{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:16:30Z","timestamp":1791476190533,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973377"],"award-info":[{"award-number":["81973377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003822"],"award-info":[{"award-number":["82003822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073906"],"award-info":[{"award-number":["82073906"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["19KJA460008"],"award-info":[{"award-number":["19KJA460008"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["20KJB310022"],"award-info":[{"award-number":["20KJB310022"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bcp.2021.114675","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:14:10Z","timestamp":1625804050000},"page":"114675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3\u03b2 signaling pathway"],"prefix":"10.1016","volume":"192","author":[{"given":"Xi-zhi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-sen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-juan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-wu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-xing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2021.114675_b0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"12","key":"10.1016\/j.bcp.2021.114675_b0010","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/s41401-019-0263-3","article-title":"Podoplanin mediates the renoprotective effect of berberine on diabetic kidney disease in mice","volume":"40","author":"Yu","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-45303-y","article-title":"Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the developmen t of protamine sulphate-induced foot process effacement","volume":"9","author":"Schwarz","year":"2019","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.bcp.2021.114675_b0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-03032-5","article-title":"Lysosomal quality control of cell fate: a novel therapeutic target for human diseases","volume":"11","author":"Zhu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5698","key":"10.1016\/j.bcp.2021.114675_b0025","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","article-title":"Autophagy in health and disease: a double-edged sword","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bcp.2021.114675_b0030","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1172\/JCI39492","article-title":"Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice","volume":"120","author":"Hartleben","year":"2010","journal-title":"J Clin Invest."},{"issue":"4","key":"10.1016\/j.bcp.2021.114675_b0035","doi-asserted-by":"crossref","first-page":"e60546","DOI":"10.1371\/journal.pone.0060546","article-title":"Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury","volume":"8","author":"Fang","year":"2013","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.bcp.2021.114675_b0040","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1080\/15548627.2015.1115173","article-title":"Emerging role of podocyte autophagy in the progression of diabetic nephropathy","volume":"11","author":"Yasuda-Yamahara","year":"2015","journal-title":"Autophagy."},{"issue":"6","key":"10.1016\/j.bcp.2021.114675_b0045","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4093\/dmj.2015.39.6.451","article-title":"Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy","volume":"39","author":"Kume","year":"2015","journal-title":"Diabetes Metab J."},{"issue":"3","key":"10.1016\/j.bcp.2021.114675_b0050","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2337\/db15-0473","article-title":"Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy","volume":"65","author":"Tagawa","year":"2016","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.bcp.2021.114675_bib276","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4196\/kjpp.2015.19.6.485","article-title":"Effects of free anthraquinones extract from the rhubarb on cell proliferation and accumulation of extracellular matrix in high glucose cultured-mesangial cells.","volume":"19","author":"Wang","year":"2015","journal-title":"Korean J Physiol Pharmacol."},{"key":"10.1016\/j.bcp.2021.114675_bib278","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jpba.2018.12.017","article-title":"Predictive metabolic signatures for the occurrence and development of diabetic nephropathy and the intervention of Ginkgo biloba leaves extract based on gas or liquid chromatography with mass spectrometry.","volume":"166","author":"Du","year":"2019","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.bcp.2021.114675_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/4032820","article-title":"Rapid Screening of Chemical Constituents in Rhizoma Anemarrhenae by UPLC-Q-TOF\/MS Combined with Data Postprocessing Techniques","volume":"2017","author":"Shan","year":"2017","journal-title":"Evid Based Complement Alternat Med."},{"issue":"1-2","key":"10.1016\/j.bcp.2021.114675_b0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2005.08.019","article-title":"A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models","volume":"1060","author":"Hu","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2021.114675_b0065","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jchromb.2015.06.015","article-title":"Metabolites characterization of timosaponin AIII in vivo and in vitro by using liquid chromatography- mass spectrometry","volume":"997","author":"Sun","year":"2015","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci."