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Rep."},{"key":"10.1016\/j.bcp.2022.115059_b0360","doi-asserted-by":"crossref","first-page":"4578809","DOI":"10.1155\/2021\/4578809","article-title":"Structure and Function of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases","volume":"2021","author":"Luan","year":"2021","journal-title":"Oxid. Med. Cell Longev"},{"issue":"7","key":"10.1016\/j.bcp.2022.115059_b0365","first-page":"981","article-title":"4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca(2+) transfer, Biochim Biophys Acta Mol","volume":"1865","author":"Bidaux","year":"2018","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.bcp.2022.115059_b0370","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1083\/jcb.200608073","article-title":"Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels","volume":"175","author":"Szabadkai","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2022.115059_b0375","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.604240","article-title":"Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases","volume":"8","author":"Gao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"50","key":"10.1016\/j.bcp.2022.115059_b0380","doi-asserted-by":"crossref","first-page":"25322","DOI":"10.1073\/pnas.1906565116","article-title":"DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.bcp.2022.115059_b0385","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.ircmb.2021.03.001","article-title":"Endolysosomal Ca(2+) signaling in cardiovascular health and disease","volume":"363","author":"Negri","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2022.115059_b0390","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035311","article-title":"Lysosomal Ca(2+) Homeostasis and Signaling in Health and Disease","volume":"12","author":"Lloyd-Evans","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.bcp.2022.115059_b0395","doi-asserted-by":"crossref","unstructured":"P. Atakpa, N.B. Thillaiappan, S. Mataragka, D.L. Prole, C.W. 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Wilde, M.P. van den Berg, J.P. van Tintelen, Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy, Eur J Heart Fail 14(11) (2012) 1199\u2013207.","DOI":"10.1093\/eurjhf\/hfs119"},{"issue":"3","key":"10.1016\/j.bcp.2022.115059_b0625","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.003273","article-title":"International Evidence Based Reappraisal of Genes Associated With Arrhythmogenic Right Ventricular Cardiomyopathy Using the Clinical Genome Resource Framework","volume":"14","author":"James","year":"2021","journal-title":"Circ Genom .Precis Med."},{"issue":"2","key":"10.1016\/j.bcp.2022.115059_b0630","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/cam.20077","article-title":"beta1 integrin: an emerging player in the modulation of tumorigenesis and response to therapy","volume":"6","author":"Howe","year":"2012","journal-title":"Cell Adh Migr"},{"issue":"12","key":"10.1016\/j.bcp.2022.115059_b0635","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1161\/CIRCULATIONAHA.119.039710","article-title":"Disruption of Ca(2+)(i) Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice","volume":"140","author":"Kim","year":"2019","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.bcp.2022.115059_b0640","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tcm.2020.07.006","article-title":"Arrhythmogenic cardiomyopathy: An in-depth look at molecular mechanisms and clinical correlates","volume":"31","author":"Costa","year":"2021","journal-title":"Trends Cardiovasc. 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