{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:24:02Z","timestamp":1772825042470,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006387","name":"Fondation Leenaards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bcp.2019.08.007","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T19:41:02Z","timestamp":1565811662000},"page":"113605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Rare and common genetic variations in the Keap1\/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively"],"prefix":"10.1016","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0959-324X","authenticated-orcid":false,"given":"Antonela","family":"Matana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panos G.","family":"Ziros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-6067","authenticated-orcid":false,"given":"Dionysios V.","family":"Chartoumpekis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric O.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozren","family":"Pola\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatijana","family":"Zemunik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-4941","authenticated-orcid":false,"given":"Gerasimos P.","family":"Sykiotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcp.2019.08.007_b0005","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"issue":"24","key":"10.1016\/j.bcp.2019.08.007_b0010","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1128\/MCB.00389-16","article-title":"Absolute amounts and status of the Nrf2-Keap1-Cul3 complex within cells","volume":"36","author":"Iso","year":"2016","journal-title":"Mol. Cell. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2019.08.007_b0015","first-page":"S128","article-title":"Direct and indirect antioxidant properties of inducers of cytoprotective proteins","volume":"52","author":"Dinkova-Kostova","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.bcp.2019.08.007_b0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2019.08.007_b0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1158\/1940-6207.CAPR-11-0538","article-title":"Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora","volume":"5","author":"Fahey","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"issue":"18","key":"10.1016\/j.bcp.2019.08.007_b0030","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700965","article-title":"Isothiocyanates: translating the power of plants to people","volume":"62","author":"Palliyaguru","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"issue":"394","key":"10.1016\/j.bcp.2019.08.007_b0035","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4477","article-title":"Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes","volume":"9","author":"Axelsson","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.bcp.2019.08.007_b0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.bcp.2019.08.007_b0045","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1089\/thy.2018.0018","article-title":"NFE2-related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland","volume":"28","author":"Ziros","year":"2018","journal-title":"Thyroid"},{"issue":"4","key":"10.1016\/j.bcp.2019.08.007_b0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/nutrit\/nuv110","article-title":"Concentrations of thiocyanate and goitrin in human plasma, their precursor concentrations in brassica vegetables, and associated potential risk for hypothyroidism","volume":"74","author":"Felker","year":"2016","journal-title":"Nutr. Rev."},{"issue":"8","key":"10.1016\/j.bcp.2019.08.007_b0055","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1158\/1940-6207.CAPR-14-0103","article-title":"Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China","volume":"7","author":"Egner","year":"2014","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"10.1016\/j.bcp.2019.08.007_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2019.02.004","article-title":"Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial","volume":"126","author":"Chartoumpekis","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.bcp.2019.08.007_b0065","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1089\/thy.2018.0661","article-title":"Genetic variants in the ST6GAL1 gene are associated with thyroglobulin plasma level in healthy individuals","volume":"29","author":"Matana","year":"2019","journal-title":"Thyroid"},{"issue":"Pt. B","key":"10.1016\/j.bcp.2019.08.007_b0070","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.freeradbiomed.2015.06.012","article-title":"Functional polymorphisms in Nrf2: implications for human disease","volume":"88","author":"Cho","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2019.08.007_b0075","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.phrs.2018.10.003","article-title":"Association of single-nucleotide polymorphisms of the KEAP1 gene with the risk of various human diseases and its functional impact using in silico analysis","volume":"137","author":"Dhamodharan","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3325\/cmj.2009.50.4","article-title":"\u201c10001 Dalmatians:\u201d Croatia launches its national biobank","volume":"50","author":"Rudan","year":"2009","journal-title":"Croat. Med. J."},{"issue":"4","key":"10.1016\/j.bcp.2019.08.007_b0085","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1172\/JCI0214192","article-title":"Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice","volume":"109","author":"Pohlenz","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0090","first-page":"35","article-title":"Identification of a thyroid-specific and cAMP-responsive enhancer in the upstream sequences of the human thyroglobulin promoter","volume":"1307","author":"Berg","year":"1996","journal-title":"BBA"},{"issue":"2","key":"10.1016\/j.bcp.2019.08.007_b0095","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1016\/0303-7207(93)90162-D","article-title":"Human, bovine, canine and rat thyroglobulin promoter sequences display species-specific differences in an in vitro study","volume":"90","author":"Donda","year":"1993","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.bcp.2019.08.007_b0100","first-page":"3365","article-title":"One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes","volume":"7","author":"Fusco","year":"1987","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2019.08.007_b0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ab.2005.02.006","article-title":"A quantitative method for normalization of transfection efficiency using enhanced green fluorescent protein","volume":"342","author":"Dandekar","year":"2005","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.bcp.2019.08.007_b0110","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.compbiomed.2011.12.012","article-title":"BootstRatio: A web-based statistical analysis of fold-change in qPCR and RT-qPCR data using resampling methods","volume":"42","author":"Cleries","year":"2012","journal-title":"Comput. Biol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2019.08.007_b0115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1155\/2010\/143142","article-title":"Functional haplotypes in the promoter region of transcription factor Nrf2 in chronic obstructive pulmonary disease","volume":"28","author":"Hua","year":"2010","journal-title":"Dis. Markers"},{"issue":"7","key":"10.1016\/j.bcp.2019.08.007_b0120","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1158\/1078-0432.CCR-14-1887","article-title":"KEAP1 genetic polymorphisms associate with breast cancer risk and survival outcomes","volume":"21","author":"Hartikainen","year":"2015","journal-title":"Clin. Cancer Res."