{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:01:24Z","timestamp":1790823684629,"version":"4.1.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bcp.2022.114930","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T20:20:29Z","timestamp":1644351629000},"page":"114930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Glucocorticoids and natural killer cells: A suppressive relationship"],"prefix":"10.1016","volume":"198","author":[{"given":"Isabella","family":"Muscari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fierabracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Adorisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Cannarile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu","family":"Thi Minh Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emira","family":"Ayroldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico V.","family":"Delfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2022.114930_b0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nri.2017.1","article-title":"Immune regulation by glucocorticoids","volume":"17","author":"Cain","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2022.114930_b0010","unstructured":"M. Nezi, G. Mastorakos, Z. Mouslech, Corticotropin Releasing Hormone And The Immune\/Inflammatory Response, in: K.R. Feingold, B. Anawalt, A. Boyce, G. Chrousos, W.W. de Herder, K. Dungan, et al., (Eds.), Endotext. South Dartmouth (MA), 2000."},{"issue":"22","key":"10.1016\/j.bcp.2022.114930_b0015","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1073\/pnas.84.22.7871","article-title":"A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression","volume":"84","author":"Strahle","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bcp.2022.114930_b0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41423-020-0477-9","article-title":"Regulation of natural killer cell activity by glucocorticoids, serotonin, dopamine, and epinephrine","volume":"17","author":"Capellino","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2011.03.027","article-title":"Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor","volume":"145","author":"Surjit","year":"2011","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bcp.2022.114930_b0030","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1083\/jcb.147.7.1365","article-title":"The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin","volume":"147","author":"Tuckermann","year":"1999","journal-title":"J. Cell Biol."},{"issue":"19","key":"10.1016\/j.bcp.2022.114930_b0035","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMoa1911326","article-title":"Emapalumab in children with primary hemophagocytic lymphohistiocytosis","volume":"382","author":"Locatelli","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"22","key":"10.1016\/j.bcp.2022.114930_b0040","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute graft-versus-host disease - biologic process, prevention, and therapy","volume":"377","author":"Longo","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bcp.2022.114930_b0045","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1056\/NEJMoa1803537","article-title":"Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis","volume":"382","author":"Walsh","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1912196","article-title":"Trial of anifrolumab in active systemic lupus erythematosus","volume":"382","author":"Morand","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.bcp.2022.114930_b0055","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1056\/NEJMoa1710988","article-title":"Quintupling inhaled glucocorticoids to prevent childhood asthma exacerbations","volume":"378","author":"Jackson","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bcp.2022.114930_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7062","article-title":"Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M","volume":"6","author":"Miyata","year":"2015","journal-title":"Nat. Commun."},{"issue":"5234","key":"10.1016\/j.bcp.2022.114930_b0065","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.270.5234.283","article-title":"Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids","volume":"270","author":"Scheinman","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bcp.2022.114930_b0070","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.3389\/fimmu.2019.01823","article-title":"Implicating the role of GILZ in glucocorticoid modulation of T-cell activation","volume":"10","author":"Cannarile","year":"2019","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.bcp.2022.114930_b0075","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s001090050242","article-title":"Transcriptional cross-talk, the second mode of steroid hormone receptor action","volume":"76","author":"G\u00f6ttlicher","year":"1998","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"23","key":"10.1016\/j.bcp.2022.114930_b0080","doi-asserted-by":"crossref","first-page":"9126","DOI":"10.1128\/MCB.00679-06","article-title":"Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling","volume":"26","author":"Smoak","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"19","key":"10.1016\/j.bcp.2022.114930_b0085","doi-asserted-by":"crossref","first-page":"15712","DOI":"10.1074\/jbc.M009905200","article-title":"Inhibition of cytosolic phospholipase A2 by annexin I. Specific interaction model and mapping of the interaction site","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0090","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/jcb.21562","article-title":"Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression","volume":"103","author":"Yang","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"1-2","key":"10.1016\/j.bcp.2022.114930_b0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mce.2013.05.014","article-title":"Molecular mechanisms of glucocorticoid action in mast cells","volume":"380","author":"Oppong","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0105","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4049\/jimmunol.1001794","article-title":"The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif","volume":"186","author":"Ishmael","year":"2011","journal-title":"J. Immunol."