},{"issue":"9","key":"10.1016\/j.bcp.2021.114675_b0070","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.6439","article-title":"Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats","volume":"33","author":"Liu","year":"2019","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bcp.2021.114675_b0075","doi-asserted-by":"crossref","first-page":"153314","DOI":"10.1016\/j.phymed.2020.153314","article-title":"Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study","volume":"78","author":"Tang","year":"2020","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.bcp.2021.114675_b0080","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nbt1007-1110","article-title":"Network pharmacology","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"10.1016\/j.bcp.2021.114675_b0085","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2021.114675_b0090","first-page":"1","article-title":"Virtual Screening Technique Used to Estimate the Mechanism of Adhatoda vasica Nees for the Treatment of Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid Based Complement Alternat Med."},{"issue":"7","key":"10.1016\/j.bcp.2021.114675_b0095","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1111\/jcmm.15051","article-title":"Hydrogen exerts neuroprotection by activation of the miR-21\/PI3K\/AKT\/GSK-3\u03b2 pathway in an in vitro model of traumatic brain injury","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.bcp.2021.114675_b0100","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3390\/molecules23040719","article-title":"Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3\u03b2 Inhibitors","volume":"23","author":"Hulcov\u00e1","year":"2018","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.bcp.2021.114675_bib277","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00210-019-01632-3","article-title":"Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1\/2 and GSK3\u03b2 signaling pathway","volume":"392","author":"Wang","year":"2019","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"9","key":"10.1016\/j.bcp.2021.114675_b0105","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1681\/ASN.2009010019","article-title":"Wnt\/beta-catenin signaling promotes podocyte dysfunction and albuminuria","volume":"20","author":"Dai","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.bcp.2021.114675_b0110","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/MNH.0b013e32835571d4","article-title":"Glycogen synthase kinase-3 regulation of urinary concentrating ability","volume":"21","author":"Rao","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bcp.2021.114675_b0115","first-page":"1","article-title":"Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy","volume":"2020","author":"Zhang","year":"2020","journal-title":"J Diabetes Res."},{"issue":"8","key":"10.1016\/j.bcp.2021.114675_b0120","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ptr.6088","article-title":"Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats","volume":"32","author":"Liu","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bcp.2021.114675_b0125","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.biopha.2019.01.030","article-title":"Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2\/ARE\/glyoxalase 1 pathway","volume":"111","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00592-020-01582-w","article-title":"YAP mediates the interaction between the Hippo and PI3K\/Akt pathways in mesangial cell proliferation in diabetic nephropathy","volume":"58","author":"Qian","year":"2021","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bcp.2021.114675_b0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molmet.2019.02.007","article-title":"Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-\u03baB\/TNF-\u03b1 pathway","volume":"23","author":"Yang","year":"2019","journal-title":"Mol Metab."},{"key":"10.1016\/j.bcp.2021.114675_b0140","doi-asserted-by":"crossref","first-page":"42764","DOI":"10.1038\/srep42764","article-title":"Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bcp.2021.114675_b0145","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-2002-6","article-title":"Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease","volume":"10","author":"Liu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0150","article-title":"Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bcp.2021.114675_b0155","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2021.114675_b0160","doi-asserted-by":"crossref","unstructured":"L.i. Xu Q. Fan X.u. Wang L. Li X. Lu Y. Yue X.u. Cao J. Liu X. Zhao L. Wang Ursolic acid improves podocyte injury caused by high glucose 32 8 2017 2017 1285 1293.","DOI":"10.1093\/ndt\/gfv382"},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.apsb.2015.07.009","article-title":"5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications","volume":"6","author":"Yao","year":"2016","journal-title":"Acta Pharm Sin B."},{"issue":"10","key":"10.1016\/j.bcp.2021.114675_b0170","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1111\/jcmm.13180","article-title":"Vitamin D3 ameliorates podocyte injury through the nephrin signalling pathway","volume":"21","author":"Trohatou","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.bcp.2021.114675_b0175","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2337\/db17-0755","article-title":"Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function","volume":"67","author":"Pan","year":"2018","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bcp.2021.114675_b0180","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/bph.12292","article-title":"NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db\/db mice","volume":"170","author":"Zhang","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"19","key":"10.1016\/j.bcp.2021.114675_b0185","doi-asserted-by":"crossref","first-page":"1800302","DOI":"10.1002\/mnfr.201800302","article-title":"Eucalyptol Inhibits Advanced Glycation End Products-Induced Disruption of Podocyte Slit Junctions by Suppressing Rage-Erk-C-Myc Signaling Pathway","volume":"62","author":"Kim","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"issue":"2","key":"10.1016\/j.bcp.2021.114675_b0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/path.5077","article-title":"Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB","volume":"245","author":"Zhao","year":"2018","journal-title":"J. Pathol."