{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:44:58Z","timestamp":1777477498643,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-NEU\/114800\/2009"],"award-info":[{"award-number":["PTDC\/SAU-NEU\/114800\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi\/00709\/2013"],"award-info":[{"award-number":["UID\/Multi\/00709\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi\/04326\/2013"],"award-info":[{"award-number":["UID\/Multi\/04326\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID \/ Multi \/ 00709\/2019"],"award-info":[{"award-number":["UID \/ Multi \/ 00709\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000019"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000019"]}],"id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014717","name":"Programa Operacional Regional do Centro","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000013"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000013"]}],"id":[{"id":"10.13039\/501100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014717","name":"Programa Operacional Regional do Centro","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007491"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007491"]}],"id":[{"id":"10.13039\/501100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bcp.2020.113953","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T19:43:37Z","timestamp":1586202217000},"page":"113953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier"],"prefix":"10.1016","volume":"177","author":[{"given":"Ana C.","family":"Duarte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago","family":"Rosado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eug\u00e9nia","family":"Gallardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telma","family":"Quintela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schwerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Schroten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia R.A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2020.113953_b0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.pharmtox.47.120505.105237","article-title":"Drug targeting to the brain","author":"de Boer","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2020.113953_b0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-018-1807-1","article-title":"Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease","volume":"135","author":"Ghersi-Egea","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bcp.2020.113953_b0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yfrne.2016.12.002","article-title":"The choroid plexus as a sex hormone target: Functional implications","volume":"44","author":"Santos","year":"2017","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bcp.2020.113953_b0020","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.2174\/1381612822666160726112115","article-title":"Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier","volume":"22","author":"Strazielle","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bcp.2020.113953_b0025","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1007\/s11095-015-1679-1","article-title":"Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier","volume":"32","author":"Bernd","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bcp.2020.113953_b0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/cne.21808","article-title":"Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces","volume":"510","author":"Gazzin","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bcp.2020.113953_b0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.canlet.2015.10.010","article-title":"Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade","volume":"370","author":"Chen","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2020.113953_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122544","article-title":"Obstacles to brain tumor therapy: Key ABC transporters","volume":"18","author":"Wijaya","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2020.113953_b0045","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)80705-9","article-title":"A novel family of mammalian taste receptors","volume":"100","author":"Adler","year":"2000","journal-title":"Cell."},{"key":"10.1016\/j.bcp.2020.113953_b0050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell."},{"key":"10.1016\/j.bcp.2020.113953_b0055","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature05401","article-title":"The receptors and cells for mammalian taste","volume":"444","author":"Chandrashekar","year":"2006","journal-title":"Nature."},{"key":"10.1016\/j.bcp.2020.113953_b0060","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"Chaudhari","year":"2010","journal-title":"J. Cell Biol."},{"issue":"5944","key":"10.1016\/j.bcp.2020.113953_b0065","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1126\/science.1173869","article-title":"Motile cilia of human airway epithelia are chemosensory","volume":"325","author":"Shah","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bcp.2020.113953_b0070","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1074\/jbc.M116.771949","article-title":"Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor","volume":"292","author":"Hariri","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2020.113953_b0075","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1096\/fj.201801661RR","article-title":"Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2020.113953_b0080","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1073\/pnas.1812901116","article-title":"Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells","volume":"116","author":"Luo","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bcp.2020.113953_b0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/BJ20110009","article-title":"Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK","volume":"438","author":"Jeon","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2020.113953_b0090","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1073\/pnas.042617699","article-title":"Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells","volume":"99","author":"Wu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2020.113953_b0095","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bbrc.2015.01.089","article-title":"Expression of bitter taste receptor Tas2r105 in mouse kidney","volume":"458","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2020.113953_b0100","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11010-016-2929-1","article-title":"Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells","volume":"428","author":"Liang","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2020.113953_b0105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/molehr\/gas005","article-title":"Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice","volume":"18","author":"Li","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bcp.2020.113953_b0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/molehr\/gas040","article-title":"Functional characterization of bitter-taste