{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:58:56Z","timestamp":1777622336552,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI2016\/01"],"award-info":[{"award-number":["PI2016\/01"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00118"],"award-info":[{"award-number":["PI18\/00118"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014717","name":"Programa Operacional Regional do Centro","doi-asserted-by":"publisher","award":["CENTRO-01-0145-FEDER-000013"],"award-info":[{"award-number":["CENTRO-01-0145-FEDER-000013"]}],"id":[{"id":"10.13039\/501100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-022122"],"award-info":[{"award-number":["POCI-01-0145-FEDER-022122"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["S2017\/BMD-3700"],"award-info":[{"award-number":["S2017\/BMD-3700"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011929","name":"Programa Operacional Tem\u00e1tico Factores de Competitividade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-NEU\/ 114800\/2009"],"award-info":[{"award-number":["PTDC\/SAU-NEU\/ 114800\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi \/04326\/2013"],"award-info":[{"award-number":["UID\/Multi \/04326\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID \/ Multi\/ 00709\/2019"],"award-info":[{"award-number":["UID \/ Multi\/ 00709\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007491"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007491"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/Multi \/00709\/2013"],"award-info":[{"award-number":["UID\/Multi \/00709\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-022122"],"award-info":[{"award-number":["POCI-01-0145-FEDER-022122"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bcp.2020.113954","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:19:39Z","timestamp":1585945179000},"page":"113954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier"],"prefix":"10.1016","volume":"177","author":[{"given":"Ana C.","family":"Duarte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina L.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Telma","family":"Quintela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schwerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Schroten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Carro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia R.A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2020.113954_b0005","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.addr.2004.07.005","article-title":"The structure of the choroid plexus and the physiology of the choroid plexus epithelium","volume":"56","author":"Redzic","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bcp.2020.113954_b0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yfrne.2016.12.002","article-title":"The choroid plexus as a sex hormone target: Functional implications","volume":"44","author":"Santos","year":"2017","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bcp.2020.113954_b0015","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-018-1807-1","article-title":"Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease","volume":"135","author":"Ghersi-Egea","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bcp.2020.113954_b0020","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.2174\/1381612822666160726112115","article-title":"Potential pathways for CNS drug delivery across the blood-cerebrospinal fluid barrier","volume":"22","author":"Strazielle","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bcp.2020.113954_b0025","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2174\/1871527315666160915120758","article-title":"Merging Transport Data for Choroid Plexus with Blood-Brain Barrier to Model CNS Homeostasis and Disease More Effectively","volume":"15","author":"Johanson","year":"2016","journal-title":"CNS Neurol. Disord. - Drug Targets."},{"key":"10.1016\/j.bcp.2020.113954_b0030","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/17425255.2018.1513493","article-title":"Impact of transporters and enzymes from blood\u2013cerebrospinal fluid barrier and brain parenchyma on CNS drug uptake","volume":"14","author":"Wang","year":"2018","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bcp.2020.113954_b0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neuroscience.2016.01.057","article-title":"\u201cTasting\u201d the cerebrospinal fluid: Another function of the choroid plexus?","volume":"320","author":"Tom\u00e1s","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.bcp.2020.113954_b0040","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1111\/febs.13700","article-title":"\u2018 Smelling \u2019 the cerebrospinal fluid : olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus","volume":"283","author":"Gon\u00e7alves","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2020.113954_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1042\/BJ20110009","article-title":"Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK","volume":"438","author":"Jeon","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2020.113954_b0050","doi-asserted-by":"crossref","first-page":"12623","DOI":"10.18632\/oncotarget.7206","article-title":"Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule","volume":"7","author":"Gaida","year":"2016","journal-title":"Oncotarget."},{"key":"10.1016\/j.bcp.2020.113954_b0055","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(01)00451-2","article-title":"Mammalian sweet taste receptors","volume":"106","author":"Nelson","year":"2001","journal-title":"Cell."},{"key":"10.1016\/j.bcp.2020.113954_b0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature726","article-title":"An amino-acid taste receptor","volume":"416","author":"Nelson","year":"2002","journal-title":"Nature."},{"key":"10.1016\/j.bcp.2020.113954_b0065","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)80705-9","article-title":"A novel family of mammalian taste receptors","volume":"100","author":"Adler","year":"2000","journal-title":"Cell."},{"key":"10.1016\/j.bcp.2020.113954_b0070","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell."},{"key":"10.1016\/j.bcp.2020.113954_b0075","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature05401","article-title":"The receptors and cells for mammalian taste","volume":"444","author":"Chandrashekar","year":"2006","journal-title":"Nature."},{"key":"10.1016\/j.bcp.2020.113954_b0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.201003144","article-title":"The cell biology of taste","volume":"190","author":"Chaudhari","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2020.113954_b0085","doi-asserted-by":"crossref","unstructured":"N.M. Dalesio, S.F. Barreto Ortiz, J.L. Pluznick, D.E. Berkowitz, Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense, Front. Physiol. 