{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:37:03Z","timestamp":1792201023002,"version":"4.4.0"},"reference-count":222,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"am","delay-in-days":348,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bcp.2023.115679","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T10:58:11Z","timestamp":1688209091000},"page":"115679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Targeting and eradicating latent CNS reservoirs of HIV-1: Original strategies and new models"],"prefix":"10.1016","volume":"214","author":[{"given":"Sepideh","family":"Saeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mentine","family":"Wallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Loustau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2023.115679_b0005","unstructured":"(https:\/\/www.who.int). \/news-room\/fact-sheets\/detail\/hiv-aids)."},{"issue":"11","key":"10.1016\/j.bcp.2023.115679_b0010","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1056\/NEJM199709113371102","article-title":"Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy","volume":"337","author":"Gulick","year":"1997","journal-title":"The New England journal of medicine."},{"key":"10.1016\/j.bcp.2023.115679_b0015","doi-asserted-by":"crossref","unstructured":"Hammer SM, Squires KE, Hughes MD, Grimes JM, Demeter LM, Currier JS, et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. The New England journal of medicine. 1997. 337 (11). 725-33.","DOI":"10.1056\/NEJM199709113371101"},{"issue":"6629","key":"10.1016\/j.bcp.2023.115679_b0020","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/387188a0","article-title":"Decay characteristics of HIV-1-infected compartments during combination therapy","volume":"387","author":"Perelson","year":"1997","journal-title":"Nature."},{"issue":"5255","key":"10.1016\/j.bcp.2023.115679_b0025","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1126\/science.271.5255.1582","article-title":"HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time","volume":"271","author":"Perelson","year":"1996","journal-title":"Science."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0030","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1097\/QAD.0000000000000243","article-title":"Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy","volume":"28","author":"May","year":"2014","journal-title":"Aids."},{"issue":"26","key":"10.1016\/j.bcp.2023.115679_b0035","doi-asserted-by":"crossref","first-page":"15109","DOI":"10.1073\/pnas.96.26.15109","article-title":"HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression","volume":"96","author":"Davey","year":"1999","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"6756","key":"10.1016\/j.bcp.2023.115679_b0040","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/44755","article-title":"Re-emergence of HIV after stopping therapy","volume":"401","author":"Chun","year":"1999","journal-title":"Nature."},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2023.115679_b0045","first-page":"S21","article-title":"Impact of nucleoside reverse transcriptase inhibitors on coronary heart disease","volume":"15","author":"Mallon","year":"2014","journal-title":"Reviews in cardiovascular medicine."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0050","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/QAD.0000000000001372","article-title":"Predictors of longitudinal change in bone mineral density in a cohort of HIV-positive and negative patients","volume":"31","author":"Tinago","year":"2017","journal-title":"Aids."},{"key":"10.1016\/j.bcp.2023.115679_b0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coviro.2021.09.009","article-title":"Drug resistance mutations in HIV: new bioinformatics approaches and challenges","volume":"51","author":"Blassel","year":"2021","journal-title":"Current Opinion in Virology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11904-012-0150-8","article-title":"Attacking the HIV Reservoir from the Immune and Viral Perspective","volume":"10","author":"Massanella","year":"2013","journal-title":"Curr HIV\/AIDS Rep."},{"issue":"5341","key":"10.1016\/j.bcp.2023.115679_b0065","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1742-4690-10-67","article-title":"HIV-1 transcription and latency: an update","volume":"10","author":"Van Lint","year":"2013","journal-title":"Retrovirology."},{"key":"10.1016\/j.bcp.2023.115679_b0075","doi-asserted-by":"crossref","unstructured":"Cho A, Gaebler C, Olveira T, Ramos V, Saad M, Lorenzi JCC, et al. Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing. 2022. 119 (4). e2117630119.","DOI":"10.1073\/pnas.2117630119"},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0080","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12977-016-0323-4","article-title":"Are T cells the only HIV-1 reservoir?","volume":"13","author":"Kandathil","year":"2016","journal-title":"Retrovirology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S2055-6640(20)30275-2","article-title":"Establishment of latent HIV-1 reservoirs: what do we really know?","volume":"5","author":"Vanhamel","year":"2019","journal-title":"J Virus Erad."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-015-0137-6","article-title":"Epigenetic control of HIV-1 post integration latency: implications for therapy","volume":"7","author":"Kumar","year":"2015","journal-title":"Clinical epigenetics."},{"issue":"18","key":"10.1016\/j.bcp.2023.115679_b0095","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1073\/pnas.83.18.7089","article-title":"Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients","volume":"83","author":"Wiley","year":"1986","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0100","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1086\/527324","article-title":"Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy","volume":"197","author":"Chun","year":"2008","journal-title":"The Journal of infectious diseases."