},{"issue":"5","key":"10.1016\/j.bcp.2021.114675_b0195","doi-asserted-by":"crossref","first-page":"e0124636","DOI":"10.1371\/journal.pone.0124636","article-title":"Globular Adiponectin Causes Tolerance to LPS-Induced TNF-\u03b1 Expression via Autophagy Induction in RAW 264.7 Macrophages: Involvement of SIRT1\/FoxO3A Axis","volume":"10","author":"Tilija Pun","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bcp.2021.114675_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01477","article-title":"Catalpol Ameliorates Podocyte Injury by Stabilizing Cytoskeleton and Enhancing Autophagy in Diabetic Nephropathy","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2021.114675_b0205","article-title":"Therapeutic Strategies to Increase Human \u03b2-Cell Growth and Proliferation by Regulating mTOR and GSK-3\u03b2-Catenin Pathways","volume":"4","author":"Rohatgi","year":"2010","journal-title":"Open Endocrinol J."},{"issue":"10","key":"10.1016\/j.bcp.2021.114675_b0210","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.2337\/diabetes.51.10.2903","article-title":"Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Z ucker diabetic fatty (fa\/fa) rats","volume":"51","author":"Cline","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2021.114675_b0215","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2147\/DMSO.S206454","article-title":"Comparison of the effect of two therapeutic exercises on the inflammatory and physiological conditions and complications of diabetic neuropathy in female patients","volume":"12","author":"Nadi","year":"2019","journal-title":"Diabetes Metab Syndr Obes."},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0220","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-16858-6","article-title":"Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling","volume":"11","author":"Lin","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0225","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/path.4692","article-title":"The \u03b2 isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy","volume":"239","author":"Li","year":"2016","journal-title":"J. Pathol."},{"issue":"8","key":"10.1016\/j.bcp.2021.114675_b0230","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1681\/ASN.2015050565","article-title":"Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3\u03b2 Reinforces the Nrf2 Antioxidant Defense against Podocytopathy","volume":"27","author":"Zhou","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"37","key":"10.1016\/j.bcp.2021.114675_b0235","doi-asserted-by":"crossref","first-page":"39493","DOI":"10.18632\/oncotarget.6303","article-title":"The redox sensitive glycogen synthase kinase 3\u03b2 suppresses the self-protective antioxidant response in podocytes upon oxidative glomerular injury","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget."},{"key":"10.1016\/j.bcp.2021.114675_b0240","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jsbmb.2017.10.014","article-title":"Corrigendum to \u201c1, 25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the \u03b2-catenin\/TCF4\/GSK-3\u03b2\/mTOR pathway\u201d","volume":"174","author":"Wei","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bcp.2021.114675_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1903627","article-title":"Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT\/GSK3\u03b2\/\u03b2-Catenin Pathway by Restoring Autophagic Activity","volume":"2020","author":"Shi","year":"2020","journal-title":"Evid Based Complement Alternat Med."},{"issue":"11","key":"10.1016\/j.bcp.2021.114675_b0250","first-page":"2690","article-title":"HGF alleviates high glucose-induced injury in podocytes by GSK3\u03b2 inhibition and autophagy restoration","volume":"1863","author":"Zhang","year":"2016","journal-title":"BBA"},{"issue":"10","key":"10.1016\/j.bcp.2021.114675_b0255","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/j.ajpath.2014.06.027","article-title":"Glycogen synthase kinase 3\u03b2 dictates podocyte motility and focal adhesion turnover by modulating paxillin activity: implications for the protective effect of low-dose lithium in podocytopathy[J]","volume":"184","author":"Xu","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bcp.2021.114675_b0260","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-811X-4-8","article-title":"Serine phosphorylation regulates paxillin turnover during cell migration[J]","volume":"4","author":"Abou Zeid","year":"2006","journal-title":"Cell Commun Signal"},{"issue":"6","key":"10.1016\/j.bcp.2021.114675_b0265","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1021\/jm011020u","article-title":"First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease[J]","volume":"45","author":"Martinez","year":"2002","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2021.114675_b0270","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2337\/db08-0691","article-title":"Insulin reduces cerebral ischemia\/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta","volume":"58","author":"Collino","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2021.114675_b0275","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.2147\/DDDT.S90016","article-title":"Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers","volume":"9","author":"Zhou","year":"2015","journal-title":"Drug Des Devel Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221002884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295221002884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:11:35Z","timestamp":1762096295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295221002884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":58,"alternative-id":["S0006295221002884"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114675","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3\u03b2 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2021.114675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114675"}}