{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:06:45Z","timestamp":1792026405185,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.bcp.2023.115497","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T10:23:00Z","timestamp":1678530180000},"page":"115497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["BRD4 promotes hepatic stellate cells activation and hepatic fibrosis via mediating P300\/H3K27ac\/PLK1 axis"],"prefix":"10.1016","volume":"210","author":[{"given":"Miao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-ni","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-cheng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-wu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong-wen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-752X","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"issue":"9","key":"10.1016\/j.bcp.2023.115497_b0015","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s40265-019-01126-9","article-title":"Fibrosis in chronic liver disease: an update on diagnostic and treatment modalities","volume":"79","author":"Manka","year":"2019","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.bcp.2023.115497_b0020","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3350\/cmh.2017.0078","article-title":"Histopathological evaluation of liver fibrosis and cirrhosis regression","volume":"23","author":"Lo","year":"2017","journal-title":"Clin. Mol. Hepatol."},{"issue":"2 Suppl 1","key":"10.1016\/j.bcp.2023.115497_b0025","article-title":"Reversal of hepatic fibrosis \u2013 fact or fantasy?","volume":"43","author":"Friedman","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.bcp.2023.115497_b0030","doi-asserted-by":"crossref","unstructured":"Scott L. Friedman, F. Joseph Roll, Janet Boylest, BISSELL ADM: Hepatic lipocytes: The principal collagen-producing cells of normal rat liver, Proc. Nati. Acad. Sci. USA 1985, 82:8681-8685.","DOI":"10.1073\/pnas.82.24.8681"},{"issue":"32","key":"10.1016\/j.bcp.2023.115497_b0035","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"7","key":"10.1016\/j.bcp.2023.115497_b0040","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2023.115497_b0045","doi-asserted-by":"crossref","unstructured":"Claus Hellerbrand, Branko Stefanovic, Frank Giordano, Burchardt. ER, Brenner. DA: The role of TGFbeta1 in initiating hepatic stellate cell activation Journal of Hepatology 1999, 30:77-87.","DOI":"10.1016\/S0168-8278(99)80010-5"},{"key":"10.1016\/j.bcp.2023.115497_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bcp.2023.115497_b0055","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"M.J.P.: Mechanisms of Spontaneous Resolution of Rat Liver Fibrosis Hepatic Stellate Cell Apoptosis and Reduced Hepatic Expression of Metalloproteinase Inhibitors","volume":"102","author":"Iredale","year":"1998","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.bcp.2023.115497_b0060","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.bcp.2023.115497_b0065","doi-asserted-by":"crossref","first-page":"9230","DOI":"10.1073\/pnas.1206645109","article-title":"Fibrogenic cell reversion underlies fibrosis regression in liver","volume":"109","author":"Friedman","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"10.1016\/j.bcp.2023.115497_b0070","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bcp.2023.115497_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153087","article-title":"O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-kappaB signaling pathway","volume":"466","author":"Li","year":"2022","journal-title":"Toxicology"},{"issue":"7453","key":"10.1016\/j.bcp.2023.115497_b0080","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature12147","article-title":"The bromodomain protein Brd4 insulates chromatin from DNA damage signalling","volume":"498","author":"Floyd","year":"2013","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bcp.2023.115497_b0085","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.celrep.2018.10.003","article-title":"Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1","volume":"25","author":"Wu","year":"2018","journal-title":"Cell Rep"},{"issue":"18","key":"10.1016\/j.bcp.2023.115497_b0090","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1074\/jbc.R700001200","article-title":"The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation","volume":"282","author":"Wu","year":"2007","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.bcp.2023.115497_b0095","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nsmb.2912","article-title":"BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones","volume":"21","author":"Kanno","year":"2014","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.bcp.2023.115497_b0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1101\/sqb.2017.82.033829","article-title":"The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure","volume":"82","author":"Hsu","year":"2017","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"7327","key":"10.1016\/j.bcp.2023.115497_b0105","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bcp.2023.115497_b0110","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41573-019-0030-7","article-title":"Bromodomains: a new target class for drug development","volume":"18","author":"Cochran","year":"2019","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"10.1016\/j.bcp.2023.115497_b0115","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1182\/blood-2013-01-478420","article-title":"Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762","volume":"123","author":"Chaidos","year":"2014","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bcp.2023.115497_b0120","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1002\/hep.30544","article-title":"Aberrant Super-Enhancer Landscape in Human Hepatocellular Carcinoma","volume":"69","author":"Tsang","year":"2019","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/cas.15190","article-title":"CPI-203 improves the efficacy of