{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:50:14Z","timestamp":1792803014337,"version":"4.5.0"},"reference-count":184,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023YFH0013"],"award-info":[{"award-number":["2023YFH0013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870224"],"award-info":[{"award-number":["81870224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274647"],"award-info":[{"award-number":["82274647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bcp.2023.115587","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T06:32:07Z","timestamp":1684132327000},"page":"115587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Regulation of the JAK\/STAT signaling pathway: The promising targets for cardiovascular disease"],"prefix":"10.1016","volume":"213","author":[{"given":"Qiuyu","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41569-021-00607-3","article-title":"Epidemiology of cardiovascular disease in Europe","volume":"19","author":"Townsend","year":"2022","journal-title":"Nat Rev Cardiol"},{"issue":"8","key":"10.1016\/j.bcp.2023.115587_b0010","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41569-018-0119-4","article-title":"Epidemiology of cardiovascular disease in China: current features and implications","volume":"16","author":"Zhao","year":"2019","journal-title":"Nat Rev Cardiol"},{"issue":"9","key":"10.1016\/j.bcp.2023.115587_b0020","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.bcp.2023.115587_b0025","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"issue":"7347","key":"10.1016\/j.bcp.2023.115587_b0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bcp.2023.115587_b0040","doi-asserted-by":"crossref","first-page":"801","DOI":"10.7150\/thno.4419","article-title":"Therapeutic angiogenesis for treating cardiovascular diseases","volume":"2","author":"Deveza","year":"2012","journal-title":"Theranostics"},{"issue":"10","key":"10.1016\/j.bcp.2023.115587_b0045","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1172\/JCI107091","article-title":"Coronary artery reperfusion. II. Reduction of myocardial infarct size at 1 week after the coronary occlusion","volume":"51","author":"Ginks","year":"1972","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0050","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCULATIONAHA.119.042276","article-title":"Cardio-Immuno-Oncology","volume":"141","author":"Zaha","year":"2020","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0055","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/CIRCULATIONAHA.117.029343","article-title":"Cardiomyocyte Regeneration: A Consensus Statement","volume":"136","author":"Eschenhagen","year":"2017","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.bcp.2023.115587_b0060","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/pro.3519","article-title":"The molecular details of cytokine signaling via the JAK\/STAT pathway","volume":"27","author":"Morris","year":"2018","journal-title":"Protein Sci"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0070","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak-STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molmed.2006.12.002","article-title":"Role of the JAK-STAT pathway in myocardial injury","volume":"13","author":"Barry","year":"2007","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0080","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.115.017472","article-title":"Critical Roles of STAT3 in \u03b2-Adrenergic Functions in the Heart","volume":"133","author":"Zhang","year":"2016","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0085","first-page":"111","article-title":"STAT transcription in the ischemic heart","volume":"1","author":"Knight","year":"2012","journal-title":"JAKSTAT"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0090","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pharmthera.2008.08.002","article-title":"The myocardial JAK\/STAT pathway: from protection to failure","volume":"120","author":"Boengler","year":"2008","journal-title":"Pharmacol Ther"},{"issue":"14","key":"10.1016\/j.bcp.2023.115587_b0095","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1074\/jbc.275.14.10002","article-title":"Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis","volume":"275","author":"Stephanou","year":"2000","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0100","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2012.03.014","article-title":"JAK and STAT signaling molecules in immunoregulation and immune-mediated disease","volume":"36","author":"O'Shea","year":"2012","journal-title":"Immunity"},{"issue":"5332","key":"10.1016\/j.bcp.2023.115587_b0105","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0110","first-page":"277","article-title":"Identification and chromosomal mapping of new human tyrosine kinase genes","volume":"5","author":"Krolewski","year":"1990","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0115","first-page":"2057","article-title":"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase","volume":"11","author":"Wilks","year":"1991","journal-title":"Mol Cell Biol"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0120","first-page":"1347","article-title":"JAK2, a third member of the JAK family of protein tyrosine kinases","volume":"7","author":"Harpur","year":"1992","journal-title":"Oncogene"},{"issue":"42","key":"10.1016\/j.bcp.2023.115587_b0125","doi-asserted-by":"crossref","first-page":"25028","DOI":"10.1074\/jbc.270.42.25028","article-title":"A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells","volume":"270","author":"Lai","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2023.115587_b0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fendo.2017.00071","article-title":"The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions","volume":"8","author":"Ferrao","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0135","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1074\/jbc.270.7.3327","article-title":"Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha\/beta and for signal transduction","volume":"270","author":"Velazquez","year":"1995","journal-title":"J