{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:17:03Z","timestamp":1770819423781,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2017R1D1A1B04035921"],"award-info":[{"award-number":["2017R1D1A1B04035921"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.bcp.2020.114087","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T21:20:33Z","timestamp":1591737633000},"page":"114087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE\/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice"],"prefix":"10.1016","volume":"178","author":[{"given":"Eui Jeong","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilekuttige Priyan Shanura","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-A","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junseong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungsook","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Heui","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kil-Nam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Jin","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginnae","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2020.114087_b0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11882-009-0082-6","article-title":"Does exposure to indoor allergens contribute to the development of asthma and allergy?","volume":"10","author":"Arshad","year":"2010","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"3","key":"10.1016\/j.bcp.2020.114087_b0010","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12016-011-8252-4","article-title":"IgE, mast cells, and eosinophils in atopic dermatitis","volume":"41","author":"Liu","year":"2011","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2020.114087_b0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1074-7613(01)00159-5","article-title":"Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival","volume":"14","author":"Kalesnikoff","year":"2001","journal-title":"Immunity"},{"issue":"4, Supplement","key":"10.1016\/j.bcp.2020.114087_b0020","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.jaci.2019.07.017","article-title":"Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions","volume":"144","author":"Maurer","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6415","key":"10.1016\/j.bcp.2020.114087_b0025","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.aav4505","article-title":"Dangerous liaisons in anaphylaxis","volume":"362","author":"Levi-Schaffer","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bcp.2020.114087_b0030","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.procbio.2011.12.014","article-title":"Marine algae as a potential pharmaceutical source for anti-allergic therapeutics","volume":"47","author":"Vo","year":"2012","journal-title":"Process Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2020.114087_b0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1039\/C6NP00124F","article-title":"Marine natural products","volume":"34","author":"Blunt","year":"2017","journal-title":"Nat. Prod. Rep."},{"issue":"7","key":"10.1016\/j.bcp.2020.114087_b0040","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3390\/md9071273","article-title":"Bromophenols in marine algae and their bioactivities","volume":"9","author":"Liu","year":"2011","journal-title":"Mar. Drugs"},{"issue":"2","key":"10.1016\/j.bcp.2020.114087_b0045","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/md11020350","article-title":"HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: synthesis and anti-diabetic effects in C57BL\/KsJ-db\/db mice","volume":"11","author":"Shi","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bcp.2020.114087_b0050","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejmech.2017.04.004","article-title":"Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors","volume":"134","author":"Zhang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2020.114087_b0055","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5487\/TR.2017.33.4.325","article-title":"Anti-inflammatory effect of 3-bromo-4,5-dihydroxybenzaldehyde, a component of Polysiphonia morrowii","volume":"33","author":"Kang","year":"2017","journal-title":"Vivo In Vitro Toxicol. Res."},{"issue":"3","key":"10.1016\/j.bcp.2020.114087_b0060","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/ptr.6266","article-title":"Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes","volume":"33","author":"Ko","year":"2019","journal-title":"Phytother. Res."},{"issue":"12","key":"10.1016\/j.bcp.2020.114087_b0065","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/exd.12814","article-title":"Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction","volume":"24","author":"Ahn","year":"2015","journal-title":"Exp. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2020.114087_b0070","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.4049\/jimmunol.174.6.3626","article-title":"Stem cell factor has a suppressive activity to IgE-mediated chemotaxis of mast cells","volume":"174","author":"Sawada","year":"2005","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2020.114087_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034259","article-title":"Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils","volume":"7","author":"Sumbayev","year":"2012","journal-title":"PLoS ONE"},{"issue":"24","key":"10.1016\/j.bcp.2020.114087_b0080","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.1021\/bi9629642","article-title":"Evidence supporting a role for microfilaments in regulating the coupling between poorly dissociable IgE\u2212 Fc\u03b5RI aggregates and downstream signaling pathways","volume":"36","author":"Pierini","year":"1997","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.bcp.2020.114087_b0085","first-page":"745","article-title":"Anti-inflammatory