{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:31:36Z","timestamp":1790753496296,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000305","name":"National Eye Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bcp.2020.114151","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T03:19:08Z","timestamp":1594783148000},"page":"114151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Etifoxine reverses weight gain and alters the colonic bacterial community in a mouse model of obesity"],"prefix":"10.1016","volume":"180","author":[{"given":"Khalid S.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2020.114151_b0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094112","article-title":"Almost all antipsychotics result in weight gain: A meta-analysis","author":"Bak","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.114151_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.orcp.2015.08.012","article-title":"Antipsychotic medications and extreme weight gain in two health systems","author":"Arterburn","year":"2016","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.bcp.2020.114151_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/nu10030365","article-title":"The western diet\u2013microbiome-host interaction and its role in metabolic disease","author":"Zin\u00f6cker","year":"2018","journal-title":"Nutrients."},{"key":"10.1016\/j.bcp.2020.114151_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00387","article-title":"The origin and understanding of the incretin concept","author":"Rehfeld","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.bcp.2020.114151_b0025","doi-asserted-by":"crossref","DOI":"10.1097\/MED.0000000000000448","article-title":"Gastrointestinal hormones and regulation of gastric emptying","author":"Camilleri","year":"2019","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.bcp.2020.114151_b0030","doi-asserted-by":"crossref","DOI":"10.1038\/nature23292","article-title":"The evolution of the host microbiome as an ecosystem on a leash","author":"Foster","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.bcp.2020.114151_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms3020213","article-title":"Does the Gut Microbiota Contribute to Obesity? Going beyond the Gut Feeling","author":"Aguirre","year":"2015","journal-title":"Microorganisms."},{"key":"10.1016\/j.bcp.2020.114151_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/nu8040202","article-title":"The intestinal microbiota in metabolic disease","author":"Woting","year":"2016","journal-title":"Nutrients."},{"key":"10.1016\/j.bcp.2020.114151_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","author":"Sayin","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2020.114151_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2020.114151_b0055","doi-asserted-by":"crossref","DOI":"10.1038\/nchembio.1864","article-title":"A biosynthetic pathway for a prominent class of microbiota-derived bile acids","author":"Devlin","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2020.114151_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","author":"David","year":"2014","journal-title":"Nature."},{"issue":"6052","key":"10.1016\/j.bcp.2020.114151_b0065","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes","volume":"334","author":"Wu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bcp.2020.114151_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2015.06.020","article-title":"Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis","author":"Li","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2020.114151_b0075","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/kfq338","article-title":"Xenobiotic metabolism, disposition, and regulation by receptors: From biochemical phenomenon to predictors of major toxicities","author":"Omiecinski","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bcp.2020.114151_b0080","doi-asserted-by":"crossref","DOI":"10.1517\/17425255.2015.1032245","article-title":"Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity","author":"Gonzalez","year":"2015","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.bcp.2020.114151_b0085","doi-asserted-by":"crossref","DOI":"10.3344\/kjp.2015.28.1.4","article-title":"Etifoxine for pain patients with anxiety","author":"Choi","year":"2015","journal-title":"Korean J. Pain."},{"key":"10.1016\/j.bcp.2020.114151_b0090","doi-asserted-by":"crossref","DOI":"10.1111\/fcp.12169","article-title":"Safety profile of etifoxine: A French pharmacovigilance survey","author":"Cottin","year":"2016","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bcp.2020.114151_b0095","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddx319","article-title":"Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration","author":"Biswas","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bcp.2020.114151_b0100","doi-asserted-by":"crossref","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"10.1016\/j.bcp.2020.114151_b0105","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies","author":"Klindworth","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.bcp.2020.114151_b0110","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.bcp.2020.114151_b0115","doi-asserted-by":"crossref","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","author":"Callahan","year":"2016","journal-title":"Nat. Methods."