{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:59:37Z","timestamp":1789840777154,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002631","name":"Gachon University","doi-asserted-by":"publisher","award":["GCU-202109950001"],"award-info":[{"award-number":["GCU-202109950001"]}],"id":[{"id":"10.13039\/501100002631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2020R1A6A1A03043708"],"award-info":[{"award-number":["2020R1A6A1A03043708"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2021R1A2C1011132"],"award-info":[{"award-number":["2021R1A2C1011132"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.bcp.2023.115534","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T20:47:27Z","timestamp":1680554847000},"page":"115534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["A small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy"],"prefix":"10.1016","volume":"211","author":[{"given":"Chae Young","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Lan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Yong","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Won","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2023.115534_b0005","first-page":"74","article-title":"AGE-RELATED MACULAR DEGENERATION","volume":"59","author":"Gheorghe","year":"2015","journal-title":"Rom J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115534_b0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12886-017-0555-7","article-title":"Plasma metabolomic study in Chinese patients with wet age-related macular degeneration","volume":"17","author":"Luo","year":"2017","journal-title":"BMC Ophthalmol."},{"issue":"11","key":"10.1016\/j.bcp.2023.115534_b0015","first-page":"1194","article-title":"Age-related macular degeneration","volume":"56","author":"Benyelles","year":"2006","journal-title":"Rev. Prat."},{"key":"10.1016\/j.bcp.2023.115534_b0020","first-page":"5397","article-title":"Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis","volume":"9","author":"Ba","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2023.115534_b0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.eurger.2014.09.007","article-title":"Age related macular degeneration - challenge for future: Pathogenesis and new perspectives for the treatment","volume":"6","author":"Michalska-Malecka","year":"2015","journal-title":"Eur Geriatr. Med."},{"issue":"3","key":"10.1016\/j.bcp.2023.115534_b0030","first-page":"353","article-title":"Age-related macular degeneration (AMD): pathogenesis and therapy","volume":"58","author":"Nowak","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bcp.2023.115534_b0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ajo.2020.11.012","article-title":"Ten-Year Progression From Intermediate to Exudative Age-Related Macular Degeneration and Risk Factors: Bundang AMD Cohort Study Report 1","volume":"224","author":"Joo","year":"2021","journal-title":"Am. J. Ophthalmol."},{"issue":"47","key":"10.1016\/j.bcp.2023.115534_b0040","doi-asserted-by":"crossref","first-page":"23724","DOI":"10.1073\/pnas.1906643116","article-title":"Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina","volume":"116","author":"Notomi","year":"2019","journal-title":"PNAS"},{"issue":"28","key":"10.1016\/j.bcp.2023.115534_b0045","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1016\/S0042-6989(03)00475-9","article-title":"A2E, a byproduct of the visual cycle","volume":"43","author":"Sparrow","year":"2003","journal-title":"Vision Res."},{"key":"10.1016\/j.bcp.2023.115534_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.06.002","article-title":"Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells","volume":"131","author":"Jeong","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2023.115534_b0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jff.2017.10.009","article-title":"Protective mechanisms of polyphenol-enriched fraction of Vaccinium uliginosum L Against blue light-induced cell death of human retinal pigmented epithelial cells","volume":"39","author":"Jin","year":"2017","journal-title":"J. Function. Foods"},{"issue":"11","key":"10.1016\/j.bcp.2023.115534_b0060","article-title":"Photooxidation of A2E by Blue Light Regulates Heme Oxygenase 1 Expression via NF-kappaB and Lysine Methyltransferase 2A in ARPE-19 Cells","volume":"12","author":"Shin","year":"2022","journal-title":"Life (Basel)"},{"issue":"3","key":"10.1016\/j.bcp.2023.115534_b0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4062\/biomolther.2021.155","article-title":"Transcriptome Analysis of Long-Term Exposure to Blue Light in Retinal Pigment Epithelial Cells","volume":"30","author":"Jin","year":"2022","journal-title":"Biomol Ther (Seoul)"},{"issue":"7","key":"10.1016\/j.bcp.2023.115534_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071736","article-title":"SETD1A Promotes Proliferation of Castration-Resistant Prostate Cancer Cells via FOXM1 Transcription","volume":"12","author":"Yang","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.bcp.2023.115534_b0075","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jpba.2015.10.010","article-title":"A novel fluorescence-based assay for measuring A2E removal from human retinal pigment epithelial cells to screen for age-related macular degeneration inhibitors","volume":"117","author":"Jin","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.bcp.2023.115534_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020359","article-title":"Solanum melongena L. Extract Protects Retinal Pigment Epithelial Cells from Blue Light-Induced Phototoxicity in In Vitro and In Vivo