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrmicro.2015.5","article-title":"HIV reservoirs: what, where and how to target them","volume":"14","author":"Churchill","year":"2016","journal-title":"Nat Rev Micro."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0110","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.ajpath.2011.06.039","article-title":"Brain cell reservoirs of latent virus in presymptomatic HIV-infected individuals","volume":"179","author":"Thompson","year":"2011","journal-title":"Am J Pathol."},{"key":"10.1016\/j.bcp.2023.115679_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198523","article-title":"HIV-1 persistence in the CNS: Mechanisms of latency, pathogenesis and an update on eradication strategies","volume":"303","author":"Sonti","year":"2021","journal-title":"Virus Res."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0120","doi-asserted-by":"crossref","first-page":"e0016222","DOI":"10.1128\/jvi.00162-22","article-title":"Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage","volume":"96","author":"Lu","year":"2022","journal-title":"J Virol."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tins.2020.06.007","article-title":"The Paradox of HIV Blood-Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies","volume":"43","author":"Osborne","year":"2020","journal-title":"Trends Neurosci."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0130","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1128\/JVI.76.8.4138-4144.2002","article-title":"Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication","volume":"76","author":"Pierson","year":"2002","journal-title":"J Virol."},{"key":"10.1016\/j.bcp.2023.115679_b0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1741-7015-7-48","article-title":"Human cellular restriction factors that target HIV-1 replication","volume":"7","author":"Strebel","year":"2009","journal-title":"BMC medicine."},{"key":"10.1016\/j.bcp.2023.115679_b0140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13148-018-0441-z","article-title":"Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins","volume":"10","author":"Khan","year":"2018","journal-title":"Clin Epigenetics."},{"issue":"6253","key":"10.1016\/j.bcp.2023.115679_b0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/343085a0","article-title":"High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients","volume":"343","author":"Pang","year":"1990","journal-title":"Nature."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0150","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.virol.2007.11.007","article-title":"Human macrophages support persistent transcription from unintegrated HIV-1 DNA","volume":"372","author":"Kelly","year":"2008","journal-title":"Virology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/v11010012","article-title":"Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection","volume":"11","author":"Debyser","year":"2018","journal-title":"Viruses."},{"issue":"28","key":"10.1016\/j.bcp.2023.115679_b0160","doi-asserted-by":"crossref","first-page":"11682","DOI":"10.1074\/jbc.M117.793521","article-title":"Exosomes from uninfected cells activate transcription of latent HIV-1","volume":"292","author":"Barclay","year":"2017","journal-title":"J Biol Chem."},{"issue":"11","key":"10.1016\/j.bcp.2023.115679_b0165","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrmicro3352","article-title":"Eradicating HIV-1 infection: seeking to clear a persistent pathogen","volume":"12","author":"Archin","year":"2014","journal-title":"Nat Rev Micro."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0170","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1128\/JVI.05065-11","article-title":"Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes","volume":"86","author":"Chiang","year":"2012","journal-title":"J Virol."},{"key":"10.1016\/j.bcp.2023.115679_b0175","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.virol.2014.02.008","article-title":"Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure","volume":"454\u2013455","author":"Mbonye","year":"2014","journal-title":"Virology."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0180","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1128\/JVI.78.5.2517-2529.2004","article-title":"Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9\/CyclinT1)","volume":"78","author":"Chiu","year":"2004","journal-title":"J Virol."},{"key":"10.1016\/j.bcp.2023.115679_b0185","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.omtn.2021.02.004","article-title":"Lnc(ing)RNAs to the \u201cshock and kill\u201d strategy for HIV-1 cure","volume":"23","author":"Boliar","year":"2021","journal-title":"Molecular Therapy - Nucleic Acids."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0190","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/QCO.0000000000000026","article-title":"Emerging strategies to deplete the HIV reservoir","volume":"27","author":"Archin","year":"2014","journal-title":"Current opinion in infectious diseases."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0195","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.cell.2013.09.044","article-title":"An integrated overview of HIV-1 latency","volume":"155","author":"Ruelas","year":"2013","journal-title":"Cell."},{"issue":"12","key":"10.1016\/j.bcp.2023.115679_b0200","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/nbt915","article-title":"Approaches for the sequence-specific knockdown of mRNA","volume":"21","author":"Scherer","year":"2003","journal-title":"Nat Biotechnol."