{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:15:26Z","timestamp":1778634926193,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1072113"],"award-info":[{"award-number":["APP1072113"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1136889"],"award-info":[{"award-number":["APP1136889"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010582","name":"National Computational Infrastructure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007622","name":"Australian Education International, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000995","name":"Australian National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.bcp.2019.113782","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T19:33:04Z","timestamp":1577215984000},"page":"113782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom"],"prefix":"10.1016","volume":"174","author":[{"given":"Karen","family":"Luna-Ramirez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agota","family":"Csoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanni K.Y.","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raveendra","family":"Anangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosby del Carmen","family":"Najera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourival D.","family":"Possani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyorgy","family":"Panyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio K.","family":"Finol-Urdaneta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/pr.57.4.10","article-title":"International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels","volume":"57","author":"Gutman","year":"2005","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.bcp.2019.113782_b0010","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0896-6273(95)90022-5","article-title":"Episodic ataxia results from voltage-dependent potassium channels with altered functions","volume":"15","author":"Adelman","year":"1995","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0015","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0896-6273(00)81018-1","article-title":"Deletion of the K(V)1.1 potassium channel causes epilepsy in mice","volume":"20","author":"Smart","year":"1998","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.bcp.2019.113782_b0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(02)00071-6","article-title":"Neurological disorders caused by inherited ion-channel mutations","volume":"1","author":"Kullmann","year":"2002","journal-title":"Lancet Neurol."},{"issue":"Pt 1","key":"10.1016\/j.bcp.2019.113782_b0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.2004.067421","article-title":"Reduced low-voltage activated K+ conductances and enhanced central excitability in a congenitally deaf (dn\/dn) mouse","volume":"559","author":"Leao","year":"2004","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2019.113782_b0030","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1152\/jn.00640.2006","article-title":"Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons","volume":"98","author":"Brew","year":"2007","journal-title":"J. Neurophysiol."},{"issue":"Pt 11","key":"10.1016\/j.bcp.2019.113782_b0035","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1113\/jphysiol.2010.188417","article-title":"Axon initial segment dysfunction in epilepsy","volume":"588","author":"Wimmer","year":"2010","journal-title":"J. Physiol."},{"issue":"10","key":"10.1016\/j.bcp.2019.113782_b0040","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/j.1460-9568.2011.07875.x","article-title":"The axon initial segment in nervous system disease and injury","volume":"34","author":"Buffington","year":"2011","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.bcp.2019.113782_b0045","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng1094-136","article-title":"Episodic ataxia\/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1","volume":"8","author":"Browne","year":"1994","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.bcp.2019.113782_b0050","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/cge.12542","article-title":"Ataxia and myoclonic epilepsy due to a heterozygous new mutation in KCNA2: proposal for a new channelopathy","volume":"87","author":"Pena","year":"2015","journal-title":"Clin. Genet."},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0055","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng.3239","article-title":"De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy","volume":"47","author":"Syrbe","year":"2015","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0060","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1111\/epi.13250","article-title":"Unexplained early onset epileptic encephalopathy: exome screening and phenotype expansion","volume":"57","author":"Allen","year":"2016","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0065","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ejpn.2016.03.011","article-title":"Severe early-onset epileptic encephalopathy due to mutations in the KCNA2 gene: expansion of the genotypic and phenotypic spectrum","volume":"20","author":"Hundallah","year":"2016","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"46","key":"10.1016\/j.bcp.2019.113782_b0070","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0605136103","article-title":"Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases","volume":"103","author":"Beeton","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.bcp.2019.113782_b0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/cei.12602","article-title":"Novel therapies for memory cells in autoimmune diseases","volume":"180","author":"Bhargava","year":"2015","journal-title":"Clin. Exp. Immunol."