{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:03:16Z","timestamp":1790625796253,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2022R1A2B5B01001453"],"award-info":[{"award-number":["2022R1A2B5B01001453"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bcp.2022.115203","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T09:51:53Z","timestamp":1659865913000},"page":"115203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK\/autophagy-associated attenuation of ER stress"],"prefix":"10.1016","volume":"203","author":[{"given":"Heeseung","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonjun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Abd El-Aty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemil","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Woo","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2022.115203_b0005","series-title":"Insulin Resistance","author":"Freeman","year":"2022"},{"issue":"Suppl 2","key":"10.1016\/j.bcp.2022.115203_b0010","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle insulin resistance is the primary defect in type 2 diabetes","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes. Care"},{"issue":"12","key":"10.1016\/j.bcp.2022.115203_b0015","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jc.2006-0587","article-title":"Review: the role of insulin resistance in nonalcoholic fatty liver disease","volume":"91","author":"Utzschneider","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bcp.2022.115203_b0020","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1053\/j.gastro.2007.10.039","article-title":"Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease","volume":"134","author":"Puri","year":"2008","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.bcp.2022.115203_b0025","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1440-1746.2004.03312.x","article-title":"Non-alcoholic steatohepatitis in type 2 diabetes mellitus","volume":"19","author":"Gupte","year":"2004","journal-title":"J. Gastroenterol. Hepatol"},{"key":"10.1016\/j.bcp.2022.115203_b0030","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/srep00799","article-title":"Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue","volume":"2","author":"Kawasaki","year":"2012","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.bcp.2022.115203_b0035","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1091\/mbc.E18-01-0013","article-title":"Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface","volume":"31","author":"Brown","year":"2020","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.bcp.2022.115203_b0040","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13098-020-0523-x","article-title":"Mechanism of increased risk of insulin resistance in aging skeletal muscle","volume":"12","author":"Shou","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bcp.2022.115203_b0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mce.2016.02.016","article-title":"Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women","volume":"425","author":"Liong","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"42","key":"10.1016\/j.bcp.2022.115203_b0050","doi-asserted-by":"crossref","first-page":"16314","DOI":"10.1073\/pnas.0808517105","article-title":"PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation","volume":"105","author":"Bobrovnikova-Marjon","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.bcp.2022.115203_b0055","doi-asserted-by":"crossref","first-page":"629","DOI":"10.2174\/1568026611109060629","article-title":"Novel anti-inflammatory\u2013pro-resolving mediators and their receptors","volume":"11","author":"Serhan","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2022.115203_b0060","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11010-018-3392-y","article-title":"Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARalpha-mediated pathway","volume":"448","author":"Jung","year":"2018","journal-title":"Mol. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.bcp.2022.115203_b0065","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1074\/jbc.RA117.000885","article-title":"Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway","volume":"293","author":"Jung","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2022.115203_b0070","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1124\/jpet.117.246686","article-title":"Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression","volume":"365","author":"Jung","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1-2","key":"10.1016\/j.bcp.2022.115203_b0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2014.04.012","article-title":"Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells","volume":"391","author":"Jung","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115203_b0080","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-13-0201","article-title":"Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance","volume":"218","author":"Asrih","year":"2013","journal-title":"J. Endocrinol."},{"issue":"7","key":"10.1016\/j.bcp.2022.115203_b0085","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1096\/fj.10-178657","article-title":"Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice","volume":"25","author":"Hellmann","year":"2011","journal-title":"FASEB J."},{"issue":"7","key":"10.1016\/j.bcp.2022.115203_b0090","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1002\/jcp.30199","article-title":"Endogenous metabolite, kynurenic acid, attenuates nonalcoholic fatty liver disease via AMPK\/autophagy- and AMPK\/ORP150-mediated signaling","volume":"236","author":"Pyun","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2022.115203_b0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.molmet.2017.01.012","article-title":"AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles","volume":"6","author":"Jensen","year":"2017","journal-title":"Mol. Metab."