{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:23:32Z","timestamp":1769045012556,"version":"3.49.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Uniwersytet Medyczny w Lublinie","doi-asserted-by":"publisher","award":["DS 477"],"award-info":[{"award-number":["DS 477"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bcp.2023.115637","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:13:51Z","timestamp":1686140031000},"page":"115637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome"],"prefix":"10.1016","volume":"214","author":[{"given":"G.","family":"W\u00f3jcicka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pradiuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fornal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stachniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Korolczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Marzec-Kotarska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nikolaichuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Czechowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kozub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Trzpil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"G\u00f3ralczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Be\u0142towski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2023.115637_b0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2362.2007.01751.x","article-title":"Comparison of different definitions of the metabolic syndrome","volume":"37","author":"Sandhofer","year":"2007","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bcp.2023.115637_b0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijcard.2016.03.239","article-title":"High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy","volume":"215","author":"Huang","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.bcp.2023.115637_b0020","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1291\/hypres.29.897","article-title":"Left ventricular diastolic dysfunction as assessed by echocardiography in metabolic syndrome","volume":"29","author":"Masugata","year":"2006","journal-title":"Hypertens. Res."},{"issue":"8","key":"10.1016\/j.bcp.2023.115637_b0025","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1152\/japplphysiol.01149.2014","article-title":"Best Heart failure with preserved ejection fraction: Defining the function of ROS and NO","volume":"119","author":"Zuo","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bcp.2023.115637_b0030","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-014-0168-x","article-title":"Diastolic dysfunction in the diabetic continuum: association with insulin resistance, metabolic syndrome and type 2 diabetes","volume":"14","author":"Fontes-Carvalho","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bcp.2023.115637_b0035","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2019.03.055","article-title":"Asymmetric dimethylarginine: An crucial regulator in tissue fibrosis","volume":"854","author":"Zhao","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115637_b0040","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/CIRCULATIONAHA.110.971853","article-title":"Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP\/protein kinase G signaling in cardiac fibroblasts","volume":"123","author":"Chen","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2023.115637_b0045","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.0000187457.24338.3D","article-title":"NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts","volume":"97","author":"Cucoranu","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2023.115637_b0050","doi-asserted-by":"crossref","DOI":"10.1038\/nrm2297","article-title":"TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility","volume":"8","author":"Schmierer","year":"2007","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2023.115637_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2023.115637_b0060","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.107.170217","article-title":"Cyclic GMP\/protein kinase G phosphorylation of Smad3 blocks transforming growth factor-beta-induced nuclear Smad translocation: a key antifibrogenic mechanism of atrial natriuretic peptide","volume":"102","author":"Buxton","year":"2008","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2008.12.013","article-title":"Protein arginine methylation in mammals: who, what, and why","volume":"33","author":"Bedford","year":"2009","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.bcp.2023.115637_b0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jjcc.2016.10.004","article-title":"Evidence of epigenetic tags in cardiac fibrosis","volume":"69","author":"Grimaldi","year":"2017","journal-title":"J. Cardiol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/HCO.0000000000000276","article-title":"Epigenetic regulation in heart failure","volume":"31","author":"Kim","year":"2016","journal-title":"Curr. Opin. Cardiol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115637_b0080","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.metabol.2010.07.027","article-title":"Plasma levels of asymmetric dimethylarginine in patients with biopsy-proven nonalcoholic fatty liver disease","volume":"60","author":"Kasumov","year":"2011","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.bcp.2023.115637_b0085","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/01.ATV.20.9.2032","article-title":"Does ADMA cause endothelial dysfunction?","volume":"20","author":"Cooke","year":"2000","journal-title":"Arterioscler Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.bcp.2023.115637_b0090","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1161\/01.ATV.0000136656.26019.6e","article-title":"Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress","volume":"24","author":"Suda","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2023.115637_b0095","doi-asserted-by":"crossref","DOI":"10.1093\/abbs\/gms077","article-title":"Actin cytoskeleton- dependent pathways for ADMA-induced NF-\u03baB activation and TGF-\u03b2 high expression in human renal glomerular endothelial cells","volume":"44","author":"Wang","year":"2012","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"issue":"5","key":"10.1016\/j.bcp.2023.115637_b0100","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1159\/000103284","article-title":"Role of asymmetric dimethylarginine in inflammatory reactions by angiotensin II","volume":"44","author":"Chen","year":"2007","journal-title":"J. Vasc. Res."