},{"issue":"11","key":"10.1016\/j.bcp.2019.113782_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24112045","article-title":"Diverse structural features of potassium channels characterized by scorpion toxins as molecular probes","volume":"24","author":"Zhao","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2019.113782_b0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuropharm.2017.07.002","article-title":"Venom-derived peptide inhibitors of voltage-gated potassium channels","volume":"127","author":"Norton","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2019.113782_b0090","doi-asserted-by":"crossref","first-page":"29431","DOI":"10.1038\/srep29431","article-title":"Mapping the interaction anatomy of BmP02 on Kv1.3 channel","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.bcp.2019.113782_b0095","doi-asserted-by":"crossref","first-page":"12321","DOI":"10.1074\/jbc.M111.329607","article-title":"New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing","volume":"287","author":"Saucedo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2019.113782_b0100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00594","article-title":"Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel","volume":"2","author":"Banerjee","year":"2013","journal-title":"Elife"},{"issue":"24","key":"10.1016\/j.bcp.2019.113782_b0105","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2174\/138161208785777441","article-title":"Animal toxins acting on voltage-gated potassium channels","volume":"14","author":"Mouhat","year":"2008","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0110","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1124\/mol.113.090183","article-title":"Structure, molecular modeling, and function of the novel potassium channel blocker urotoxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi","volume":"86","author":"Luna-Ramirez","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2019.113782_b0115","series-title":"Peptide Science 2003","article-title":"Synthesis and characterization of spinoxin, a novel peptide toxin from the Malaysian black scorpion","author":"Sugahara","year":"2003"},{"issue":"12","key":"10.1016\/j.bcp.2019.113782_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052965","article-title":"Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers","volume":"7","author":"Anangi","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bcp.2019.113782_b0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063865","article-title":"Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli","volume":"8","author":"Klint","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bcp.2019.113782_b0130","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3390\/md10071605","article-title":"Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3","volume":"10","author":"Anangi","year":"2012","journal-title":"Mar. Drugs"},{"issue":"14","key":"10.1016\/j.bcp.2019.113782_b0135","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1021\/ja00897a025","article-title":"Solid, phase peptide synthesis. I. the synthesis of a Tetrapeptide","volume":"85","author":"Merrifield","year":"1963","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"10.1016\/j.bcp.2019.113782_b0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nmeth0607-467","article-title":"An automated tool for maximum entropy reconstruction of biomolecular NMR spectra","volume":"4","author":"Mobli","year":"2007","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0145","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/prot.20449","article-title":"The CCPN data model for NMR spectroscopy: development of a software pipeline","volume":"59","author":"Vranken","year":"2005","journal-title":"Proteins"},{"issue":"3","key":"10.1016\/j.bcp.2019.113782_b0150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10858-013-9741-y","article-title":"Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks","volume":"56","author":"Shen","year":"2013","journal-title":"J. Biomol. NMR"},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0155","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10858-015-9924-9","article-title":"Combined automated NOE assignment and structure calculation with CYANA","volume":"62","author":"Guntert","year":"2015","journal-title":"J. Biomol. NMR"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2019.113782_b0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s002320010033","article-title":"Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24","volume":"179","author":"Peter","year":"2001","journal-title":"J. Membr. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0170","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1124\/mol.104.007187","article-title":"Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes","volume":"67","author":"Bagdany","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2019.113782_b0175","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.bcp.2008.08.018","article-title":"A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus","volume":"76","author":"Corzo","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2019.113782_b0180","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein-protein docking approach based on biochemical or biophysical information","volume":"125","author":"Dominguez","year":"2003","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.bcp.2019.113782_b0185","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in empirical pKa predictions","volume":"7","author":"Olsson","year":"2011","journal-title":"J. Chem. Theory Comput."