{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:23:11Z","timestamp":1792182191479,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["UMR5292"],"award-info":[{"award-number":["UMR5292"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["U1028"],"award-info":[{"award-number":["U1028"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.bcp.2021.114514","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T16:00:49Z","timestamp":1615478449000},"page":"114514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Is REM sleep a paradoxical state?: Different neurons are activated in the cingulate cortices and the claustrum during wakefulness and paradoxical sleep hypersomnia"],"prefix":"10.1016","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7630-6450","authenticated-orcid":false,"given":"Renato","family":"Maciel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"De Laet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Agnorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-5468","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Arthaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Antoine","family":"Libourel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-8631","authenticated-orcid":false,"given":"Patrice","family":"Fort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-7702","authenticated-orcid":false,"given":"Claudio","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-423X","authenticated-orcid":false,"given":"Pierre-Herv\u00e9","family":"Luppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2021.114514_b0005","first-page":"1024","article-title":"Sur un stade d'activit\u00e9 \u00e9lectrique c\u00e9r\u00e9brale rapide au cours du sommeil physiologique","volume":"153","author":"Jouvet","year":"1959","journal-title":"CR Seances Soc. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2021.114514_b0010","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuron.2009.08.024","article-title":"Cortical firing and sleep homeostasis","volume":"63","author":"Vyazovskiy","year":"2009","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.bcp.2021.114514_b0015","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1152\/jn.2001.85.5.1969","article-title":"Natural waking and sleep states: a view from inside neocortical neurons","volume":"85","author":"Steriade","year":"2001","journal-title":"J. Neurophysiol."},{"issue":"6596","key":"10.1016\/j.bcp.2021.114514_b0020","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/383163a0","article-title":"Functional neuroanatomy of human rapid-eye-movement sleep and dreaming","volume":"383","author":"Maquet","year":"1996","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2021.114514_b0025","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0006-8993(97)00807-X","article-title":"Forebrain activation in REM sleep: an FDG PET study","volume":"770","author":"Nofzinger","year":"1997","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.bcp.2021.114514_b0030","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400177","article-title":"The supramammillary nucleus and the claustrum activate the cortex during REM sleep","volume":"1","author":"Renouard","year":"2015","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.bcp.2021.114514_b0035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/jsr.12269","article-title":"Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin\/orexin neuronal activation before, during and after deprivation","volume":"24","author":"Arthaud","year":"2015","journal-title":"J. Sleep Res."},{"issue":"5","key":"10.1016\/j.bcp.2021.114514_b0040","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuron.2013.03.025","article-title":"Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations","volume":"78","author":"Guenthner","year":"2013","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.bcp.2021.114514_b0045","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41593-018-0318-7","article-title":"Temporal evolution of cortical ensembles promoting remote memory retrieval","volume":"22","author":"DeNardo","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"6356","key":"10.1016\/j.bcp.2021.114514_b0050","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.aan6747","article-title":"Thirst-associated preoptic neurons encode an aversive motivational drive","volume":"357","author":"Allen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bcp.2021.114514_b0055","article-title":"Targeted recombination in active populations as a new mouse genetic model to study sleep-active neuronal populations: demonstration that Lhx6+ neurons in the ventral zona incerta are activated during paradoxical sleep hypersomnia","author":"Lee","year":"2020","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.bcp.2021.114514_b0060","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaa003","article-title":"Insights into paradoxical (REM) sleep homeostatic regulation in mice using an innovative automated sleep deprivation method","author":"Arthaud","year":"2020","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.bcp.2021.114514_b0065","doi-asserted-by":"crossref","first-page":"815","DOI":"10.5665\/sleep.4682","article-title":"Unsupervised online classifier in sleep scoring for sleep deprivation studies","volume":"38","author":"Libourel","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.bcp.2021.114514_b0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.conb.2017.05.014","article-title":"Genetic strategies to access activated neurons","volume":"45","author":"DeNardo","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bcp.2021.114514_b0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00312","article-title":"Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice","volume":"2","author":"Deng","year":"2013","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.bcp.2021.114514_b0080","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.neuron.2018.07.031","article-title":"Inhibitory control of prefrontal cortex by the claustrum","volume":"99","author":"Jackson","year":"2018","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.bcp.2021.114514_b0085","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41593-020-0625-7","article-title":"The claustrum coordinates cortical slow-wave activity","volume":"23","author":"Narikiyo","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"50","key":"10.1016\/j.bcp.2021.114514_b0090","doi-asserted-by":"crossref","first-page":"10071","DOI":"10.1523\/JNEUROSCI.1005-19.2019","article-title":"The claustrum-prefrontal cortex pathway regulates impulsive-like behavior","volume":"39","author":"Liu","year":"2019","journal-title":"J. Neurosci."},{"issue":"33","key":"10.1016\/j.bcp.2021.114514_b0095","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1523\/JNEUROSCI.0026-17.2017","article-title":"Electrophysiological evidence that the retrosplenial cortex displays a strong and specific activation phased with hippocampal theta during paradoxical (REM) Sleep","volume":"37","author":"Koike","year":"2017","journal-title":"J. Neurosci."},{"issue":"17","key":"10.1016\/j.bcp.2021.114514_b0100","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.1073\/pnas.1818432116","article-title":"Optogenetic reactivation of memory ensembles in the retrosplenial cortex induces systems consolidation","volume":"116","author":"de Sousa","year":"2019","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221001106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221001106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:09:00Z","timestamp":1762096140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295221001106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":20,"alternative-id":["S0006295221001106"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114514","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is REM sleep a paradoxical state?: Different neurons are activated in the cingulate cortices and the claustrum during wakefulness and paradoxical sleep hypersomnia","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114514"}}