{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:06:55Z","timestamp":1792667215094,"version":"4.5.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.bcp.2022.115029","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T03:01:34Z","timestamp":1649041294000},"page":"115029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation"],"prefix":"10.1016","volume":"199","author":[{"given":"Xiaodong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengjiao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rugang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2022.115029_b0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/cancers11030317","article-title":"Tumor energy metabolism and potential of 3-bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment","volume":"11","author":"Fan","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.bcp.2022.115029_b0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Matthew","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bcp.2022.115029_b0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Douglas","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2022.115029_b0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/stem.1273","article-title":"Effective elimination of cancer stem cells by a novel drug combination strategy","volume":"31","author":"Yuan","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2022.115029_b0025","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jprot.2016.11.013","article-title":"3-Bromopyruvate treatment induces alterations of metabolic and stress-related pathways in glioblastoma cells","volume":"152","author":"Chiasserini","year":"2017","journal-title":"J. Proteomics"},{"issue":"1-2","key":"10.1016\/j.bcp.2022.115029_b0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijpharm.2018.08.039","article-title":"Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity","volume":"551","author":"Ishiguro","year":"2018","journal-title":"Int. J. Pharmaceut."},{"key":"10.1016\/j.bcp.2022.115029_b0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-1110(95)90005-5","article-title":"Genotoxicity of 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU)","volume":"339","author":"Wiencke","year":"1995","journal-title":"Mutat. Res."},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0040","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/cr941192h","article-title":"A critical appraisal of the evolution of N-nitrosoureas as anticancer drugs","volume":"97","author":"Gnewuch","year":"1997","journal-title":"Chem. Rev."},{"issue":"5","key":"10.1016\/j.bcp.2022.115029_b0045","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/jo00344a020","article-title":"Discrimination between alternative pathways of aqueous decompstion of anti-tumor (2-chloroethyl) nitrosoureas using specific O18 labeling","volume":"47","author":"Lown","year":"1982","journal-title":"J. Org. Chem."},{"issue":"12","key":"10.1016\/j.bcp.2022.115029_b0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/poc.2970","article-title":"Comparative theoretical investigation of the formation of DNA interstrand crosslinks induced by two kinds of N-nitroso compounds: nitrosoureas and nitrosamines","volume":"25","author":"Zhao","year":"2012","journal-title":"J. Phys. Org. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2022.115029_b0055","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/qua.24283","article-title":"A density functional theory investigation on the formation mechanisms of DNA interstrand crosslinks induced by chloroethylnitrosoureas","volume":"113","author":"Zhao","year":"2013","journal-title":"Int. J. Quantum Chem."},{"key":"10.1016\/j.bcp.2022.115029_b0060","first-page":"221","article-title":"The induction and repair of DNA interstrand crosslinks and implications in cancer chemotherapy","volume":"16","author":"Sun","year":"2016","journal-title":"Anti-Cancer Agent. Me."},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0065","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11060-008-9715-1","article-title":"DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response","volume":"91","author":"Bodell","year":"2009","journal-title":"J. Neuro-Oncol."},{"issue":"7","key":"10.1016\/j.bcp.2022.115029_b0070","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/tx500143b","volume":"27","author":"Sun","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bcp.2022.115029_b0075","first-page":"29","article-title":"Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling","volume":"2017","author":"Nikolova","year":"1868","journal-title":"BBA-Rev. Cancer"},{"key":"10.1016\/j.bcp.2022.115029_b0080","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/B978-0-444-53502-3.00029-X","article-title":"Complications of chemotherapy in neuro-oncology","volume":"105","author":"Christine","year":"2012","journal-title":"Handbook of Clinical Neurology"},{"key":"10.1016\/j.bcp.2022.115029_b0085","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.4155\/fmc-2018-0069","article-title":"The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy","volume":"10","author":"Sun","year":"2018","journal-title":"Future Med. