{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T09:31:27Z","timestamp":1775381487926,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Qing Lan Project of Jiangsu Province"},{"name":"Fundamental Research Funds","award":["KYCX17_1731"],"award-info":[{"award-number":["KYCX17_1731"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.bcp.2020.113849","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T05:36:54Z","timestamp":1581485814000},"page":"113849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Thrombin\/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes"],"prefix":"10.1016","volume":"175","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuang-Zhuang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Fen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng-Fei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Wu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.bcp.2020.113849_b0005","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"Group","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.bcp.2020.113849_b0010","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1515\/jpem-2001-0803","article-title":"Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility","volume":"14","author":"Dabelea","year":"2001","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"9677","key":"10.1016\/j.bcp.2020.113849_b0015","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60731-5","article-title":"Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis","volume":"373","author":"Bellamy","year":"2009","journal-title":"Lancet"},{"issue":"Suppl 2","key":"10.1016\/j.bcp.2020.113849_b0020","doi-asserted-by":"crossref","first-page":"ii75","DOI":"10.1093\/bja\/aev374","article-title":"Disorders of coagulation in pregnancy","volume":"115","author":"Katz","year":"2015","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"10.1016\/j.bcp.2020.113849_b0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12933-018-0783-z","article-title":"Platelet activity and hypercoagulation in type 2 diabetes","volume":"17","author":"Pretorius","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"issue":"2","key":"10.1016\/j.bcp.2020.113849_b0030","first-page":"83","article-title":"Hemostasis and levels of cytoadhesion molecules in gestational diabetes","volume":"64","author":"Bendl","year":"1999","journal-title":"Ceska Gynekol."},{"issue":"4","key":"10.1016\/j.bcp.2020.113849_b0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/09513590.2010.501884","article-title":"Sevgili, Levels of thrombin activatable fibrinolysis inhibitor in gestational diabetes mellitus","volume":"29","author":"Gumus","year":"2013","journal-title":"Gynecol. Endocrinol."},{"issue":"6801","key":"10.1016\/j.bcp.2020.113849_b0040","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/35025229","article-title":"Thrombin signalling and protease-activated receptors","volume":"407","author":"Coughlin","year":"2000","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2020.113849_b0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/1479164118779924","article-title":"Biomarkers of vascular injury and endothelial dysfunction after recent glucose intolerance in pregnancy","volume":"15","author":"Bajaj","year":"2018","journal-title":"Diab. Vasc. Dis. Res."},{"issue":"1","key":"10.1016\/j.bcp.2020.113849_b0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1067\/mob.2002.119111","article-title":"Impaired vascular reactivity in pregnant women with insulin-dependent diabetes mellitus","volume":"186","author":"Savvidou","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.bcp.2020.113849_b0055","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2015.04.006","article-title":"Inflammation in maternal obesity and gestational diabetes mellitus","volume":"36","author":"Pantham","year":"2015","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.bcp.2020.113849_b0060","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1309\/LMF8R2KSTOW3FLKD","article-title":"Associations between inflammatory markers, hemostatic markers, and microvascular complications in 182 chinese patients with Type 2 diabetes mellitus","volume":"46","author":"Zheng","year":"2015","journal-title":"Lab Med."},{"issue":"12","key":"10.1016\/j.bcp.2020.113849_b0065","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1161\/01.ATV.19.12.3014","article-title":"Altered vascular injury responses in mice deficient in protease-activated receptor-1","volume":"19","author":"Cheung","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.bcp.2020.113849_b0070","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1055\/s-0038-1655767","article-title":"Inhibition of protease-activated receptor (PAR1) reduces activation of the endothelium, coagulation, fibrinolysis and inflammation during human endotoxemia","volume":"118","author":"Schoergenhofer","year":"2018","journal-title":"Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.bcp.2020.113849_b0075","doi-asserted-by":"crossref","first-page":"E982","DOI":"10.1073\/pnas.1718600115","article-title":"PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury","volume":"115","author":"De Ceunynck","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2020.113849_b0080","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1475-2840-13-60","article-title":"Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression","volume":"13","author":"Ishibashi","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"issue":"53","key":"10.1016\/j.bcp.2020.113849_b0085","doi-asserted-by":"crossref","first-page":"41432","DOI":"10.1074\/jbc.M110.158949","article-title":"Thrombin-dependent NF-{kappa}B activation and monocyte\/endothelial adhesion are mediated by the CARMA3.Bcl10.MALT1 