},{"issue":"5688","key":"10.1016\/j.bcp.2023.115679_b0205","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.1101372","article-title":"Small interfering RNA-induced transcriptional gene silencing in human cells","volume":"305","author":"Morris","year":"2004","journal-title":"Science."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virusres.2004.01.016","article-title":"RNA interference against retroviruses","volume":"102","author":"Hu","year":"2004","journal-title":"Virus Res."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0215","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jmb.2011.03.054","article-title":"T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway","volume":"410","author":"Kim","year":"2011","journal-title":"J Mol Biol."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0220","first-page":"2104126","volume":"9","author":"Fan","year":"2022","journal-title":"SUMOylation in Viral Replication and Antiviral Defense."},{"issue":"5762","key":"10.1016\/j.bcp.2023.115679_b0225","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1124000","article-title":"Histone H4\u2013K16 acetylation controls chromatin structure and protein interactions","volume":"311","author":"Shogren-Knaak","year":"2006","journal-title":"Science."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0230","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tim.2013.02.005","article-title":"Reactivation of latent HIV by histone deacetylase inhibitors","volume":"21","author":"Shirakawa","year":"2013","journal-title":"Trends in microbiology."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0235","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/aps.2015.22","article-title":"Progress and challenges in the use of latent HIV-1 reactivating agents","volume":"36","author":"Shang","year":"2015","journal-title":"Acta Pharmacol Sin."},{"key":"10.1016\/j.bcp.2023.115679_b0240","article-title":"New and emerging HDAC inhibitors for cancer treatment","volume":"124(124 (1)):30\u20139","author":"West","year":"2014","journal-title":"The Journal of clinical investigation."},{"issue":"362","key":"10.1016\/j.bcp.2023.115679_b0245","article-title":"Microglial Cells: The Main HIV-1 Reservoir in the Brain. Frontiers in Cellular and Infection","volume":"9","author":"Wallet","year":"2019","journal-title":"Microbiology."},{"issue":"17","key":"10.1016\/j.bcp.2023.115679_b0250","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1128\/JVI.00836-11","article-title":"Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2","volume":"85","author":"Friedman","year":"2011","journal-title":"J Virol."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0255","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.emboj.7601517","article-title":"Suv39H1 and HP1gamma are responsible for chromatin-mediated HIV-1 transcriptional silencing and post-integration latency","volume":"26","author":"du Ch\u00e9n\u00e9","year":"2007","journal-title":"Embo j."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0260","doi-asserted-by":"crossref","first-page":"e1000495","DOI":"10.1371\/journal.ppat.1000495","article-title":"Epigenetic regulation of HIV-1 latency by cytosine methylation","volume":"5","author":"Kauder","year":"2009","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b0265","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1128\/JVI.00040-12","article-title":"Paucity of HIV DNA methylation in latently infected, resting CD4+ T cells from infected individuals receiving antiretroviral therapy","volume":"86","author":"Blazkova","year":"2012","journal-title":"J Virol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0270","doi-asserted-by":"crossref","first-page":"22993","DOI":"10.1038\/s41598-021-02463-0","article-title":"Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response","volume":"11","author":"Mantovani","year":"2021","journal-title":"Scientific Reports."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0275","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/JVI.02413-12","article-title":"Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells","volume":"87","author":"Budhiraja","year":"2013","journal-title":"J Virol."},{"issue":"31","key":"10.1016\/j.bcp.2023.115679_b0280","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1073\/pnas.1220136110","article-title":"CTIP2 is a negative regulator of P-TEFb","volume":"110","author":"Cherrier","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0285","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12985-018-0959-x","article-title":"Inhibition of HIV early replication by the p53 and its downstream gene p21","volume":"15","author":"Shi","year":"2018","journal-title":"Virology journal."},{"key":"10.1016\/j.bcp.2023.115679_b0290","doi-asserted-by":"crossref","unstructured":"Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, et al. TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. 2019. 8.","DOI":"10.7554\/eLife.42426"},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0295","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s13365-021-00995-9","article-title":"Viruses, SUMO, and immunity: the interplay between viruses and the host SUMOylation system","volume":"27","author":"Imbert","year":"2021","journal-title":"J Neurovirol."},{"issue":"6664","key":"10.1016\/j.bcp.2023.115679_b0300","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/34571","article-title":"A new classification for HIV-1","volume":"391","author":"Berger","year":"1998","journal-title":"Nature."