{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:35Z","timestamp":1793136995443,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["18KJA310005"],"award-info":[{"award-number":["18KJA310005"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong City","doi-asserted-by":"publisher","award":["JC2019101"],"award-info":[{"award-number":["JC2019101"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016806","name":"Natural Science Foundation of Nantong City","doi-asserted-by":"publisher","award":["MS22020006"],"award-info":[{"award-number":["MS22020006"]}],"id":[{"id":"10.13039\/100016806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["2018-WSN-062"],"award-info":[{"award-number":["2018-WSN-062"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bcp.2021.114665","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T12:28:55Z","timestamp":1624624135000},"page":"114665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation"],"prefix":"10.1016","volume":"192","author":[{"given":"Yue","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieru","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8523-6543","authenticated-orcid":false,"given":"Guoliang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bcp.2021.114665_b0005","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","article-title":"Atherosclerosis","volume":"123","author":"Kobiyama","year":"2018","journal-title":"Circ. Res."},{"issue":"43","key":"10.1016\/j.bcp.2021.114665_b0010","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/eurheartj\/ehx362","article-title":"Infections, atherosclerosis, and coronary heart disease","volume":"38","author":"Pothineni","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bcp.2021.114665_b0015","doi-asserted-by":"crossref","first-page":"5245308","DOI":"10.1155\/2020\/5245308","article-title":"Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis","volume":"2020","author":"Khatana","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2021.114665_b0020","doi-asserted-by":"crossref","unstructured":"C. Pellegrini A. Martelli L. Antonioli M. Fornai C. Blandizzi V. Calderone NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications 41 4 2021 1890 1926.","DOI":"10.1002\/med.21781"},{"issue":"18","key":"10.1016\/j.bcp.2021.114665_b0025","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.7150\/thno.45922","article-title":"Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2021.114665_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2020.08.021","article-title":"Advances in characterization of SIRT3 deacetylation targets in mitochondrial function","volume":"179","author":"Wang","year":"2020","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.bcp.2021.114665_b0035","doi-asserted-by":"crossref","first-page":"e22249","DOI":"10.1002\/jbt.22249","article-title":"Sirtuin3 deficiency exacerbates carbon tetrachloride-induced hepatic injury in mice","volume":"33","author":"Li","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2021.114665_b0040","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41401-020-0490-7","article-title":"Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation","volume":"42","author":"Song","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.bcp.2021.114665_b0045","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1111\/jcmm.15100","article-title":"SIRT3 deficiency delays diabetic skin wound healing via oxidative stress and necroptosis enhancement","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"8","key":"10.1016\/j.bcp.2021.114665_b0050","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/bph.13861","article-title":"Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner","volume":"175","author":"Meng","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2021.114665_b0055","doi-asserted-by":"crossref","first-page":"9396089","DOI":"10.1155\/2018\/9396089","article-title":"Exogenous hydrogen sulfide supplement attenuates isoproterenol-induced myocardial hypertrophy in a sirtuin 3-dependent manner","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.bcp.2021.114665_b0060","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/ars.2015.6331","article-title":"SIRT3 mediates the antioxidant effect of hydrogen sulfide in endothelial cells","volume":"24","author":"Xie","year":"2016","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.bcp.2021.114665_b0065","doi-asserted-by":"crossref","first-page":"6803943","DOI":"10.1155\/2019\/6803943","article-title":"Dihydromyricetin ameliorates cardiac ischemia\/reperfusion injury through Sirt3 activation","volume":"2019","author":"Wei","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.bcp.2021.114665_b0070","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/ars.2017.7172","article-title":"Dihydromyricetin ameliorates nonalcoholic fatty liver disease by improving mitochondrial respiratory capacity and redox homeostasis through modulation of SIRT3 signaling","volume":"30","author":"Zeng","year":"2019","journal-title":"Antioxid. Redox. Signal."},{"issue":"10","key":"10.1016\/j.bcp.2021.114665_b0075","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1007\/s12035-015-9627-y","article-title":"Dihydromyricetin improves hypobaric hypoxia-induced memory impairment via modulation of SIRT3 signaling","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.bcp.2021.114665_b0080","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s12020-015-0599-5","article-title":"Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1alpha-Sirt3 signaling pathway","volume":"50","author":"Shi","year":"2015","journal-title":"Endocrine"},{"issue":"9","key":"10.1016\/j.bcp.2021.114665_b0085","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.3390\/ijms19092592","article-title":"Dihydromyricetin attenuates myocardial hypertrophy induced by transverse aortic constriction via oxidative stress inhibition and SIRT3 pathway enhancement","volume":"19","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.bcp.2021.114665_b0090","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.3390\/ijms21186699","article-title":"Dihydromyricetin improves endothelial dysfunction in diabetic mice via oxidative stress inhibition in a SIRT3-dependent