{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:10:17Z","timestamp":1776060617495,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bcp.2020.113948","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:19:25Z","timestamp":1585945165000},"page":"113948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes"],"prefix":"10.1016","volume":"177","author":[{"given":"Sureshbabu","family":"Mangali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audesh","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirtikumar","family":"Jadhav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaspreet","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmarajan","family":"Sriram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata","family":"Vamsi Krishna Venuganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arti","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2020.113948_b0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bcp.2020.113948_b0010","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/CS20080500","article-title":"Diabetic cardiomyopathy","volume":"116","author":"Asghar","year":"2009","journal-title":"Clin. Sci. (Lond.)"},{"issue":"8","key":"10.1016\/j.bcp.2020.113948_b0015","article-title":"Diabetic cardiomyopathy","volume":"11","author":"Acar","year":"2011","journal-title":"Anatolian J. Cardiol.\/Anadolu Kardiyoloji Dergisi"},{"key":"10.1016\/j.bcp.2020.113948_b0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10741-012-9313-3","article-title":"Diabetic cardiomyopathy: pathophysiology and clinical features","volume":"18","author":"Miki","year":"2013","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.bcp.2020.113948_b0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s00059-011-3429-4","article-title":"Diabetic cardiomyopathy\u2014fact or fiction","volume":"36","author":"Maisch","year":"2011","journal-title":"Herz."},{"key":"10.1016\/j.bcp.2020.113948_b0030","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","article-title":"Nutrient sensing and inflammation in metabolic diseases","volume":"8","author":"Hotamisligil","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2020.113948_b0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11897-013-0133-0","article-title":"Cardiac lipotoxicity: molecular pathways and therapeutic implications","volume":"10","author":"Drosatos","year":"2013","journal-title":"Curr. Heart Fail. Rep."},{"issue":"50","key":"10.1016\/j.bcp.2020.113948_b0040","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1021\/bi101923r","article-title":"Molecular mechanism by which palmitate inhibits PKR autophosphorylation","volume":"15","author":"Cho","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2020.113948_b0045","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1002\/jcb.27643","article-title":"Inhibition of protein kinase R protects against palmitic acid\u2013induced inflammation, oxidative stress, and apoptosis through the JNK\/NF-kB\/NLRP3 pathway in cultured H9C2 cardiomyocytes","volume":"120","author":"Mangali","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2020.113948_b0050","doi-asserted-by":"crossref","first-page":"38753","DOI":"10.1038\/srep38753","article-title":"Inhibition of PKR protects against H 2 O 2-induced injury on neonatal cardiac myocytes by attenuating apoptosis and inflammation","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep."},{"key":"10.1016\/j.bcp.2020.113948_b0055","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/CIRCULATIONAHA.113.002209","article-title":"Double-stranded RNA\u2013dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure","volume":"129","author":"Wang","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2020.113948_b0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000441727","article-title":"The small molecule indirubin-3'-oxime inhibits protein kinase R: antiapoptotic and antioxidant effect in rat cardiac myocytes","volume":"97","author":"Udumula","year":"2016","journal-title":"Pharmacology"},{"key":"10.1016\/j.bcp.2020.113948_b0065","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bcp.2020.113948_b0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1358\/mf.2004.26.5.831322","article-title":"Reversal of glucose intolerance by pioglitazone in high fat diet-fed rats","volume":"26","author":"Srinivasan","year":"2004","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.bcp.2020.113948_b0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.phrs.2015.01.001","article-title":"Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model","volume":"93","author":"Liu","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2020.113948_b0080","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1016\/j.febslet.2007.08.022","article-title":"The oxindole\/imidazole derivative C16 reduces in vivo brain PKR activation","volume":"581","author":"Ingrand","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2020.113948_b0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bcp.2020.113948_b0090","doi-asserted-by":"crossref","unstructured":"J. Kalra, S. Mangali, A. Bhat, K. Jadhav, A. Dhar, Selective inhibition of PKR improves vascular inflammation and remodelling in high fructose treated primary vascular smooth muscle cells. Biochim. Biophys. Acta Mol. Basis Dis. Nov 15:165606. doi: 10.1016\/j.bbadis.2019.165606.","DOI":"10.1016\/j.bbadis.2019.165606"},{"key":"10.1016\/j.bcp.2020.113948_b0095","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.2337\/diabetes.50.9.2105","article-title":"Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes","volume":"50","author":"Dyntar","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2020.113948_b0100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12944-015-0123-1","article-title":"The