{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:09:25Z","timestamp":1778638165866,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2016\/25896-5"],"award-info":[{"award-number":["2016\/25896-5"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2013\/08139-8"],"award-info":[{"award-number":["2013\/08139-8"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/06863-3"],"award-info":[{"award-number":["2014\/06863-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08617-7"],"award-info":[{"award-number":["2013\/08617-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/15104-0"],"award-info":[{"award-number":["2018\/15104-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/07749-2"],"award-info":[{"award-number":["2015\/07749-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309595\/2016-9"],"award-info":[{"award-number":["309595\/2016-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301596\/2017-4"],"award-info":[{"award-number":["301596\/2017-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011875","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia, Inova\u00e7\u00f5es e Comunica\u00e7\u00f5es","doi-asserted-by":"publisher","award":["2018\/18257-1"],"award-info":[{"award-number":["2018\/18257-1"]}],"id":[{"id":"10.13039\/501100011875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011875","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia, Inova\u00e7\u00f5es e Comunica\u00e7\u00f5es","doi-asserted-by":"publisher","award":["2018\/15549-1"],"award-info":[{"award-number":["2018\/15549-1"]}],"id":[{"id":"10.13039\/501100011875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011875","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia, Inova\u00e7\u00f5es e Comunica\u00e7\u00f5es","doi-asserted-by":"publisher","award":["423532\/2018-9"],"award-info":[{"award-number":["423532\/2018-9"]}],"id":[{"id":"10.13039\/501100011875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bcp.2020.114230","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T11:50:22Z","timestamp":1600861822000},"page":"114230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase"],"prefix":"10.1016","volume":"182","author":[{"given":"Mariane A.D.","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela V.","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila P.","family":"Zenatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1326-3841","authenticated-orcid":false,"given":"Natacha A.","family":"Migita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Yunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4221-9505","authenticated-orcid":false,"given":"Carlota O.","family":"Rangel-Yagui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus M.","family":"de S\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto","family":"Pessoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tales A.","family":"Costa-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos H.","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Breyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos A.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-9532","authenticated-orcid":false,"given":"Veronica F.","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Palmisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiano M.V.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina B.","family":"Hebeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra H.P.","family":"Farsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-047X","authenticated-orcid":false,"given":"Gisele","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2020.114230_b0005","doi-asserted-by":"crossref","first-page":"100651","DOI":"10.1016\/j.blre.2020.100651","article-title":"Critical overview of the main features and techniques used for the evaluation of the clinical applicability of L-asparaginase as a biopharmaceutical to treat blood cancer","volume":"43","author":"Costa-Silva","year":"2020","journal-title":"Blood Rev."},{"issue":"8","key":"10.1016\/j.bcp.2020.114230_b0010","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.3109\/10428194.2014.1003056","article-title":"Asparaginase pharmacokinetics and implications of therapeutic drug monitoring","volume":"56","author":"Asselin","year":"2015","journal-title":"Leukemia Lymphoma"},{"issue":"2","key":"10.1016\/j.bcp.2020.114230_b0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/clpt.2010.94","article-title":"Genetic Variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity","volume":"88","author":"Chen","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2020.114230_b0020","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood.V97.5.1211","article-title":"Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91\u201301","volume":"97","author":"Silverman","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2020.114230_b0025","first-page":"1964","article-title":"A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase","volume":"119","author":"Patel","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2020.114230_b0030","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1182\/blood-2010-07-298422","article-title":"Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity","volume":"117","author":"Offman","year":"2011","journal-title":"Blood"},{"issue":"43","key":"10.1016\/j.bcp.2020.114230_b0035","doi-asserted-by":"crossref","first-page":"70822","DOI":"10.18632\/oncotarget.12224","article-title":"Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids","volume":"7","author":"Dutta","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2020.114230_b0040","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1182\/blood-2010-09-307330","article-title":"RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia","volume":"118","author":"Holland","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2020.114230_b0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/sj.leu.2403629","article-title":"Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia","volume":"19","author":"Robinson","year":"2005","journal-title":"Leukemia"},{"issue":"17","key":"10.1016\/j.bcp.2020.114230_b0050","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1021\/acs.jmedchem.7b00228","article-title":"Blockade of asparagine endopeptidase inhibits cancer