signalosome","volume":"285","author":"Delekta","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2020.113849_b0090","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jcb.20533","article-title":"PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism","volume":"96","author":"Tantivejkul","year":"2005","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2020.113849_b0095","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12974-017-0901-y","article-title":"Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1beta","volume":"14","author":"Lee","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bcp.2020.113849_b0100","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molimm.2019.01.006","article-title":"Anagliptin ameliorates high glucose-induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1","volume":"107","author":"Jiang","year":"2019","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2020.113849_b0105","first-page":"340","article-title":"Effect of timosaponin AIII on formation of thrombus","volume":"30","author":"Su-Yan Li","year":"2006","journal-title":"Bull. Acad. Mil. Med. Sci."},{"issue":"7","key":"10.1016\/j.bcp.2020.113849_b0110","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1440-1681.2011.05530.x","article-title":"Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides","volume":"38","author":"Lu","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"10","key":"10.1016\/j.bcp.2020.113849_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23102631","article-title":"Anti-inflammatory activities of compounds isolated from the rhizome of Anemarrhena asphodeloides","volume":"23","author":"Wang","year":"2018","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.bcp.2020.113849_b0120","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s12272-009-1916-4","article-title":"Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells","volume":"32","author":"Lu","year":"2009","journal-title":"Arch. Pharm. Res."},{"issue":"7","key":"10.1016\/j.bcp.2020.113849_b0125","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.fct.2009.04.009","article-title":"Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways","volume":"47","author":"Kim","year":"2009","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2020.113849_b0130","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.intimp.2015.02.016","article-title":"Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-kappaB and MAPK activation and restoring Th17\/Treg cell balance","volume":"25","author":"Lim","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2020.113849_b0135","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ptr.6088","article-title":"Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats","volume":"32","author":"Liu","year":"2018","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.bcp.2020.113849_b0140","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bcp.2020.113849_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104320","article-title":"Quercetin inhibited mesangial cell proliferation of early diabetic nephropathy through the Hippo pathway","volume":"146","author":"Lei","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2020.113849_b0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/15376516.2016.1172691","article-title":"Thrombin-induced apoptosis in neurons through activation of c-Jun-N-terminal kinase","volume":"27","author":"Bao","year":"2017","journal-title":"Toxicol. Mech. Methods"},{"issue":"3","key":"10.1016\/j.bcp.2020.113849_b0155","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s12031-013-0072-y","article-title":"Quantitative detection of thrombin activity in an ischemic stroke model","volume":"51","author":"Bushi","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bcp.2020.113849_b0160","article-title":"A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1\/Nrf2 signaling","author":"Du","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bcp.2020.113849_b0165","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.3389\/fimmu.2018.01900","article-title":"Inflammasomes in tissue damages and immune disorders after trauma","volume":"9","author":"Bortolotti","year":"2018","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.bcp.2020.113849_b0170","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/hc0702.104183","article-title":"Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses","volume":"105","author":"Basta","year":"2002","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.bcp.2020.113849_b0175","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00592-019-01304-x","article-title":"Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1-RAGE and VIP-VPAC2 pathways in human gestational diabetes mellitus","volume":"56","author":"Santangelo","year":"2019","journal-title":"Acta Diabetol."},{"issue":"2","key":"10.1016\/j.bcp.2020.113849_b0180","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12013-014-0233-9","article-title":"Protective effect of sRAGE on fetal development in pregnant rats with gestational diabetes mellitus","volume":"71","author":"Tang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2020.113849_b0185","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11010-019-03503-0","article-title":"Hyperglycaemia cause vascular inflammation through advanced glycation end products\/early growth response-1 axis in gestational diabetes mellitus","volume":"456","author":"Rajaraman","year":"2019","journal-title":"Mol. Cell. Biochem."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220300708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220300708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:10:41Z","timestamp":1757769041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220300708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":37,"alternative-id":["S0006295220300708"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113849","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombin\/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113849"}}