{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:16Z","timestamp":1792512076477,"version":"4.5.0"},"reference-count":221,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["EFOP-3.6.2-16-2017-00006"],"award-info":[{"award-number":["EFOP-3.6.2-16-2017-00006"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["813834 - pHioniC - H2020-MSCA-ITN-2018"],"award-info":[{"award-number":["813834 - pHioniC - H2020-MSCA-ITN-2018"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["OTKA K119417"],"award-info":[{"award-number":["OTKA K119417"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bcp.2020.114146","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T23:09:07Z","timestamp":1594336147000},"page":"114146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides"],"prefix":"10.1016","volume":"181","author":[{"given":"Gabor","family":"Tajti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy C.C.","family":"Wai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Panyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond S.","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2020.114146_b0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cbpa.2017.02.015","article-title":"Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease","volume":"38","author":"Chandy","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bcp.2020.114146_b0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neuropharm.2017.07.002","article-title":"Venom-derived peptide inhibitors of voltage-gated potassium channels","volume":"127","author":"Norton","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2020.114146_b0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-immunol-032414-112212","article-title":"Ion channels in innate and adaptive immunity","volume":"33","author":"Feske","year":"2015","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0020","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.2009.00816.x","article-title":"The functional network of ion channels in T lymphocytes","volume":"231","author":"Cahalan","year":"2009","journal-title":"Immunol. Rev."},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b0025","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3233","article-title":"Ion channels and transporters in lymphocyte function and immunity","volume":"12","author":"Feske","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2020.114146_b0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceca.2018.07.005","article-title":"CRAC channels as targets for drug discovery and development","volume":"74","author":"Stauderman","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcp.2020.114146_b0035","doi-asserted-by":"crossref","first-page":"14644","DOI":"10.1038\/ncomms14644","article-title":"Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions","volume":"8","author":"Chiang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2020.114146_b0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bcp.2019.03.016","article-title":"Fighting rheumatoid arthritis: Kv1.3 as a therapeutic target","volume":"165","author":"Serrano-Albarras","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2020.114146_b0045","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI16921","article-title":"The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS","volume":"111","author":"Wulff","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2020.114146_b0050","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxicon.2011.07.016","article-title":"Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases","volume":"59","author":"Chi","year":"2012","journal-title":"Toxicon"},{"issue":"18","key":"10.1016\/j.bcp.2020.114146_b0055","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2174\/138161206777585120","article-title":"K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression","volume":"12","author":"Panyi","year":"2006","journal-title":"Curr. Pharm. Des."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2020.114146_b0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.imlet.2009.12.015","article-title":"Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases","volume":"130","author":"Varga","year":"2010","journal-title":"Immunol. Lett."},{"issue":"9","key":"10.1016\/j.bcp.2020.114146_b0065","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/14712598.2017.1346606","article-title":"Treating autoimmune disorders with venom-derived peptides","volume":"17","author":"Shen","year":"2017","journal-title":"Expert Opin. Biol. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0070","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1517\/14728222.2016.1112792","article-title":"The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies","volume":"20","author":"Perez-Verdaguer","year":"2016","journal-title":"Expert. Opin. Ther. Targets"},{"issue":"12","key":"10.1016\/j.bcp.2020.114146_b0075","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nrd2983","article-title":"Voltage-gated potassium channels as therapeutic targets","volume":"8","author":"Wulff","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mehy.2015.03.023","article-title":"Roles of lymphocyte Kv1.3-channels in gut mucosal immune system: novel therapeutic implications for inflammatory bowel disease","volume":"85","author":"Kazama","year":"2015","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.bcp.2020.114146_b0085","series-title":"Gastrointestinal Pharmacology","first-page":"115","article-title":"Inflammatory bowel disease: pathophysiology and current therapeutic approaches","author":"Abraham","year":"2017"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: current state of the art","volume":"13","author":"De Souza","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"18","key":"10.1016\/j.bcp.2020.114146_b0095","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"Danese","year":"2011","journal-title":"New Engl. J. Med."},{"issue":"4\u20135","key":"10.1016\/j.bcp.2020.114146_b0100","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.autrev.2014.01.028","article-title":"Diagnosis and classification of ulcerative colitis","volume":"13","author":"Conrad","year":"2014","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.bcp.2020.114146_b0105","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.crohns.2013.06.001","article-title":"European consensus on the histopathology of inflammatory bowel disease","volume":"7","author":"Magro","year":"2013","journal-title":"J. Crohn's Colitis"},{"issue":"suppl. 92","key":"10.1016\/j.bcp.2020.114146_b0110","first-page":"S19","article-title":"Immunopathogenesis of inflammatory bowel diseases: functional role of T cells and T cell homing","volume":"33","author":"Zundler","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"issue":"9853","key":"10.1016\/j.bcp.2020.114146_b0115","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","article-title":"Crohn's disease","volume":"380","author":"Baumgart","year":"2012","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bcp.2020.114146_b0120","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.20011956","article-title":"The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease","volume":"195","author":"Neurath","year":"2002","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0125","first-page":"823","article-title":"Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease","volume":"150","author":"Parronchi","year":"1997","journal-title":"Am. J. Pathol."