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2022.115029_b0090","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1021\/tx200031q","article-title":"Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools","volume":"24","author":"Pegg","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bcp.2022.115029_b0095","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.dnarep.2019.04.007","article-title":"DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas","volume":"78","author":"Kaina","year":"2019","journal-title":"DNA Repair"},{"issue":"10","key":"10.1016\/j.bcp.2022.115029_b0100","first-page":"2525","article-title":"Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen-mustard","volume":"47","author":"Evans","year":"1987","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2022.115029_b0105","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0006-2952(94)90420-0","article-title":"Role of cellular glutathione and glutathione-S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells","volume":"47","author":"Chen","year":"1994","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2022.115029_b0110","first-page":"4155","article-title":"Inactivation of p53 sensitizes U87MG glioma cells to 1,3-bis (2-chloroethyl)-1-nitrosourea","volume":"61","author":"Xu","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2022.115029_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113988","article-title":"3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells","volume":"177","author":"Sun","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2022.115029_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152413","article-title":"Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation","volume":"435","author":"Sun","year":"2020","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.bcp.2022.115029_b0125","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nsmb791","article-title":"DNA binding and nucleotide flipping by the human DNA repair protein AGT","volume":"11","author":"Daniels","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bcp.2022.115029_b0130","first-page":"119","article-title":"Repair of O6-(2-chloroethyl) guanine mediates the biological effects of chloroethylnitrosoureas","volume":"62","author":"Bodell","year":"1985","journal-title":"Environ. Health Persp."},{"issue":"23","key":"10.1016\/j.bcp.2022.115029_b0135","first-page":"6185","article-title":"Characterization of a novel reaction by human O6-alkylguanine-DNA alkyltransferase with 1,3-bis(2-chloroethyl)-1-nitrosoureatreated DNA","volume":"47","author":"Brent","year":"1987","journal-title":"Cancer Res."},{"issue":"47","key":"10.1016\/j.bcp.2022.115029_b0140","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1038\/sj.onc.1206940","article-title":"The role of glutathione-S-transferase in anti-cancer drug resistance","volume":"22","author":"Townsend","year":"2003","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0145","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1021\/tx950143c","article-title":"Glutathione conjugation of alkylating cytostatic drugs with a nitrogen mustard group and the role of glutathione Stransferases","volume":"9","author":"Dirven","year":"1996","journal-title":"Chem. Res. Toxicol."},{"issue":"19","key":"10.1016\/j.bcp.2022.115029_b0150","first-page":"5258","article-title":"Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione","volume":"49","author":"Ali-Osman","year":"1989","journal-title":"Cancer Res."},{"issue":"21","key":"10.1016\/j.bcp.2022.115029_b0155","first-page":"5954","article-title":"Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after invitro reaction with glutathione","volume":"49","author":"Ali-Osman","year":"1989","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2022.115029_b0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jms.1190300111","article-title":"Studies on the formation of reactive intermediates from the antineoplastic agent N, N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) in vitro and in vivo \u2013 characterization of novel glutathione adducts by ionspray tandem massspectrometry","volume":"30","author":"Davis","year":"1995","journal-title":"J. Mass Spectrom."},{"issue":"10","key":"10.1016\/j.bcp.2022.115029_b0165","first-page":"2621","article-title":"Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class-Mu glutathione transferases and its role in cellular resistance in rat brain tumor cells","volume":"49","author":"Smith","year":"1989","journal-title":"Cancer Res."