9 (2018) 1673\u20131691. https:\/\/doi.org\/10.3389\/fphys.2018.01673.","DOI":"10.3389\/fphys.2018.01673"},{"key":"10.1016\/j.bcp.2020.113954_b0090","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41573-018-0002-3","article-title":"Therapeutic potential of ectopic olfactory and taste receptors","volume":"18","author":"Lee","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2020.113954_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.07.012.2009","article-title":"Sweet taste signaling functions as a hypothalamic glucose sensor","volume":"3","author":"Ren","year":"2009","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.bcp.2020.113954_b0100","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1096\/fj.12-215087","article-title":"Extraoral bitter taste receptors as mediators of off-target drug effects","volume":"26","author":"Clark","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2020.113954_b0105","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1074\/jbc.M116.771949","article-title":"Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor","volume":"292","author":"Hariri","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2020.113954_b0110","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1113\/EP086824","article-title":"Artesunate attenuates airway resistance in vivo and relaxes airway smooth muscle cells in vitro via bitter taste receptor-dependent calcium signalling","volume":"104","author":"Wang","year":"2019","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bcp.2020.113954_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0176851","article-title":"Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells","volume":"12","author":"Seo","year":"2017","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.113954_b0120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1096\/fj.14-262246","article-title":"TAS2R bitter taste receptors regulate thyroid function","volume":"29","author":"Clark","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2020.113954_b0125","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3390\/ijms20040967","article-title":"Taste Receptors: New Players in Sperm Biology","volume":"20","author":"Luddi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2020.113954_b0130","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1189\/jlb.2A0714-331RR","article-title":"Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes","volume":"97","author":"Malki","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bcp.2020.113954_b0135","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/chemse\/bjp092","article-title":"The molecular receptive ranges of human TAS2R bitter taste receptors","volume":"35","author":"Meyerhof","year":"2009","journal-title":"Chem. Senses."},{"key":"10.1016\/j.bcp.2020.113954_b0140","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1016\/j.bmc.2015.04.025","article-title":"Promiscuity and selectivity of bitter molecules and their receptors","volume":"23","author":"Di Pizio","year":"2015","journal-title":"Bioorganic Med. Chem."},{"key":"10.1016\/j.bcp.2020.113954_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030069","article-title":"Polar invasion and translocation of neisseria meningitidis and streptococcus suis in a novel human model of the blood-cerebrospinal fluid barrier","volume":"7","author":"Schwerk","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.113954_b0150","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1007\/s11095-015-1679-1","article-title":"Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier","volume":"32","author":"Bernd","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bcp.2020.113954_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083345","article-title":"Gene expression and functional annotation of the human and mouse choroid plexus epithelium","volume":"8","author":"Janssen","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.113954_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-014-0163-x","article-title":"Neisseria meningitidis elicits a pro-inflammatory response involving I\u03baB\u03b6 in a human blood-cerebrospinal fluid barrier model","volume":"11","author":"Borkowski","year":"2014","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.bcp.2020.113954_b0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1749-0774.2005.tb00059.x","article-title":"Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP)","volume":"18","author":"Ishiwata","year":"2005","journal-title":"Hum Cell."},{"key":"10.1016\/j.bcp.2020.113954_b0170","doi-asserted-by":"crossref","unstructured":"A.S. Shah, B.S. Yehuda, T.O. Moninger, J.N. Kline, M.J. Welsh, Motile cilia of human airway epithelia are chemosensory, Science (80) 325 (2009) 1131\u20131134. https:\/\/doi.org\/10.1126\/science.1173869.","DOI":"10.1126\/science.1173869"},{"key":"10.1016\/j.bcp.2020.113954_b0175","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1096\/fj.13-242594","article-title":"The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14","volume":"27","author":"Levit","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2020.113954_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060199","article-title":"Analysis of the effects of sex hormone background on the rat choroid plexus transcriptome by cDNA microarrays","volume":"8","author":"Quintela","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.113954_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110521","article-title":"Bitter taste signaling mediated by Tas2r144 is down-regulated by 17\u03b2-estradiol and progesterone in the rat choroid plexus","volume":"495","author":"Tom\u00e1s","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bcp.2020.113954_b0190","doi-asserted-by":"crossref","first-page":"D1179","DOI":"10.1093\/nar\/gky974","article-title":"Bitterdb: Taste ligands and receptors database in 2019","volume":"47","author":"Dagan-Wiener","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2020.113954_b0195","doi-asserted-by":"crossref","first-page":"D413","DOI":"10.1093\/nar\/gkr755","article-title":"BitterDB: a database of bitter compounds","volume":"40","author":"Wiener","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2020.113954_b0200","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1021\/jf403387p","article-title":"Bitter taste receptor activation by flavonoids and isoflavonoids: Modeled structural requirements for activation of hTAS2R14 and hTAS2R39","volume":"61","author":"Roland","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2020.113954_b0205","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1080\/09168451.2014.930326","article-title":"Activation of the hTAS2R14 Human Bitter-Taste Receptor by (\u2212) -Epigallocatechin Gallate and (\u2212) - Epicatechin Gallate","volume":"8451","author":"Yamazaki","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.bcp.2020.113954_b0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainres.2018.12.017","article-title":"Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats","volume":"1708","author":"R\u00edos","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2020.113954_b0215","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/ptr.5133","article-title":"In vitro antitumoral activity of compounds isolated from artemisia gorgonum webb","volume":"1334","author":"Martins","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.bcp.2020.113954_b0220","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2018.04.033","article-title":"Inhibition of NF-\u03baB results in anti-glioma activity and reduces temozolomide-induced chemoresistance by down-regulating MGMT gene expression","volume":"428","author":"Yu","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2020.113954_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109078","article-title":"A review for the neuroprotective effects of andrographolide in the central nervous system","volume":"117","author":"Lu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2020.113954_b9000","article-title":"The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier","author":"Duarte","year":"2020","journal-title":"Biochem. Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220301829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220301829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:09:33Z","timestamp":1777414173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220301829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":46,"alternative-id":["S0006295220301829"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113954","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.113954","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113954"}}