effects of enzymatic extract from Ecklonia cava on TPA-induced ear skin edema","volume":"17","author":"Ahn","year":"2008","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.bcp.2020.114087_b0090","doi-asserted-by":"crossref","DOI":"10.1039\/C8RA01967C","article-title":"3\u03b2-Hydroxy-\u03945-steroidal congeners from a column fraction of Dendronephthya puetteri attenuate LPS-induced inflammatory responses in RAW 264.7 macrophages and zebrafish embryo model","author":"Fernando","year":"2018","journal-title":"RSC Advances"},{"issue":"6793","key":"10.1016\/j.bcp.2020.114087_b0095","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/35018500","article-title":"Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc\u03b5RI\u03b1","volume":"406","author":"Garman","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2020.114087_b0100","doi-asserted-by":"crossref","unstructured":"H. Evans, K.E. Killoran, E. Mitre, Measuring local anaphylaxis in mice, J. Visual. Exp.: JoVE (92) (2014) e52005\u2013e52005.","DOI":"10.3791\/52005-v"},{"key":"10.1016\/j.bcp.2020.114087_b0105","unstructured":"N. Gaudenzio, R. Sibilano, P. Starkl, M. Tsai, S.J. Galli, L.L. Reber, Analyzing the functions of mast cells in vivo using 'mast cell knock-in' mice, JoVE (99) (2015) e52753."},{"key":"10.1016\/j.bcp.2020.114087_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00722","article-title":"3-Bromo-4,5-dihydroxybenzaldehyde protects against myocardial ischemia and reperfusion injury through the Akt-PGC1\u03b1-Sirt3 pathway","volume":"9","author":"Qin","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114087_b0115","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1248\/bpb.31.212","article-title":"Human cathelicidin CAP18\/LL-37 changes mast cell function toward innate immunity","volume":"31","author":"Yoshioka","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.bcp.2020.114087_b0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0041-0101(89)90411-X","article-title":"Edema formation and degranulation of mast cells by a basic phospholipase A2 purified from Trimeresurus mucrosquamatus snake venom","volume":"27","author":"Chiu","year":"1989","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.bcp.2020.114087_b0125","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.coi.2009.09.006","article-title":"Mast cells in atopic dermatitis","volume":"21","author":"Kawakami","year":"2009","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114087_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.54.1","article-title":"The high affinity IgE receptor (Fc\u03b5RI) as a target for anti-allergic agents","volume":"54","author":"Takahashi","year":"2005","journal-title":"Allergol. Int."},{"issue":"2","key":"10.1016\/j.bcp.2020.114087_b0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3390\/ijms17020144","article-title":"Insights into protein-ligand interactions: mechanisms, models, and methods","volume":"17","author":"Du","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2020.114087_b0140","article-title":"Treatment with 3-bromo-4,5-dihydroxybenzaldehyde improves cardiac function by inhibiting macrophage infiltration in mice","volume":"48","author":"Ji","year":"2018","journal-title":"Kor. Circ. J."},{"key":"10.1016\/j.bcp.2020.114087_b0145","unstructured":"Y.S. Koh, E.S. Yoo, H.K. Kang, J.W. Hyoun, Composition comprising 3-bromo-4,5-dihydroxybenzaldehyde for prevention and treatment of autiimmune disease or inflammatory disease, in: I.-A.C. Foundation (Ed.) Industry-Academia Collaboration Foundation, Republic of Korea, 2013."},{"key":"10.1016\/j.bcp.2020.114087_b0150","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3389\/fphar.2019.00869","article-title":"Gomisin M2 inhibits mast cell-mediated allergic inflammation via attenuation of Fc\u03b5RI-mediated Lyn and Fyn activation and intracellular calcium levels","volume":"10","author":"Dhakal","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114087_b0155","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10616-019-00309-2","article-title":"Inhibitory effect of aqueous extract of Cuminum cyminum L. seed on degranulation of RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice","volume":"71","author":"Hada","year":"2019","journal-title":"Cytotechnology"},{"issue":"8","key":"10.1016\/j.bcp.2020.114087_b0160","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.4014\/jmb.1904.04062","article-title":"Protective effect of 3-bromo-4,5-dihydroxybenzaldehyde from Polysiphonia morrowii Harvey against hydrogen peroxide-induced oxidative stress in vitro and in vivo","volume":"29","author":"Cho","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"issue":"9","key":"10.1016\/j.bcp.2020.114087_b0165","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1080\/10715762.2018.1505044","article-title":"Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts","volume":"52","author":"Park","year":"2018","journal-title":"Free Radical Res."},{"key":"10.1016\/j.bcp.2020.114087_b0170","series-title":"Adv. Food Nutr. Res.","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/B978-0-12-387669-0.00021-1","article-title":"Chapter 21 \u2013 antiallergic benefit of marine algae in medicinal foods","author":"Kim","year":"2011"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220303233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220303233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:16:27Z","timestamp":1757769387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220303233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":34,"alternative-id":["S0006295220303233"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114087","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE\/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114087"}}