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0130","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/gut.2008.163667","article-title":"Crohn\u2019s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn\u2019s disease","volume":"58","author":"Brand","year":"2009","journal-title":"Gut"},{"issue":"5804","key":"10.1016\/j.bcp.2020.114146_b0135","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"Duerr","year":"2006","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cei.13294","article-title":"Distinct patterns of naive, activated and memory T and B cells in blood of patients with ulcerative colitis or Crohn\u2019s disease","volume":"197","author":"Rabe","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1023\/B:JOCI.0000019784.20191.7f","article-title":"Active Crohn's disease patients show a distinctive expansion of circulating memory CD4+ CD45RO+ CD28 null T cells","volume":"24","author":"De Tena","year":"2004","journal-title":"J. Clin. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0150","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/phar.1236","article-title":"Targeting potassium channels Kv1.3 and KCa3.1: routes to selective immunomodulators in autoimmune disorder treatment?","volume":"33","author":"Wang","year":"2013","journal-title":"Pharmacotherapy"},{"issue":"33","key":"10.1016\/j.bcp.2020.114146_b0155","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0160","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/08830180009048389","article-title":"TNBS-colitis","volume":"19","author":"Neurath","year":"2000","journal-title":"Int. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0165","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1097\/MIB.0000000000000468","article-title":"A multihit model: colitis lessons from the interleukin-10\u2013deficient mouse","volume":"21","author":"Keubler","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0170","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2020.114146_b0175","series-title":"Mouse Models of Innate Immunity","first-page":"207","article-title":"Adoptive transfer colitis","author":"Eden","year":"2019"},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0180","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"125","key":"10.1016\/j.bcp.2020.114146_b0185","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"10415","author":"Chassaing","year":"2014","journal-title":"Curr. Prot. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0190","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4049\/jimmunol.1700453","article-title":"Of mice, dirty mice, and men: using mice to understand human immunology","volume":"199","author":"Masopust","year":"2017","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0195","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1124\/mol.104.008193","article-title":"Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases","volume":"67","author":"Beeton","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0200","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ncpgasthep0687","article-title":"Current management of severe ulcerative colitis","volume":"4","author":"Caprilli","year":"2007","journal-title":"Nat. Clin. Prac. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrgastro.2016.208","article-title":"Current and emerging therapeutic targets for IBD","volume":"14","author":"Neurath","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2020.114146_b0210","first-page":"00","article-title":"Management of patients with inflammatory bowel disease: current and future treatments","volume":"10","author":"Love","year":"2019","journal-title":"Acute Pain"},{"issue":"12","key":"10.1016\/j.bcp.2020.114146_b0215","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1080\/17474124.2018.1545574","article-title":"Adverse events in IBD therapy: the 2018 update","volume":"12","author":"Quezada","year":"2018","journal-title":"Expert. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0220","doi-asserted-by":"crossref","DOI":"10.1093\/crocol\/otz027","article-title":"The early experience with vedolizumab in the United States","volume":"1","author":"Kochar","year":"2019","journal-title":"Crohn's Colitis 360"},{"issue":"13","key":"10.1016\/j.bcp.2020.114146_b0225","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa1900750","article-title":"Ustekinumab as induction and maintenance therapy for ulcerative colitis","volume":"381","author":"Sands","year":"2019","journal-title":"New Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0230","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/annrheumdis-2017-211555","article-title":"Novel therapies for immune-mediated inflammatory diseases: what can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn\u2019s disease and ulcerative colitis?","volume":"77","author":"Baker","year":"2018","journal-title":"Annal. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0235","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2015.63","article-title":"Loss of response to anti-TNFs: definition, epidemiology, and management","volume":"7","author":"Roda","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0240","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/ecco-jcc\/jjz162","article-title":"Therapeutic drug monitoring of biologics during induction to prevent primary non-response","volume":"14","author":"Sparrow","year":"2020","journal-title":"J. Crohns Colitis"},{"issue":"9317","key":"10.1016\/j.bcp.2020.114146_b0245","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","article-title":"Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bcp.2020.114146_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2017.03.032","article-title":"Association between ustekinumab trough concentrations and clinical, biomarker, and endoscopic outcomes in patients with Crohn\u2019s disease","volume":"15","author":"Battat","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0255","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12876-018-0868-x","article-title":"Vedolizumab use after failure of TNF-\u03b1 antagonists in children and adolescents with inflammatory bowel disease","volume":"18","author":"Schneider","year":"2018","journal-title":"BMC Gastroenterol."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2018.06.026","article-title":"Loss of response to vedolizumab and ability of dose intensification to restore response in patients with Crohn\u2019s disease or ulcerative colitis: a systematic review and meta-analysis","volume":"17","author":"Peyrin-Biroulet","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0265","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.4049\/jimmunol.164.3.1153","article-title":"Differential Ca2+ influx, KCa channel activity, and Ca2+ clearance distinguish Th1 and Th2 lymphocytes","volume":"164","author":"Fanger","year":"2000","journal-title":"J. Immunol."},{"issue":"7746","key":"10.1016\/j.bcp.2020.114146_b0270","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41586-019-0992-y","article-title":"Colonic epithelial cell diversity in health and inflammatory bowel disease","volume":"567","author":"Parikh","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0275","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1158\/1078-0432.CCR-06-1940","article-title":"Expression of voltage-gated potassium channels in human and mouse colonic carcinoma","volume":"13","author":"Ousingsawat","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2020.114146_b0280","first-page":"B4946","article-title":"The role of T cell potassium channels, KV1.3 and KCa3.1, in the inflammatory cascade in ulcerative colitis","volume":"61","author":"Hansen","year":"2014","journal-title":"Dan. Med. J."