},{"issue":"18","key":"10.1016\/j.bcp.2022.115029_b0170","first-page":"4257","article-title":"Contribution of glutathione transferase M3\u20133 to 1,3-bis(2-chloroethyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line","volume":"53","author":"Berhane","year":"1993","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1006\/abbi.1993.1602","article-title":"Denitrosation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione-S-transferase and cytochrome P450 monooxygenases","volume":"307","author":"Weber","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.bcp.2022.115029_b0180","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1021\/tx500197t","article-title":"Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine","volume":"27","author":"Penketh","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bcp.2022.115029_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104511","article-title":"Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy","volume":"150","author":"Abdel-Wahab","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2022.115029_b0190","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1038\/s41598-019-39789-9","article-title":"O'Driscoll, 2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype","volume":"9","author":"O'Neill","year":"2019","journal-title":"Sci. Rep.-UK"},{"issue":"24","key":"10.1016\/j.bcp.2022.115029_b0195","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1111\/febs.14687","article-title":"2-Deoxy-D-glucose has distinct and cell line-specific effects on the survival of different cancer cells upon antitumor drug treatment","volume":"285","author":"Maximchik","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2022.115029_b0200","first-page":"63551","article-title":"Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer","volume":"8","author":"Sun","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2022.115029_b0205","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/ijms20030697","article-title":"Novel targeted anti-tumor nanoparticles developed from folic acid-modified 2-deoxyglucose","volume":"20","author":"Jin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.bcp.2022.115029_b0210","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1038\/onc.2011.454","article-title":"2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines","volume":"31","author":"Zagorodna","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2022.115029_b0215","first-page":"9","article-title":"Differential Toxic Mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells","volume":"9","author":"Kurtoglu","year":"2007","journal-title":"Antioxid. Redox Sign."},{"issue":"10","key":"10.1016\/j.bcp.2022.115029_b0220","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-11-3928","article-title":"Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death","volume":"72","author":"Cheng","year":"2012","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0225","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.canlet.2014.09.003","article-title":"2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy","volume":"355","author":"Zhang","year":"2014","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0230","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.freeradbiomed.2007.08.032","article-title":"2-Deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer","volume":"44","author":"Coleman","year":"2008","journal-title":"Free Radical Bio. Med."},{"key":"10.1016\/j.bcp.2022.115029_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114213","article-title":"Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms","volume":"182","author":"Laussel","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0240","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1742-4658.2007.05639.x","article-title":"ER Stress and Diseases","volume":"274","author":"Yoshida","year":"2007","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.bcp.2022.115029_b0245","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ."},{"issue":"14","key":"10.1016\/j.bcp.2022.115029_b0250","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1016\/j.febslet.2006.05.021","article-title":"CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation","volume":"580","author":"Tajiri","year":"2006","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.bcp.2022.115029_b0255","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-03-3294","article-title":"2-Deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo","volume":"64","author":"Maschek","year":"2004","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2022.115029_b0260","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1158\/0008-5472.CAN-08-2872","article-title":"Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy","volume":"69","author":"Wu","year":"2009","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0265","first-page":"485","article-title":"Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose","volume":"21","author":"Landau","year":"1958","journal-title":"J. Natl. Cancer I."},{"issue":"4","key":"10.1016\/j.bcp.2022.115029_b0270","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.3892\/or.2017.5491","article-title":"Co-treatment of breast cancer cells with pharmacologic doses of 2-deoxy-D-glucose and metformin: starving tumors","volume":"37","author":"Wokoun","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bcp.2022.115029_b0275","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.biopha.2016.10.037","article-title":"Combination of 2-deoxy D-glucose and metformin for synergistic inhibition of non-small cell lung cancer: A reactive oxygen species and P-p38 mediated mechanism","volume":"84","author":"Hou","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2022.115029_b0280","doi-asserted-by":"crossref","DOI":"10.1002\/mc.23170","article-title":"Saccharide Analog, 2-deoxy-d-glucose Enhances 4\u20131BB-mediated Antitumor Immunity via PD-L1 Deglycosylation","author":"Kim","year":"2020","journal-title":"Mol. Carcinogen."