},{"issue":"2","key":"10.1016\/j.bcp.2019.113782_b0190","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/toxins4020110","article-title":"Developing a comparative docking protocol for the prediction of peptide selectivity profiles: investigation of potassium channel toxins","volume":"4","author":"Chen","year":"2012","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.bcp.2019.113782_b0195","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi0506s15","article-title":"Comparative protein structure modeling using modeller","author":"Eswar","year":"2006","journal-title":"Curr. Protoc. Bioinformatics"},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0200","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0205","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0006-3495(93)81200-1","article-title":"Mechanism of charybdotoxin block of a voltage-gated K+ channel","volume":"65","author":"Goldstein","year":"1993","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1085\/jgp.114.1.141","article-title":"A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels","volume":"114","author":"Garcia","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.bcp.2019.113782_b0215","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jmgm.2018.11.012","article-title":"Molecular basis of Tityus stigmurus alpha toxin and potassium channel kV1.2 interactions","volume":"87","author":"Freire","year":"2019","journal-title":"J. Mol. Graph Model"},{"issue":"8","key":"10.1016\/j.bcp.2019.113782_b0220","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.toxicon.2004.03.024","article-title":"Toxin determinants required for interaction with voltage-gated K+ channels","volume":"43","author":"Jouirou","year":"2004","journal-title":"Toxicon"},{"issue":"34","key":"10.1016\/j.bcp.2019.113782_b0225","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1021\/bi00149a002","article-title":"Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin","volume":"31","author":"Park","year":"1992","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.bcp.2019.113782_b0230","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1073\/pnas.1813161116","article-title":"Conotoxin kappaM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels","volume":"116","author":"Cordeiro","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"10","key":"10.1016\/j.bcp.2019.113782_b0235","article-title":"Structural basis of the selective block of Kv1.2 by maurotoxin from computer simulations","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0240","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00235395","article-title":"Quaternary ammonium ion blockade of IK in nerve axons revisited. Open channel block vs. state independent block","volume":"147","author":"Clay","year":"1995","journal-title":"J. Membr. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0245","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41597-019-0074-x","article-title":"Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels","volume":"6","author":"Tabakmakher","year":"2019","journal-title":"Sci. Data"},{"issue":"20","key":"10.1016\/j.bcp.2019.113782_b0250","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/anie.200250684","article-title":"A conformational flexibility scale for amino acids in peptides","volume":"42","author":"Huang","year":"2003","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"6","key":"10.1016\/j.bcp.2019.113782_b0255","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0141-0229(94)90014-0","article-title":"C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity","volume":"16","author":"Merkler","year":"1994","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/j.bcp.2019.113782_b0260","series-title":"Reference Module in Biomedical Sciences","article-title":"Amidation\u2606","author":"Kumar","year":"2014"},{"key":"10.1016\/j.bcp.2019.113782_b0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxicon.2014.02.010","article-title":"Functional and structural study comparing the C-terminal amidated beta-neurotoxin Ts1 with its isoform Ts1-G isolated from Tityus serrulatus venom","volume":"83","author":"Coelho","year":"2014","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.bcp.2019.113782_b0270","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.peptides.2010.11.001","article-title":"Addition of positive charges at the C-terminal peptide region of CssII, a mammalian scorpion peptide toxin, improves its affinity for sodium channels Nav1.6","volume":"32","author":"Estrada","year":"2011","journal-title":"Peptides"},{"issue":"7","key":"10.1016\/j.bcp.2019.113782_b0275","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11070425","article-title":"The dual alpha-amidation system in scorpion venom glands","volume":"11","author":"Delgado-Prudencio","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"4","key":"10.1016\/j.bcp.2019.113782_b0280","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/mol.111.073460","article-title":"Interactions of key charged residues contributing to selective block of neuronal sodium channels by mu-conotoxin KIIIA","volume":"80","author":"McArthur","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2019.113782_b0285","series-title":"Three-Dimensional Solution Structure of Spinoxin, a Potassium Channel Blocker","author":"Kobayashi","year":"2005"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219304812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295219304812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:48:12Z","timestamp":1778633292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295219304812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":57,"alternative-id":["S0006295219304812"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2019.113782","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2019.113782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113782"}}