},{"issue":"11","key":"10.1016\/j.bcp.2020.114146_b0285","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.crohns.2014.04.003","article-title":"Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis","volume":"8","author":"Hansen","year":"2014","journal-title":"J. Crohns Colitis"},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0290","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1124\/mol.105.015669","article-title":"Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases","volume":"68","author":"Schmitz","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b0295","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1182\/blood-2002-05-1433","article-title":"ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice","volume":"101","author":"Stocker","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2020.114146_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105776","article-title":"PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway","volume":"75","author":"Mei","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0305","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0005-2736(03)00198-6","article-title":"The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia","volume":"1616","author":"Grunnet","year":"2003","journal-title":"Biochim. Biophys. Acta-Biomemb."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0310","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.bcp.2015.10.017","article-title":"Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration by disrupting calpain signaling","volume":"98","author":"Silver","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"17","key":"10.1016\/j.bcp.2020.114146_b0315","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3748\/wjg.v17.i17.2161","article-title":"Wound healing of intestinal epithelial cells","volume":"17","author":"Iizuka","year":"2011","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b0320","doi-asserted-by":"crossref","first-page":"bio042200","DOI":"10.1242\/bio.042200","article-title":"Different functional roles for K+ channel subtypes in regulating small intestinal glucose and ion transport","volume":"8","author":"Du","year":"2019","journal-title":"Biol. Open"},{"issue":"10","key":"10.1016\/j.bcp.2020.114146_b0325","doi-asserted-by":"crossref","first-page":"G873","DOI":"10.1152\/ajpgi.00156.2013","article-title":"Upregulation of KCa3. 1 K+ channel in mesenteric lymph node CD4+ T lymphocytes from a mouse model of dextran sodium sulfate-induced inflammatory bowel disease","volume":"306","author":"Ohya","year":"2014","journal-title":"Am. J. Physiol.-Gastrointestinal Liver Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0330","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1073\/pnas.0910133107","article-title":"Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis","volume":"107","author":"Di","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0335","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1476-5381.2012.02143.x","article-title":"NS 6180, a new KCa 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease","volume":"168","author":"Str\u00f8b\u00e6k","year":"2013","journal-title":"Brit. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b0340","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ddr.20467","article-title":"The lymphocyte potassium channels Kv1. 3 and KCa3. 1 as targets for immunosuppression","volume":"72","author":"Lam","year":"2011","journal-title":"Drug Dev. Res."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0345","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.4049\/jimmunol.0802887","article-title":"Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease","volume":"183","author":"Di Sabatino","year":"2009","journal-title":"J. Immunol."},{"issue":"29","key":"10.1016\/j.bcp.2020.114146_b0350","doi-asserted-by":"crossref","first-page":"44966","DOI":"10.18632\/oncotarget.10036","article-title":"Altered calcium influx of peripheral Th2 cells in pediatric Crohn's disease: infliximab may normalize activation patterns","volume":"7","author":"Orban","year":"2016","journal-title":"Oncotarget"},{"issue":"47","key":"10.1016\/j.bcp.2020.114146_b0355","first-page":"6001","article-title":"Immune phenotype in children with therapy-naive remitted and relapsed Crohn's disease","volume":"16","author":"Cseh","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bcp.2020.114146_b0360","doi-asserted-by":"crossref","unstructured":"C. World journal of gastroenterology: WJGBioorg Med ChemOrban, D. Szabo, A. Bajnok, B. Vasarhelyi, T. Tulassay, A. Arato, G. Veres, G. Toldi, Altered activation of peripheral CD8+ T cells in pediatric Crohn's disease, Immunol. Lett. 185 (2017) 48\u201351.","DOI":"10.1016\/j.imlet.2017.03.009"},{"key":"10.1016\/j.bcp.2020.114146_b0365","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.addr.2016.01.010","article-title":"Oral delivery of macromolecular drugs: where we are after almost 100 years of attempts","volume":"101","author":"Moroz","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"Pt B","key":"10.1016\/j.bcp.2020.114146_b0370","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.addr.2016.02.004","article-title":"Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials","volume":"106","author":"Aguirre","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bcp.2020.114146_b0375","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1038\/srep04509","article-title":"A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases","volume":"4","author":"Rashid","year":"2014","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.bcp.2020.114146_b0380","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1021\/bi300060n","article-title":"Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes","volume":"51","author":"Gurrola","year":"2012","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0385","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0041-0101(95)00013-C","article-title":"Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus","volume":"33","author":"Castaneda","year":"1995","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0390","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsb0496-317","article-title":"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone","volume":"3","author":"Tudor","year":"1996","journal-title":"Nat. Struct. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0395","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1124\/mol.108.052704","article-title":"Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes","volume":"75","author":"Pennington","year":"2009","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0400","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41573-019-0053-0","article-title":"Advances in oral peptide therapeutics","volume":"19","author":"Drucker","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0405","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/dia.2019.0185","article-title":"Oral semaglutide: a review of the first oral glucagon-like peptide 1 receptor agonist","volume":"22","author":"Bucheit","year":"2020","journal-title":"Diabetes Technol. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2220\/biomedres.39.1","article-title":"Absorption and metabolism of orally administered collagen hydrolysates evaluated by the vascularly perfused rat intestine and liver in situ","volume":"39","author":"Osawa","year":"2018","journal-title":"Biomed. Res."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0415","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0420","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pharmthera.2014.02.011","article-title":"Of worms, mice and man: an overview of experimental and clinical helminth-based therapy for inflammatory bowel disease","volume":"143","author":"Heylen","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b0425","first-page":"741","article-title":"The emerging role of helminths in treatment of the inflammatory bowel disorders","volume":"65","author":"Szkudlapski","year":"2014","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2020.114146_b0430","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1096\/fj.14-251967","article-title":"Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases","volume":"28","author":"Chhabra","year":"2014","journal-title":"FASEB J."