manner","volume":"21","author":"Hua","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2021.114665_b0095","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3389\/fgene.2019.01285","article-title":"Higher order organization of the mtDNA: Beyond mitochondrial transcription factor A","volume":"10","author":"Mishmar","year":"2019","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.bcp.2021.114665_b0100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"issue":"9","key":"10.1016\/j.bcp.2021.114665_b0105","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bbabio.2018.05.019","article-title":"Mitochondrial uncoupling, ROS generation and cardioprotection","volume":"1859","author":"Cadenas","year":"2018","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"2","key":"10.1016\/j.bcp.2021.114665_b0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/10715762.2018.1549732","article-title":"Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases","volume":"53","author":"Wu","year":"2019","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bcp.2021.114665_b0115","doi-asserted-by":"crossref","first-page":"7293861","DOI":"10.1155\/2018\/7293861","article-title":"SIRT3: A new regulator of cardiovascular diseases","volume":"2018","author":"Sun","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2021.114665_b0120","article-title":"Exendin-4 protects against myocardial ischemia-reperfusion injury by upregulation of SIRT1 and SIRT3 and activation of AMPK","author":"Eid","year":"2020","journal-title":"J. Cardiovasc Transl. Res."},{"issue":"3","key":"10.1016\/j.bcp.2021.114665_b0125","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/jcp.27200","article-title":"Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease","volume":"234","author":"He","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2021.114665_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119178","article-title":"Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis","volume":"272","author":"Liu","year":"2021","journal-title":"Life Sci"},{"issue":"7","key":"10.1016\/j.bcp.2021.114665_b0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/biomedicines8070206","article-title":"NADPH oxidases and their role in atherosclerosis","volume":"8","author":"Poznyak","year":"2020","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.bcp.2021.114665_b0140","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of vascular oxidative stress and Nitric Oxide in the pathogenesis of atherosclerosis","volume":"120","author":"F\u00f6rstermann","year":"2017","journal-title":"Circ. Res."},{"issue":"6917","key":"10.1016\/j.bcp.2021.114665_b0145","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bcp.2021.114665_b0150","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/cells10020226","article-title":"Inflammatory chemokines in atherosclerosis","volume":"10","author":"Gencer","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2021.114665_b0155","article-title":"Overview of oxLDL and its impact on cardiovascular health: Focus on atherosclerosis","volume":"11","author":"Poznyak","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2021.114665_b0160","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fphar.2018.01204","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2021.114665_b0165","doi-asserted-by":"crossref","first-page":"1053617","DOI":"10.1155\/2017\/1053617","article-title":"The versatile effects of dihydromyricetin in health","volume":"2017","author":"Li","year":"2017","journal-title":"Evid. Based Complement Alternat. Med."},{"issue":"13","key":"10.1016\/j.bcp.2021.114665_b0170","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.7150\/ijbs.27746","article-title":"SIRT3 activation by dihydromyricetin suppresses chondrocytes degeneration via maintaining mitochondrial homeostasis","volume":"14","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2021.114665_b0175","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fcell.2020.00702","article-title":"Dihydromyricetin protects against gentamicin-induced ototoxicity via PGC-1alpha\/SIRT3 signaling in vitro","volume":"8","author":"Han","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2021.114665_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2020.10.002","article-title":"Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK\/Sirt-1\/PGC-1alpha signaling axis","volume":"91","author":"Silva","year":"2021","journal-title":"Alcohol."},{"key":"10.1016\/j.bcp.2021.114665_b0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2017.05.003","article-title":"Dihydromyricetin ameliorates atherosclerosis in LDL receptor deficient mice","volume":"262","author":"Liu","year":"2017","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/j.bcp.2021.114665_b0190","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1111\/jcmm.15278","article-title":"Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bcp.2021.114665_b0195","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.biopha.2018.02.124","article-title":"Dihydromyricetin ameliorates foam cell formation via LXRalpha-ABCA1\/ABCG1-dependent cholesterol efflux in macrophages","volume":"101","author":"Zeng","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.bcp.2021.114665_b0200","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.apsb.2020.01.001","article-title":"Natural products, PGC-1 alpha, and Duchenne muscular dystrophy","volume":"10","author":"Suntar","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.bcp.2021.114665_b0205","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.119.315767","article-title":"Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress","volume":"126","author":"Dikalova","year":"2020","journal-title":"Circ. Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221002781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221002781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:11:47Z","timestamp":1762096307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295221002781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":41,"alternative-id":["S0006295221002781"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114665","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114665"}}