},{"issue":"21","key":"10.1016\/j.bcp.2022.114930_b0110","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.89.21.9991","article-title":"A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1","volume":"89","author":"Cronstein","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bcp.2022.114930_b0115","doi-asserted-by":"crossref","first-page":"8434","DOI":"10.4049\/jimmunol.180.12.8434","article-title":"Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis","volume":"180","author":"W\u00fcst","year":"2008","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0120","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1182\/blood-2006-02-001115","article-title":"Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes","volume":"109","author":"Ehrchen","year":"2007","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0125","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4049\/jimmunol.167.2.976","article-title":"Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin\/pyk2 phosphorylation, and high levels of active Rac","volume":"167","author":"Giles","year":"2001","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0130","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.4049\/jimmunol.162.6.3639","article-title":"Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes","volume":"162","author":"Liu","year":"1999","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.bcp.2022.114930_b0135","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nrd3792","article-title":"The potential of biologics for the treatment of asthma","volume":"11","author":"Pelaia","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"29","key":"10.1016\/j.bcp.2022.114930_b0140","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.2174\/138161211798157621","article-title":"Manipulating thymic apoptosis for future therapy of autoimmune diseases","volume":"17","author":"Delfino","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bcp.2022.114930_b0145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jaut.2017.09.001","article-title":"SUMO proteins: Guardians of immune system","volume":"84","author":"Adorisio","year":"2017","journal-title":"J. Autoimmun."},{"issue":"18","key":"10.1016\/j.bcp.2022.114930_b0150","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1038\/emboj.2008.160","article-title":"Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function","volume":"27","author":"Szatmari","year":"2008","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.bcp.2022.114930_b0155","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI200418975","article-title":"Enhancement of MEK\/ERK signaling promotes glucocorticoid resistance in CD4+ T cells","volume":"113","author":"Tsitoura","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bcp.2022.114930_b0160","doi-asserted-by":"crossref","DOI":"10.1186\/2050-6511-15-35","article-title":"Transcriptional regulation of kinases downstream of the T cell receptor: another immunomodulatory mechanism of glucocorticoids","volume":"15","author":"Petrillo","year":"2014","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"4","key":"10.1016\/j.bcp.2022.114930_b0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molmed.2007.02.001","article-title":"Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression","volume":"13","author":"L\u00f6wenberg","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.bcp.2022.114930_b0170","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1179\/joc.2007.19.5.562","article-title":"IL-2 induces and altered CD4\/CD8 ratio of splenic T lymphocytes from transgenic mice overexpressing the glucocorticoid-induced protein GILZ","volume":"19","author":"Pozzesi","year":"2007","journal-title":"J. Chemother."},{"key":"10.1016\/j.bcp.2022.114930_b0175","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1196\/annals.1321.010","article-title":"Glucocorticoids and the Th1\/Th2 balance","volume":"1024","author":"Elenkov","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0180","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.jaci.2004.07.014","article-title":"Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma","volume":"114","author":"Karagiannidis","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7446","key":"10.1016\/j.bcp.2022.114930_b0185","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature11981","article-title":"Dynamic regulatory network controlling TH17 cell differentiation","volume":"496","author":"Yosef","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2022.114930_b0190","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaut.2015.05.010","article-title":"GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation","volume":"61","author":"Jones","year":"2015","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.bcp.2022.114930_b0195","first-page":"1","article-title":"Generation of natural killer cells from long-term cultures of mouse bone marrow","volume":"12","author":"Vecchini","year":"1993","journal-title":"Nat. Immun."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0200","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1182\/blood.V87.6.2394.bloodjournal8762394","article-title":"Natural killer cell precursors in the CD44neg\/dim T-cell receptor population of mouse bone marrow","volume":"87","author":"Delfino","year":"1996","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0205","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/1521-4141(200106)31:6<1900::AID-IMMU1900>3.0.CO;2-M","article-title":"Identification of committed NK cell progenitors in adult murine bone marrow","volume":"31","author":"Rosmaraki","year":"2001","journal-title":"Eur. J. Immunol."