},{"issue":"24","key":"10.1016\/j.bcp.2020.114146_b0435","doi-asserted-by":"crossref","first-page":"10680","DOI":"10.1523\/JNEUROSCI.19-24-10680.1999","article-title":"A Kv1.5 to Kv1.3 switch in endogenous hippocampal microglia and a role in proliferation","volume":"19","author":"Kotecha","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2020.114146_b0440","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fimmu.2015.00497","article-title":"The role of ion channels in microglial activation and proliferation \u2013 a complex interplay between ligand-gated Ion channels, K+ channels, and intracellular Ca2+","volume":"6","author":"Stebbing","year":"2015","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0445","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.mcn.2006.08.009","article-title":"The potassium channels Kv1.5 and Kv1.3 modulate distinct functions of microglia","volume":"33","author":"Pannasch","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"issue":"31","key":"10.1016\/j.bcp.2020.114146_b0450","doi-asserted-by":"crossref","first-page":"7139","DOI":"10.1523\/JNEUROSCI.1251-05.2005","article-title":"Microglia Kv1.3 channels contribute to their ability to kill neurons","volume":"25","author":"Fordyce","year":"2005","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.bcp.2020.114146_b0455","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1002\/jcp.22675","article-title":"Amyloid-b-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia","volume":"226","author":"Schilling","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0460","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3233\/JAD-141704","article-title":"Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease","volume":"44","author":"Rangaraju","year":"2015","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0465","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/glia.23078","article-title":"Differential Kv1.3, KCa3.1, and Kir2.1 expression in \u201cclassically\u201d and \u201calternatively\u201d activated microglia","volume":"65","author":"Nguyen","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.bcp.2020.114146_b0470","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fnagi.2017.00176","article-title":"Targeting microglial activation states as a therapeutic avenue in Parkinson's disease","volume":"9","author":"Subramaniam","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.bcp.2020.114146_b0475","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/glia.23457","article-title":"The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo","volume":"66","author":"Di Lucente","year":"2018","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0480","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12974-017-0906-6","article-title":"A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation","volume":"14","author":"Rangaraju","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0485","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/md13010529","article-title":"Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK","volume":"13","author":"Pennington","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bcp.2020.114146_b0490","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.addr.2018.04.009","article-title":"Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics","volume":"135","author":"Pan","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0495","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13024-018-0254-8","article-title":"Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease","volume":"13","author":"Rangaraju","year":"2018","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0500","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/brain\/awx346","article-title":"Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept","volume":"141","author":"Maezawa","year":"2018","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0505","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12974-017-0941-3","article-title":"Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration","volume":"14","author":"Lam","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0510","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/19336950.2017.1300738","article-title":"Potassium channel expression and function in microglia: plasticity and possible species variations","volume":"11","author":"Nguyen","year":"2017","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.bcp.2020.114146_b0515","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3389\/fncel.2018.00433","article-title":"Sex- and development-dependent responses of rat microglia to pro- and anti-inflammatory stimulation","volume":"12","author":"Lively","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0520","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/acn3.513","article-title":"Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke","volume":"5","author":"Chen","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0525","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/neuonc\/not221","article-title":"Blockade of Kv1.3 channels ameliorates radiation-induced brain injury","volume":"16","author":"Peng","year":"2014","journal-title":"Neuro Oncol."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0530","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006770","article-title":"Predominant functional expression of Kv1.3 by activated microglia of the hippocampus after Status epilepticus","volume":"4","author":"Menteyne","year":"2009","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0535","doi-asserted-by":"crossref","DOI":"10.3390\/cells7040026","article-title":"Microglia after seizures and in epilepsy","volume":"7","author":"Hiragi","year":"2018","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064904","article-title":"HIV-1 Tat protein increases microglial outward K+ current and resultant neurotoxic activity","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bcp.2020.114146_b0545","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2015.02.008","article-title":"The relation between a-synuclein and microglia in Parkinson's disease: recent developments","volume":"302","author":"Sanchez-Guajardo","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2020.114146_b0550","doi-asserted-by":"crossref","first-page":"814.12","DOI":"10.1096\/fasebj.31.1_supplement.814.12","article-title":"Microglial Kv1.3, a voltage-gated potassium channel, mediates neuroinflammation and neurodegeneration in cell culture and animal models of Parkinson\u2019s disease","volume":"31","author":"Sarkar","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2020.114146_b0555","doi-asserted-by":"crossref","first-page":"553.1","DOI":"10.1096\/fasebj.2018.32.1_supplement.553.1","article-title":"The Fyn-dependent voltage-gated potassium channel Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson\u2019s disease models","volume":"32","author":"Sarkar","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2020.114146_b0560","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3389\/fnins.2019.01393","article-title":"Kv1.3 channel as a key therapeutic target for neuroinflammatory diseases: state of the art and beyond","volume":"13","author":"Wang","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bcp.2020.114146_b0565","first-page":"136174","article-title":"Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease","author":"Sarkar","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0570","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1471-4159.2006.03967.x","article-title":"Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation","volume":"99","author":"Liebau","year":"2006","journal-title":"J. Neurochem."