{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:52:37Z","timestamp":1782921157509,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31861143050"],"award-info":[{"award-number":["31861143050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772476"],"award-info":[{"award-number":["31772476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31911530077"],"award-info":[{"award-number":["31911530077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004240","name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.bcp.2023.115471","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T21:03:23Z","timestamp":1678223003000},"page":"115471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Characterization of a novel LTA\/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae)"],"prefix":"10.1016","volume":"210","author":[{"given":"Jinqiao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiena","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.bcp.2023.115471_b0005","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.3390\/ijms20215376","article-title":"The pathogenesis of sepsis and potential therapeutic targets","volume":"20","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2023.115471_b0010","doi-asserted-by":"crossref","first-page":"e1003871","DOI":"10.1371\/journal.ppat.1003871","article-title":"Igniting the fire: Staphylococcus aureus virulence factors in the pathogenesis of sepsis","volume":"10","author":"Powers","year":"2014","journal-title":"PLOS. Pathog."},{"issue":"2","key":"10.1016\/j.bcp.2023.115471_b0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12098-019-03106-z","article-title":"Neonatal sepsis: mortality and morbidity in neonatal sepsis due to multidrug-resistant (MDR) organisms: Part 1","volume":"87","author":"Wattal","year":"2020","journal-title":"Indian. J. Pediatr."},{"key":"10.1016\/j.bcp.2023.115471_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.583415","article-title":"Advancing antimicrobial resistance research through quantitative modeling and synthetic biology","volume":"8","author":"Farquhar","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115471_b0025","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/jam.15314","article-title":"Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds","volume":"132","author":"Erdem","year":"2022","journal-title":"J. Appl. Microbiol."},{"issue":"4","key":"10.1016\/j.bcp.2023.115471_b0030","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1021\/cr4006704","article-title":"The chemistry and biological activities of peptides from amphibian skin secretions","volume":"115","author":"Xu","year":"2015","journal-title":"Chem. Rev."},{"issue":"23","key":"10.1016\/j.bcp.2023.115471_b0035","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1021\/acs.jmedchem.8b01358","article-title":"Functional characterization of a novel lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide in vitro and in vivo","volume":"61","author":"Zeng","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2023.115471_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.788358","article-title":"The Protective Effects of Cath-MH with Anti-Propionibacterium Acnes and Anti-Inflammation Functions on Acne Vulgaris","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"18","key":"10.1016\/j.bcp.2023.115471_b0045","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.3390\/ijms20184341","article-title":"Inflammatory Response to Different Toxins in Experimental Sepsis Models","volume":"20","author":"Dickson","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2023.115471_b0050","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cca.2006.05.045","article-title":"LTA and LPS mediated activation of protein kinases in the regulation of inflammatory cytokines expression in macrophages","volume":"374","author":"Su","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bcp.2023.115471_b0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-1-4939-6737-7_27","article-title":"Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization","volume":"1548","author":"Skovbakke","year":"2017","journal-title":"Methods. Mol. Biol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115471_b0060","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1432-1033.1996.0788r.x","article-title":"Temporins, antimicrobial peptides from the European red frog Rana temporaria","volume":"242","author":"Simmaco","year":"1996","journal-title":"Eur. J. Biochem"},{"issue":"8","key":"10.1016\/j.bcp.2023.115471_b0065","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.bbamem.2009.04.021","article-title":"Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification","volume":"1788","author":"Mangoni","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.bcp.2023.115471_b0070","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/sur.2019.266","article-title":"Temporins: An Approach of Potential Pharmaceutic Candidates","volume":"21","author":"Romero","year":"2020","journal-title":"Surg. Infect. (Larchmt)"},{"issue":"7","key":"10.1016\/j.bcp.2023.115471_b0075","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2108\/zsj.26.476","article-title":"Effects