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0305","doi-asserted-by":"crossref","first-page":"e90620","DOI":"10.1371\/journal.pone.0090620","article-title":"HIV-1 entry and trans-infection of astrocytes involves CD81 vesicles","volume":"9","author":"Gray","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2023.115679_b0310","article-title":"Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy","volume":"2(2):vew020","author":"Gianella","year":"2016","journal-title":"Virus Evol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0315","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/pathogens8030137","article-title":"Insights into the HIV Latency and the Role of Cytokines","volume":"8","author":"Hokello","year":"2019","journal-title":"Pathogens."},{"issue":"15","key":"10.1016\/j.bcp.2023.115679_b0320","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1212\/WNL.0b013e31828c2e9e","article-title":"Molecular and pathologic insights from latent HIV-1 infection in the human brain","volume":"80","author":"Desplats","year":"2013","journal-title":"Neurology."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0325","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/mp.2015.111","article-title":"CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies","volume":"21","author":"Gray","year":"2016","journal-title":"Mol Psychiatry."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0330","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s13365-015-0406-3","article-title":"Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders","volume":"22","author":"Levine","year":"2016","journal-title":"J Neurovirol."},{"key":"10.1016\/j.bcp.2023.115679_b0335","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.3389\/fmicb.2019.02828","article-title":"The Role of Macrophages in HIV-1 Persistence and Pathogenesis","volume":"10","author":"Kruize","year":"2019","journal-title":"Front Microbiol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002030-199901140-00003","article-title":"Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis","volume":"13","author":"Brack-Werner","year":"1999","journal-title":"Aids."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0345","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jaci.2014.05.026","article-title":"Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1","volume":"134","author":"Siliciano","year":"2014","journal-title":"Journal of Allergy and Clinical Immunology."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0350","doi-asserted-by":"crossref","first-page":"e1002818","DOI":"10.1371\/journal.ppat.1002818","article-title":"Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency","volume":"8","author":"Pace","year":"2012","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b0355","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1128\/JVI.01910-08","article-title":"Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells","volume":"83","author":"Dai","year":"2009","journal-title":"J Virol."},{"key":"10.1016\/j.bcp.2023.115679_b0360","article-title":"MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV\/HIV neurological disease","volume":"1(9):e77-e","author":"Yelamanchili","year":"2010","journal-title":"Cell death & disease."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0365","doi-asserted-by":"crossref","first-page":"12866","DOI":"10.1038\/s41598-017-12758-w","article-title":"HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim","volume":"7","author":"Castellano","year":"2017","journal-title":"Scientific Reports."},{"issue":"10","key":"10.1016\/j.bcp.2023.115679_b0370","doi-asserted-by":"crossref","DOI":"10.3390\/cells8101245","article-title":"New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System","volume":"8","author":"Rojas-Celis","year":"2019","journal-title":"Cells."},{"key":"10.1016\/j.bcp.2023.115679_b0375","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3389\/fimmu.2017.01698","article-title":"Myeloid Cell Interaction with HIV: A Complex Relationship","volume":"8","author":"Rodrigues","year":"2017","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0380","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.celrep.2013.03.017","article-title":"Phosphorylation of SAMHD1 by cyclin A2\/CDK1 regulates its restriction activity toward HIV-1","volume":"3","author":"Cribier","year":"2013","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0385","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1189\/jlb.0403180","article-title":"Regulation of HIV-1 gene transcription: from lymphocytes to microglial cells","volume":"74","author":"Rohr","year":"2003","journal-title":"J Leukoc Biol."},{"issue":"49","key":"10.1016\/j.bcp.2023.115679_b0390","doi-asserted-by":"crossref","first-page":"31149","DOI":"10.1074\/jbc.272.49.31149","article-title":"COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells","volume":"272","author":"Rohr","year":"1997","journal-title":"J Biol Chem."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0395","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/JVI.74.1.65-73.2000","article-title":"Functional interactions between C\/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells","volume":"74","author":"Schwartz","year":"2000","journal-title":"J Virol."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0400","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1086\/500983","article-title":"Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model","volume":"193","author":"Barber","year":"2006","journal-title":"The Journal of infectious diseases."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0405","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/jmbi.1996.0516","article-title":"Regulation of HIV-1 gene expression by NF-IL6","volume":"262","author":"Tesmer","year":"1996","journal-title":"J Mol Biol."