Biol Chem"},{"issue":"Suppl","key":"10.1016\/j.bcp.2023.115587_b0140","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/S0092-8674(02)00701-8","article-title":"Cytokine signaling in 2002: new surprises in the Jak\/Stat pathway","volume":"109","author":"O'Shea","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2023.115587_b0145","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2016.06.017","article-title":"JAK-STAT signaling in cancer: From cytokines to non-coding genome","volume":"87","author":"Pencik","year":"2016","journal-title":"Cytokine"},{"issue":"5155","key":"10.1016\/j.bcp.2023.115587_b0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.8140422","article-title":"Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6","volume":"264","author":"Zhong","year":"1994","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0155","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/j.1460-2075.1995.tb07100.x","article-title":"Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs","volume":"14","author":"Mui","year":"1995","journal-title":"Embo j"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0160","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/1074-7613(95)90140-X","article-title":"Identification and purification of human Stat proteins activated in response to interleukin-2","volume":"2","author":"Hou","year":"1995","journal-title":"Immunity"},{"issue":"5353","key":"10.1016\/j.bcp.2023.115587_b0165","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.279.5353.1048","article-title":"Structure of the amino-terminal protein interaction domain of STAT-4","volume":"279","author":"Vinkemeier","year":"1998","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.bcp.2023.115587_b0170","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1038\/sj.onc.1203522","article-title":"Modulation of STAT signaling by STAT-interacting proteins","volume":"19","author":"Shuai","year":"2000","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.bcp.2023.115587_b0175","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1128\/MCB.20.19.7132-7139.2000","article-title":"The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6","volume":"20","author":"Zhang","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"19","key":"10.1016\/j.bcp.2023.115587_b0180","doi-asserted-by":"crossref","first-page":"10418","DOI":"10.1073\/pnas.190318397","article-title":"Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain","volume":"97","author":"Begitt","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1-2","key":"10.1016\/j.bcp.2023.115587_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00398-0","article-title":"Signaling through the JAK\/STAT pathway, recent advances and future challenges","volume":"285","author":"Kisseleva","year":"2002","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0190","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1128\/MCB.19.7.5106","article-title":"The linker domain of Stat1 is required for gamma interferon-driven transcription","volume":"19","author":"Yang","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0195","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0092-8674(00)80276-7","article-title":"SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium","volume":"89","author":"Kawata","year":"1997","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0200","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0092-8674(00)81443-9","article-title":"Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA","volume":"93","author":"Chen","year":"1998","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0205","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1073\/pnas.91.11.4806","article-title":"Stat3 and Stat4: members of the family of signal transducers and activators of transcription","volume":"91","author":"Zhong","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5179","key":"10.1016\/j.bcp.2023.115587_b0210","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1126\/science.8085155","article-title":"An interleukin-4-induced transcription factor: IL-4 Stat","volume":"265","author":"Hou","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.bcp.2023.115587_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role of JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0220","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.0000134921.50377.61","article-title":"Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury","volume":"95","author":"Hilfiker-Kleiner","year":"2004","journal-title":"Circ Res"},{"issue":"1-2","key":"10.1016\/j.bcp.2023.115587_b0225","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jacbts.2016.01.007","article-title":"Kinetics and Signal Activation Properties of Circulating Factor(s) From Healthy Volunteers Undergoing Remote Ischemic Pre-Conditioning","volume":"1","author":"Hildebrandt","year":"2016","journal-title":"JACC Basic Transl Sci"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0230","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00395-010-0124-1","article-title":"Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia\/reperfusion","volume":"105","author":"Boengler","year":"2010","journal-title":"Basic Research in Cardiology"},{"key":"10.1016\/j.bcp.2023.115587_b0235","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yjmcc.2018.03.019","article-title":"Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser(727)","volume":"118","author":"Zhang","year":"2018","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.bcp.2023.115587_b0240","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejphar.2019.04.046","article-title":"IL33 attenuates ventricular remodeling after myocardial infarction through inducing alternatively activated macrophages ethical standards statement","volume":"854","author":"Li","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bcp.2023.115587_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174689","article-title":"Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation","volume":"915","author":"Jin","year":"2022","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0250","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1111\/jcmm.13201","article-title":"miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1\/c-Fos