},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2014.06.062","article-title":"Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease","volume":"176","author":"Charytan","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"15","key":"10.1016\/j.bcp.2023.115637_b0110","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.clinbiochem.2017.05.007","article-title":"Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury","volume":"50","author":"Jayachandran","year":"2017","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bcp.2023.115637_b0115","article-title":"DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH\/ADMA\/NOS\/NO pathway in rats","volume":"43","author":"Zhu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2023.115637_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2012.09.040","article-title":"Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure","volume":"225","author":"Hsu","year":"2012","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0125","doi-asserted-by":"crossref","first-page":"e33795","DOI":"10.1371\/journal.pone.0033795","article-title":"Asymmetrical dimethylarginine-more sensitive than NT-ProBNP to diagnose heart failure in adults with congenital heart disease","volume":"7","author":"Tutarel","year":"2012","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00380-003-0715-y","article-title":"High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level","volume":"18","author":"Saitoh","year":"2003","journal-title":"Heart Vessels"},{"key":"10.1016\/j.bcp.2023.115637_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.niox.2011.04.009","article-title":"The endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) predicts LV mass independent of afterload","volume":"25","author":"Sverdlov","year":"2011","journal-title":"Nitric Oxide"},{"issue":"18","key":"10.1016\/j.bcp.2023.115637_b0140","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.jacc.2012.08.004","article-title":"Brutsaert Endothelial dysfunction: a pathophysiologic factor in heart failure with preserved ejection fraction","volume":"60","author":"Lam","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0145","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s13300-017-0282-3","article-title":"Effects of insulin plus glucagon- like peptide-1 receptor agonists (GLP-1RAs) in treating type 1 diabetes mellitus: A systematic review and meta-analysis","volume":"8","author":"Wang","year":"2017","journal-title":"Diabetes. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0150","doi-asserted-by":"crossref","first-page":"H295","DOI":"10.1152\/ajpheart.00990.2012","article-title":"Glucagon-like peptide-1 receptor activation reverses cardiac remodeling via normalizing cardiac steatosis and oxidative stress in type 2 diabetes","volume":"305","author":"Monji","year":"2013","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1161\/CIRCULATIONAHA.112.091215","article-title":"A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity","volume":"127","author":"Noyan-Ashraf","year":"2013","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0160","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/1479164115605000","article-title":"Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist- mediated attenuation of cardiac fibrosis","volume":"13","author":"Gaspari","year":"2016","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.bcp.2023.115637_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-020-01000-z","article-title":"Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet","volume":"19","author":"Sukumaran","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bcp.2023.115637_b0170","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-015-0476-7","article-title":"Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix","volume":"110","author":"Robinson","year":"2015","journal-title":"Basic. Res. Cardiol."},{"key":"10.1016\/j.bcp.2023.115637_b0175","article-title":"Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: randomized placebo-controlled trial","volume":"18","author":"Bizino","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"issue":"2","key":"10.1016\/j.bcp.2023.115637_b0180","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jdiacomp.2016.10.003","article-title":"Exenatide improves diastolic function and attenuates arterial stiffness but does not alter exercise capacity in individuals with type 2 diabetes","volume":"31","author":"Scalzo","year":"2017","journal-title":"J. Diabetes. Compl."},{"key":"10.1016\/j.bcp.2023.115637_b0185","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-019-0916-z","article-title":"Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis","volume":"18","author":"Fei","year":"2019","journal-title":"Cardiovasc. Diabetol"},{"issue":"12","key":"10.1016\/j.bcp.2023.115637_b0190","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.2337\/db16-0682","article-title":"Diabetic cardiomyopathy: The case for a role of fructose in disease etiology","volume":"65","author":"Delbridge","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bcp.2023.115637_b0195","doi-asserted-by":"crossref","DOI":"10.2119\/2008-00024.Xing","article-title":"Felodipine reduces cardiac expression of IL-18 and perivascular fibrosis in fructose-fed rats","volume":"14","author":"Xing","year":"2008","journal-title":"Mol. Med."},{"issue":"11-12","key":"10.1016\/j.bcp.2023.115637_b0200","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2119\/molmed.2010.00028","article-title":"Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats","volume":"16","author":"Xing","year":"2010","journal-title":"Mol. Med."},{"key":"10.1016\/j.bcp.2023.115637_b0205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejphar.2019.02.014","article-title":"The effect of exenatide (a GLP-1 analog) and sitagliptin (a DPP-4 inhibitor) on plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and concentration in normal and fructose-fed rats","volume":"850","author":"W\u00f3jcicka","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115637_b0210","doi-asserted-by":"crossref","unstructured":"O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193 (1951), https:\/\/doi.org\/193(1):265-75.","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"10.1016\/j.bcp.2023.115637_b0215","doi-asserted-by":"crossref","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bcp.2023.115637_b0220","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2016.07.034","article-title":"The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats","volume":"789","author":"W\u00f3jcicka","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115637_b0225","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.3892\/or.2014.3135","article-title":"Aberrant histone methylation and the effect of Suv39H1 siRNA on gastric carcinoma","volume":"31","author":"Cai","year":"2014","journal-title":"Oncol. Rep"},{"key":"10.1016\/j.bcp.2023.115637_b0230","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-018-0596-7","article-title":"DNA methylation and histone post-translational modification stability in post-mortem brain tissue","volume":"11","author":"Jarmasz","year":"2019","journal-title":"Clin. Epigenet."