},{"issue":"5","key":"10.1016\/j.bcp.2022.115029_b0285","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1111\/jcmm.14276","article-title":"Targeting the ROS\/PI3K\/AKT\/HIF-1\u03b1\/HK2 axis of breast cancer cells: combined administration of polydatin and 2-deoxy-D-glucose","volume":"23","author":"Zhang","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2022.115029_b0290","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpharm.2017.08.095","article-title":"Targeting energy metabolism of cancer cells: combined administration of NCL-240 and 2-DG","volume":"532","author":"Pattni","year":"2017","journal-title":"Int. J. Pharmaceut."},{"key":"10.1016\/j.bcp.2022.115029_b0295","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1038\/srep05006","article-title":"Synergism of ursolic acid derivative US597 With 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis","volume":"4","author":"Wang","year":"2014","journal-title":"Sci. Rep.-UK"},{"issue":"9","key":"10.1016\/j.bcp.2022.115029_b0300","doi-asserted-by":"crossref","first-page":"12347","DOI":"10.1007\/s13277-016-5089-8","article-title":"Synergistic increase in efficacy of a combination of 2-deoxy-D-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis","volume":"37","author":"Jalota","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bcp.2022.115029_b0305","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.4103\/0973-1482.55136","article-title":"Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects","volume":"1","author":"Dwarakanath","year":"2009","journal-title":"J. Cancer Res. Ther."},{"issue":"4","key":"10.1016\/j.bcp.2022.115029_b0310","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/tx00034a008","article-title":"Chemical synthesis and detection of the cross-link 1-[N3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)]ethane in DNA reacted with 1-(2-chloroethyl)-1-nitrosourea","volume":"6","author":"Bodell","year":"1993","journal-title":"Chem. Res. Toxicol."},{"issue":"17","key":"10.1016\/j.bcp.2022.115029_b0315","first-page":"4363","article-title":"Direct demonstration in synthetic oligonucleotides that N, N'-bis(2-chloroethyl)-nitrosourea cross links N1 of deoxyguanosine to N3 of deoxycytidine on opposite strands of duplex DNA","volume":"59","author":"Fischhabe","year":"1999","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0320","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/abbi.1993.1311","article-title":"Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction","volume":"303","author":"Berridge","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0325","first-page":"146","article-title":"About the evaluation of drug combination","volume":"25","author":"Jin","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bcp.2022.115029_b0330","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0300-483X(95)03210-7","article-title":"Isobolographic analysis of interaction: an update on applications and utility","volume":"105","author":"Gessner","year":"1995","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.bcp.2022.115029_b0335","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2022.115029_b0340","first-page":"6623","article-title":"2-Deoxy-D-glucose sensitizes cancer cells to barasertib and everolimus by ROS-independent mechanism(s)","volume":"35","author":"Zhelev","year":"2015","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2022.115029_b0345","first-page":"128","article-title":"Flow-cytometric characterization of stimulation, free-radical formation, peroxidase-activity and phagocytosis of human-granulocytes with 2,7-dichlorofluorescein (DCF)","volume":"43","author":"Burow","year":"1987","journal-title":"Eur. J. Cell Biol."},{"issue":"17","key":"10.1016\/j.bcp.2022.115029_b0350","doi-asserted-by":"crossref","first-page":"1900212","DOI":"10.1002\/smll.201900212","article-title":"Light-induced ROS generation and 2-DG-activated endoplasmic reticulum stress by antitumor nanosystems: an effective combination therapy by regulating the tumor microenvironment","volume":"15","author":"Dong","year":"2019","journal-title":"Small"},{"issue":"9","key":"10.1016\/j.bcp.2022.115029_b0355","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1073\/pnas.88.9.3671","article-title":"Intracellular heterogeneity in mitochondrial-membrane potentials revealed by a j-aggregate-forming lipophilic cation JC-1","volume":"88","author":"Smiley","year":"1991","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2022.115029_b0360","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jchromb.2016.08.010","article-title":"Measurement of O6-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS\/MS","volume":"1033","author":"Sun","year":"2016","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.bcp.2022.115029_b0365","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"issue":"9","key":"10.1016\/j.bcp.2022.115029_b0370","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.bmc.2016.03.041","article-title":"Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: designed to release a DNA cross-linking agent and an inhibitor of O6-alkylguanine-DNA alkyltransferase","volume":"24","author":"Sun","year":"2016","journal-title":"Bioorgan. Med. Chem."