role of fatty acids in insulin resistance","volume":"2914","author":"Sears","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bcp.2020.113948_b0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.lfs.2018.07.055","article-title":"Pharmacological evaluation of novel PKR inhibitor indirubin-3-hydrazone in-vitro in cardiac myocytes and in-vivo in wistar rats","volume":"209","author":"Udumula","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2020.113948_b0110","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.celrep.2015.03.021","article-title":"A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2\u03b1 phosphorylation in obesity","volume":"11","author":"Nakamura","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2020.113948_b0115","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"29","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2020.113948_b0120","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/jdi.12250","article-title":"Diabetic cardiomyopathy and its mechanisms: role of oxidative stress and damage","volume":"5","author":"Liu","year":"2014","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.bcp.2020.113948_b0125","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jacc.2010.07.033","article-title":"Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy","volume":"56","author":"Rajesh","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2020.113948_b0130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12020-012-9633-z","article-title":"Mitochondrial reactive oxygen species (ROS) inhibition ameliorates palmitate-induced INS-1 beta cell death","volume":"42","author":"Lin","year":"2012","journal-title":"Endocrine"},{"issue":"22","key":"10.1016\/j.bcp.2020.113948_b0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12929-015-0211-6","article-title":"High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats","volume":"24","author":"Yida","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bcp.2020.113948_b0140","doi-asserted-by":"crossref","first-page":"H656","DOI":"10.1152\/ajpheart.00726.2001","article-title":"Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS","volume":"282","author":"Hickson-Bick","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2020.113948_b0145","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1432-1327.1999.00255.x","article-title":"Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA","volume":"260","author":"Klotz","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2020.113948_b0150","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/ATVBAHA.109.188813","article-title":"Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation","volume":"29","author":"Maloney","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2020.113948_b0155","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3892\/ijo.2014.2252","article-title":"ROS-mediated JNK\/p38-MAPK activation regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells","volume":"44","author":"Park","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bcp.2020.113948_b0160","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.lfs.2013.01.003","article-title":"Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts","volume":"92","author":"Fowlkes","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2020.113948_b0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0531-5565(98)00015-1","article-title":"Effect of high-glucose concentrations on the expression of collagens and fibronectin by fibroblasts in culture","volume":"33","author":"Benazzoug","year":"1998","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bcp.2020.113948_b0170","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/j.1523-1755.2004.66004.x","article-title":"AGEs activate mesangial TGF-\u03b2\u2013Smad signaling via an angiotensin II type I receptor interaction","volume":"66","author":"Fukami","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.bcp.2020.113948_b0175","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06320.x","article-title":"Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications","volume":"1243","author":"Ramasamy","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bcp.2020.113948_b0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12013-012-9501-8","article-title":"Cell hypertrophy and MEK\/ERK phosphorylation are regulated by glyceraldehyde-derived AGEs in cardiomyocyte H9c2 cells","volume":"66","author":"Ko","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bcp.2020.113948_b0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.freeradbiomed.2015.11.013","article-title":"Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy","volume":"90","author":"Ni","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2020.113948_b0190","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/JME-12-0194","article-title":"IGFBP5 mediates high glucose-induced cardiac fibroblast activation","volume":"50","author":"Song","year":"2013","journal-title":"J. Mol. Endocrinol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220301763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220301763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:14:53Z","timestamp":1757769293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220301763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":38,"alternative-id":["S0006295220301763"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113948","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113948"}}