},{"issue":"5","key":"10.1016\/j.bcp.2023.115637_b0235","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/jop.12016","article-title":"TGF-\u03b21, Smad-2\/-3, Smad-1\/-5\/-8, and Smad-4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study","volume":"42","author":"Karathanasi","year":"2013","journal-title":"J. Oral. Pathol. Med"},{"key":"10.1016\/j.bcp.2023.115637_b0240","doi-asserted-by":"crossref","DOI":"10.1111\/j.1601-0825.2007.01421.x","article-title":"Expression and alterations of the PTEN\/AKT\/mTOR pathway in ameloblastomas","volume":"14","author":"Scheper","year":"2008","journal-title":"Oral. Dis"},{"key":"10.1016\/j.bcp.2023.115637_b0245","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.peptides.2017.02.008","article-title":"Exendin-4 inhibits structural remodeling and improves Ca2+ homeostasis in rats with heart failure via the GLP-1 receptor through the eNOS\/cGMP\/PKG pathway","volume":"90","author":"Chen","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.bcp.2023.115637_b0250","first-page":"1","article-title":"Alleviation of hyperglycemia induced vascular endothelial injury by exenatide might be related to the reduction of nitrooxidative stress","volume":"2013","author":"Zhao","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0255","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/aps.2011.149","article-title":"Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells","volume":"33","author":"Ding","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bcp.2023.115637_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2005.05.048","article-title":"Regulation of the mammalian heart function by nitric oxide","volume":"142","author":"Massion","year":"2005","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.bcp.2023.115637_b0265","doi-asserted-by":"crossref","DOI":"10.2337\/db09-1694","article-title":"Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4","volume":"59","author":"Arakawa","year":"2010","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0270","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/dmrr.2580","article-title":"GLP-1 receptor agonists: effects on the progression of non-alcoholic fatty liver disease","volume":"31","author":"Liu","year":"2015","journal-title":"Diabetes\/Metab. Res. Rev."},{"issue":"8","key":"10.1016\/j.bcp.2023.115637_b0275","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1152\/japplphysiol.01149.2014","article-title":"Heart failure with preserved ejection fraction: Defining the function of ROS and NO","volume":"119","author":"Zuo","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bcp.2023.115637_b0280","doi-asserted-by":"crossref","DOI":"10.1186\/1479-5876-11-84","article-title":"Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies","volume":"11","author":"Wohlfart","year":"2013","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0285","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1210\/en.2018-00004","article-title":"GLP-1 receptor expression within the human heart","volume":"159","author":"Baggio","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2023.115637_b0290","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-015-0518-1","article-title":"Exendin-4 attenuates adverse cardiac remodelling in streptozocin-induced diabetes via specific actions on infiltrating macrophages","volume":"111","author":"Tate","year":"2016","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0295","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/cvr\/cvu223","article-title":"Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4","volume":"104","author":"Hamdani","year":"2014","journal-title":"Cardiovasc. Res"},{"issue":"22","key":"10.1016\/j.bcp.2023.115637_b0300","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1111\/bph.13686","article-title":"Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction","volume":"174","author":"Esposito","year":"2017","journal-title":"Br. J. Pharmacol"},{"issue":"2","key":"10.1016\/j.bcp.2023.115637_b0305","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.107.156901","article-title":"Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2","volume":"101","author":"Hasegawa","year":"2007","journal-title":"Circ. Res"},{"issue":"2","key":"10.1016\/j.bcp.2023.115637_b0310","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12241","article-title":"Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway","volume":"35","author":"Zhou","year":"2017","journal-title":"Cardiovasc. Ther"},{"key":"10.1016\/j.bcp.2023.115637_b0315","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-015-0032-3","article-title":"Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemia","volume":"14","author":"Sun","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bcp.2023.115637_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104206","article-title":"Effect of liraglutide on microcirculation in rat model with absolute insulin deficiency","volume":"138","author":"Ivanov","year":"2021","journal-title":"Microvasc. Res"},{"key":"10.1016\/j.bcp.2023.115637_b0325","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfg452","article-title":"Handling of asymmetrical dimethylarginine and symmetrical dimethylarginine by the rat kidney under basal conditions and during endotoxaemia","volume":"18","author":"Nijveldt","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0330","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2337\/db06-1772","article-title":"Expression of NG, NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers","volume":"57","author":"Onozato","year":"2008","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0335","doi-asserted-by":"crossref","first-page":"F854","DOI":"10.1152\/ajprenal.00258.2017","article-title":"Renal hemodynamic effects of glucagon-like peptide-1 agonist are mediated by nitric oxide but not prostaglandin","volume":"313","author":"Thomson","year":"2017","journal-title":"Am. J. Physiol. Renal