},{"issue":"11","key":"10.1016\/j.bcp.2022.115029_b0375","first-page":"5656","article-title":"Enhanced sensitivity of Pe-postlabeling analysis of aromatic carcinogendna adducts","volume":"45","author":"Gupta","year":"1985","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2022.115029_b0380","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00007890-199306000-00011","article-title":"Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury","volume":"55","author":"Suzuki","year":"1993","journal-title":"Transplantation"},{"key":"10.1016\/j.bcp.2022.115029_b0385","series-title":"A step by step guide to data analysis using IBM SPSS","author":"SPSS survival manual","year":"2020"},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0390","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ijc.23525","article-title":"Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir","volume":"123","author":"Hernlund","year":"2008","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0395","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrc2789","article-title":"ABC transporters in cancer: more than just drug efflux pumps","volume":"10","author":"Fletcher","year":"2010","journal-title":"Nat. Rev. Cancer"},{"issue":"46","key":"10.1016\/j.bcp.2022.115029_b0400","doi-asserted-by":"crossref","first-page":"17807","DOI":"10.1073\/pnas.0803090105","article-title":"A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth","volume":"105","author":"Ralser","year":"2008","journal-title":"P. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.bcp.2022.115029_b0405","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2220\/biomedres.34.221","article-title":"Impact of 2-deoxy-D-glucose on the target metabolome profile of a human endometrial cancer cell line","volume":"34","author":"Urakami","year":"2013","journal-title":"Biomed. Res.-Tokyo"},{"issue":"6","key":"10.1016\/j.bcp.2022.115029_b0410","first-page":"1575","article-title":"p53 protects lung cancer cells against metabolic stress","volume":"37","author":"Sinthupibulyakit","year":"2010","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.bcp.2022.115029_b0415","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta, Mol. Cell. Biol. Lipids"},{"issue":"12","key":"10.1016\/j.bcp.2022.115029_b0420","first-page":"2977","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Maureen","year":"2016","journal-title":"BBA-Mol. Cell Res."},{"issue":"8","key":"10.1016\/j.bcp.2022.115029_b0425","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1021\/cr9800199","article-title":"DNA cross-linking agents as antitumor drugs","volume":"98","author":"Rajski","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bcp.2022.115029_b0430","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13046-019-1214-z","article-title":"The roles of glucose metabolic reprogramming in chemo- and radio-resistance","volume":"38","author":"Lin","year":"2019","journal-title":"J. Exp. Clin. Canc. Res."},{"issue":"4","key":"10.1016\/j.bcp.2022.115029_b0435","first-page":"783","article-title":"Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine","volume":"56","author":"Belanich","year":"1996","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.bcp.2022.115029_b0440","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1200\/JCO.1998.16.10.3310","article-title":"Correlation of tumor O6-methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a southwest oncology group study","volume":"16","author":"Jaeckle","year":"1998","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.bcp.2022.115029_b0445","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1200\/JCO.2002.06.110","article-title":"Clinical relevance of MGMT in the treatment of cancer","volume":"20","author":"Gerson","year":"2002","journal-title":"J. Clin. Oncol."