pathway","volume":"21","author":"Zhu","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bcp.2023.115587_b0255","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.ijcard.2016.11.198","article-title":"Remote ischemic preconditioning attenuates EGR-1 expression following myocardial ischemia reperfusion injury through activation of the JAK-STAT pathway","volume":"228","author":"Mudaliar","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.bcp.2023.115587_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109617","article-title":"Dapagliflozin attenuates diabetic cardiomyopathy through erythropoietin up-regulation of AKT\/JAK\/MAPK pathways in streptozotocin-induced diabetic rats","volume":"347","author":"El-Sayed","year":"2021","journal-title":"Chem Biol Interact"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0265","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.008145","article-title":"Protective Roles of Interferon-gamma in Cardiac Hypertrophy Induced by Sustained Pressure Overload","volume":"7","author":"Kimura","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.bcp.2023.115587_b0270","doi-asserted-by":"crossref","first-page":"4253457","DOI":"10.1155\/2020\/4253457","article-title":"Adiponectin Facilitates Postconditioning Cardioprotection through Both AMPK-Dependent Nuclear and AMPK-Independent Mitochondrial STAT3 Activation","volume":"2020","author":"Zhu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0275","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-018-0671-4","article-title":"Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2\/STAT3 signaling","volume":"113","author":"Eid","year":"2018","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0280","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-015-0509-2","article-title":"Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury","volume":"110","author":"Szczepanek","year":"2015","journal-title":"Basic Res Cardiol"},{"issue":"10","key":"10.1016\/j.bcp.2023.115587_b0285","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/CIRCRESAHA.118.313859","article-title":"Vago-Splenic Axis in Signal Transduction of Remote Ischemic Preconditioning in Pigs and Rats","volume":"123","author":"Lieder","year":"2018","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0290","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-020-0809-z","article-title":"Remote ischemic preconditioning reduces myocardial ischemia-reperfusion injury through unacylated ghrelin-induced activation of the JAK\/STAT pathway","volume":"115","author":"Sawashita","year":"2020","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0295","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-019-0747-9","article-title":"Cardioprotection of post-ischemic moderate ROS against ischemia\/reperfusion via STAT3-induced the inhibition of MCU opening","volume":"114","author":"Wu","year":"2019","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0300","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41418-018-0171-y","article-title":"STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses","volume":"26","author":"Avalle","year":"2019","journal-title":"Cell Death Differ"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0305","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/cvr\/cvy014","article-title":"Stat5-dependent cardioprotection in late remote ischaemia preconditioning","volume":"114","author":"Chen","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0310","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/CIRCRESAHA.111.259556","article-title":"STAT5 activation and cardioprotection by remote ischemic preconditioning in humans: short communication","volume":"110","author":"Heusch","year":"2012","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0315","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.ccr.2013.04.008","article-title":"Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells","volume":"23","author":"Kim","year":"2013","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0320","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10549-012-2069-6","article-title":"Auto-acetylation stabilizes p300 in cardiac myocytes during acute oxidative stress, promoting STAT3 accumulation and cell survival","volume":"135","author":"Jain","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0325","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/CIRCRESAHA.117.311143","article-title":"TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression","volume":"121","author":"Nan","year":"2017","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0330","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1172\/JCI16491","article-title":"The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury","volume":"111","author":"Yasukawa","year":"2003","journal-title":"J Clin Invest"},{"issue":"22","key":"10.1016\/j.bcp.2023.115587_b0335","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1161\/CIRCULATIONAHA.106.642454","article-title":"Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling","volume":"114","author":"Yajima","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2023.115587_b0340","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/437623","article-title":"Protective Function of STAT3 in CVB3-Induced Myocarditis","volume":"2012","author":"Lindner","year":"2012","journal-title":"Cardiol Res Pract"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0345","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10557-013-6464-y","article-title":"Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice","volume":"27","author":"Tajiri","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0350","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/CIRCULATIONAHA.121.055727","article-title":"DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics","volume":"145","author":"Zhuang","year":"2022","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.bcp.2023.115587_b0355","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia-reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0360","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"issue":"13","key":"10.1016\/j.bcp.2023.115587_b0365","first-page":"935","article-title":"Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations","volume":"38","author":"Hausenloy","year":"2017","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0370","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/j.2040-4603.2015.tb00650.x","article-title":"Treatment