of salinity on the survival, growth, development, and metamorphosis of Fejervarya limnocharis tadpoles living in brackish water","volume":"26","author":"Wu","year":"2009","journal-title":"Zoolog. Sci"},{"key":"10.1016\/j.bcp.2023.115471_b0080","doi-asserted-by":"crossref","first-page":"2615178","DOI":"10.1155\/2022\/2615178","article-title":"Multiple Mechanistic Action of Brevinin-1FL Peptide against Oxidative Stress Effects in an Acute Inflammatory Model of Carrageenan-Induced Damage","volume":"2022","author":"Chai","year":"2022","journal-title":"Oxid. Med. Cell. Longev"},{"issue":"12","key":"10.1016\/j.bcp.2023.115471_b0085","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.3390\/v13122382","article-title":"Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity","volume":"13","author":"Xiong","year":"2021","journal-title":"Viruses"},{"issue":"9","key":"10.1016\/j.bcp.2023.115471_b0090","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1021\/acsomega.1c00033","article-title":"Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41","volume":"6","author":"Xiong","year":"2021","journal-title":"ACS. Omega"},{"key":"10.1016\/j.bcp.2023.115471_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.783108","article-title":"Antimicrobial and Anti-inflammatory Effects of a Novel Peptide from the Skin of Frog Microhyla pulchra","volume":"12","author":"Tian","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115471_b0100","doi-asserted-by":"crossref","first-page":"e64411","DOI":"10.7554\/eLife.64411","article-title":"Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties","volume":"10","author":"Chai","year":"2021","journal-title":"ELIFE"},{"key":"10.1016\/j.bcp.2023.115471_b0105","doi-asserted-by":"crossref","unstructured":"Z. Du, H. Su, W. Wang, L. Ye, H. Wei, Z. Peng, I. Anishchenko, D. Baker, J. Yang, The trRosetta server for fast and accurate protein structure prediction, Nat. Protoc. 16(12) (2021) 5634-5651.","DOI":"10.1038\/s41596-021-00628-9"},{"issue":"21","key":"10.1016\/j.bcp.2023.115471_b0110","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.3390\/ijms222111401","article-title":"Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities","volume":"22","author":"Luo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115471_b0115","doi-asserted-by":"crossref","unstructured":"S. Kang, S.J. Park, T. Mishig-Ochir, B. Lee, Antimicrobial peptides: therapeutic potentials., Expert. Rev. Anti-Infe 12(12) (2014) 1477-1486.","DOI":"10.1586\/14787210.2014.976613"},{"issue":"2","key":"10.1016\/j.bcp.2023.115471_b0120","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s11033-012-2152-4","article-title":"Five novel antimicrobial peptides from the Kuhl's wart frog skin secretions, Limnonectes kuhlii","volume":"40","author":"Wang","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.bcp.2023.115471_b0125","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2108\/zsj.26.220","article-title":"Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis","volume":"26","author":"Shang","year":"2009","journal-title":"Zoolog. Sci"},{"issue":"1","key":"10.1016\/j.bcp.2023.115471_b0130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ygeno.2009.09.004","article-title":"Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata","volume":"95","author":"Ma","year":"2010","journal-title":"Genomics"},{"issue":"12","key":"10.1016\/j.bcp.2023.115471_b0135","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.biochi.2013.09.002","article-title":"Identification of multiple antimicrobial peptides from the skin of fine-spined frog, Hylarana spinulosa (Ranidae)","volume":"95","author":"Yang","year":"2013","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.bcp.2023.115471_b0140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.peptides.2008.10.016","article-title":"The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae)","volume":"30","author":"Wang","year":"2009","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.bcp.2023.115471_b0145","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.peptides.2006.10.016","article-title":"Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii","volume":"28","author":"Suzuki","year":"2007","journal-title":"Peptides"},{"issue":"6","key":"10.1016\/j.bcp.2023.115471_b0150","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/oxfordjournals.molbev.a004143","article-title":"Roles of diversifying selection and coordinated evolution in the evolution of amphibian antimicrobial peptides","volume":"19","author":"Duda","year":"2002","journal-title":"Mol. Biol. Evol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115471_b0155","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.peptides.2006.10.013","article-title":"Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs","volume":"28","author":"Ohnuma","year":"2007","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.bcp.2023.115471_b0160","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","article-title":"Molecular basis of bacterial outer membrane permeability