{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:20:22Z","timestamp":1762096822311,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016642","name":"Japan Chemical Industry Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21KD1004","21K21332","22H03339"],"award-info":[{"award-number":["21KD1004","21K21332","22H03339"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bcp.2022.115332","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T17:53:33Z","timestamp":1667152413000},"page":"115332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity"],"prefix":"10.1016","volume":"206","author":[{"given":"Keishi","family":"Ishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanoko","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Minamigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Matsumaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisamitsu","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunari","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bcp.2022.115332_b0005","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1001\/jama.2015.10078","article-title":"Molecular diagnostic yield of chromosomal microarray analysis and whole-exome sequencing in children with autism spectrum disorder","volume":"314","author":"Tammimies","year":"2015","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.bcp.2022.115332_b0010","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archgenpsychiatry.2011.76","article-title":"Genetic heritability and shared environmental factors among twin pairs with autism","volume":"68","author":"Hallmayer","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.bcp.2022.115332_b0015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbrc.2014.08.108","article-title":"Genomic and genetic aspects of autism spectrum disorder","volume":"452","author":"Liu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7\u20138","key":"10.1016\/j.bcp.2022.115332_b0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.crvi.2016.05.004","article-title":"Current knowledge on the genetics of autism and propositions for future research","volume":"339","author":"Bourgeron","year":"2016","journal-title":"C. R. Biol."},{"issue":"Suppl 3","key":"10.1016\/j.bcp.2022.115332_b0025","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bcp.2022.115332_b0030","unstructured":"US EPA, Health effects guidelines OPPTS 870.6300 Developmental Neurotoxicity Study, EPA\/ 712\/c-98\/239. Office of Prevention Pesticides and Toxic Substances. (1998)."},{"key":"10.1016\/j.bcp.2022.115332_b0035","unstructured":"OECD Guideline for the Testing of Chemicals, Developmental Neurotoxicity Study No. 426, (2007)."},{"issue":"3","key":"10.1016\/j.bcp.2022.115332_b0040","doi-asserted-by":"crossref","first-page":"306","DOI":"10.14573\/altex.1712081","article-title":"Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity","volume":"35","author":"Bal-Price","year":"2018","journal-title":"ALTEX"},{"issue":"1","key":"10.1016\/j.bcp.2022.115332_b0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/toxsci\/kfac018","article-title":"Integrating data from in vitro new approach methodologies for developmental neurotoxicity","volume":"187","author":"Carstens","year":"2022","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.bcp.2022.115332_b0050","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2741\/4064","article-title":"Compound selection for in vitro modeling of developmental neurotoxicity","volume":"17","author":"Kadereit","year":"2012","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"4","key":"10.1016\/j.bcp.2022.115332_b0055","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1530\/EC-18-0029","article-title":"Thyroid-disrupting chemicals and brain development: an update","volume":"7","author":"Mughal","year":"2018","journal-title":"Endocr. Connect"},{"issue":"2","key":"10.1016\/j.bcp.2022.115332_b0060","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1021\/ac3031724","article-title":"Advances in fluorescence and bioluminescence imaging","volume":"85","author":"Ozawa","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bcp.2022.115332_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121526","article-title":"In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced estrogenic\/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice","volume":"385","author":"Yoshida","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bcp.2022.115332_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118096","article-title":"Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist","volume":"290","author":"Ma","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.bcp.2022.115332_b0075","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1248\/bpb.b22-00383","article-title":"Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo","volume":"45","author":"Ishida","year":"2022","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.bcp.2022.115332_b0080","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2013.05.019","article-title":"Metabolic pitfalls of CNS Cre-based technology","volume":"18","author":"Harno","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2022.115332_b0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneumeth.2013.12.004","article-title":"Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter","volume":"223","author":"Matsuzaki","year":"2014","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.bcp.2022.115332_b0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115332_b0095","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn.2741","article-title":"Dendritic spine pathology in neuropsychiatric disorders","volume":"14","author":"Penzes","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"16","key":"10.1016\/j.bcp.2022.115332_b0100","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.bcp.2022.115332_b0105","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.neuroscience.2010.06.069","article-title":"Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid","volume":"170","author":"Roullet","year":"2010","journal-title":"Neuroscience"},{"issue":"Pt A","key":"10.1016\/j.bcp.2022.115332_b0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ntt.2015.10.001","article-title":"Expanding the test set: chemicals with potential to disrupt mammalian brain development","volume":"52","author":"Mundy","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bcp.2022.115332_b0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.bioeng.4.111901.093336","article-title":"Advances in in vivo bioluminescence imaging of gene expression","volume":"4","author":"Contag","year":"2002","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.bcp.2022.115332_b0120","first-page":"127","article-title":"Non-invasive in vivo imaging in small animal research","volume":"28","author":"Koo","year":"2006","journal-title":"Cell Oncol"},{"issue":"2","key":"10.1016\/j.bcp.2022.115332_b0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2144\/05392ST02","article-title":"Comparison of the responsiveness of the pGL3 and pGL4 luciferase reporter vectors to steroid hormones","volume":"39","author":"Dougherty","year":"2005","journal-title":"Biotechniques"},{"issue":"2","key":"10.1016\/j.bcp.2022.115332_b0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tibtech.2005.12.006","article-title":"E unum pluribus: multiple proteins from a self-processing polyprotein","volume":"24","author":"de Felipe","year":"2006","journal-title":"Trends Biotechnol."},{"issue":"4","key":"10.1016\/j.bcp.2022.115332_b0135","doi-asserted-by":"crossref","first-page":"e18556","DOI":"10.1371\/journal.pone.0018556","article-title":"High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.bcp.2022.115332_b0140","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1038\/s41598-017-02460-2","article-title":"Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2022.115332_b0145","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/gene.20183","article-title":"Synapsin I Cre transgene expression in male mice produces germline recombination in progeny","volume":"44","author":"Rempe","year":"2006","journal-title":"Genesis"},{"issue":"2","key":"10.1016\/j.bcp.2022.115332_b0150","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/jnc.12261","article-title":"Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders","volume":"126","author":"Penzes","year":"2013","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bcp.2022.115332_b0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004010050401","article-title":"Hippocampus in autism: a Golgi analysis","volume":"91","author":"Raymond","year":"1996","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.bcp.2022.115332_b0160","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2990.2004.00574.x","article-title":"Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals","volume":"30","author":"Mukaetova-Ladinska","year":"2004","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bcp.2022.115332_b0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2009.09.120","article-title":"Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders","volume":"1309","author":"Hutsler","year":"2010","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.bcp.2022.115332_b0170","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/dneu.22417","article-title":"Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models","volume":"77","author":"Mart\u00ednez-Cerde\u00f1o","year":"2017","journal-title":"Dev. Neurobiol."},{"issue":"8","key":"10.1016\/j.bcp.2022.115332_b0175","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1111\/febs.15733","article-title":"Protein synthesis as a modifiable target for autism-related dendritic spine pathophysiologies","volume":"289","author":"Lu","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2022.115332_b0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pbb.2014.08.013","article-title":"Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism","volume":"126","author":"Takuma","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bcp.2022.115332_b0185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2017.06.035","article-title":"Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice","volume":"333","author":"Yamaguchi","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"Spec","key":"10.1016\/j.bcp.2022.115332_b0190","first-page":"SP69-SP79","article-title":"Developmental neurotoxicity test guidelines: problems and perspectives","volume":"41","author":"Tohyama","year":"2016","journal-title":"J. Toxicol. Sci."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222004269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222004269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:15:43Z","timestamp":1762096543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295222004269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":38,"alternative-id":["S0006295222004269"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115332","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115332"}}