{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:37:37Z","timestamp":1791934657977,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H060010"],"award-info":[{"award-number":["LQ21H060010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYYW202028"],"award-info":[{"award-number":["KYYW202028"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["WMUDELC202109"],"award-info":[{"award-number":["WMUDELC202109"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bcp.2022.115402","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T19:26:05Z","timestamp":1672428365000},"page":"115402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Chrysophanol prevents IL-1\u03b2-Induced inflammation and ECM degradation in osteoarthritis via the Sirt6\/NF-\u03baB and Nrf2\/NF-\u03baB axis"],"prefix":"10.1016","volume":"208","author":[{"given":"Jiajie","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"libin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunren","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2022.115402_b0005","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.biopha.2017.05.148","article-title":"The potential of chrysophanol in protecting against high fat-induced cardiac injury through Nrf2-regulated anti-inflammation, anti-oxidant and anti-fibrosis in Nrf2 knockout mice","volume":"93","author":"Lian","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"10264","key":"10.1016\/j.bcp.2022.115402_b0010","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a Lancet Commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bcp.2022.115402_b0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/1573397113666170807122312","article-title":"Novel Insights into the Pathogenesis of Osteoarthritis","volume":"14","author":"Geyer","year":"2018","journal-title":"Curr. Rheumatol. Rev."},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0020","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1756-185X.2010.01529.x","article-title":"Development of a questionnaire for identification of the risk factors for osteoarthritis of the knees in developing countries. A pilot study in Iran and Bangladesh. An ILAR-COPCORD phase III study","volume":"13","author":"Haq","year":"2010","journal-title":"Int. J. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.bcp.2022.115402_b0025","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F","article-title":"Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets","volume":"44","author":"Pelletier","year":"2001","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.clim.2012.12.011","article-title":"Immunopathogenesis of osteoarthritis","volume":"146","author":"Haseeb","year":"2013","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2022.115402_b0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/rheumatology\/keh344","article-title":"Osteoarthritis, angiogenesis and inflammation","volume":"44","author":"Bonnet","year":"2005","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"10.1016\/j.bcp.2022.115402_b0040","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joca.2007.01.020","article-title":"Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis","volume":"15","author":"Walsh","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.bcp.2022.115402_b0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tibs.2013.12.002","article-title":"Chromatin and beyond: the multitasking roles for SIRT6","volume":"39","author":"Kugel","year":"2014","journal-title":"Trends Biochem. Sci"},{"issue":"6","key":"10.1016\/j.bcp.2022.115402_b0050","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2016.04.033","article-title":"SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b","volume":"165","author":"Kugel","year":"2016","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bcp.2022.115402_b0055","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1039\/C9FO00742C","article-title":"Cyanidin ameliorates the progression of osteoarthritis via the Sirt6\/NF-\u03baB axis in vitro and in vivo","volume":"10","author":"Jiang","year":"2019","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2015.09.019","article-title":"Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis","volume":"466","author":"Ailixiding","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2022.115402_b0065","doi-asserted-by":"crossref","first-page":"7374086","DOI":"10.1155\/2020\/7374086","article-title":"Chrysophanol Alleviates Metabolic Syndrome by Activating the SIRT6\/AMPK Signaling Pathway in Brown Adipocytes","volume":"2020","author":"Liu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.bcp.2022.115402_b0070","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.3390\/molecules15096436","article-title":"Anti-Inflammatory activity of chrysophanol through the suppression of NF-kappaB\/caspase-1 activation in vitro and in vivo","volume":"15","author":"Kim","year":"2010","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.bcp.2022.115402_b0075","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s12272-012-0514-z","article-title":"Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells","volume":"35","author":"Ni","year":"2012","journal-title":"Arch. Pharm. Res."},{"issue":"9","key":"10.1016\/j.bcp.2022.115402_b0080","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s12272-013-0325-x","article-title":"Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus","volume":"37","author":"Chang","year":"2014","journal-title":"Arch. Pharm. Res."},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0085","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jep.2014.03.059","article-title":"Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages","volume":"153","author":"Hu","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2022.115402_b0090","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1248\/bpb.31.2154","article-title":"Anti-diabetic properties of chrysophanol and its glucoside from rhubarb rhizome","volume":"31","author":"Lee","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bcp.2022.115402_b0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neulet.2015.12.043","article-title":"P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice","volume":"613","author":"Zhang","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bcp.2022.115402_b0100","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/370530","article-title":"Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia\/reperfusion in mice","volume":"2014","author":"Zhang","year":"2014","journal-title":"Mediators Inflamm."},{"issue":"10","key":"10.1016\/j.bcp.2022.115402_b0105","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1002\/ptr.6444","article-title":"Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma","volume":"33","author":"Song","year":"2019","journal-title":"Phytother. Res."