{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:04:21Z","timestamp":1761897861180,"version":"3.32.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bcp.2023.115544","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T06:02:08Z","timestamp":1681192928000},"page":"115544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control"],"prefix":"10.1016","volume":"212","author":[{"given":"A.","family":"Coulter-Parkhill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SWM.","family":"Dobbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Tanday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VA.","family":"Gault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"McClean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-964X","authenticated-orcid":false,"given":"N.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2023.115544_b0005","doi-asserted-by":"crossref","unstructured":"Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice., 157 (2019) pp. 107843.","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"10.1016\/j.bcp.2023.115544_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110708","article-title":"Type II diabetes mellitus: a review on recent drug-based therapeutics","volume":"131","author":"Padhi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2023.115544_b0015","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/molecules25081987","article-title":"Type 2 Diabetes Mellitus: a review of multi-target drugs","volume":"25","author":"Artasensi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2023.115544_b0020","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S2213-8587(20)30381-8","article-title":"Management of diabetes and hyperglycaemia in the hospital","volume":"9","author":"Pasquel","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.bcp.2023.115544_b0025","doi-asserted-by":"crossref","unstructured":"Coulter-Parkhill A, McClean S, Gault V, Irwin N. Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes. Clinical Medicine Insights: Endocrinology and Diabetes., 14 (2021) pp. 117955142110060.","DOI":"10.1177\/11795514211006071"},{"key":"10.1016\/j.bcp.2023.115544_b0030","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1080\/17460441.2021.1922386","article-title":"Advances in venom peptide drug discovery: where are we at and where are we heading?","volume":"16","author":"Smallwood","year":"2021","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bcp.2023.115544_b0035","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1016\/S0021-9258(18)42531-8","article-title":"Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas","volume":"267","author":"Eng","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2023.115544_b0040","first-page":"228","article-title":"Chemical biology approach to probing the folding pathways of the inhibitory cystine knot (ICK) Peptide ProTx-II. Frontiers","volume":"8","author":"McCarthy","year":"2020","journal-title":"Chemistry"},{"key":"10.1016\/j.bcp.2023.115544_b0045","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(00)80306-2","article-title":"Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites","volume":"18","author":"Swartz","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2023.115544_b0050","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.2337\/diabetes.55.04.06.db05-0788","article-title":"Blockers of the delayed-rectifier potassium current in pancreatic -cells enhance glucose-dependent insulin secretion","volume":"55","author":"Herrington","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2023.115544_b0055","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuropharm.2017.07.001","article-title":"Venom peptides as pharmacological tools and therapeutics for diabetes","volume":"127","author":"Robinson","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2023.115544_b0060","doi-asserted-by":"crossref","unstructured":"Lafferty R, Gault V, Flatt P, Irwin N. Effects of 2 Novel PYY (1-36) Analogues, (P3L31P34) PYY (1-36) and PYY (1-36) (Lys12PAL), on Pancreatic Beta-Cell Function, Growth, and Survival. Clinical Medicine Insights: Endocrinology and Diabetes., 12 2019 117955141985562.","DOI":"10.1177\/1179551419855626"},{"key":"10.1016\/j.bcp.2023.115544_b0065","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/diab.45.8.1132","article-title":"Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion","volume":"45","author":"McClenaghan","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2023.115544_b0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","article-title":"Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas","volume":"16","author":"Lacy","year":"1967","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2023.115544_b0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00726-015-2107-x","article-title":"In vitro and in vivo insulinotropic properties of the multifunctional frog skin peptide hymenochirin-1B: a structure\u2013activity study","volume":"48","author":"Owolabi","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.bcp.2023.115544_b0080","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ceca.2003.11.007","article-title":"Time-correlation between membrane depolarization and intracellular calcium in insulin-secreting BRIN-BD11 cells: studies using