},{"issue":"6536","key":"10.1016\/j.bcp.2022.114930_b0210","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba4177","article-title":"Liver type 1 innate lymphoid cells develop locally via an interferon-gamma-dependent loop","volume":"371","author":"Bai","year":"2021","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0215","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.4049\/jimmunol.152.11.5171","article-title":"Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow","volume":"152","author":"Delfino","year":"1994","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0220","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.autrev.2017.11.018","article-title":"NK cells in autoimmune diseases: Linking innate and adaptive immune responses","volume":"17","author":"Gianchecchi","year":"2018","journal-title":"Autoimmun. Rev."},{"issue":"7846","key":"10.1016\/j.bcp.2022.114930_b0225","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","article-title":"Gut-licensed IFNgamma(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes","volume":"590","author":"Sanmarco","year":"2021","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0230","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-019-0052-1","article-title":"NK cells for cancer immunotherapy","volume":"19","author":"Shimasaki","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0235","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","article-title":"Exploring the NK cell platform for cancer immunotherapy","volume":"18","author":"Myers","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.bcp.2022.114930_b0240","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"16","key":"10.1016\/j.bcp.2022.114930_b0245","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1182\/blood.2020009871","article-title":"Activated natural killer cells predict poor clinical prognosis in high-risk B- and T- cell acute lymphoblastic leukemia","volume":"138","author":"Duault","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2022.114930_b0250","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-03614-z","article-title":"Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy","author":"Correia","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bcp.2022.114930_b0255","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.4049\/jimmunol.162.8.4511","article-title":"Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response","volume":"162","author":"Fehniger","year":"1999","journal-title":"J. Immunol."},{"issue":"6808","key":"10.1016\/j.bcp.2022.114930_b0260","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/35040504","article-title":"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function","volume":"408","author":"Parrish-Novak","year":"2000","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2022.114930_b0265","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.4049\/jimmunol.175.4.2167","article-title":"IL-21 enhances tumor rejection through a NKG2D-dependent mechanism","volume":"175","author":"Takaki","year":"2005","journal-title":"J. Immunol."},{"issue":"13","key":"10.1016\/j.bcp.2022.114930_b0270","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1084\/jem.20120944","article-title":"Sustained effector function of IL-12\/15\/18-preactivated NK cells against established tumors","volume":"209","author":"Ni","year":"2012","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bcp.2022.114930_b0275","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.immuni.2018.09.016","article-title":"Tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells to activate the NK cell response","volume":"49","author":"Marcus","year":"2018","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0280","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/leu.2017.226","article-title":"Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity","volume":"32","author":"Liu","year":"2018","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0285","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJMoa1910607","article-title":"Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors","volume":"382","author":"Liu","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bcp.2022.114930_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030264","article-title":"Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells","volume":"7","author":"Denman","year":"2012","journal-title":"PLoS One."},{"issue":"14","key":"10.1016\/j.bcp.2022.114930_b0295","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1158\/1078-0432.CCR-15-2710","article-title":"IL15 trispecific killer engagers (TriKE) make natural killer cells specific to CD33+ targets while also inducing persistence, in vivo expansion, and enhanced function","volume":"22","author":"Vallera","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2022.114930_b0300","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbi.2016.02.025","article-title":"Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period","volume":"56","author":"Levi","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bcp.2022.114930_b0305","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.psyneuen.2015.04.006","article-title":"Sleep-deprivation reduces NK cell number and function mediated by beta-adrenergic signalling","volume":"57","author":"De Lorenzo","year":"2015","journal-title":"Psychoneuroendocrinology."