},{"issue":"20","key":"10.1016\/j.bcp.2019.08.007_b0125","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.7150\/jca.27052","article-title":"Variants in the 3'-untranslated region of CUL3 is associated with risk of esophageal squamous cell carcinoma","volume":"9","author":"Hu","year":"2018","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.taap.2009.08.028","article-title":"Targeting NRF2 signaling for cancer chemoprevention","volume":"244","author":"Kwak","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/j.seminoncol.2015.09.013","article-title":"Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane","volume":"43","author":"Yang","year":"2016","journal-title":"Semin. Oncol."},{"issue":"5","key":"10.1016\/j.bcp.2019.08.007_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065141","article-title":"Identification of a KEAP1 germline mutation in a family with multinodular goitre","volume":"8","author":"Teshiba","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2019.08.007_b0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fendo.2016.00131","article-title":"A novel germline mutation of KEAP1 (R483H) associated with a non-toxic multinodular goiter","volume":"7","author":"Nishihara","year":"2016","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bcp.2019.08.007_b0150","article-title":"The 100,000 genomes project","volume":"353","author":"Peplow","year":"2016","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.bcp.2019.08.007_b0155","doi-asserted-by":"crossref","first-page":"325","DOI":"10.7150\/ijms.14849","article-title":"Genetic polymorphisms of transcription factor NRF2 and of its host gene sulfiredoxin (SRXN1) are associated with cerebrovascular disease in a finnish cohort, the TAMRISK Study","volume":"13","author":"Kunnas","year":"2016","journal-title":"Int. J. Med. Sci."},{"issue":"82\u201383","key":"10.1016\/j.bcp.2019.08.007_b0160","first-page":"394","article-title":"Nrf2 gene promoter polymorphism is associated with ulcerative colitis in a Japanese population","volume":"55","author":"Arisawa","year":"2008","journal-title":"Hepatogastroenterology"},{"issue":"6","key":"10.1016\/j.bcp.2019.08.007_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.08.047","article-title":"Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma","volume":"126","author":"Shaheen","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bcp.2019.08.007_b0170","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2350-11-36","article-title":"Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson\u2019s disease","volume":"11","author":"von Otter","year":"2010","journal-title":"BMC Med. Genet."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2019.08.007_b0175","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/21678421.2013.839708","article-title":"Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis","volume":"15","author":"Bergstrom","year":"2014","journal-title":"Amyotroph Lateral Scler. Frontotemporal Degener."},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12687-011-0075-8","article-title":"Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population","volume":"3","author":"Ungvari","year":"2012","journal-title":"J. Commun. Genet."},{"key":"10.1016\/j.bcp.2019.08.007_b0185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1465-9921-10-73","article-title":"Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population","volume":"10","author":"Siedlinski","year":"2009","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.bcp.2019.08.007_b0190","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2133\/dmpk.22.212","article-title":"Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese","volume":"22","author":"Fukushima-Uesaka","year":"2007","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"7","key":"10.1016\/j.bcp.2019.08.007_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071333","article-title":"Pharmacogenomic variants may influence the urinary excretion of novel kidney injury biomarkers in patients receiving cisplatin","volume":"18","author":"Chang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2019.08.007_b0200","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.gene.2015.06.055","article-title":"Association of KEAP1 and NFE2L2 polymorphisms with temporal lobe epilepsy and drug resistant epilepsy","volume":"571","author":"Liu","year":"2015","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.bcp.2019.08.007_b0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127244","article-title":"Dietary intake of sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood","volume":"10","author":"Shirai","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bcp.2019.08.007_b0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mad.2009.12.007","article-title":"Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer\u2019s disease and age-related cataract","volume":"131","author":"von Otter","year":"2010","journal-title":"Mech. Ageing Dev."},{"issue":"10","key":"10.1016\/j.bcp.2019.08.007_b0215","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/0961203310367917","article-title":"The NRF2 gene variant,-653G\/A, is associated with nephritis in childhood-onset systemic lupus erythematosus","volume":"19","author":"Cordova","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.bcp.2019.08.007_b0220","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4020198","article-title":"Genetic variations and mRNA expression of NRF2 in Parkinson\u2019s disease","author":"Ran","year":"2017","journal-title":"Parkinsons Dis-Us"},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0225","first-page":"143","article-title":"The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis","volume":"19","author":"Arisawa","year":"2007","journal-title":"Int. J. Mol. Med."},{"issue":"82\u201383","key":"10.1016\/j.bcp.2019.08.007_b0230","first-page":"750","article-title":"Nrf2 gene promoter polymorphism and gastric carcinogenesis","volume":"55","author":"Arisawa","year":"2008","journal-title":"Hepatogastroenterology"},{"issue":"10","key":"10.1016\/j.bcp.2019.08.007_b0235","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1111\/jcmm.12874","article-title":"Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations","volume":"20","author":"Song","year":"2016","journal-title":"J. Cell Mol. Med."