anti-PD-1 therapy by inhibiting the induced PD-L1 overexpression in liver cancer","volume":"113","author":"Niu","year":"2022","journal-title":"Cancer Sci"},{"issue":"10","key":"10.1016\/j.bcp.2023.115497_b0130","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.metabol.2016.07.001","article-title":"BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver","volume":"65","author":"Yamada","year":"2016","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.bcp.2023.115497_b0135","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.M410078200","article-title":"Adipogenic transcriptional regulation of hepatic stellate cells","volume":"280","author":"She","year":"2005","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bcp.2023.115497_b0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"7","key":"10.1016\/j.bcp.2023.115497_b0145","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/rccm.201812-2275OC","article-title":"Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension","volume":"200","author":"Van der Feen","year":"2019","journal-title":"Am J Resp Crit Care"},{"issue":"13","key":"10.1016\/j.bcp.2023.115497_b0150","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1111\/jcmm.15356","article-title":"PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt\/beta-catenin signalling pathway","volume":"24","author":"Chen","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0155","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-020-01957-w","article-title":"Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells","volume":"21","author":"Zhang","year":"2020","journal-title":"Genome Biol"},{"issue":"7","key":"10.1016\/j.bcp.2023.115497_b0160","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.celrep.2018.07.041","article-title":"Enhancer Activity Requires CBP\/P300 Bromodomain-Dependent Histone H3K27 Acetylation","volume":"24","author":"Raisner","year":"2018","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.bcp.2023.115497_b0165","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1053\/j.gastro.2018.02.015","article-title":"P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts","volume":"154","author":"Dou","year":"2018","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bcp.2023.115497_b0170","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jhep.2018.12.003","article-title":"Fibrosis and alcohol-related liver disease","volume":"70","author":"Lackner","year":"2019","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jcmgh.2017.04.007","article-title":"Epigenetics and Liver Fibrosis","volume":"4","author":"Moran-Salvador","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115497_b0180","doi-asserted-by":"crossref","first-page":"e88032","DOI":"10.1172\/jci.insight.88032","article-title":"BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo","volume":"2","author":"Kumar","year":"2017","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0185","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/mol.112.081661","article-title":"BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis","volume":"83","author":"Tang","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2023.115497_b0190","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/CIRCRESAHA.119.315125","article-title":"Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation","volume":"125","author":"Stratton","year":"2019","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bcp.2023.115497_b0195","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.molcel.2018.06.036","article-title":"DUB3 Promotes BET inhibitor resistance and cancer progression by deubiquitinating BRD4","volume":"71","author":"Jin","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2023.115497_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.753119","article-title":"ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways","volume":"11","author":"Liao","year":"2021","journal-title":"Front. Oncol."},{"issue":"34","key":"10.1016\/j.bcp.2023.115497_b0205","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1038\/onc.2017.113","article-title":"Playing polo during mitosis: PLK1 takes the lead","volume":"36","author":"Combes","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2023.115497_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114747","article-title":"Polo-like kinase 1 (PLK1) signaling in cancer and beyond","volume":"193","author":"Iliaki","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2023.115497_b0215","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cell.2016.01.036","article-title":"Shelterin protects chromosome ends by compacting telomeric chromatin","volume":"164","author":"Bandaria","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bcp.2023.115497_b0220","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12943-018-0915-9","article-title":"BRD4 and Cancer: going beyond transcriptional regulation","volume":"17","author":"Donati","year":"2018","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.bcp.2023.115497_b0225","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00021.2015","article-title":"CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET","volume":"308","author":"Clifford","year":"2015","journal-title":"Am. J. Physiol.-Lung. C"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223000886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223000886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:20:41Z","timestamp":1736342441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223000886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":45,"alternative-id":["S0006295223000886"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115497","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BRD4 promotes hepatic stellate cells activation and hepatic fibrosis via mediating P300\/H3K27ac\/PLK1 axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115497","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115497"}}