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0410","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jcp.24490","article-title":"The many lives of CTIP2: from AIDS to cancer and cardiac hypertrophy","volume":"229","author":"Le Douce","year":"2014","journal-title":"J Cell Physiol."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2023.115679_b0415","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1042\/bj20020496","article-title":"COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein","volume":"368","author":"Avram","year":"2002","journal-title":"Biochem J."},{"issue":"14","key":"10.1016\/j.bcp.2023.115679_b0420","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1074\/jbc.275.14.10315","article-title":"Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors","volume":"275","author":"Avram","year":"2000","journal-title":"J Biol Chem."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0425","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/nar\/gki529","article-title":"COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells","volume":"33","author":"Marban","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0430","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/sj.emboj.7601516","article-title":"Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing","volume":"26","author":"Marban","year":"2007","journal-title":"Embo j."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0435","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/nar\/gkr857","article-title":"LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing","volume":"40","author":"Le Douce","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0440","doi-asserted-by":"crossref","first-page":"e1010110","DOI":"10.1371\/journal.ppat.1010110","article-title":"Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1\/NR4A2) mediates silencing of HIV in microglial cells","volume":"18","author":"Ye","year":"2022","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0445","doi-asserted-by":"crossref","first-page":"34920","DOI":"10.1038\/srep34920","article-title":"HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1","volume":"6","author":"Le Douce","year":"2016","journal-title":"Scientific Reports."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0450","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/QAD.0000000000002076","article-title":"HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection","volume":"33","author":"Cysique","year":"2019","journal-title":"Aids."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0455","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1038\/s41598-021-82164-w","article-title":"Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage","volume":"11","author":"Ait-Ammar","year":"2021","journal-title":"Scientific Reports."},{"issue":"50","key":"10.1016\/j.bcp.2023.115679_b0460","doi-asserted-by":"crossref","first-page":"36177","DOI":"10.1074\/jbc.M706912200","article-title":"Role for KAP1 serine 824 phosphorylation and sumoylation\/desumoylation switch in regulating KAP1-mediated transcriptional repression","volume":"282","author":"Li","year":"2007","journal-title":"J Biol Chem."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0465","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.virol.2008.07.035","article-title":"BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex","volume":"380","author":"Cismasiu","year":"2008","journal-title":"Virology."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0470","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/embor.2009.60","article-title":"Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells","volume":"10","author":"Tomimatsu","year":"2009","journal-title":"EMBO reports."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0475","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molcel.2015.11.004","article-title":"KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II","volume":"61","author":"McNamara","year":"2016","journal-title":"Mol Cell."},{"key":"10.1016\/j.bcp.2023.115679_b0480","doi-asserted-by":"crossref","unstructured":"Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, et al. TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. eLife. 2019. 8.","DOI":"10.7554\/eLife.42426"},{"key":"10.1016\/j.bcp.2023.115679_b0485","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fncel.2018.00401","article-title":"Astrocyte Heterogeneity in the Adult Central Nervous System","volume":"12","author":"Miller","year":"2018","journal-title":"Frontiers in cellular neuroscience."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0490","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/QAD.0000000000002512","article-title":"Productive HIV infection in astrocytes can be established via a nonclassical mechanism","volume":"34","author":"Li","year":"2020","journal-title":"Aids."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0495","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.celrep.2017.01.027","article-title":"Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material","volume":"18","author":"Russell","year":"2017","journal-title":"Cell Reports."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0500","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13550280600748946","article-title":"Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues","volume":"12","author":"Churchill","year":"2006","journal-title":"J Neurovirol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0505","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nchembio721","article-title":"Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3\u20139","volume":"1","author":"Greiner","year":"2005","journal-title":"Nature Chemical Biology."