FLIPR","volume":"36","author":"Miguel","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcp.2023.115544_b0085","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF00252768","article-title":"Abnormal plasma glucose and insulin responses in heterozygous lean (ob\/+) mice","volume":"20","author":"Flatt","year":"1981","journal-title":"Diabetologia"},{"key":"10.1016\/j.bcp.2023.115544_b0090","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/312446a0","article-title":"Glucose induces closure of single potassium channels in isolated rat pancreatic \u03b2-cells","volume":"312","author":"Ashcroft","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2023.115544_b0095","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1021\/bi100246u","article-title":"Solution Structure of GxTX-1E, a High-Affinity Tarantula Toxin Interacting with Voltage Sensors in Kv2.1 Potassium Channels","volume":"49","author":"Lee","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2023.115544_b0100","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3390\/toxins13090621","article-title":"Stability and Safety of Inhibitor Cystine Knot Peptide, GTx1-15, from the Tarantula Spider Grammostola rosea","volume":"13","author":"Kimura","year":"2021","journal-title":"Toxins."},{"key":"10.1016\/j.bcp.2023.115544_b0105","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1111\/dom.14171","article-title":"Role of exendin-4 in the Gila monster: further lessons regarding human oral glucagon-like peptide-1 therapy?","volume":"22","author":"Graham","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bcp.2023.115544_b0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2020.05.007","article-title":"Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches","volume":"157","author":"Brayden","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bcp.2023.115544_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.645617","article-title":"Efficacy of semaglutide in a subcutaneous and an oral formulation","volume":"12","author":"Meier","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bcp.2023.115544_b0120","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.2337\/diacare.28.5.1092","article-title":"Effects of Exendin-4 (Exenatide) on glycemic control and weight over 30 weeks in metformin-treated patients with Type 2 Diabetes","volume":"28","author":"DeFronzo","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bcp.2023.115544_b0125","doi-asserted-by":"crossref","first-page":"12189","DOI":"10.1074\/jbc.R114.557314","article-title":"A fresh view of glycolysis and glucokinase regulation: history and current status","volume":"289","author":"Lenzen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2023.115544_b0130","doi-asserted-by":"crossref","unstructured":"Zhou T, Quan L, Chen L, Du T, Sun K, Zhang J et al. SP6616 as a new Kv2.1 channel inhibitor efficiently promotes \u03b2-cell survival involving both PKC\/Erk1\/2 and CaM\/PI3K\/Akt signalling pathways. Cell Death & Disease., 7 2016 e2216.","DOI":"10.1038\/cddis.2016.119"},{"key":"10.1016\/j.bcp.2023.115544_b0135","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.toxicon.2007.03.006","article-title":"Solution structure of Jingzhaotoxin-III, a peptide toxin inhibiting both Nav1.5 and Kv2.1 channels","volume":"50","author":"Liao","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.bcp.2023.115544_b0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1463-1326.2011.01452.x","article-title":"Regulation of glucagon secretion by incretins","volume":"13","author":"Holst","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bcp.2023.115544_b0145","doi-asserted-by":"crossref","unstructured":"MacDonald P, El-kholy W, Riedel M, Salapatek A, Light P Wheeler M. The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion. Diabetes., 51 2002 S434-S442.","DOI":"10.2337\/diabetes.51.2007.S434"},{"key":"10.1016\/j.bcp.2023.115544_b0150","doi-asserted-by":"crossref","unstructured":"Irwin N, Pathak V, Flatt P. A Novel CCK-8\/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions with Significant Therapeutic Potential in High-Fat\u2013Fed Mice. Diabetes., 65 (2016) pp. 1120-1120.","DOI":"10.2337\/db16-er04"},{"key":"10.1016\/j.bcp.2023.115544_b0155","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1210\/en.2014-1728","article-title":"Partial Blockade of Kv2.1 Channel Potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in Type 2 Diabetic Male Mice","volume":"156","author":"Sukma Rita","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2023.115544_b0160","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/bph.15485","article-title":"Metabolic responses and benefits of glucagon-like peptide-1 (GLP-1) receptor ligands","volume":"179","author":"Tanday","year":"2021","journal-title":"Br. J. Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223001351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223001351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:51:48Z","timestamp":1736329908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223001351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":32,"alternative-id":["S0006295223001351"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115544","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115544"}}