},{"issue":"4","key":"10.1016\/j.bcp.2022.115203_b0100","doi-asserted-by":"crossref","first-page":"E730","DOI":"10.1152\/ajpendo.00225.2016","article-title":"Treatment of nonalcoholic fatty liver disease: role of AMPK","volume":"311","author":"Smith","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.bcp.2022.115203_b0105","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: Autophagy induction, inhibition and selection","volume":"11","author":"Rashid","year":"2015","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.bcp.2022.115203_b0110","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2337\/dc05-2565","article-title":"Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects","volume":"29","author":"Larson-Meyer","year":"2006","journal-title":"Diabetes. Care"},{"issue":"3","key":"10.1016\/j.bcp.2022.115203_b0115","doi-asserted-by":"crossref","first-page":"100256","DOI":"10.1016\/j.jhepr.2021.100256","article-title":"Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet - a randomised controlled trial","volume":"3","author":"Holmer","year":"2021","journal-title":"JHEP Rep."},{"issue":"2","key":"10.1016\/j.bcp.2022.115203_b0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(87)80292-2","article-title":"A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis","volume":"223","author":"Carling","year":"1987","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.bcp.2022.115203_b0125","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tem.2017.05.004","article-title":"AMPK as a therapeutic target for treating metabolic diseases","volume":"28","author":"Day","year":"2017","journal-title":"Trends. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.bcp.2022.115203_b0130","doi-asserted-by":"crossref","first-page":"e49935","DOI":"10.1371\/journal.pone.0049935","article-title":"The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2022.115203_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114557","article-title":"Valdecoxib improves lipid-induced skeletal muscle insulin resistance via simultaneous suppression of inflammation and endoplasmic reticulum stress","volume":"188","author":"Kim","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2022.115203_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120129","article-title":"Dimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK\/FGF21\/PPARdelta-mediated suppression of inflammation","volume":"287","author":"Park","year":"2021","journal-title":"Life. Sci."},{"key":"10.1016\/j.bcp.2022.115203_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111464","article-title":"Patchouli alcohol ameliorates skeletal muscle insulin resistance and NAFLD via AMPK\/SIRT1-mediated suppression of inflammation","volume":"538","author":"Pyun","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2022.115203_b0150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cmet.2016.06.006","article-title":"Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function","volume":"24","author":"Mottillo","year":"2016","journal-title":"Cell. Metab."},{"issue":"3","key":"10.1016\/j.bcp.2022.115203_b0155","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2337\/db09-0482","article-title":"AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol","volume":"59","author":"Um","year":"2010","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.bcp.2022.115203_b0160","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1210\/en.2012-1418","article-title":"Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator","volume":"153","author":"Lu","year":"2012","journal-title":"Endocrinology"},{"issue":"S2","key":"10.1016\/j.bcp.2022.115203_b0165","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/sj.cdd.4401765","article-title":"Autophagy: molecular machinery for self-eating","volume":"12","author":"Yorimitsu","year":"2005","journal-title":"Cell. Death. Differ"},{"issue":"1","key":"10.1016\/j.bcp.2022.115203_b0170","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10059-013-0140-8","article-title":"Autophagy: a critical regulator of cellular metabolism and homeostasis","volume":"36","author":"Ryter","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bcp.2022.115203_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.708431","article-title":"Communication Between Autophagy and Insulin Action: At the Crux of Insulin Action-Insulin Resistance?","volume":"9","author":"Frendo-Cumbo","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2022.115203_b0180","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/JME-17-0096","article-title":"Adiponectin improves insulin sensitivity via activation of autophagic flux","volume":"59","author":"Ahlstrom","year":"2017","journal-title":"J. Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.bcp.2022.115203_b0185","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s13679-021-00431-3","article-title":"Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives","volume":"10","author":"Flessa","year":"2021","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.bcp.2022.115203_b0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2015.09.027","article-title":"C1q\/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress","volume":"417","author":"Jung","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bcp.2022.115203_b0195","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/272313","article-title":"Rapamycin improves palmitate-induced ER stress\/NF kappa B pathways associated with stimulating autophagy in adipocytes","volume":"2015","author":"Yin","year":"2015","journal-title":"Mediators. Inflamm."},{"issue":"1","key":"10.1016\/j.bcp.2022.115203_b0200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/1319-3767.91738","article-title":"The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight\/obese children","volume":"18","author":"El-Koofy","year":"2012","journal-title":"Saudi. J. Gastroenterol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222002970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222002970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:42:35Z","timestamp":1757770955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295222002970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":40,"alternative-id":["S0006295222002970"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115203","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK\/autophagy-associated attenuation of ER stress","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115203"}}