},{"issue":"24","key":"10.1016\/j.bcp.2020.114146_b0575","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.1073\/pnas.241497298","article-title":"Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis","volume":"98","author":"Beeton","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0580","doi-asserted-by":"crossref","first-page":"936","DOI":"10.4049\/jimmunol.166.2.936","article-title":"Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation","volume":"166","author":"Beeton","year":"2001","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0585","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.immuni.2008.07.015","article-title":"Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block","volume":"29","author":"Matheu","year":"2008","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0590","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/14728220903018957","article-title":"Kv1.3 potassium channels as a therapeutic target in multiple sclerosis","volume":"13","author":"Rangaraju","year":"2009","journal-title":"Expert. Opin. Ther. Targets"},{"issue":"35","key":"10.1016\/j.bcp.2020.114146_b0595","doi-asserted-by":"crossref","first-page":"29479","DOI":"10.1074\/jbc.M112.379594","article-title":"Selective inhibition of CCR7- effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model","volume":"287","author":"Li","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2020.114146_b0600","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/cns.12848","article-title":"A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis","volume":"24","author":"Yuan","year":"2018","journal-title":"CNS Neurosci. Ther."},{"issue":"31","key":"10.1016\/j.bcp.2020.114146_b0605","doi-asserted-by":"crossref","first-page":"11094","DOI":"10.1073\/pnas.0501770102","article-title":"The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain","volume":"102","author":"Rus","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2020.114146_b0610","article-title":"A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis","author":"Lioudyno","year":"2020","journal-title":"J. Neurosci. Res."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0615","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/acs.accounts.7b00204","article-title":"Jumping hurdles: peptides able to overcome biological barriers","volume":"50","author":"Sanchez-Navarro","year":"2017","journal-title":"Acc. Chem. Res."},{"issue":"17","key":"10.1016\/j.bcp.2020.114146_b0620","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1039\/C6CS00076B","article-title":"Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery","volume":"45","author":"Oller-Salvia","year":"2016","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0625","doi-asserted-by":"crossref","DOI":"10.1002\/bip.22928","article-title":"Phage display as a tool to discover blood-brain barrier (BBB)-shuttle peptides: panning against a human BBB cellular model","volume":"108","author":"Diaz-Perlas","year":"2017","journal-title":"Biopolymers"},{"issue":"44","key":"10.1016\/j.bcp.2020.114146_b0630","doi-asserted-by":"crossref","first-page":"8409","DOI":"10.1039\/C8SC02415D","article-title":"Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood-brain barrier transport","volume":"9","author":"Diaz-Perlas","year":"2018","journal-title":"Chem. Sci."},{"issue":"13","key":"10.1016\/j.bcp.2020.114146_b0635","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1002\/anie.201411408","article-title":"Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier","volume":"54","author":"Prades","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0640","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/anie.201508445","article-title":"MiniAp-4: a venom-inspired peptidomimetic for brain delivery","volume":"55","author":"Oller-Salvia","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0645","doi-asserted-by":"crossref","DOI":"10.1002\/psc.3172","article-title":"Expanding the MiniAp-4 BBB-shuttle family: evaluation of proline cis-trans ratio as tool to fine-tune transport","volume":"25","author":"Fuster","year":"2019","journal-title":"J. Pept. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0650","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1124\/jpet.107.131318","article-title":"Identification and design of peptides as a new drug delivery system for the brain","volume":"324","author":"Demeule","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.bcp.2020.114146_b0655","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1021\/mp500086e","article-title":"Retro-inverso isomer of Angiopep-2: a stable d-peptide ligand inspires brain-targeted drug delivery","volume":"11","author":"Wei","year":"2014","journal-title":"Mol. Pharm."},{"issue":"10","key":"10.1016\/j.bcp.2020.114146_b0660","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1177\/0271678X18772998","article-title":"A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model","volume":"39","author":"Thom","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"14","key":"10.1016\/j.bcp.2020.114146_b0665","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1016\/j.jmb.2020.04.002","article-title":"A TfR-binding cystine-dense peptide promotes blood-brain barrier penetration of bioactive molecules","volume":"432","author":"Crook","year":"2020","journal-title":"J. Mol. Biol."},{"issue":"S1","key":"10.1016\/j.bcp.2020.114146_b0670","doi-asserted-by":"crossref","first-page":"52","DOI":"10.33594\/000000195","article-title":"Mitochondrial Kv1. 3: a new target in cancer biology?","volume":"53","author":"Checchetto","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0675","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/chem.201801578","article-title":"Molecular probes for imaging fibrosis and fibrogenesis","volume":"25","author":"D\u00e9sog\u00e8re","year":"2019","journal-title":"Chemistry"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0680","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1172\/JCI93563","article-title":"Resolution of organ fibrosis","volume":"128","author":"Jun","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bcp.2020.114146_b0685","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/581581","article-title":"Overexpression of delayed rectifier K+ channels promotes in situ proliferation of leukocytes in rat kidneys with advanced chronic renal failure","volume":"2012","author":"Kazama","year":"2012","journal-title":"Int. J. Nephrol."},{"key":"10.1016\/j.bcp.2020.114146_b0690","doi-asserted-by":"crossref","first-page":"7567638","DOI":"10.1155\/2019\/7567638","article-title":"Delayed rectifier K+-channel is a novel therapeutic target for interstitial renal fibrosis in rats with unilateral ureteral obstruction","volume":"2019","author":"Abe","year":"2019","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0695","first-page":"103","article-title":"Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling","volume":"45","author":"Wu","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0700","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0705","doi-asserted-by":"crossref","first-page":"671","DOI":"10.7150\/ijbs.38950","article-title":"Blockage of Kv1.3 regulates macrophage migration in acute liver injury by targeting \u03b4-catenin through RhoA signaling","volume":"16","author":"Wu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2020.114146_b0710","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.toxicon.2014.05.002","article-title":"Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels","volume":"87","author":"Bartok","year":"2014","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0715","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4049\/jimmunol.151.2.610","article-title":"Lack of voltage sensitive potassium channels and generation of membrane potential by sodium potassium ATPase in murine T lymphocytes","volume":"151","author":"Ishida","year":"1993","journal-title":"J. Immunol."