{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:03:40Z","timestamp":1789927420061,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bcp.2021.114486","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T23:49:18Z","timestamp":1614037758000},"page":"114486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Ferroptosis and its potential as a therapeutic target"],"prefix":"10.1016","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-4817","authenticated-orcid":false,"given":"Hanshu","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-352X","authenticated-orcid":false,"given":"Justin","family":"Pratte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Giardina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bcp.2021.114486_b0005","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1083\/jcb.201804161","article-title":"Glutathione metabolism in cancer progression and treatment resistance","volume":"217","author":"Bansal","year":"2018","journal-title":"J. Cell Biol."},{"issue":"7784","key":"10.1016\/j.bcp.2021.114486_b0010","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ Oxidoreductase FSP1 Acts Parallel to GPX4 to Inhibit Ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0015","first-page":"275","article-title":"Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile","volume":"1666","author":"van den Brink-van der Laan","year":"2004","journal-title":"Lipid-Protein Interact."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.bcp.2021.114486_b0025","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3390\/cancers11050678","article-title":"The non-essential amino acid cysteine becomes essential for tumor proliferation and survival","volume":"11","author":"Combs","year":"2019","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.bcp.2021.114486_b0030","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2021.114486_b0035","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"issue":"7","key":"10.1016\/j.bcp.2021.114486_b0040","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/acschembio.5b00245","article-title":"Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death","volume":"10","author":"Dixon","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 Dictates Ferroptosis Sensitivity by Shaping Cellular Lipid Composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"7784","key":"10.1016\/j.bcp.2021.114486_b0050","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bcp.2021.114486_b0055","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin receptor is a specific ferroptosis marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: recommendations of the NCCD 2015","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.bcp.2021.114486_b0065","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.bcp.2021.114486_b0070","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2021.114486_b0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2017.01.004","article-title":"Ferroptosis and cell death mechanisms in Parkinson\u2019s disease","volume":"104","author":"Guiney","year":"2017","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.bcp.2021.114486_b0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2015.93","article-title":"Loss of Cysteinyl-TRNA Synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation","volume":"23","author":"Hayano","year":"2016","journal-title":"Cell Death Differ."},{"issue":"16","key":"10.1016\/j.bcp.2021.114486_b0085","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1073\/pnas.1001006107","article-title":"Glutaminase 2, a Novel P53 target gene regulating energy metabolism and antioxidant function","volume":"107","author":"Hu","year":"2010","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0090","first-page":"153","article-title":"Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal","volume":"533","author":"Huang","year":"2003","journal-title":"Met. Hum. Cancer"},{"issue":"7545","key":"10.1016\/j.bcp.2021.114486_b0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a P53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and Adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"10.1016\/j.bcp.2021.114486_b0105","first-page":"6417","article-title":"Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors","volume":"34","author":"Lachaier","year":"2014","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0110","article-title":"The interaction between ferroptosis and lipid metabolism in cancer","volume":"5","author":"Li","year":"2020","journal-title":"Signal Trans. Target. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2021.114486_b0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41420-020-0256-5","article-title":"The nuclear envelope: target and mediator of the apoptotic process","volume":"6","author":"Lindenboim","year":"2020","journal-title":"Cell Death Discovery"},{"issue":"47","key":"10.1016\/j.bcp.2021.114486_b0125","doi-asserted-by":"crossref","first-page":"16836","DOI":"10.1073\/pnas.1415518111","article-title":"Synchronized renal tubular cell death involves ferroptosis","volume":"111","author":"Linkermann","year":"2014","journal-title":"Proc. Nat. Acad. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2021.114486_b0130","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1096\/fj.10-177212","article-title":"Dopaminergic neurons of system Xc\u2013-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity","volume":"25","author":"Massie","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2021.114486_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/srep10903","article-title":"Pharmacological chaperones and coenzyme Q10 treatment improves Mutant \u03b2-glucocerebrosidase activity and mitochondrial function in neuronopathic forms of Gaucher disease","volume":"5","author":"de la Mata","year":"2015","journal-title":"Sci. Rep."},{"issue":"40","key":"10.1016\/j.bcp.2021.114486_b0140","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41388-018-0315-z","article-title":"The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma","volume":"37","author":"Miess","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2021.114486_b0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bcp.2017.06.112","article-title":"Lipoxygenase inhibitors protect acute lymphoblastic Leukemia cells from ferroptotic cell death","volume":"140","author":"Probst","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2021.114486_b0150","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2021.114486_b0155","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chembiol.2015.11.016","article-title":"Cell-line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity","volume":"23","author":"Shimada","year":"2016","journal-title":"Cell Chem. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2021.114486_b0160","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2021.114486_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01371","article-title":"RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer","volume":"9","author":"Sui","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0170","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the P62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology (Baltimore, MD)"},{"issue":"6718","key":"10.1016\/j.bcp.2021.114486_b0175","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/17135","article-title":"Molecular characterization of mitochondrial apoptosis-inducing factor","volume":"397","author":"Susin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2021.114486_b0180","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.freeradbiomed.2017.04.024","article-title":"Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis","volume":"108","author":"Toyokuni","year":"2017","journal-title":"Free Radical Biol. Med."},{"issue":"11","key":"10.1016\/j.bcp.2021.114486_b0185","first-page":"1618","article-title":"PPAR\u03b2 MRNA expression, reduced by N\u22123 PUFA diet in mammary tumor, controls breast cancer cell growth","volume":"1831","author":"Wannous","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Cell Biol. Lipids"},{"issue":"3","key":"10.1016\/j.bcp.2021.114486_b0190","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"issue":"34","key":"10.1016\/j.bcp.2021.114486_b0195","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bcp.2021.114486_b0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by Lipid Peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bcp.2021.114486_b0205","series-title":"The Ovary","first-page":"353","article-title":"Chapter 20 - reactive oxygen species and ovarian function","author":"Bertout","year":"2004"},{"issue":"3","key":"10.1016\/j.bcp.2021.114486_b0210","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2021.114486_b0215","series-title":"BioMed Research International 2014","article-title":"Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium","author":"Nunes","year":"2014"},{"issue":"1","key":"10.1016\/j.bcp.2021.114486_b0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1756-9966-30-87","article-title":"Apoptosis in cancer: from pathogenesis to treatment","volume":"30","author":"Wong","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.bcp.2021.114486_b0225","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1038\/sj.gt.3301041","article-title":"Cancer gene therapy using a pro-apoptotic gene, caspase-3","volume":"6","author":"Yamabe","year":"1999","journal-title":"Gene Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221000824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221000824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:28:38Z","timestamp":1757770118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295221000824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":45,"alternative-id":["S0006295221000824"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114486","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis and its potential as a therapeutic target","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114486"}}