016.01.002","article-title":"2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors","volume":"24","author":"Di Micco","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0200","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1016\/j.bmc.2018.06.019","article-title":"Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors","volume":"26","author":"Di Micco","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0205","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1139\/y89-073","article-title":"L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor","volume":"67","author":"Gillard","year":"1989","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2019.03.003_b0210","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1182\/blood.V99.3.1044","article-title":"Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes","volume":"99","author":"Werz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2019.03.003_b0215","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0090-6980(02)00052-7","article-title":"Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes","volume":"68\u201369","author":"Lam","year":"2002","journal-title":"Prostaglandins Other Lipid. Mediat."},{"key":"10.1016\/j.bcp.2019.03.003_b0220","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1084\/jem.147.3.952","article-title":"Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages","volume":"147","author":"Kurland","year":"1978","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2019.03.003_b0225","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/nmeth947","article-title":"Direct observation of individual endogenous protein complexes in situ by proximity ligation","volume":"3","author":"Soderberg","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bcp.2019.03.003_b0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.0030055","article-title":"Dynamic simulations on the arachidonic acid metabolic network","volume":"3","author":"Yang","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bcp.2019.03.003_b0235","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1038\/s41598-017-03696-8","article-title":"Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation","volume":"7","author":"Pace","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2019.03.003_b0240","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1084\/jem.20052371","article-title":"Neutrophil-derived leukotriene B4 is required for inflammatory arthritis","volume":"203","author":"Chen","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2019.03.003_b0245","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1073\/pnas.92.2.517","article-title":"Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis","volume":"92","author":"Griffiths","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.bcp.2019.03.003_b0250","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.smim.2017.09.009","article-title":"LTB4 and BLT1 in inflammatory arthritis","volume":"33","author":"Miyabe","year":"2017","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.bcp.2019.03.003_b0255","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.4049\/jimmunol.176.10.6254","article-title":"Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice","volume":"176","author":"Shao","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2019.03.003_b0260","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1084\/jem.178.4.1347","article-title":"Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen","volume":"178","author":"Surette","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2019.03.003_b0265","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ejmech.2018.07.031","article-title":"Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation","volume":"156","author":"Cheung","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0270","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2019.03.003_b0275","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1021\/acs.jmedchem.5b01011","article-title":"Discovery of novel 15-lipoxygenase activators to shift the human arachidonic acid metabolic network toward inflammation resolution","volume":"59","author":"Meng","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2019.03.003_b0280","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.berh.2006.05.005","article-title":"Treating very early rheumatoid arthritis","volume":"20","author":"Raza","year":"2006","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bcp.2019.03.003_b0285","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/art.39269","article-title":"Perspectives from masters in rheumatology and autoimmunity: can we get closer to a cure for rheumatoid arthritis?","volume":"67","author":"Feldmann","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"2011","key":"10.1016\/j.bcp.2019.03.003_b0290","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1136\/ard.2010.149260","article-title":"Association with joint damage and physical functioning of nine composite indices and the, ACR\/EULAR remission criteria in rheumatoid arthritis","volume":"70","author":"Klarenbeek","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2019.03.003_b0295","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrrheum.2016.193","article-title":"Immune resolution mechanisms in inflammatory arthritis","volume":"13","author":"Perretti","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bcp.2019.03.003_b0300","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mam.2017.04.005","article-title":"Actions of SPM in regulating host responses in arthritis","volume":"58","author":"Perretti","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bcp.2019.03.003_b0305","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.4049\/jimmunol.1502268","article-title":"Resolvin D3 Is dysregulated in arthritis and reduces arthritic inflammation","volume":"197","author":"Arnardottir","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2019.03.003_b0310","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85922","article-title":"Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis","volume":"1","author":"Norling","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.bcp.2019.03.003_b0315","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/A:1014837110735","article-title":"Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes","volume":"26","author":"Kolaczkowska","year":"2002","journal-title":"Inflammation"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219300899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219300899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T10:41:14Z","timestamp":1565174474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295219300899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":63,"alternative-id":["S0006295219300899"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2019.03.003","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel benzoxanthene lignans that favorably modulate lipid mediator biosynthesis: A promising pharmacological strategy for anti-inflammatory therapy","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2019.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}