},{"issue":"49","key":"10.1016\/j.bcp.2020.114146_b0720","doi-asserted-by":"crossref","first-page":"37675","DOI":"10.1074\/jbc.M605617200","article-title":"Association of Kv1.5 and Kv1.3 Contributes to the Major Voltage-dependent K+ Channel in Macrophages","volume":"281","author":"Vicente","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0725","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.4049\/jimmunol.174.8.4736","article-title":"Pattern of Kv beta subunit expression in macrophages depends upon proliferation and the mode of activation","volume":"174","author":"Vicente","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0730","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.173.2.776","article-title":"K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity","volume":"173","author":"Wulff","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2020.114146_b0735","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3389\/fimmu.2017.01205","article-title":"Kv1.3 channel blockade modulates the effector function of B cells in granulomatosis with polyangiitis","volume":"8","author":"Land","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0740","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/hep.21522","article-title":"AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers","volume":"45","author":"Moritoki","year":"2007","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0745","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12427","article-title":"Kv channels and vascular smooth muscle cell proliferation","volume":"25","author":"L\u00f3pez-L\u00f3pez","year":"2018","journal-title":"Microcirculation"},{"issue":"9","key":"10.1016\/j.bcp.2020.114146_b0750","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.CIR.0000086464.04719.DD","article-title":"Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis","volume":"108","author":"K\u00f6hler","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b0755","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/ATVBAHA.110.205187","article-title":"Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle Cells","volume":"30","author":"Cidad","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0760","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/cells9040913","article-title":"Contribution of the potassium channels KV1.3 and KCa3.1 to smooth muscle cell proliferation in growing collateral arteries","volume":"9","author":"Lasch","year":"2020","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.bcp.2020.114146_b0765","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1161\/ATVBAHA.119.313492","article-title":"Myocardin-dependent Kv1.5 channel expression prevents phenotypic modulation of human vessels in organ culture","volume":"39","author":"Ar\u00e9valo-Mart\u00ednez","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0770","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/ATVBAHA.111.242727","article-title":"Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism","volume":"32","author":"Cidad","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b0775","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1074\/jbc.M115.678995","article-title":"Molecular determinants of Kv1.3 potassium channels-induced proliferation","volume":"291","author":"Jim\u00e9nez-P\u00e9rez","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.bcp.2020.114146_b0780","doi-asserted-by":"crossref","first-page":"E2239","DOI":"10.1073\/pnas.1221206110","article-title":"Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance","volume":"110","author":"Upadhyay","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0785","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1124\/mol.112.078006","article-title":"Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells","volume":"82","author":"Varga","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2020.114146_b0790","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lfs.2017.05.027","article-title":"The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats","volume":"181","author":"Jaimes-Hoy","year":"2017","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0795","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1365-2826.2012.02314.x","article-title":"Diet-induced obesity resistance of Kv1.3-\/- mice is olfactory bulb dependent","volume":"24","author":"Tucker","year":"2012","journal-title":"J. Neuroendocrinol."},{"issue":"20","key":"10.1016\/j.bcp.2020.114146_b0800","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14254","article-title":"Long-term obesogenic diet and targeted deletion of potassium channel Kv1.3 have differing effects on voluntary exercise in mice","volume":"7","author":"Chelette","year":"2019","journal-title":"Physiol. Rep."},{"issue":"21","key":"10.1016\/j.bcp.2020.114146_b0805","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1007\/s00018-018-2851-7","article-title":"Caveolar targeting links Kv1.3 with the insulin-dependent adipocyte physiology","volume":"75","author":"P\u00e9rez-Verdaguer","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0810","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.imlet.2010.06.009","article-title":"Lymphocyte activation in type 1 diabetes mellitus: the increased significance of Kv1.3 potassium channels","volume":"133","author":"Toldi","year":"2010","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bcp.2020.114146_b0815","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jff.2018.11.009","article-title":"The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: the role of potassium channels","volume":"52","author":"Gojkovic-Bukarica","year":"2019","journal-title":"J. Function. Food"},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0820","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(03)00844-4","article-title":"Kv1.3 channel gene-targeted deletion produces \u201cSuper-Smeller Mice\u201d with altered glomeruli, interacting scaffolding proteins, and biophysics","volume":"41","author":"Fadool","year":"2004","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b0825","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180762","article-title":"Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: a randomized phase 1b trial","volume":"12","author":"Tarcha","year":"2017","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.bcp.2020.114146_b0830","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1460-9568.1995.tb00641.x","article-title":"Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain","volume":"7","author":"Veh","year":"1995","journal-title":"Eur. J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2020.114146_b0835","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.imlet.2003.11.020","article-title":"Ion channels and lymphocyte activation","volume":"92","author":"Panyi","year":"2004","journal-title":"Immunol. Lett."