receptors expressed in mammalian testis","volume":"19","author":"Xu","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.bcp.2020.113953_b0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000367631","article-title":"Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes","volume":"28","author":"W\u00f6lfle","year":"2015","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.bcp.2020.113953_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0205322","article-title":"Personalized expression of bitter \u201ctaste\u201d receptors in human skin","volume":"13","author":"Shaw","year":"2018","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.113953_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.07.012.2009","article-title":"Sweet taste signaling functions as a hypothalamic glucose sensor","volume":"3","author":"Ren","year":"2009","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.bcp.2020.113953_b0130","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuroscience.2016.01.057","article-title":"\u201cTasting\u201d the cerebrospinal fluid: Another function of the choroid plexus?","volume":"320","author":"Tom\u00e1s","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.bcp.2020.113953_b0135","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41573-018-0002-3","article-title":"Therapeutic potential of ectopic olfactory and taste receptors","volume":"18","author":"Lee","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2020.113953_b0140","doi-asserted-by":"crossref","first-page":"D1179","DOI":"10.1093\/nar\/gky974","article-title":"Bitterdb: Taste ligands and receptors database in 2019","volume":"47","author":"Dagan-Wiener","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2020.113953_b0145","doi-asserted-by":"crossref","first-page":"D413","DOI":"10.1093\/nar\/gkr755","article-title":"BitterDB: a database of bitter compounds","volume":"40","author":"Wiener","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2020.113953_b0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-018-3464-z","article-title":"Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival","volume":"454","author":"Martin","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2020.113953_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1465-9921-14-134","article-title":"The expression and relaxant effect of bitter taste receptors in human bronchi","volume":"14","author":"Grassin-Delyle","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.bcp.2020.113953_b0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11010-016-2902-z","article-title":"Analysis of the expression of human bitter taste receptors in extraoral tissues","volume":"426","author":"Jaggupilli","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2020.113953_b0165","article-title":"Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier","author":"Duarte","year":"2020","journal-title":"Biochem. Pharmacol. in press"},{"key":"10.1016\/j.bcp.2020.113953_b0170","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1749-0774.2005.tb00059.x","article-title":"Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP)","volume":"18","author":"Ishiwata","year":"2005","journal-title":"Hum Cell."},{"key":"10.1016\/j.bcp.2020.113953_b0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030069","article-title":"Polar invasion and translocation of neisseria meningitidis and streptococcus suis in a novel human model of the blood-cerebrospinal fluid barrier","volume":"7","author":"Schwerk","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.113953_b0180","series-title":"Experimental Tools to Study the Regulation and Function of the Choroid Plexus., in: Barichello T. Blood-Brain Barrier","author":"Gon\u00e7alves","year":"2018"},{"key":"10.1016\/j.bcp.2020.113953_b0185","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2020.113953_b0190","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1021\/jf403387p","article-title":"Bitter taste receptor activation by flavonoids and isoflavonoids: Modeled structural requirements for activation of hTAS2R14 and hTAS2R39","volume":"61","author":"Roland","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2020.113953_b0195","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1016\/j.bmc.2015.04.025","article-title":"Promiscuity and selectivity of bitter molecules and their receptors","volume":"23","author":"Di Pizio","year":"2015","journal-title":"Bioorganic Med. Chem."},{"key":"10.1016\/j.bcp.2020.113953_b0200","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biocel.2016.03.005","article-title":"Bitter taste receptors: Novel insights into the biochemistry and pharmacology","volume":"77","author":"Jaggupilli","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bcp.2020.113953_b0205","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/chemse\/bjp092","article-title":"The molecular receptive ranges of human TAS2R bitter taste receptors","volume":"35","author":"Meyerhof","year":"2009","journal-title":"Chem. Senses."},{"key":"10.1016\/j.bcp.2020.113953_b0210","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbr.2019.03.043","article-title":"Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice","volume":"367","author":"Liu","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.bcp.2020.113953_b0215","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1080\/10408398.2016.1263597","article-title":"Resveratrol as an anti-cancer agent: A review","volume":"58","author":"Butt","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bcp.2020.113953_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2018.00373","article-title":"Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation","volume":"12","author":"Hornedo-Ortega","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bcp.2020.113953_b0225","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4619865","article-title":"Resveratrol enhances apoptotic and oxidant effects of paclitaxel through TRPM2 channel activation in DBTRG glioblastoma cells","volume":"2019","author":"\u00d6zt\u00fcrk","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2020.113953_b0230","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0891-5849(02)00911-5","article-title":"Inhibition of cancer growth by resveratrol is related to its low bioavailability","volume":"33","author":"Asensi","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2020.113953_b0235","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0006-8993(02)03543-6","article-title":"Resveratrol protects against global cerebral ischemic injury in gerbils","volume":"958","author":"Wang","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2020.113953_b0240","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology."},{"key":"10.1016\/j.bcp.2020.113953_b0245","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s13311-014-0334-6","article-title":"Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications","volume":"12","author":"Shu","year":"2015","journal-title":"Neurotherapeutics."