of Myocardial Ischemia\/Reperfusion Injury by Ischemic and Pharmacological Postconditioning","volume":"5","author":"Heusch","year":"2015","journal-title":"Compr Physiol"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0375","doi-asserted-by":"crossref","first-page":"H891","DOI":"10.1152\/ajpheart.00259.2019","article-title":"Guidelines for evaluating myocardial cell death","volume":"317","author":"Mishra","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0380","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00395-019-0756-8","article-title":"Coronary microvascular obstruction: the new frontier in cardioprotection","volume":"114","author":"Heusch","year":"2019","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0385","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/cvr\/cvs232","article-title":"Contribution of calpains to myocardial ischaemia\/reperfusion injury","volume":"96","author":"Inserte","year":"2012","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0390","doi-asserted-by":"crossref","first-page":"S644","DOI":"10.1016\/S0003-4975(02)04686-6","article-title":"Cellular mechanisms of ischemia-reperfusion injury","volume":"75","author":"Piper","year":"2003","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0395","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-013-0392-7","article-title":"Redox balance and cardioprotection","volume":"108","author":"Tullio","year":"2013","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0400","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1050-1738(02)00230-X","article-title":"Role of the JAK-STAT pathway in protection against myocardial ischemia\/reperfusion injury","volume":"13","author":"Bolli","year":"2003","journal-title":"Trends Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0405","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cellsig.2012.12.008","article-title":"p42\/p44-MAPK and PI3K are sufficient for IL-6 family cytokines\/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK\/STAT activation","volume":"25","author":"Fahmi","year":"2013","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0410","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-019-0763-9","article-title":"Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection","volume":"115","author":"Billah","year":"2020","journal-title":"Basic Res Cardiol"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0415","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0008-6363(02)00283-3","article-title":"Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene","volume":"55","author":"Smith","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0420","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/jmcc.2002.1533","article-title":"Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection","volume":"34","author":"Lecour","year":"2002","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0425","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-021-00898-0","article-title":"Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function","volume":"116","author":"Comit\u00e0","year":"2021","journal-title":"Basic Res Cardiol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0430","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/cvr\/cvp274","article-title":"Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway","volume":"84","author":"Lacerda","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0435","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/CIRCIMAGING.110.957340","article-title":"Remote Ischemic Conditioning in Patients With Myocardial Infarction Treated With Primary Angioplasty: Impact on Left Ventricular Function Assessed by Comprehensive Echocardiography and Gated Single-Photon Emission CT","volume":"3","author":"Munk","year":"2010","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0440","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jcin.2009.10.015","article-title":"Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention: enhancement by opioid action","volume":"3","author":"Rentoukas","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0445","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jcin.2014.05.015","article-title":"Remote ischemic conditioning reduces myocardial infarct size and edema in patients with ST-segment elevation myocardial infarction","volume":"8","author":"White","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0450","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00059-017-4550-9","article-title":"Effect of remote ischemic postconditioning during thrombolysis in STEMIWirksamkeit der indirekten isch\u00e4mischen Postkonditionierung w\u00e4hrend Thrombolyse bei STEMI","volume":"43","author":"Ghaffari","year":"2018","journal-title":"Herz"},{"issue":"14","key":"10.1016\/j.bcp.2023.115587_b0455","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1161\/01.CIR.0000126294.81407.7D","article-title":"Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection","volume":"109","author":"Hausenloy","year":"2004","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.bcp.2023.115587_b0460","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1161\/01.CIR.97.24.2463","article-title":"Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?","volume":"97","author":"Liu","year":"1998","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0465","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yjmcc.2004.03.012","article-title":"Tumor necrosis factor-alpha does not modulate ischemia\/reperfusion injury in na\u00efve myocardium but is essential for the development of