},{"issue":"13","key":"10.1016\/j.bcp.2020.114146_b0840","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1074\/jbc.M413548200","article-title":"A novel potassium channel in lymphocyte mitochondria","volume":"280","author":"Szabo","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0845","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1085\/jgp.200910334","article-title":"Immunomodulation of voltage-dependent K+ channels in macrophages: molecular and biophysical consequences","volume":"135","author":"Villalonga","year":"2010","journal-title":"J. Gen. Physiol."},{"issue":"47","key":"10.1016\/j.bcp.2020.114146_b0850","doi-asserted-by":"crossref","first-page":"46307","DOI":"10.1074\/jbc.M304388200","article-title":"Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages","volume":"278","author":"Vicente","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0855","doi-asserted-by":"crossref","first-page":"L862","DOI":"10.1152\/ajplung.00095.2003","article-title":"Kv1.3 potassium channels in human alveolar macrophages","volume":"285","author":"Mackenzie","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2020.114146_b0860","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0165-5728(01)00462-3","article-title":"Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1-associated dementia","volume":"122","author":"Chung","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bcp.2020.114146_b0865","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.abb.2015.12.013","article-title":"Kv1.3 potassium channel mediates macrophage migration in atherosclerosis by regulating ERK activity","volume":"591","author":"Kan","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b0870","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.4049\/jimmunol.0803003","article-title":"Developmental switch of the expression of ion channels in human dendritic cells","volume":"183","author":"Zsiros","year":"2009","journal-title":"J. Immunol."},{"issue":"1638","key":"10.1016\/j.bcp.2020.114146_b0875","doi-asserted-by":"crossref","first-page":"20130106","DOI":"10.1098\/rstb.2013.0106","article-title":"Ion channels and anti-cancer immunity","volume":"369","author":"Panyi","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bcp.2020.114146_b0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.trsl.2020.06.002","article-title":"Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo","author":"Bobi","year":"2020","journal-title":"Transl. Res."},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b0885","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/ATVBAHA.110.205187","article-title":"Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells","volume":"30","author":"Cidad","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.bcp.2020.114146_b0890","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s00424-014-1607-y","article-title":"Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR signaling pathway","volume":"467","author":"Cidad","year":"2015","journal-title":"Pflugers Arch."},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b0895","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10557-014-6554-5","article-title":"K+ channel expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation","volume":"28","author":"Cidad","year":"2014","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b0900","first-page":"281","article-title":"Mammalian osteoclasts express a transient potassium channel with properties of Kv1.3","volume":"2","author":"Arkett","year":"1994","journal-title":"Recept. Channels"},{"issue":"11","key":"10.1016\/j.bcp.2020.114146_b0905","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1172\/JCI118700","article-title":"Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney","volume":"97","author":"Yao","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bcp.2020.114146_b0910","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1073\/pnas.0308450100","article-title":"The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity","volume":"101","author":"Xu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2020.114146_b0915","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1113\/jphysiol.1987.sp016750","article-title":"A patch-clamp study of mammalian platelets and their voltage-gated potassium current","volume":"391","author":"Maruyama","year":"1987","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0920","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1464-410X.2006.05874.x","article-title":"K channel expression in prostate epithelium and its implications in men with chronic prostatitis","volume":"97","author":"Liang","year":"2006","journal-title":"BJU Int."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0925","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/aps.2012.142","article-title":"Voltage-gated K+ channels in adipogenic differentiation of bone marrow-derived human mesenchymal stem cells","volume":"34","author":"You","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0930","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0005-2736(03)00198-6","article-title":"The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia","volume":"1616","author":"Grunnet","year":"2003","journal-title":"BBA"},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b0935","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s11064-018-2509-8","article-title":"Voltage gated potassium channel Kv1.3 is upregulated on activated astrocytes in experimental autoimmune encephalomyelitis","volume":"43","author":"Bozic","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bcp.2020.114146_b0940","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3389\/fonc.2019.00933","article-title":"Voltage-gated potassium channel Kv1.3 as a target in therapy of cancer","volume":"9","author":"Teisseyre","year":"2019","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b0945","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/14728222.2017.1420170","article-title":"Kv1.3: a multifunctional channel with many pathological implications","volume":"22","author":"Serrano-Albarras","year":"2018","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/j.bcp.2020.114146_b0950","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fphys.2013.00283","article-title":"The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer","volume":"4","author":"Comes","year":"2013","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0955","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1159\/000430223","article-title":"Biophysical characterization and expression analysis of Kv1.3 potassium channel in primary human leukemic B cells","volume":"37","author":"Szabo","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"49","key":"10.1016\/j.bcp.2020.114146_b0960","doi-asserted-by":"crossref","first-page":"32697","DOI":"10.1074\/jbc.273.49.32697","article-title":"ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide","volume":"273","author":"Kalman","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bcp.2020.114146_b0965","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1111\/febs.13294","article-title":"N-Terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3","volume":"282","author":"Chang","year":"2015","journal-title":"FEBS J."},{"issue":"11","key":"10.1016\/j.bcp.2020.114146_b0970","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078712","article-title":"A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation","volume":"8","author":"Rashid","year":"2013","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b0975","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1124\/jpet.112.191890","article-title":"Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease","volume":"342","author":"Tarcha","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b0980","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1038\/s41598-017-03998-x","article-title":"Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats","volume":"7","author":"Bergmann","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2020.114146_b0985","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.clim.2017.03.014","article-title":"Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog","volume":"180","author":"Tanner","year":"2017","journal-title":"Clin. Immunol."