{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:58:51Z","timestamp":1758049131279,"version":"3.44.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01-GM079123","R01-GM127788"],"award-info":[{"award-number":["R01-GM079123","R01-GM127788"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bcp.2022.115387","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T10:57:51Z","timestamp":1671447471000},"page":"115387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo"],"prefix":"10.1016","volume":"208","author":[{"given":"Yunzhou","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoxun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofeng","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bcp.2022.115387_b0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s13238-015-0148-2","article-title":"The physiological role of drug transporters","volume":"6","author":"Liang","year":"2015","journal-title":"Protein Cell"},{"issue":"10","key":"10.1016\/j.bcp.2022.115387_b0010","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1124\/dmd.113.052647","article-title":"Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways","volume":"41","author":"Wu","year":"2013","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2022.115387_b0015","article-title":"New insight into organic anion transporters from the perspective of potentially important interactions and drugs toxicity","volume":"69","author":"Mor","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2022.115387_b0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.addr.2016.09.004","article-title":"The effects of dietary and herbal phytochemicals on drug transporters","volume":"116","author":"Li","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.bcp.2022.115387_b0025","first-page":"673","article-title":"Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3","volume":"1762","author":"Brandoni","year":"2006","journal-title":"BBA"},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0030","doi-asserted-by":"crossref","first-page":"F247","DOI":"10.1152\/ajprenal.00139.2008","article-title":"Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis","volume":"295","author":"Chen","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115387_b0035","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.taap.2009.06.008","article-title":"Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex","volume":"239","author":"Zlender","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115387_b0040","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/MAJ.0b013e3182831740","article-title":"Decreased renal organic anion transporter 3 expression in type 1 diabetic rats","volume":"347","author":"Phatchawan","year":"2014","journal-title":"Am. J. Med. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2022.115387_b0045","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1111\/j.1523-1755.2005.00741.x","article-title":"Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction","volume":"68","author":"Villar","year":"2005","journal-title":"Kidney Int."},{"issue":"14","key":"10.1016\/j.bcp.2022.115387_b0050","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1042\/CS20180148","article-title":"Probiotic Lactobacillus paracasei HII01 protects rats against obese-insulin resistance-induced kidney injury and impaired renal organic anion transporter 3 function","volume":"132","author":"Wanchai","year":"2018","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1530\/JOE-17-0471","article-title":"Prebiotic prevents impaired kidney and renal Oat3 functions in obese rats","volume":"237","author":"Wanchai","year":"2018","journal-title":"J. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2022.115387_b0060","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ejps.2012.11.008","article-title":"Inhibitory effect of 1alpha,25-dihydroxyvitamin D(3) on excretion of JBP485 via organic anion transporters in rats","volume":"48","author":"Miao","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0065","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1038\/s41598-017-13206-5","article-title":"The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats","volume":"7","author":"Thongnak","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2022.115387_b0070","first-page":"242","article-title":"Short-term and long-term effects of protein kinase C on the trafficking and stability of human organic anion transporter 3","volume":"3","author":"Zhang","year":"2012","journal-title":"Int. J. Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2022.115387_b0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1208\/s12248-019-0303-4","article-title":"Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3","volume":"21","author":"Wang","year":"2019","journal-title":"AAPS J."},{"issue":"2","key":"10.1016\/j.bcp.2022.115387_b0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jphs.2017.12.011","article-title":"The activity of organic anion transporter-3: Role of dexamethasone","volume":"136","author":"Wang","year":"2018","journal-title":"J. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0085","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.apsb.2019.05.005","article-title":"Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway","volume":"10","author":"Zhang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"1\u20133","key":"10.1016\/j.bcp.2022.115387_b0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2009.10.048","article-title":"Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: accelerating endocytosis of the transporter","volume":"627","author":"Duan","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115387_b0095","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jphs.2018.01.006","article-title":"AG490, a JAK2-specific inhibitor, downregulates the expression and activity of organic anion transporter-3","volume":"136","author":"Zhang","year":"2018","journal-title":"J. Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2022.115387_b0100","doi-asserted-by":"crossref","first-page":"F1021","DOI":"10.1152\/ajprenal.00080.2004","article-title":"Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules","volume":"287","author":"Soodvilai","year":"2004","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"2","key":"10.1016\/j.bcp.2022.115387_b0105","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/acs.molpharmaceut.5b00839","article-title":"An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3","volume":"13","author":"Xu","year":"2016","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.bcp.2022.115387_b0110","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2010.11.012","article-title":"Ubiquitin: same molecule, different degradation pathways","volume":"143","author":"Clague","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00012.2016","article-title":"Ubiquitination and the Regulation of Membrane Proteins","volume":"97","author":"Foot","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2022.115387_b0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.cellbio.19.110701.154617","article-title":"Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins","volume":"19","author":"Hicke","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.bcp.2022.115387_b0125","first-page":"2615","article-title":"Proteasome inhibitors: a novel class of potent and effective antitumor agents","volume":"59","author":"Adams","year":"1999","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.bcp.2022.115387_b0130","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1172\/JCI109562","article-title":"Renal adaptation to a low phosphate diet in rats","volume":"64","author":"Shah","year":"1979","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bcp.2022.115387_b0135","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1124\/dmd.113.055194","article-title":"Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat","volume":"42","author":"Wang","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2022.115387_b0140","article-title":"Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination","volume":"107647","author":"Zhang","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.bcp.2022.115387_b0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ceb.2007.07.002","article-title":"Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes","volume":"19","author":"Piper","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"issue":"17","key":"10.1016\/j.bcp.2022.115387_b0150","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1128\/MCB.00350-08","article-title":"Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway","volume":"28","author":"Varghese","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bcp.2022.115387_b0155","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/acs.molpharmaceut.5b00763","article-title":"Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions","volume":"13","author":"Alam","year":"2016","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.bcp.2022.115387_b0160","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1161\/ATVBAHA.114.305182","article-title":"Cellular Cholesterol Accumulation Facilitates Ubiquitination and Lysosomal Degradation of Cell Surface-Resident ABCA1","volume":"35","author":"Mizuno","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2022.115387_b0165","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1124\/mol.119.118653","article-title":"Proteasome Inhibitors Bortezomib and Carfilzomib Stimulate the Transport Activity of Human Organic Anion Transporter 1","volume":"97","author":"Fan","year":"2020","journal-title":"Mol. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2022.115387_b0170","doi-asserted-by":"crossref","first-page":"F1169","DOI":"10.1152\/ajprenal.00630.2012","article-title":"Chronic regulation of the renal Na(+)\/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms","volume":"304","author":"Hu","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"25","key":"10.1016\/j.bcp.2022.115387_b0175","doi-asserted-by":"crossref","first-page":"9175","DOI":"10.1073\/pnas.1405355111","article-title":"An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14","volume":"111","author":"Zhao","year":"2014","journal-title":"PNAS"},{"issue":"12","key":"10.1016\/j.bcp.2022.115387_b0180","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41573-019-0036-1","article-title":"Lysosomes as a therapeutic target","volume":"18","author":"Bonam","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.bcp.2022.115387_b0185","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1158\/2159-8290.CD-17-0996","article-title":"Targeting the Lysosome for Cancer Therapy","volume":"7","author":"Towers","year":"2017","journal-title":"Cancer Discov."},{"issue":"2","key":"10.1016\/j.bcp.2022.115387_b0190","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/pr.117.015370","article-title":"A Practical Review of Proteasome Pharmacology","volume":"71","author":"Thibaudeau","year":"2019","journal-title":"Pharmacol. Rev."},{"issue":"14","key":"10.1016\/j.bcp.2022.115387_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143379","article-title":"Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond","volume":"20","author":"Albornoz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt 9","key":"10.1016\/j.bcp.2022.115387_b0200","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1242\/jcs.00370","article-title":"Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels","volume":"116","author":"Arabi","year":"2003","journal-title":"J. Cell Sci."