late preconditioning","volume":"37","author":"Dawn","year":"2004","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0470","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.RES.0000255031.15793.86","article-title":"Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction","volume":"100","author":"Skyschally","year":"2007","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0475","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2014.10.031","article-title":"Remote ischemic conditioning","volume":"65","author":"Heusch","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0480","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00424-016-1922-6","article-title":"Cardioprotection by remote ischemic conditioning and its signal transduction","volume":"469","author":"Kleinbongard","year":"2017","journal-title":"Pflugers Arch"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0485","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-018-0684-z","article-title":"Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects","volume":"113","author":"Basalay","year":"2018","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0490","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","article-title":"Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ Res"},{"issue":"19","key":"10.1016\/j.bcp.2023.115587_b0495","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1161\/CIRCULATIONAHA.108.805242","article-title":"Cardioprotection: nitric oxide, protein kinases, and mitochondria","volume":"118","author":"Heusch","year":"2008","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0500","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1089\/ars.2010.3360","article-title":"Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signaling pathways in ischemic postconditioning: two sides of the same coin","volume":"14","author":"Hausenloy","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0505","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00395-011-0210-z","article-title":"RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning","volume":"106","author":"Tamareille","year":"2011","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0510","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-016-0588-8","article-title":"Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery","volume":"111","author":"Hausenloy","year":"2016","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0515","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"Yellon","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bcp.2023.115587_b0520","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/928954","article-title":"Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation","volume":"2012","author":"Vassalli","year":"2012","journal-title":"J Transplant"},{"issue":"12","key":"10.1016\/j.bcp.2023.115587_b0525","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/eurheartj\/ehx030","article-title":"Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial","volume":"39","author":"Wu","year":"2018","journal-title":"Eur Heart J"},{"issue":"5915","key":"10.1016\/j.bcp.2023.115587_b0530","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.1164551","article-title":"Function of mitochondrial Stat3 in cellular respiration","volume":"323","author":"Wegrzyn","year":"2009","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0535","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.111.255604","article-title":"Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia\/reperfusion","volume":"109","author":"Heusch","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2023.115587_b0540","article-title":"STAT3 but Not STAT5 Contributes to the Protective Effect of Electroacupuncture Against Myocardial Ischemia\/Reperfusion Injury in Mice","volume":"8","author":"Guo","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0545","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00395-020-00829-5","article-title":"Mouse models of atherosclerosis and their suitability for the study of myocardial infarction","volume":"115","author":"Golforoush","year":"2020","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0550","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/cvr\/cvaa287","article-title":"Angiogenesis after acute myocardial infarction","volume":"117","author":"Wu","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"15","key":"10.1016\/j.bcp.2023.115587_b0555","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.3390\/ijms22157831","article-title":"Targeting Inflammation after Myocardial Infarction: A Therapeutic Opportunity for Extracellular Vesicles?","volume":"22","author":"Viola","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0560","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/cvr\/cvs109","article-title":"Novel therapeutic approaches to post-infarction remodelling","volume":"94","author":"Fraccarollo","year":"2012","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0565","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11033-010-0126-y","article-title":"Postconditioning reduces infarct size and cardiac myocyte apoptosis via the opioid receptor and JAK-STAT signaling pathway","volume":"38","author":"You","year":"2011","journal-title":"Mol Biol Rep"},{"issue":"9","key":"10.1016\/j.bcp.2023.115587_b0570","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0575","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/gad.364306","article-title":"Acetylation of Stat1 modulates NF-kappaB