Physiol"},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0340","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ki.2013.427","article-title":"The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential","volume":"85","author":"Fujita","year":"2014","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0345","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ajpath.2012.09.016","article-title":"Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression","volume":"182","author":"Ojima","year":"2013","journal-title":"Am. J. Pathol"},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0350","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.vph.2005.09.005","article-title":"Lysophosphatidylcholine- induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells","volume":"44","author":"Jia","year":"2006","journal-title":"Vascul. Pharmacol"},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0355","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2008.01.029","article-title":"Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH\/ADMA\/NOS\/NO pathway in endothelial cells induced by lysophosphatidylcholine","volume":"584","author":"Feng","year":"2008","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.bcp.2023.115637_b0360","doi-asserted-by":"crossref","DOI":"10.1590\/s0102-865020190010000001","article-title":"An experimental study of exenatide effects on renal injury in diabetic rats1","volume":"34","author":"Wang","year":"2019","journal-title":"Acta Cir\u00fargica Brasileira"},{"issue":"5","key":"10.1016\/j.bcp.2023.115637_b0365","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2337\/dc09-1961","article-title":"Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes","volume":"33","author":"Koska","year":"2010","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.bcp.2023.115637_b0370","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/abbs\/gmv027","article-title":"Exendin-4 regulates redox homeostasis in rats fed with high-fat diet","volume":"47","author":"Niu","year":"2015","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"6","key":"10.1016\/j.bcp.2023.115637_b0375","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1210\/endo.141.6.7490","article-title":"Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats","volume":"141","author":"Szayna","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2023.115637_b0380","doi-asserted-by":"crossref","DOI":"10.1097\/00005344-200308000-00006","article-title":"Elevated levels of the serum endogenous inhibitor of nitric oxide synthase and metabolic control in rats with streptozotocin-induced diabetes","volume":"42","author":"Xiong","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"21","key":"10.1016\/j.bcp.2023.115637_b0385","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/hc4601.098514","article-title":"Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine","volume":"104","author":"St\u00fchlinger","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2023.115637_b0390","article-title":"Weight loss-dependent and -independent effects of moderate calorie restriction on endothelial cell markers in obesity","volume":"68","author":"Korybalska","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0395","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.atherosclerosis.2010.04.024","article-title":"One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress","volume":"212","author":"Bunck","year":"2010","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.bcp.2023.115637_b0400","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/dmrr.2525","article-title":"Effect of linagliptin compared with glimepiride on postprandial glucose metabolism, islet cell function and vascular function parameters in patients with type 2 diabetes mellitus receiving ongoing metformin treatment","volume":"30","author":"Forst","year":"2014","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"10.1016\/j.bcp.2023.115637_b0405","article-title":"Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients","volume":"8","author":"Cakirca","year":"2014","journal-title":"Drug Design Devel. Ther."},{"key":"10.1016\/j.bcp.2023.115637_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2011.07.053","article-title":"A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice","volume":"59","author":"Matsubara","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115637_b0415","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/HYPERTENSIONAHA.112.195115","article-title":"Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism","volume":"60","author":"Liu","year":"2012","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.bcp.2023.115637_b0420","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(01)00423-8","article-title":"State of the arg: protein methylation at arginine comes of age","volume":"106","author":"McBride","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2023.115637_b0425","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00202","article-title":"Exenatide protects against cardiac dysfunction by attenuating oxidative stress in the diabetic mouse heart","volume":"10","author":"Ding","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bcp.2023.115637_b0430","article-title":"Sitagliptin inhibits EndMT in vitro and improves cardiac function of diabetic rats through the SDF-1\u03b1\/PKA pathway","volume":"23","author":"Wu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci"},{"issue":"S6","key":"10.1016\/j.bcp.2023.115637_b0435","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/ijo.2008.204","article-title":"Sugary drinks in the pathogenesis of obesity and cardiovascular diseases","volume":"32","author":"Brown","year":"2008","journal-title":"Int. J. Obes. (Lond)"},{"issue":"4","key":"10.1016\/j.bcp.2023.115637_b0440","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/nu9040335","article-title":"High dietary fructose: direct or indirect dangerous factors disturbing tissue and organ functions","volume":"9","author":"Zhang","year":"2017","journal-title":"Nutrients"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223002289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223002289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:42:29Z","timestamp":1757770949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223002289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":88,"alternative-id":["S0006295223002289"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115637","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115637"}}