},{"key":"10.1016\/j.bcp.2020.114151_b0120","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-018-0470-z","article-title":"Caporaso, Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2\u2019s q2-feature-classifier plugin","author":"Bokulich","year":"2018","journal-title":"Microbiome."},{"key":"10.1016\/j.bcp.2020.114151_b0125","doi-asserted-by":"crossref","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","author":"McDonald","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.bcp.2020.114151_b0130","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: A versatile open source tool for metagenomics","author":"Rognes","year":"2016","journal-title":"PeerJ."},{"key":"10.1016\/j.bcp.2020.114151_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bcp.2020.114151_b0140","doi-asserted-by":"crossref","DOI":"10.1038\/ijo.2017.280","article-title":"High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats","author":"Poret","year":"2018","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bcp.2020.114151_b0145","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00098.2010","article-title":"Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation","author":"De La Serre","year":"2010","journal-title":"Am. J. Physiol. - Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bcp.2020.114151_b0150","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-15-511","article-title":"Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats","author":"Petriz","year":"2014","journal-title":"BMC Genomics."},{"key":"10.1016\/j.bcp.2020.114151_b0155","doi-asserted-by":"crossref","DOI":"10.1007\/s00441-015-2132-9","article-title":"Prolonged high fat diet ingestion, obesity, and type 2 diabetes symptoms correlate with phenotypic plasticity in myenteric neurons and nerve damage in the mouse duodenum","author":"Stenkamp-Strahm","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bcp.2020.114151_b0160","series-title":"Biochemical Interactions Between the Gut Microbiome and Host In Obesity\/Type II Diabetes","author":"Ibrahim","year":"2017"},{"key":"10.1016\/j.bcp.2020.114151_b0165","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00162-16","article-title":"Balance Trees Reveal Microbial Niche Differentiation","author":"Morton","year":"2017","journal-title":"MSystems."},{"key":"10.1016\/j.bcp.2020.114151_b0170","doi-asserted-by":"crossref","DOI":"10.1038\/nchembio.1136","article-title":"Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism","author":"Gut","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2020.114151_b0175","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.7b00027","article-title":"The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity","author":"Costa","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bcp.2020.114151_b0180","article-title":"Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation","author":"Lin","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.bcp.2020.114151_b0185","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and reverse cholesterol transport: Basic mechanisms and their roles in vascular health and disease","author":"Ouimet","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2020.114151_b0190","doi-asserted-by":"crossref","DOI":"10.1042\/CS20140047","article-title":"Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype","author":"Taylor","year":"2014","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bcp.2020.114151_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123740","article-title":"TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells","author":"Biswas","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2020.114151_b0200","doi-asserted-by":"crossref","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2020.114151_b0205","doi-asserted-by":"crossref","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: A double-edged sword for health?","author":"Liu","year":"2018","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bcp.2020.114151_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2017.00387","article-title":"Interactions of intestinal bacteria with components of the intestinal mucus","author":"Sicard","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2020.114151_b0215","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v17.i12.1519","article-title":"Potential beneficial effects of butyrate in intestinal and extraintestinal diseases","author":"Canani","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bcp.2020.114151_b0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092193","article-title":"Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity","author":"Evans","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2020.114151_b0225","doi-asserted-by":"crossref","DOI":"10.1038\/nature23874","article-title":"Commensal bacteria make GPCR ligands that mimic human signalling molecules","author":"Cohen","year":"2017","journal-title":"Nature."