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0310","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00281-020-00827-8","article-title":"Control of immunity by glucocorticoids in health and disease","volume":"42","author":"Shimba","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bcp.2022.114930_b0315","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbi.2019.05.027","article-title":"Stress-elicited glucocorticoid receptor signaling upregulates TIGIT in innate-like invariant T lymphocytes","volume":"80","author":"Rudak","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0320","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1038\/npp.2017.137","article-title":"Evidence for immune activation and resistance to glucocorticoids following childhood maltreatment in adolescents without psychopathology","volume":"42","author":"do Prado","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bcp.2022.114930_b0325","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/bs.pmbts.2015.08.001","article-title":"Exercise and the regulation of immune functions","volume":"135","author":"Simpson","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0330","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<880::AID-IJC14>3.0.CO;2-Y","article-title":"Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity","volume":"80","author":"Ben-Eliyahu,","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2022.114930_b0335","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbi.2013.12.007","article-title":"In vivo suppression of NK cell cytotoxicity by stress and surgery: glucocorticoids have a minor role compared to catecholamines and prostaglandins","volume":"37","author":"Rosenne","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bcp.2022.114930_b0340","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbi.2014.12.020","article-title":"The misleading nature of in vitro and ex vivo findings in studying the impact of stress hormones on NK cell cytotoxicity","volume":"45","author":"Gotlieb","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0345","doi-asserted-by":"crossref","first-page":"100283","DOI":"10.1016\/j.jhepr.2021.100283","article-title":"Differential blood transcriptome modules predict response to corticosteroid therapy in alcoholic hepatitis","volume":"3","author":"Sharma","year":"2021","journal-title":"JHEP Rep."},{"issue":"12","key":"10.1016\/j.bcp.2022.114930_b0350","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1084\/jem.20171048","article-title":"Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells","volume":"214","author":"Quatrini","year":"2017","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.bcp.2022.114930_b0355","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1172\/JCI28034","article-title":"Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy","volume":"117","author":"Tuckermann","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bcp.2022.114930_b0360","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41590-018-0185-0","article-title":"Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells","volume":"19","author":"Quatrini","year":"2018","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0365","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0889-1591(91)90023-4","article-title":"Stress-induced effects on cell-mediated innate and adaptive memory components of the murine immune response to herpes simplex virus infection","volume":"5","author":"Bonneau","year":"1991","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bcp.2022.114930_b0370","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0889-1591(91)90015-3","article-title":"Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection","volume":"5","author":"Bonneau","year":"1991","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bcp.2022.114930_b0375","doi-asserted-by":"crossref","first-page":"104361","DOI":"10.1016\/j.jcv.2020.104361","article-title":"The clinical course and its correlated immune status in COVID-19 pneumonia","volume":"127","author":"He","year":"2020","journal-title":"J. Clin. Virol."},{"issue":"6","key":"10.1016\/j.bcp.2022.114930_b0380","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3390\/ijms20061511","article-title":"Therapeutic targeting steroid resistant pro-inflammatory NK and NKT-like cells in chronic inflammatory lung disease","volume":"20","author":"Hodge","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0385","doi-asserted-by":"crossref","first-page":"e1641390","DOI":"10.1080\/2162402X.2019.1641390","article-title":"Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy\/checkpoint blockade combination treatment","volume":"8","author":"Aston","year":"2019","journal-title":"Oncoimmunology."},{"key":"10.1016\/j.bcp.2022.114930_b0390","doi-asserted-by":"crossref","first-page":"104066","DOI":"10.1016\/j.biosystems.2019.104066","article-title":"Mathematical modeling of immune modulation by glucocorticoids","volume":"187","author":"Yakimchuk","year":"2020","journal-title":"Biosystems."},{"issue":"8","key":"10.1016\/j.bcp.2022.114930_b0395","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1530\/ERC-21-0048","article-title":"Adrenal tumors provide insight into the role of cortisol in NK cell activity","volume":"28","author":"Greenstein","year":"2021","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bcp.2022.114930_b0400","doi-asserted-by":"crossref","first-page":"106117","DOI":"10.1016\/j.dib.2020.106117","article-title":"Data on the modulatory effects of a single bolus dexamethasone on the surface marker expression of various leucocyte subsets","volume":"32","author":"Draxler","year":"2020","journal-title":"Data Brief."},{"issue":"7","key":"10.1016\/j.bcp.2022.114930_b0405","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1182\/bloodadvances.2020003300","article-title":"Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells","volume":"5","author":"Parri","year":"2021","journal-title":"Blood Adv."},{"issue":"5","key":"10.1016\/j.bcp.2022.114930_b0410","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s10787-017-0418-0","article-title":"Regulatory effects of dexamethasone on NK and T cell immunity","volume":"26","author":"Chen","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bcp.2022.114930_b0415","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.786190","article-title":"Editorial: The role of natural killer cells in autoimmune diseases","volume":"12","author":"Fierabracci","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2022.114930_b0420","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.616853","article-title":"Natural killer cells: potential biomarkers and therapeutic target in autoimmune diseases?","volume":"12","author":"Gianchecchi","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2022.114930_b0425","article-title":"NK cell subsets changes in partial