activity","volume":"20","author":"Kr\u00e4mer","year":"2006","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0580","first-page":"e29554","article-title":"Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase\/AKT","volume":"3","author":"Shravah","year":"2014","journal-title":"Jakstat"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0585","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.109.933127","article-title":"Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction","volume":"122","author":"Hilfiker-Kleiner","year":"2010","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0590","doi-asserted-by":"crossref","first-page":"H471","DOI":"10.1152\/ajpheart.00730.2014","article-title":"Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling","volume":"309","author":"Enomoto","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0595","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10741-015-9513-8","article-title":"Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine","volume":"21","author":"Altara","year":"2016","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.bcp.2023.115587_b0600","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trsl.2017.10.001","article-title":"Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction","volume":"191","author":"Ma","year":"2018","journal-title":"Transl Res"},{"issue":"18","key":"10.1016\/j.bcp.2023.115587_b0605","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.118.035047","article-title":"IL (Interleukin)-10-STAT3-Galectin-3 Axis Is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction","volume":"138","author":"Shirakawa","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2023.115587_b0610","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2017.01.035","article-title":"Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts","volume":"104","author":"Lee","year":"2017","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0615","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1016\/j.athoracsur.2017.05.040","article-title":"Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis","volume":"104","author":"Zgheib","year":"2017","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0620","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1586\/14779072.6.5.703","article-title":"G-CSF- and erythropoietin-based cell therapy: a promising strategy for angiomyogenesis in myocardial infarction","volume":"6","author":"Kang","year":"2008","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0625","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCRESAHA.116.304269","article-title":"Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration","volume":"116","author":"O\u2019Meara","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2023.115587_b0630","doi-asserted-by":"crossref","first-page":"4396351","DOI":"10.1155\/2018\/4396351","article-title":"Regulatory Role of CD4(+) T Cells in Myocarditis","volume":"2018","author":"Vdovenko","year":"2018","journal-title":"J Immunol Res"},{"issue":"9817","key":"10.1016\/j.bcp.2023.115587_b0635","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0140-6736(11)60648-X","article-title":"Myocarditis","volume":"379","author":"Sagar","year":"2012","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0640","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrcardio.2015.108","article-title":"Viral myocarditis\u2013diagnosis, treatment options, and current controversies","volume":"12","author":"Pollack","year":"2015","journal-title":"Nat Rev Cardiol"},{"issue":"8","key":"10.1016\/j.bcp.2023.115587_b0645","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1161\/01.CIR.0000085168.02782.2C","article-title":"Parvovirus B19 infection mimicking acute myocardial infarction","volume":"108","author":"K\u00fchl","year":"2003","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0650","doi-asserted-by":"crossref","first-page":"e007405","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","article-title":"Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy: An Expert Consensus Document","volume":"13","author":"Ammirati","year":"2020","journal-title":"Circ Heart Fail"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0655","first-page":"101","article-title":"Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress","volume":"1","author":"Zgheib","year":"2012","journal-title":"Jakstat"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0660","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/emmm.201201876","article-title":"STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy","volume":"5","author":"Camporeale","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0665","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s11481-015-9601-5","article-title":"Activation of the Macrophage \u03b17 Nicotinic Acetylcholine Receptor and Control of Inflammation","volume":"10","author":"B\u00e1ez-Pag\u00e1n","year":"2015","journal-title":"J Neuroimmune Pharmacol"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0670","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0675","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCRESAHA.114.300507","article-title":"Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure","volume":"114","author":"Oka","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2023.115587_b0680","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"5","key":"10.1016\/j.bcp.2023.115587_b0685","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/0002-9149(79)90230-3","article-title":"Cardiac hypertrophy in early hypertension","volume":"44","author":"Yamori","year":"1979","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0690","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/01.HYP.0000156878.17006.02","article-title":"Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system","volume":"45","author":"Booz","year":"2005","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0695","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res"},{"issue":"13","key":"10.1016\/j.bcp.2023.115587_b0700","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: a new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0705","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1073\/pnas.97.1.315","article-title":"Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy","volume":"97","author":"Kunisada","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.bcp.2023.115587_b0710","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1161\/01.RES.84.10.1127","article-title":"Mechanical stretch activates the JAK\/STAT pathway in rat