},{"issue":"41","key":"10.1016\/j.bcp.2020.114146_b0990","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1073\/pnas.1612803113","article-title":"Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"52","key":"10.1016\/j.bcp.2020.114146_b0995","doi-asserted-by":"crossref","first-page":"22211","DOI":"10.1073\/pnas.0910123106","article-title":"A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library","volume":"106","author":"Takacs","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2020.114146_b1000","unstructured":"A. Klostermann, J. Stockhaus, KV1.3 potassium channel antagonists, WO\/2015\/169901 (2015)."},{"issue":"3","key":"10.1016\/j.bcp.2020.114146_b1005","doi-asserted-by":"crossref","DOI":"10.3390\/md18030173","article-title":"Marine toxins targeting Kv1 channels: pharmacological tools and therapeutic scaffolds","volume":"18","author":"Finol-Urdaneta","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bcp.2020.114146_b1010","doi-asserted-by":"crossref","DOI":"10.1590\/1678-9199-jvatitd-1481-18","article-title":"Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression","volume":"25","author":"Oliveira","year":"2019","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"issue":"4","key":"10.1016\/j.bcp.2020.114146_b1015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/toxins12040230","article-title":"Centipede venom peptides acting on ion channels","volume":"12","author":"Chu","year":"2020","journal-title":"Toxins"},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b1020","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00249-016-1196-0","article-title":"The small neurotoxin apamin blocks not only small conductance Ca2+ activated K+ channels (SK type) but also the voltage-dependent Kv1.3 channel","volume":"46","author":"Voos","year":"2017","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.bcp.2020.114146_b1025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.peptides.2017.03.005","article-title":"Discovery of three toxin peptides with Kv1.3 channel and IL-2 cytokine-inhibiting activities from Non-Buthidae scorpions, Chaerilus tricostatus and Chaerilus tryznai","volume":"91","author":"Ding","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.bcp.2020.114146_b1030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijbiomac.2020.01.133","article-title":"Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights origin of neurotoxins in telson formed in Paleozoic scorpions","volume":"148","author":"Meng","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b1035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13578-019-0364-1","article-title":"Immunosuppressive effects of a novel potassium channel toxin Ktx-Sp2 from Scorpiops pocoki","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.bcp.2020.114146_b1040","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13578-017-0187-x","article-title":"Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki","volume":"7","author":"Zou","year":"2017","journal-title":"Cell Biosci."},{"key":"10.1016\/j.bcp.2020.114146_b1045","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.toxicon.2017.05.011","article-title":"Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels","volume":"133","author":"Olamendi-Portugal","year":"2017","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b1050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/toxins11020076","article-title":"Centipede KCNQ inhibitor SsTx also targets KV1.3","volume":"11","author":"Du","year":"2019","journal-title":"Toxins"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2020.114146_b1055","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3280321","article-title":"A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom","volume":"328","author":"Lebrun","year":"1997","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bcp.2020.114146_b1060","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22244","article-title":"Bldesin, the first functionally characterized pathogenic fungus defensin with Kv1.3 channel and chymotrypsin inhibitory activities","volume":"33","author":"Luo","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bcp.2020.114146_b1065","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.peptides.2018.08.005","article-title":"Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: evidence of diversity in beta-defensin-potassium channel interactions","volume":"108","author":"Zhao","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.bcp.2020.114146_b1070","doi-asserted-by":"crossref","DOI":"10.1021\/acsptsci.0c00035","article-title":"Modulation of lymphocyte potassium channel KV1.3 by membrane-penetrating, joint-targeting immunomodulatory plant defensin,","author":"Ong","year":"2020","journal-title":"ACS Pharmacol. Trans. Sci."},{"issue":"7","key":"10.1016\/j.bcp.2020.114146_b1075","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1073\/pnas.1714760115","article-title":"Centipedes subdue giant prey by blocking KCNQ channels","volume":"115","author":"Luo","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2020.114146_b1080","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/bioinformatics\/bty697","article-title":"A quantitative map of protein sequence space for the cis-defensin superfamily","volume":"35","author":"Shafee","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bcp.2020.114146_b1085","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/prot.25679","article-title":"Evolution of cnidarian trans-defensins: sequence, structure and exploration of chemical space","volume":"87","author":"Mitchell","year":"2019","journal-title":"Proteins"},{"issue":"18","key":"10.1016\/j.bcp.2020.114146_b1090","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1073\/pnas.0408677102","article-title":"Solving the protein sequence metric problem","volume":"102","author":"Atchley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bcp.2020.114146_b1095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxicon.2019.04.008","article-title":"Mapping the chemical and sequence space of the ShKT superfamily","volume":"165","author":"Shafee","year":"2019","journal-title":"Toxicon"},{"key":"10.1016\/j.bcp.2020.114146_b1100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10126-020-09945-8","article-title":"Tentacle transcriptomes of the speckled anemone (Actiniaria: Actiniidae: Oulactis sp.): venom-related components and their domain structure","volume":"22","author":"Mitchell","year":"2020","journal-title":"Mar. Biotechnol. (NY)"},{"issue":"6","key":"10.1016\/j.bcp.2020.114146_b1105","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/17460441.2017.1317243","article-title":"Enhancing the therapeutic potential of peptide toxins","volume":"12","author":"Norton","year":"2017","journal-title":"Expert. Opin. Drug Discov."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220303828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220303828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:07:32Z","timestamp":1762096052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220303828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":221,"alternative-id":["S0006295220303828"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114146","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The voltage-gated potassium channel KV1.3 as a therapeutic target for venom-derived peptides","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114146"}}