},{"issue":"7","key":"10.1016\/j.bcp.2019.08.007_b0240","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7150\/ijms.8590","article-title":"Polymorphism of Nrf2, an antioxidative gene, is associated with blood pressure and cardiovascular mortality in hemodialysis patients","volume":"11","author":"Shimoyama","year":"2014","journal-title":"Int. J. Med. Sci."},{"issue":"8","key":"10.1016\/j.bcp.2019.08.007_b0245","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/FPC.0b013e32835516e5","article-title":"Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans","volume":"22","author":"Marczak","year":"2012","journal-title":"Pharmacogenet. Genom."},{"issue":"11","key":"10.1016\/j.bcp.2019.08.007_b0250","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00109-012-0914-z","article-title":"Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans","volume":"90","author":"Yu","year":"2012","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0255","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/clpt.2010.241","article-title":"Effect of NFE2L2 genetic polymorphism on the association between oral estrogen therapy and the risk of venous thromboembolism in postmenopausal women","volume":"89","author":"Bouligand","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2019.08.007_b0260","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-015-0981-y","article-title":"Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis","volume":"19","author":"Acosta-Herrera","year":"2015","journal-title":"Crit. Care"},{"issue":"9","key":"10.1016\/j.bcp.2019.08.007_b0265","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1096\/fj.06-7759com","article-title":"Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury","volume":"21","author":"Marzec","year":"2007","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.bcp.2019.08.007_b0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051104","article-title":"Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study","volume":"7","author":"O'Mahony","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2019.08.007_b0275","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7367641","article-title":"Association of nuclear factor-erythroid 2-related factor 2, thioredoxin interacting protein, and heme oxygenase-1 gene polymorphisms with diabetes and obesity in mexican patients","author":"Jimenez-Osorio","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.bcp.2019.08.007_b0280","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/pr.2014.200","article-title":"Antioxidant response genes sequence variants and BPD susceptibility in VLBW infants","volume":"77","author":"Sampath","year":"2015","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0285","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.113.109389","article-title":"Cigarette smoking is associated with human semen quality in synergy with functional NRF2 polymorphisms","volume":"89","author":"Yu","year":"2013","journal-title":"Biol. Reprod."},{"issue":"9","key":"10.1016\/j.bcp.2019.08.007_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073794","article-title":"SNP (-617C > A) in ARE-Like Loci of the NRF2 Gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women","volume":"8","author":"Okano","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2019.08.007_b0295","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2350-12-97","article-title":"An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study","volume":"12","author":"Masuko","year":"2011","journal-title":"BMC Med. Genet."},{"issue":"12","key":"10.1016\/j.bcp.2019.08.007_b0300","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1152\/physiolgenomics.00178.2013","article-title":"NFE2L2 polymorphisms, mortality, and metabolism in the general population","volume":"46","author":"Figarska","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.bcp.2019.08.007_b0305","first-page":"181","article-title":"Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes","volume":"6","author":"Masuko","year":"2011","journal-title":"Int. J. Chronic. Obstr."},{"issue":"4","key":"10.1016\/j.bcp.2019.08.007_b0310","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/EDE.0b013e3182572563","article-title":"PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease the modifying effect of individual characteristics","volume":"23","author":"Canova","year":"2012","journal-title":"Epidemiology"},{"issue":"18","key":"10.1016\/j.bcp.2019.08.007_b0315","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3109\/14767058.2013.799648","article-title":"Association of SNPs in genes involved in folate metabolism with the risk of congenital heart disease","volume":"26","author":"Wang","year":"2013","journal-title":"J. Matern-Fetal Neo. M"},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0320","first-page":"298","article-title":"Association of NRF2 polymorphism with cholangiocarcinoma prognosis in Thai patients","volume":"15","author":"Khunluck","year":"2014","journal-title":"Asian Pac. J. Cancer P"},{"key":"10.1016\/j.bcp.2019.08.007_b0325","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2741\/4088","article-title":"Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD","volume":"18","author":"Synowiec","year":"2013","journal-title":"Front. Biosci-Landmrk"},{"issue":"5","key":"10.1016\/j.bcp.2019.08.007_b0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128030","article-title":"Comprehensive assessment of genetic sequence variants in the antioxidant \u2018master regulator' Nrf2 in idiopathic Parkinson\u2019s disease","volume":"10","author":"Todorovic","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2019.08.007_b0335","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41467-017-00932-7","article-title":"Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder","volume":"8","author":"Huppke","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2019.08.007_b0340","doi-asserted-by":"crossref","DOI":"10.1186\/s12890-018-0603-y","article-title":"RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs","volume":"18","author":"Yeo","year":"2018","journal-title":"BMC Pulm. Med."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219302953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219302953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:12:45Z","timestamp":1757769165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295219302953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":68,"alternative-id":["S0006295219302953"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2019.08.007","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rare and common genetic variations in the Keap1\/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels, respectively","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2019.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113605"}}