},{"issue":"17","key":"10.1016\/j.bcp.2022.115387_b0205","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.yexcr.2008.08.003","article-title":"Proteasome inhibition compromises direct retention of cytochrome P450 2C2 in the endoplasmic reticulum","volume":"314","author":"Szczesna-Skorupa","year":"2008","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.bcp.2022.115387_b0210","first-page":"340","article-title":"Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors, Cell","volume":"26","author":"Besse","year":"2019","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bcp.2022.115387_b0215","unstructured":"FDA., Pharmacology Review(s) of Kyprolis\u00ae (carfilzomib). https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2012\/202714Orig1s000PharmR.pdf."},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00280-010-1283-3","article-title":"Pharmacokinetic and pharmacodynamic study of two doses of bortezomib in patients with relapsed multiple myeloma","volume":"67","author":"Reece","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2022.115387_b0225","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1182\/blood-2007-01-065888","article-title":"Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma","volume":"110","author":"Kuhn","year":"2007","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bcp.2022.115387_b0230","doi-asserted-by":"crossref","first-page":"F1114","DOI":"10.1152\/ajprenal.00201.2012","article-title":"Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys","volume":"304","author":"Breljak","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"2","key":"10.1016\/j.bcp.2022.115387_b0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbamem.2003.08.015","article-title":"The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules","volume":"1618","author":"Dantzler","year":"2003","journal-title":"BBA"},{"issue":"7","key":"10.1016\/j.bcp.2022.115387_b0240","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1074\/jbc.RA119.010729","article-title":"Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning","volume":"295","author":"Nigam","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bcp.2022.115387_b0245","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nchembio.250","article-title":"Targeting proteins for degradation","volume":"5","author":"Schrader","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2022.115387_b0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fmolb.2019.00048","article-title":"Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms","volume":"6","author":"Kors","year":"2019","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.bcp.2022.115387_b0255","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41467-018-03509-0","article-title":"A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers","volume":"9","author":"Thibaudeau","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2022.115387_b0260","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pharmthera.2014.11.002","article-title":"Deubiquitinase inhibition as a cancer therapeutic strategy","volume":"147","author":"D'Arcy","year":"2015","journal-title":"Pharmacol. Ther."},{"issue":"10262","key":"10.1016\/j.bcp.2022.115387_b0265","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0140-6736(20)32292-3","article-title":"Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial","volume":"396","author":"Grosicki","year":"2020","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bcp.2022.115387_b0270","doi-asserted-by":"crossref","first-page":"e48978","DOI":"10.15252\/embr.201948978","article-title":"Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations","volume":"21","author":"Jenkins","year":"2020","journal-title":"EMBO Rep."},{"issue":"9","key":"10.1016\/j.bcp.2022.115387_b0275","article-title":"Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities","volume":"10","author":"Martinez de Toda","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"15","key":"10.1016\/j.bcp.2022.115387_b0280","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1016\/j.bmc.2007.05.041","article-title":"A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer","volume":"15","author":"Osanai","year":"2007","journal-title":"Bioorg. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2022.115387_b0285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2014.08.024","article-title":"Melatonin as a proteasome inhibitor. Is there any clinical evidence?","volume":"115","author":"Vriend","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2022.115387_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101897","article-title":"Modulation of the ubiquitin-proteasome system by marine natural products","volume":"41","author":"Vasilopoulou","year":"2021","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.bcp.2022.115387_b0295","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1158\/0008-5472.CAN-06-3546","article-title":"Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts","volume":"67","author":"Chen","year":"2007","journal-title":"Cancer Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522200483X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522200483X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:42:22Z","timestamp":1757770942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522200483X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":59,"alternative-id":["S000629522200483X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115387","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115387"}}