Models","volume":"13","author":"Pham","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.bcp.2023.115534_b0085","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1002\/ijc.31853","article-title":"Aberrant expression of SETD1A promotes survival and migration of estrogen receptor alpha-positive breast cancer cells","volume":"143","author":"Jin","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"9","key":"10.1016\/j.bcp.2023.115534_b0090","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1248\/cpb.c19-00207","article-title":"Synthesis of Either C2- or C4'-Alkylated Derivatives of Honokiol and Their Biological Evaluation for Anti-inflammatory Activity","volume":"67","author":"Lee","year":"2019","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"1","key":"10.1016\/j.bcp.2023.115534_b0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12272-015-0683-7","article-title":"Preventive effect of Vaccinium uliginosum L. extract and its fractions on age-related macular degeneration and its action mechanisms","volume":"39","author":"Yoon","year":"2016","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bcp.2023.115534_b0100","doi-asserted-by":"crossref","first-page":"e1972","DOI":"10.1038\/cddis.2015.330","article-title":"Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration","volume":"6","author":"Zhang","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2023.115534_b0105","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.fob.2014.11.003","article-title":"Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E","volume":"4","author":"Saadat","year":"2014","journal-title":"FEBS Open Bio"},{"issue":"7","key":"10.1016\/j.bcp.2023.115534_b0110","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrm3139","article-title":"Autophagy: TFEB perfects multitasking","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.bcp.2023.115534_b0115","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1136\/bjophthalmol-2019-314422","article-title":"Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis","volume":"104","author":"Li","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bcp.2023.115534_b0120","first-page":"24","article-title":"Eye Conditions in Older Adults: Age-Related Macular Degeneration","volume":"445","author":"Iroku-Malize","year":"2016","journal-title":"FP Essent"},{"key":"10.1016\/j.bcp.2023.115534_b0125","first-page":"519","volume":"6","author":"Bahadorani","year":"2017","journal-title":"Recent advances in the management and understanding of macular degeneration"},{"issue":"13","key":"10.1016\/j.bcp.2023.115534_b0130","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.2146\/ahjp080052","article-title":"Lutein and zeaxanthin for macular degeneration","volume":"65","author":"Zhao","year":"2008","journal-title":"Am. J. Health Syst. Pharm."},{"issue":"7","key":"10.1016\/j.bcp.2023.115534_b0135","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/aje\/kwn409","article-title":"Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) study","volume":"169","author":"Satia","year":"2009","journal-title":"Am. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.bcp.2023.115534_b0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tem.2014.03.010","article-title":"Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis","volume":"25","author":"Sergin","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.bcp.2023.115534_b0145","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2023.115534_b0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4614-0631-0_12","article-title":"Autophagy in the retina: a potential role in age-related macular degeneration","volume":"723","author":"Mitter","year":"2012","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.bcp.2023.115534_b0155","first-page":"3632169","article-title":"Autophagy Dysfunction","volume":"2019","author":"Wang","year":"2019","journal-title":"Cellular Senescence, and Abnormal Immune-Inflammatory Responses in AMD: From Mechanisms to Therapeutic Potential, Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.bcp.2023.115534_b0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2023.115534_b0165","doi-asserted-by":"crossref","first-page":"9015765","DOI":"10.1155\/2018\/9015765","article-title":"Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells","volume":"2018","author":"Chang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.bcp.2023.115534_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030813","article-title":"Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells","volume":"21","author":"Josifovska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115534_b0175","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.freeradbiomed.2019.12.003","article-title":"Protective effect of Prunella vulgaris var. L extract against blue light induced damages in ARPE-19 cells and mouse retina","volume":"152","author":"Kim","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.bcp.2023.115534_b0180","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41419-017-0200-7","article-title":"Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223001259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223001259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:41:37Z","timestamp":1757770897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223001259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":36,"alternative-id":["S0006295223001259"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115534","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A small molecule compound that inhibits blue light-induced retinal damage via activation of autophagy","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115534"}}