},{"issue":"25","key":"10.1016\/j.bcp.2022.115029_b0450","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1200\/JCO.2007.11.5964","article-title":"Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity","volume":"26","author":"Hegi","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.bcp.2022.115029_b0455","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3390\/molecules21070823","article-title":"Identification of the structural features of guanine derivatives as MGMT inhibitors using 3D-QSAR modeling combined with molecular docking","volume":"21","author":"Sun","year":"2016","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.bcp.2022.115029_b0460","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.3390\/molecules23112892","article-title":"In silico prediction of O6-methylguanine-DNA methyltransferase inhibitory potency of base analogs with QSAR and machine learning methods","volume":"23","author":"Sun","year":"2018","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0465","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1021\/jm301804p","article-title":"Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine","volume":"56","author":"Zhu","year":"2013","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.bcp.2022.115029_b0470","doi-asserted-by":"crossref","first-page":"7720","DOI":"10.1021\/jm201115f","article-title":"Sartorelli, 4-Nitrobenzyloxycarbonyl derivatives of O6-benzylguanine as hypoxia-activated prodrug inhibitors of O6-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O6 position of DNA guanine","volume":"54","author":"Zhu","year":"2011","journal-title":"J. Med. Chem."},{"issue":"23","key":"10.1016\/j.bcp.2022.115029_b0475","first-page":"5292","article-title":"Transient induction of the MRP\/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea in human glioma cells","volume":"57","author":"Gomi","year":"1997","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2022.115029_b0480","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01052726","article-title":"Drug-resistance in brain-tumors","volume":"20","author":"Feun","year":"1994","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.bcp.2022.115029_b0485","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0074-7696(08)60166-7","article-title":"The glutathione status of cells","volume":"54","author":"Kosowe","year":"1978","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.bcp.2022.115029_b0490","doi-asserted-by":"crossref","unstructured":"A.K. Godwin, A. Meister, P.J. O'Dwyer, C.S. Huang, T.C. Hamilton, M.E. Anderson, High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis, Proc. Natl. Acad. Sci. USA 89 (1992) 3070-3074.","DOI":"10.1073\/pnas.89.7.3070"},{"key":"10.1016\/j.bcp.2022.115029_b0495","doi-asserted-by":"crossref","unstructured":"M. Lee, A. Jo, S. Lee, J.B. Kim, Y. Chang, J.Y. Nam, H. Cho, Y.Y. Cho, E.J. Cho, J.H. Lee, S.J. Yu, J.H. Yoon, Y.J. Kim, 3-Bromopyruvate and buthionine sulfoximine effectively kill anoikis-resistant hepatocellular carcinoma cells, PLoS One 12(3) (2017) e0174271.","DOI":"10.1371\/journal.pone.0174271"},{"issue":"7","key":"10.1016\/j.bcp.2022.115029_b0500","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-06-3717","article-title":"2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells","volume":"67","author":"Simons","year":"2007","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2022.115029_b0505","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0006-2952(97)00010-5","article-title":"Carbamoylation of glutathione reductase by N, N-bis(2-chloroethyl)-N-nitrosourea associated with inhibition of multidrug resistance protein (MRP) function","volume":"53","author":"Vanhoefer","year":"1997","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115029_b0510","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2003.10.017","article-title":"Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in sprague-dawley and fischer-344 rats","volume":"147","author":"Davis","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bcp.2022.115029_b0515","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mehy.2017.01.014","article-title":"The promising anticancer drug 3-bromopyruvate is metabolized through glutathione conjugation which affects chemoresistance and clinical practice: an evidence-based view","volume":"100","author":"Sayed","year":"2017","journal-title":"Med. Hypotheses"},{"issue":"18","key":"10.1016\/j.bcp.2022.115029_b0520","first-page":"4833","article-title":"ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein","volume":"54","author":"Jedlitschky","year":"1994","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2022.115029_b0525","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0968-0004(92)90489-V","article-title":"The ATP-dependent glutathione S-conjugate export pump","volume":"17","author":"Ishikawa","year":"1992","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bcp.2022.115029_b0530","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.3390\/cancers12113332","article-title":"The potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment","volume":"12","author":"Huang","year":"2020","journal-title":"Cancers"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522200123X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522200123X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:35:29Z","timestamp":1757770529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522200123X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":106,"alternative-id":["S000629522200123X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115029","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2-Deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: In vitro and in vivo validation","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115029"}}