},{"issue":"8","key":"10.1016\/j.bcp.2022.115402_b0110","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1002\/jcp.26460","article-title":"Blocking PI3K\/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis","volume":"233","author":"Lin","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.bcp.2022.115402_b0115","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 3","key":"10.1016\/j.bcp.2022.115402_b0120","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2022.115402_b0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fphar.2019.00163","article-title":"Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K\/AKT\/mTOR and MAPK Pathways","volume":"10","author":"Yao","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2022.115402_b0130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13075-019-2085-6","article-title":"Inhibition of Nrf2\/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis","volume":"21","author":"Chen","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bcp.2022.115402_b0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"issue":"4","key":"10.1016\/j.bcp.2022.115402_b0140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.joca.2005.10.009","article-title":"NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes","volume":"14","author":"Lianxu","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.bcp.2022.115402_b0145","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.joca.2009.03.002","article-title":"Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix","volume":"17","author":"Loeser","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"9991","key":"10.1016\/j.bcp.2022.115402_b0150","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2022.115402_b0155","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.diabres.2016.10.021","article-title":"Osteoarthritis and type 2 diabetes mellitus: What are the links?","volume":"122","author":"Courties","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9","key":"10.1016\/j.bcp.2022.115402_b0160","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.joca.2021.05.062","article-title":"Joint obesity as a pathogenic factor in osteoarthritis","volume":"29","author":"Largo","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2022.115402_b0165","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejpb.2015.09.005","article-title":"Efficacy study of two novel hyaluronic acid-based formulations for viscosupplementation therapy in an early osteoarthrosic rabbit model","volume":"96","author":"Kaderli","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.bcp.2022.115402_b0170","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000245898","article-title":"Pathophysiology of osteoarthritis: evidence against the viscoelastic theory","volume":"76","author":"Dunn","year":"2009","journal-title":"Pathobiology"},{"key":"10.1016\/j.bcp.2022.115402_b0175","doi-asserted-by":"crossref","unstructured":"M. Essouma, Commentary to the article: Di D, Zhang L, Wu X, Leng R. Long-term exposure to outdoor air pollution and the risk of development of rheumatoid arthritis: a systematic review and meta-analysis. Semin arthritis rheum. 2020;50(2):266-275, Semin Arthritis Rheum 50(6) (2020) e3.","DOI":"10.1016\/j.semarthrit.2020.09.005"},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0180","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/art.21994","article-title":"Osteoarthritis and therapy","volume":"55","author":"Ge","year":"2006","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.bcp.2022.115402_b0185","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.bcp.2022.115402_b0190","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.joca.2017.02.791","article-title":"ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'","volume":"25","author":"Yang","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.bcp.2022.115402_b0195","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bcp.2022.115402_b0200","doi-asserted-by":"crossref","unstructured":"D. Bagchi, C.K. Sen, M. Bagchi, M. Atalay, Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula, Biochemistry (Mosc) 69(1) (2004) 75-80, 1 p preceding 75.","DOI":"10.1023\/B:BIRY.0000016355.19999.93"},{"key":"10.1016\/j.bcp.2022.115402_b0205","doi-asserted-by":"crossref","unstructured":"M. Rahnasto-Rilla, J. Tyni, M. Huovinen, E. Jarho, T. Kulikowicz, S. Ravichandran, A.B. V, L. Ferrucci, M. Lahtela-Kakkonen, R. Moaddel, Natural polyphenols as sirtuin 6 modulators, Sci Rep 8(1) (2018) 4163.","DOI":"10.1038\/s41598-018-22388-5"},{"key":"10.1016\/j.bcp.2022.115402_b0210","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ebiom.2018.11.005","article-title":"Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium","volume":"38","author":"Woo","year":"2018","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0215","first-page":"4035","article-title":"Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy","volume":"17","author":"Zhi","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.bcp.2022.115402_b0220","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jbspin.2012.04.005","article-title":"Epigenetics, sirtuins and osteoarthritis","volume":"79","author":"Gabay","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"1","key":"10.1016\/j.bcp.2022.115402_b0225","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2022.115402_b0230","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.gene.2019.04.034","article-title":"Expression of type II collagen and aggrecan genes is regulated through distinct epigenetic modifications of their multiple enhancer elements","volume":"704","author":"Nham","year":"2019","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.bcp.2022.115402_b0235","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yexcr.2017.02.023","article-title":"Sirtuin 6 prevents matrix degradation through inhibition of the NF-\u03baB pathway in intervertebral disc degeneration","volume":"352","author":"Kang","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.bcp.2022.115402_b0240","doi-asserted-by":"crossref","first-page":"e1002153","DOI":"10.1371\/journal.pgen.1002153","article-title":"Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks","volume":"7","author":"Kawahara","year":"2011","journal-title":"PLoS Genet."},{"issue":"7","key":"10.1016\/j.bcp.2022.115402_b0245","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41419-020-2695-6","article-title":"Downregulation of RKIP promotes radioresistance of nasopharyngeal carcinoma by activating NRF2\/NQO1 axis via downregulating miR-450b-5p","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"17","key":"10.1016\/j.bcp.2022.115402_b0250","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bcp.2022.115402_b0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","article-title":"Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1\/Nrf2\/HO-1\/Gpx4 pathway","volume":"19","author":"Dang","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.bcp.2022.115402_b0260","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/SHK.0000000000001751","article-title":"Etomidate Attenuates the Ferroptosis in Myocardial Ischemia\/Reperfusion Rat Model via Nrf2\/HO-1 Pathway","volume":"56","author":"Lv","year":"2021","journal-title":"Shock"},{"key":"10.1016\/j.bcp.2022.115402_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106300","article-title":"The potential role of SIRT6 in regulating the crosstalk between Nrf2 and NF-\u03baB pathways in cardiovascular diseases","volume":"182","author":"Casper","year":"2022","journal-title":"Pharmacol. Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222004981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295222004981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:18:54Z","timestamp":1762096734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295222004981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":53,"alternative-id":["S0006295222004981"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115402","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chrysophanol prevents IL-1\u03b2-Induced inflammation and ECM degradation in osteoarthritis via the Sirt6\/NF-\u03baB and Nrf2\/NF-\u03baB axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2022.115402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115402"}}