cardiomyocytes","volume":"84","author":"Pan","year":"1999","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0715","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.CIR.98.4.346","article-title":"Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes","volume":"98","author":"Kunisada","year":"1998","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0720","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/01.CIR.0000057545.82749.FF","article-title":"Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy","volume":"107","author":"Podewski","year":"2003","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.bcp.2023.115587_b0725","doi-asserted-by":"crossref","first-page":"256","DOI":"10.21037\/atm.2018.06.21","article-title":"Mitochondria and cardiovascular diseases-from pathophysiology to treatment","volume":"6","author":"Siasos","year":"2018","journal-title":"Ann Transl Med"},{"issue":"8","key":"10.1016\/j.bcp.2023.115587_b0730","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.119.315861","article-title":"Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3","volume":"126","author":"Ye","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.bcp.2023.115587_b0735","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3389\/fphar.2016.00436","article-title":"Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension","volume":"7","author":"Altara","year":"2016","journal-title":"Front Pharmacol"},{"issue":"14","key":"10.1016\/j.bcp.2023.115587_b0740","doi-asserted-by":"crossref","first-page":"10561","DOI":"10.1074\/jbc.275.14.10561","article-title":"Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes","volume":"275","author":"Funamoto","year":"2000","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0745","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1158\/0008-5472.CAN-05-3612","article-title":"Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis","volume":"66","author":"Battle","year":"2006","journal-title":"Cancer Res"},{"issue":"41","key":"10.1016\/j.bcp.2023.115587_b0750","doi-asserted-by":"crossref","first-page":"40026","DOI":"10.1074\/jbc.M301866200","article-title":"Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation","volume":"278","author":"Yahata","year":"2003","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0755","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1074\/jbc.M111.246173","article-title":"Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart","volume":"287","author":"Mir","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bcp.2023.115587_b0760","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev-physiol-021119-034527","article-title":"Cardiac Fibroblast Diversity","volume":"82","author":"Tallquist","year":"2020","journal-title":"Annu Rev Physiol"},{"issue":"12","key":"10.1016\/j.bcp.2023.115587_b0765","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1172\/JCI99245","article-title":"\u03b2IV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload","volume":"128","author":"Unudurthi","year":"2018","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0770","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/CIRCRESAHA.117.311045","article-title":"EphrinB2 Regulates Cardiac Fibrosis Through Modulating the Interaction of Stat3 and TGF-\u03b2\/Smad3 Signaling","volume":"121","author":"Su","year":"2017","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0775","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/CIRCULATIONAHA.107.695346","article-title":"Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling","volume":"117","author":"Tsai","year":"2008","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0780","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00611-16","article-title":"Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy","volume":"37","author":"Datta","year":"2017","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0785","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bcp.2023.115587_b0790","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.semcancer.2019.10.002","article-title":"The potential and controversy of targeting STAT family members in cancer","volume":"60","author":"Verhoeven","year":"2020","journal-title":"Semin Cancer Biol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0795","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/FJC.0b013e318068dd49","article-title":"Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signaling","volume":"50","author":"Kurdi","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"issue":"42","key":"10.1016\/j.bcp.2023.115587_b0800","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1093\/eurheartj\/ehab447","article-title":"The JAK-STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms","volume":"42","author":"Baldini","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.bcp.2023.115587_b0805","doi-asserted-by":"crossref","first-page":"13595","DOI":"10.1038\/srep13595","article-title":"A novel recombinant slow-release TNF \u03b1-derived peptide effectively inhibits tumor growth and angiogensis","volume":"5","author":"Ma","year":"2015","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0810","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000505099","article-title":"Interleukin-6: A Masterplayer in the Cytokine Network","volume":"98","author":"Uciechowski","year":"2020","journal-title":"Oncology"},{"issue":"36","key":"10.1016\/j.bcp.2023.115587_b0815","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.2174\/0929867324666170712160621","article-title":"Immunotherapeutic Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities","volume":"25","author":"Kampan","year":"2018","journal-title":"Curr Med Chem"},{"issue":"9865","key":"10.1016\/j.bcp.2023.115587_b0820","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0140-6736(12)61424-X","article-title":"Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial","volume":"381","author":"Burmester","year":"2013","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.bcp.2023.115587_b0825","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1136\/annrheumdis-2016-209131","article-title":"Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis","volume":"75","author":"Curtis","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.bcp.2023.115587_b0830","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/art.40911","article-title":"Risk