revisited","volume":"67","author":"Nikaido","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev"},{"issue":"5","key":"10.1016\/j.bcp.2023.115471_b0165","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000414","article-title":"The bacterial cell envelope","volume":"2","author":"Silhavy","year":"2010","journal-title":"Cold. Spring. Harb. Perspect. Biol"},{"issue":"7","key":"10.1016\/j.bcp.2023.115471_b0170","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1128\/AAC.01553-05","article-title":"Interaction of antimicrobial peptide temporin L with lipopolysaccharide in vitro and in experimental rat models of septic shock caused by gram-negative bacteria","volume":"50","author":"Giacometti","year":"2006","journal-title":"Antimicrob. Agents. Chemother"},{"issue":"11","key":"10.1016\/j.bcp.2023.115471_b0175","doi-asserted-by":"crossref","first-page":"10378","DOI":"10.1074\/jbc.M412865200","article-title":"A molecular mechanism for lipopolysaccharide protection of Gram-negative bacteria from antimicrobial peptides","volume":"280","author":"Papo","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2023.115471_b0180","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1574-6968.2004.tb09482.x","article-title":"Interactions of lactoferricin-derived peptides with LPS and antimicrobial activity","volume":"233","author":"Farnaud","year":"2004","journal-title":"FEMS. Microbiol. Lett."},{"issue":"1","key":"10.1016\/j.bcp.2023.115471_b0185","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/ijms23010545","article-title":"Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms","volume":"23","author":"Vanzolini","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.bcp.2023.115471_b0190","first-page":"73","article-title":"Membrane active antimicrobial peptides: translating mechanistic insights to design","volume":"11","author":"Li","year":"2017","journal-title":"Front. Neurosci"},{"issue":"3","key":"10.1016\/j.bcp.2023.115471_b0195","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1042\/bj20031975","article-title":"Effects of the antimicrobial peptide temporin L on cell morphology, membrane permeability and viability of Escherichia coli","volume":"380","author":"Mangoni","year":"2004","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.bcp.2023.115471_b0200","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s00018-005-5536-y","article-title":"Temporins, anti-infective peptides with expanding properties","volume":"63","author":"Mangoni","year":"2006","journal-title":"Cell. Mol. Life. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2023.115471_b0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/07388551.2011.594423","article-title":"Antimicrobial peptides: key components of the innate immune system","volume":"32","author":"Pasupuleti","year":"2012","journal-title":"Crit. Rev. Biotechnol."},{"issue":"8","key":"10.1016\/j.bcp.2023.115471_b0210","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/toxins10080320","article-title":"Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii","volume":"10","author":"Tan","year":"2018","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.bcp.2023.115471_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.707013","article-title":"Bioevaluation and Targeted Modification of Temporin-FL from the Skin Secretion of Dark-Spotted Frog (Pelophylax nigromaculatus)","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Mol. Biosci"},{"issue":"5","key":"10.1016\/j.bcp.2023.115471_b0220","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1747-0285.2012.01363.x","article-title":"Design of potent, non-toxic antimicrobial agents based upon the structure of the frog skin peptide, temporin-1CEb from Chinese brown frog, Rana chensinensis","volume":"79","author":"Shang","year":"2012","journal-title":"Chem. Biol. Drug. Des."},{"issue":"5","key":"10.1016\/j.bcp.2023.115471_b0225","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1021\/jm1012853","article-title":"Structure-activity relationship, conformational and biological studies of temporin L analogues","volume":"54","author":"Mangoni","year":"2011","journal-title":"J. Med. Chem."},{"issue":"42","key":"10.1016\/j.bcp.2023.115471_b0230","doi-asserted-by":"crossref","first-page":"35391","DOI":"10.1074\/jbc.M505042200","article-title":"A role for human Sp alpha as a pattern recognition receptor","volume":"280","author":"Sarrias","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2023.115471_b0235","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care. Med."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522300062X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522300062X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:20:10Z","timestamp":1736360410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522300062X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":47,"alternative-id":["S000629522300062X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115471","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of a novel LTA\/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae)","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115471"}}