},{"key":"10.1016\/j.bcp.2020.113953_b0250","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/jpet.106.102319","article-title":"Specific Plasma Membrane Binding Sites for Polyphenols, Including Resveratrol, in the Rat Brain","volume":"318","author":"Han","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2020.113953_b0255","doi-asserted-by":"crossref","first-page":"17154","DOI":"10.3390\/molecules191117154","article-title":"Enhancing the delivery of resveratrol in humans: If low bioavailability is the problem, what is the solution?","volume":"19","author":"Smoliga","year":"2014","journal-title":"Molecules."},{"key":"10.1016\/j.bcp.2020.113953_b0260","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/mol.106.028167","article-title":"The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models","volume":"71","author":"Breedveld","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2020.113953_b0265","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1021\/jf9042858","article-title":"Involvement of breast cancer resistance protein (BCRP1\/ABCG2) in the bioavailability and tissue distribution of trans- resveratrol in knockout mice","volume":"58","author":"Alfaras","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2020.113953_b0270","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3945\/jn.109.114959","article-title":"Multidrug Resistance Proteins Restrain the Intestinal Absorption of trans-Resveratrol in Rats","volume":"140","author":"Juan","year":"2010","journal-title":"J. Nutr."},{"key":"10.1016\/j.bcp.2020.113953_b0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.abb.2012.06.004","article-title":"The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters","volume":"527","author":"Planas","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2020.113953_b0280","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/fcp.12205","article-title":"Protective mechanisms of resveratrol against methotrexate-induced renal damage may involve BCRP\/ABCG2","volume":"30","author":"El-Sheikh","year":"2016","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bcp.2020.113953_b0285","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.addr.2016.09.004","article-title":"The effects of dietary and herbal phytochemicals on drug transporters","volume":"116","author":"Li","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bcp.2020.113953_b0290","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phymed.2018.06.046","article-title":"Resveratrol mediated cancer cell apoptosis, and modulation of multidrug resistance proteins and metabolic enzymes","volume":"55","author":"El-Readi","year":"2019","journal-title":"Phytomedicine."},{"key":"10.1016\/j.bcp.2020.113953_b0295","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ijpharm.2015.09.042","article-title":"Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro","volume":"495","author":"Jia","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2020.113953_b0300","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.taap.2016.06.030","article-title":"P-gp, MRP2 and OAT1\/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate","volume":"306","author":"Jia","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2020.113953_b0305","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3892\/etm.2014.1662","article-title":"Resveratrol reverses multidrug resistance in human breast cancer doxorubicin-resistant cells","volume":"7","author":"Huang","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bcp.2020.113953_b0310","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbrc.2004.03.040","article-title":"Interaction of the breast cancer resistance protein with plant polyphenols","volume":"317","author":"Cooray","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2020.113953_b0315","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.3892\/ol.2016.5136","article-title":"Resveratrol reverses P-glycoprotein-mediated multidrug resistance of U2OS\/ADR cells by suppressing the activation of the NF-\u03baB and p38 MAPK signaling pathways","volume":"12","author":"Zhang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bcp.2020.113953_b0320","doi-asserted-by":"crossref","unstructured":"A. Basseville, M.D. Hall, C.H. Chau, R.W. Robey, M. Gottesman, W.D. Figg, S.E. Bates, The ABCG2 Multidrug Transporter, in: G. A. (Ed.), ABC Transp. - 40 Years, Springer, Cham, 2016: pp. 195\u2013226. doi:10.1007\/978-3-319-23476-2.","DOI":"10.1007\/978-3-319-23476-2_9"},{"key":"10.1016\/j.bcp.2020.113953_b0325","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1097\/00001756-200211150-00014","article-title":"Localisation of breast cancer resistance protein in microvessel endothelium of human brain","volume":"13","author":"Cooray","year":"2002","journal-title":"Neuroreport."},{"key":"10.1016\/j.bcp.2020.113953_b0330","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/mol.111.072421","article-title":"The Antiepileptic Drugs Phenobarbital and Carbamazepine Reduce Transport of Methotrexate in Rat Choroid Plexus by Down-Regulation of the Reduced Folate Carrier","volume":"80","author":"Halwachs","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2020.113953_b0335","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuroscience.2008.06.015","article-title":"Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation","volume":"155","author":"Roberts","year":"2008","journal-title":"Neuroscience."},{"key":"10.1016\/j.bcp.2020.113953_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.00354","article-title":"Neurosteroid transport in the brain: Role of ABC and SLC transporters","volume":"9","author":"Grube","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2020.113953_b0345","doi-asserted-by":"crossref","unstructured":"J. Hofrichter, M. Krohn, T. Schumacher, C. Lange, B. Feistel, B. Walbroel, H.-J. Heinze, S. Crockett, T.F. Sharbel, J. Pahnke, Reduced Alzheimer\u2019s disease pathology by St. John\u2019s wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice, Curr Alzheimer Res. 10 (2013) 1057\u20131069. doi:10.2174\/15672050113106660171.","DOI":"10.2174\/15672050113106660171"},{"key":"10.1016\/j.bcp.2020.113953_b0350","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1172\/JCI57867","article-title":"Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice","volume":"121","author":"Krohn","year":"2011","journal-title":"J Clin Invest."},{"key":"10.1016\/j.bcp.2020.113953_b0355","doi-asserted-by":"crossref","first-page":"7612","DOI":"10.1128\/MCB.24.17.7612-7621.2004","article-title":"Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy","volume":"24","author":"Leggas","year":"2004","journal-title":"Mol. Cell. Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220301817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220301817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:58:43Z","timestamp":1777384723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220301817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":71,"alternative-id":["S0006295220301817"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113953","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113953"}}