Factors for Major Adverse Cardiovascular Events in Phase III and Long-Term Extension Studies of Tofacitinib in Patients With Rheumatoid Arthritis","volume":"71","author":"Charles-Schoeman","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"10.1016\/j.bcp.2023.115587_b0835","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.4049\/jimmunol.1201348","article-title":"Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases","volume":"191","author":"Van Rompaey","year":"2013","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0840","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13045-018-0675-4","article-title":"FLT3 inhibitors in acute myeloid leukemia","volume":"11","author":"Wu","year":"2018","journal-title":"J Hematol Oncol"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0845","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1158\/1535-7163.261.3.3","article-title":"Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity","volume":"3","author":"Turkson","year":"2004","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0850","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1142\/S0192415X16500075","article-title":"Oleanolic Acid Inhibiting the Differentiation of Neural Stem Cells into Astrocyte by Down-Regulating JAK\/STAT Signaling Pathway","volume":"44","author":"Zhang","year":"2016","journal-title":"Am J Chin Med"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0855","first-page":"155","article-title":"A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis","volume":"10","author":"Auzenne","year":"2012","journal-title":"J Exp Ther Oncol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0860","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ijmm.2020.4784","article-title":"Pimozide augments bromocriptine lethality in prolactinoma cells and in a xenograft model via the STAT5\/cyclin D1 and STAT5\/Bcl-xL signaling pathways","volume":"47","author":"Xiao","year":"2021","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.bcp.2023.115587_b0865","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1080\/13880209.2020.1779318","article-title":"Baicalin regulates macrophages polarization and alleviates myocardial ischaemia\/reperfusion injury via inhibiting JAK\/STAT pathway","volume":"58","author":"Xu","year":"2020","journal-title":"Pharm Biol"},{"issue":"4","key":"10.1016\/j.bcp.2023.115587_b0870","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/cpt.1671","article-title":"Exposure-Response Analyses of Upadacitinib Efficacy and Safety in Phase II and III Studies to Support Benefit-Risk Assessment in Rheumatoid Arthritis","volume":"107","author":"Nader","year":"2020","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.bcp.2023.115587_b0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173505","article-title":"Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases","volume":"885","author":"Covington","year":"2020","journal-title":"Eur J Pharmacol"},{"issue":"15","key":"10.1016\/j.bcp.2023.115587_b0880","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1517\/14656566.2015.1088831","article-title":"Pacritinib: a new agent for the management of myelofibrosis?","volume":"16","author":"Beauverd","year":"2015","journal-title":"Expert Opin Pharmacother"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0885","doi-asserted-by":"crossref","DOI":"10.3390\/jpm10030130","article-title":"Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature","volume":"10","author":"Liu","year":"2020","journal-title":"J Pers Med"},{"key":"10.1016\/j.bcp.2023.115587_b0890","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.leukres.2018.06.014","article-title":"Phase 2 study of gandotinib (LY2784544) in patients with myeloproliferative neoplasms","volume":"71","author":"Berdeja","year":"2018","journal-title":"Leuk Res"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0895","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/cpdd.751","article-title":"Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function","volume":"9","author":"Miyatake","year":"2020","journal-title":"Clin Pharmacol Drug Dev"},{"issue":"2","key":"10.1016\/j.bcp.2023.115587_b0900","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/jpet.114.221176","article-title":"VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease","volume":"353","author":"Mahajan","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"10.1016\/j.bcp.2023.115587_b0905","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem Biol"},{"issue":"13","key":"10.1016\/j.bcp.2023.115587_b0910","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1073\/pnas.0409894102","article-title":"A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells","volume":"102","author":"Song","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.bcp.2023.115587_b0915","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ptr.5061","article-title":"Quercetin and EGCG exhibit chemopreventive effects in cholangiocarcinoma cells via suppression of JAK\/STAT signaling pathway","volume":"28","author":"Senggunprai","year":"2014","journal-title":"Phytother Res"},{"issue":"3","key":"10.1016\/j.bcp.2023.115587_b0920","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/abbs\/gmu135","article-title":"Anti-inflammatory effect of resveratrol through the suppression of NF-\u03baB and JAK\/STAT signaling pathways","volume":"47","author":"Ma","year":"2015","journal-title":"Acta Biochim Biophys Sin (Shanghai)"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223001788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223001788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:41:54Z","timestamp":1757770914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223001788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":184,"alternative-id":["S0006295223001788"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115587","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of the JAK\/STAT signaling pathway: The promising targets for cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115587"}}