},{"key":"10.1016\/j.bcp.2020.114151_b0230","doi-asserted-by":"crossref","unstructured":"T. Schulze, S. Golfier, C. Tabeling, K. Rab\u0308el, M.H. Gr\u00e4ler, M. Witzenrath, M. Lipp, Sphingosine-1-phospate receptor 4 (S1P 4) deficiency profoundly affects dendritic cell function and T H17-cell differentiation in a murine model, FASEB J. (2011). https:\/\/doi.org\/10.1096\/fj.10-179028.","DOI":"10.1096\/fj.10-179028"},{"key":"10.1016\/j.bcp.2020.114151_b0235","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/cit280","article-title":"Obesity as a risk factor for Clostridium difficile infection","author":"Bishara","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bcp.2020.114151_b0240","doi-asserted-by":"crossref","DOI":"10.3201\/eid1911.130618","article-title":"Possible association between obesity and Clostridium difficile infection","author":"Leung","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bcp.2020.114151_b0245","doi-asserted-by":"crossref","unstructured":"T. Nakatsuji, D. chu C. Tang, L. Zhang, R.L. Gallo, C.M. Huang, Propionibacterium acnes camp factor and host acid sphingomyelinase contribute to bacterial virulence: Potential targets for inflammatory acne treatment, PLoS One. (2011). https:\/\/doi.org\/10.1371\/journal.pone.0014797.","DOI":"10.1371\/journal.pone.0014797"},{"key":"10.1016\/j.bcp.2020.114151_b0250","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2018.00272","article-title":"Is IL-1\u03b2 further evidence for the role of Propionibacterium acnes in degenerative disc disease? Lessons from the study of the inflammatory skin condition acne vulgaris","author":"Slaby","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2020.114151_b0255","doi-asserted-by":"crossref","unstructured":"B.R. Vowels, S. Yang, J.J. Leyden, Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: Implications for chronic inflammatory acne, Infect. Immun. (1995).","DOI":"10.1128\/iai.63.8.3158-3165.1995"},{"key":"10.1016\/j.bcp.2020.114151_b0260","doi-asserted-by":"crossref","DOI":"10.1124\/pr.118.015768","article-title":"Gut reactions: Breaking down xenobiotic\u2013microbiome interactions","author":"Clarke","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2020.114151_b0265","doi-asserted-by":"crossref","DOI":"10.3390\/nu10122009","article-title":"Gut microbiota and endothelial dysfunction markers in obese Mexican children and adolescents","author":"Nirmalkar","year":"2018","journal-title":"Nutrients."},{"key":"10.1016\/j.bcp.2020.114151_b0270","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10902-0","article-title":"YeeJ is an inverse autotransporter from Escherichia coli that binds to peptidoglycan and promotes biofilm formation","author":"Martinez-Gil","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2020.114151_b0275","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.micro.55.1.165","article-title":"Quorum Sensing in Bacteria","author":"Miller","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2020.114151_b0280","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.73.6.3197-3209.2005","article-title":"Bacterial cell-to-cell signaling in the gastrointestinal tract","author":"Kaper","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2020.114151_b0285","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-018-0116-8","article-title":"Prebiotic attenuation of olanzapine-induced weight gain in rats: Analysis of central and peripheral biomarkers and gut microbiota","author":"Kao","year":"2018","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.bcp.2020.114151_b0290","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05184-7","article-title":"Gut microbiota associations with common diseases and prescription medications in a population-based cohort","author":"Jackson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2020.114151_b0295","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.05496-11","article-title":"Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis","author":"Buffie","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2020.114151_b0300","doi-asserted-by":"crossref","DOI":"10.1097\/MOG.0000000000000057","article-title":"Bile acids and the gut microbiome","author":"Ridlon","year":"2014","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.bcp.2020.114151_b0305","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.200900092","article-title":"General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: Applications and constraints","author":"Sauvage","year":"2009","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.bcp.2020.114151_b0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148291","article-title":"Unique \u00df-glucuronidase locus in gut microbiomes of Crohn\u2019s disease patients and unaffected first-degree relatives","author":"Gloux","year":"2016","journal-title":"PLoS One."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220303877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220303877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:17:02Z","timestamp":1757769422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220303877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":62,"alternative-id":["S0006295220303877"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114151","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etifoxine reverses weight gain and alters the colonic bacterial community in a mouse model of obesity","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2020 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114151"}}