metastasis","volume":"60","author":"Qi","year":"2017","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.bcp.2020.114230_b0055","doi-asserted-by":"crossref","first-page":"8167","DOI":"10.1073\/pnas.0602360103","article-title":"Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21","volume":"103","author":"Strefford","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5\u20136","key":"10.1016\/j.bcp.2020.114230_b0060","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/prca.201300105","article-title":"Cathepsin B: multiple roles in cancer","volume":"8","author":"Aggarwal","year":"2014","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.bcp.2020.114230_b0065","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cmet.2016.05.025","article-title":"Running-induced systemic Cathepsin B secretion is associated with memory function","volume":"24","author":"Moon","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.bcp.2020.114230_b0070","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1016\/j.celrep.2016.08.035","article-title":"STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1\u03b1 activation","volume":"16","author":"Yan","year":"2016","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bcp.2020.114230_b0075","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju012","article-title":"Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis","volume":"106","author":"Lin","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bcp.2020.114230_b0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.biochi.2015.09.022","article-title":"Structure and function of legumain in health and disease","volume":"122","author":"Dall","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.bcp.2020.114230_b0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","article-title":"Cysteine cathepsins: from structure, function and regulation to new frontiers","volume":"1824","author":"Turk","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA) - Proteins Proteomics"},{"key":"10.1016\/j.bcp.2020.114230_b0090","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/1046-5928(91)90063-O","article-title":"Construction of expression systems for Escherichia coli Asparaginase II and two-step purification of the recombinant enzyme from periplasmic extracts","volume":"2","author":"Harms","year":"1991","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.bcp.2020.114230_b0095","doi-asserted-by":"crossref","first-page":"36239","DOI":"10.1038\/srep36239","article-title":"Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity","volume":"6","author":"Costa","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2020.114230_b0100","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bcp.2020.114230_b0105","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bcp.2020.114230_b0110","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0010-4655(95)00042-E","article-title":"GROMACS: a message-passing parallel molecular dynamics implementation","volume":"91","author":"Berendsen","year":"1995","journal-title":"Comput. Phys. Commun"},{"issue":"4","key":"10.1016\/j.bcp.2020.114230_b0115","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1073\/pnas.90.4.1474","article-title":"Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.","volume":"90","author":"Swain","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.bcp.2020.114230_b0120","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain torsion potentials for the Amber ff99SB protein force field: Improved Protein Side-Chain Potentials","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins"},{"key":"10.1016\/j.bcp.2020.114230_b0125","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bcp.2020.114230_b0130","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bcp.2020.114230_b0135","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: A new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.bcp.2020.114230_b0140","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/sj.leu.2401592","article-title":"Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease: report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in acute leukemia","volume":"13","author":"van Dongen","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2020.114230_b0145","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2020.114230_b0150","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.biologicals.2009.11.003","article-title":"Validation of a PCR method for the detection of mycoplasmas according to European Pharmacopoeia section 2.6.7","volume":"38","author":"Zhi","year":"2010","journal-title":"Biologicals"},{"key":"10.1016\/j.bcp.2020.114230_b0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for celular growth and survival: application to proliferation and citotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bcp.2020.114230_b0160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0003-2697(02)00232-4","article-title":"Analytical validation of a microplate reader-based method for the therapeutic drug monitoring of L-asparaginase in human serum","volume":"309","author":"Lanvers","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bcp.2020.114230_b0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ebiom.2018.03.005","article-title":"Low bioavailability and high immunogenicity of a new brand of E. coli l-Asparaginase with active host contaminating proteins","volume":"30","author":"Zenatti","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2020.114230_b0170","first-page":"193","article-title":"Patterns of gene expression and the cellular origins of human leukemias","volume":"516","author":"Greaves","year":"1978","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2020.114230_b0175","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.exphem.2012.04.005","article-title":"Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase","volume":"40","author":"Hermanova","year":"2012","journal-title":"Exp. Hematol."