remission and early stages of pediatric type 1 diabetes","volume":"11","author":"Gomez-Mu\u00f1oz","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2022.114930_b0430","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.633658","article-title":"Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus","volume":"12","author":"Hervier","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2022.114930_b0435","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01981","article-title":"Leukocyte dynamics reveal a persistent myeloid dominance in giant cell arteritis and polymyalgia rheumatica","volume":"10","author":"van Sleen","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0440","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00011-019-01277-1","article-title":"Familial hypogammaglobulinemia with high RTE and naive T lymphocytes","volume":"68","author":"Piscianz","year":"2019","journal-title":"Inflamm. Res."},{"issue":"12","key":"10.1016\/j.bcp.2022.114930_b0445","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1136\/ard.2007.076976","article-title":"Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells","volume":"67","author":"Eklow","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2022.114930_b0450","first-page":"97","article-title":"Relevance of multidrug resistance to rheumatoid arthritis: development of a new therapeutic hypothesis","volume":"44","author":"Salmon","year":"1996","journal-title":"J. Rheumatol. Suppl."},{"issue":"1","key":"10.1016\/j.bcp.2022.114930_b0455","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/archneur.58.1.91","article-title":"High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes","volume":"58","author":"Leussink","year":"2001","journal-title":"Arch. Neurol."},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0460","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.autrev.2013.05.003","article-title":"Recent insights into the role of the PD-1\/PD-L1 pathway in immunological tolerance and autoimmunity","volume":"12","author":"Gianchecchi","year":"2013","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.bcp.2022.114930_b0465","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s11904-020-00525-y","article-title":"Anti-PD-1 and Anti-PD-L1 monoclonal antibodies in people living with HIV and cancer","volume":"17","author":"Lurain","year":"2020","journal-title":"Curr HIV\/AIDS Rep."},{"issue":"9","key":"10.1016\/j.bcp.2022.114930_b0470","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41590-018-0190-3","article-title":"Glucocorticoids and NK cell PD-1","volume":"19","author":"Biron","year":"2018","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2022.114930_b0475","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41423-018-0190-0","article-title":"Commentary: Endogenous glucocorticoids control host resistance to viral infection through tissue-specific regulation of PD-1 expression on NK cells","volume":"16","author":"Thomsen","year":"2019","journal-title":"Cell. Mol. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2022.114930_b0480","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41419-018-0558-1","article-title":"A dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression?","volume":"9","author":"Ayroldi","year":"2018","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0485","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1096\/fj.09-134684","article-title":"Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action","volume":"23","author":"Ayroldi","year":"2009","journal-title":"FASEB J."},{"issue":"13","key":"10.1016\/j.bcp.2022.114930_b0490","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1182\/blood-2004-03-0920","article-title":"Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice","volume":"104","author":"Delfino","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2022.114930_b0495","doi-asserted-by":"crossref","first-page":"100035","DOI":"10.1016\/j.jtauto.2020.100035","article-title":"Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes","volume":"3","author":"Muscari","year":"2020","journal-title":"J. Transl. Autoimmun."},{"issue":"1","key":"10.1016\/j.bcp.2022.114930_b0500","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2020.04.044","article-title":"Glucocorticoids and the cytokines IL-12, IL-15, and IL-18 present in the tumor microenvironment induce PD-1 expression on human natural killer cells","volume":"147","author":"Quatrini","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"10.1016\/j.bcp.2022.114930_b0505","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.3390\/cancers12113285","article-title":"The immune checkpoint PD-1 in natural killer cells: expression, function and targeting in tumour immunotherapy","volume":"12","author":"Quatrini","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bcp.2022.114930_b0510","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fimmu.2017.00432","article-title":"Distinct effects of dexamethasone on human natural killer cell responses dependent on cytokines","volume":"8","author":"Morgan","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2022.114930_b0515","doi-asserted-by":"crossref","DOI":"10.1093\/carcin\/bgz017","article-title":"Depression promotes hepatocellular carcinoma progression through a glucocorticoids mediated up-regulation of PD-1 expression in tumor infiltrating NK cells","author":"Zhao","year":"2019","journal-title":"Carcinogenesis"},{"issue":"8","key":"10.1016\/j.bcp.2022.114930_b0520","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:31:49Z","timestamp":1757770309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295222000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":104,"alternative-id":["S0006295222000247"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2022.114930","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucocorticoids and natural killer cells: A suppressive relationship","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2022.114930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114930"}}