},{"issue":"66","key":"10.1016\/j.bcp.2020.114230_b0180","doi-asserted-by":"crossref","first-page":"109915","DOI":"10.18632\/oncotarget.18565","article-title":"Identification of a cytogenetic and molecular subgroup of acute myeloid leukemias showing sensitivity to L-Asparaginase","volume":"8","author":"Bertuccio","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2020.114230_b0185","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.20111696","article-title":"A germinal center\u2013independent pathway generates unswitched memory B cells early in the primary response","volume":"209","author":"Taylor","year":"2012","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bcp.2020.114230_b0190","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri3802","article-title":"Memory B cells","volume":"15","author":"Kurosaki","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2020.114230_b0195","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2020.114230_b0200","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature25465","article-title":"Asparagine bioavailability governs metastasis in a model of breast cancer","volume":"554","author":"Knott","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2020.114230_b0205","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1182\/blood-2014-06-582627","article-title":"A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics","volume":"124","author":"van der Meer","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2020.114230_b0210","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2967\/jnumed.116.177741","article-title":"In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage-mediated clearance from the bone marrow","volume":"58","author":"van der Meer","year":"2017","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bcp.2020.114230_b0215","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12026-012-8372-9","article-title":"Division of labor during primary humoral immunity","volume":"55","author":"Swanson","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bcp.2020.114230_b0220","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.4049\/jimmunol.173.12.7317","article-title":"Plasmablast and plasma cell production and distribution in trout immune tissues","volume":"173","author":"Bromage","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2020.114230_b0225","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1084\/jem.20110740","article-title":"Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants","volume":"208","author":"Purtha","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2020.114230_b0230","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1038\/s41467-017-01901-w","article-title":"Plasma cell survival in the absence of B cell memory","volume":"8","author":"Hammarlund","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2020.114230_b0235","doi-asserted-by":"crossref","first-page":"429","DOI":"10.12688\/f1000research.13567.1","article-title":"Role of B-cell receptors for B-cell development and antigen-induced differentiation","volume":"7","author":"Yam-Puc","year":"2018","journal-title":"F1000Res"},{"issue":"12","key":"10.1016\/j.bcp.2020.114230_b0240","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.4049\/jimmunol.1300161","article-title":"What is and what should always have been: long-lived plasma cells induced by T cell\u2013independent antigens","volume":"190","author":"Bortnick","year":"2013","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2020.114230_b0245","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1073\/pnas.1014739108","article-title":"Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift","volume":"108","author":"Cantor","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bcp.2020.114230_b0250","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1182\/blood-2014-03-563742","article-title":"HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies","volume":"124","author":"Fernandez","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bcp.2020.114230_b0255","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2020.114230_b0260","doi-asserted-by":"crossref","first-page":"100021","DOI":"10.1016\/j.jtauto.2019.100021","article-title":"The development of human immune system mice and their use to study tolerance and autoimmunity [published correction appears in J Transl Autoimmun. 2020; 25;3:100041]","volume":"2","author":"Alves da Costa","year":"2019","journal-title":"J. Transl. Autoimmun."},{"issue":"2","key":"10.1016\/j.bcp.2020.114230_b0265","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3324\/haematol.2018.199448","article-title":"Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors Fc\u03b5RI and Fc\u03b3RIII","volume":"104","author":"Rathod","year":"2019","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.bcp.2020.114230_b0270","doi-asserted-by":"crossref","first-page":"10996","DOI":"10.1096\/fj.201900857","article-title":"Asparaginase immune complexes induce Fc\u2010\u03b3RIII\u2013dependent hypersensitivity in naive mice","volume":"33","author":"Rathod","year":"2019","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.bcp.2020.114230_b0275","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1124\/jpet.114.220780","article-title":"Effect of premedications in a murine model of asparaginase hypersensitivity","volume":"352","author":"Fernandez","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2020.114230_b0280","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/08880018.2019.1634778","article-title":"PEGylated E. coli asparaginase desensitization: an effective and feasible option for pediatric patients with acute lymphoblastic leukemia who have developed hypersensitivity to pegaspargase in the absence of asparaginase Erwinia chrysanthemi availability","volume":"36","author":"Verma","year":"2019","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2020.114230_b0285","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1200\/JCO.19.03024","article-title":"Impact of asparaginase discontinuation on outcome in childhood acute lymphoblastic leukemia: a report from the children\u2019s oncology group","volume":"38","author":"Gupta","year":"2020","journal-title":"J. Clin. Oncol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220304664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295220304664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:15:46Z","timestamp":1778634946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295220304664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":57,"alternative-id":["S0006295220304664"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114230","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2020.114230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114230"}}