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0510","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1128\/JVI.03333-13","article-title":"Epigenetic regulation of HIV-1 latency in astrocytes","volume":"88","author":"Narasipura","year":"2014","journal-title":"J Virol."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b0515","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.micinf.2015.05.006","article-title":"Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent","volume":"17","author":"Chauhan","year":"2015","journal-title":"Microbes and Infection."},{"key":"10.1016\/j.bcp.2023.115679_b0520","doi-asserted-by":"crossref","unstructured":"Premeaux TA, Mediouni S, Leda A, Furler RL, Valente ST, Fine HA, et al. Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research. mBio. 2021. 12 (4). e0068021.","DOI":"10.1128\/mBio.00680-21"},{"key":"10.1016\/j.bcp.2023.115679_b0525","doi-asserted-by":"crossref","unstructured":"LaNoce E, Dumeng-Rodriguez J, Christian KM. Using 2D and 3D pluripotent stem cell models to study neurotropic viruses. 2022. 2.","DOI":"10.3389\/fviro.2022.869657"},{"key":"10.1016\/j.bcp.2023.115679_b0530","doi-asserted-by":"crossref","DOI":"10.1002\/JLB.5VMR0322-161R","article-title":"Animal models for studies of HIV-1 brain reservoirs","author":"Waight","year":"2022","journal-title":"J Leukoc Biol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0535","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.ajpath.2015.01.033","article-title":"SIV encephalitis lesions are composed of CD163(+) macrophages present in the central nervous system during early SIV infection and SIV-positive macrophages recruited terminally with AIDS","volume":"185","author":"Nowlin","year":"2015","journal-title":"Am J Pathol."},{"issue":"12","key":"10.1016\/j.bcp.2023.115679_b0540","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1128\/JVI.73.12.10480-10488.1999","article-title":"High viral load in the cerebrospinal fluid and brain correlates with severity of simian immunodeficiency virus encephalitis","volume":"73","author":"Zink","year":"1999","journal-title":"J Virol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0545","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1086\/653213","article-title":"Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA","volume":"202","author":"Zink","year":"2010","journal-title":"The Journal of infectious diseases."},{"issue":"Suppl 2","key":"10.1016\/j.bcp.2023.115679_b0550","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1097\/QAD.0000000000002269","article-title":"Brain macrophages harbor latent, infectious simian immunodeficiency virus","volume":"33","author":"Abreu","year":"2019","journal-title":"Aids."},{"key":"10.1016\/j.bcp.2023.115679_b0555","series-title":"HIV-1 Latency","first-page":"1","article-title":"Molecular Control of HIV and SIV Latency","author":"Darcis","year":"2018"},{"issue":"20","key":"10.1016\/j.bcp.2023.115679_b0560","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.1128\/JVI.00674-16","article-title":"HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads","volume":"90","author":"Lamers","year":"2016","journal-title":"J Virol."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0565","doi-asserted-by":"crossref","first-page":"e1007632","DOI":"10.1371\/journal.ppat.1007632","article-title":"Rational design and in vivo selection of SHIVs encoding transmitted\/founder subtype C HIV-1 envelopes","volume":"15","author":"O'Brien","year":"2019","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b0570","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02267-18","article-title":"Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants","volume":"93","author":"Zhou","year":"2019","journal-title":"J Virol."},{"issue":"7512","key":"10.1016\/j.bcp.2023.115679_b0575","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature13594","article-title":"Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys","volume":"512","author":"Whitney","year":"2014","journal-title":"Nature."},{"key":"10.1016\/j.bcp.2023.115679_b0580","article-title":"Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3+CD4+ T","volume":"9","author":"Iwabuchi","year":"2018","journal-title":"Cells."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0585","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1750-1326-9-58","article-title":"Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice","volume":"9","author":"Boska","year":"2014","journal-title":"Molecular Neurodegeneration."},{"issue":"12","key":"10.1016\/j.bcp.2023.115679_b0590","first-page":"1489","article-title":"Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains","volume":"10","author":"Li","year":"2017","journal-title":"Disease models & mechanisms."},{"key":"10.1016\/j.bcp.2023.115679_b0595","doi-asserted-by":"crossref","unstructured":"Gillgrass A, Wessels JM, Yang JX, Kaushic C. Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses. 2021. 11.","DOI":"10.3389\/fimmu.2020.617516"},{"key":"10.1016\/j.bcp.2023.115679_b0600","doi-asserted-by":"crossref","unstructured":"Pearson T, Greiner DL, Shultz LD. Creation of \u201chumanized\u201d mice to study human immunity. Curr Protoc Immunol. 2008. Chapter 15:Unit 15.21.","DOI":"10.1002\/0471142735.im1521s81"},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0605","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s13365-014-0299-6","article-title":"Humanized mouse models for HIV-1 infection of the CNS","volume":"21","author":"Honeycutt","year":"2015","journal-title":"J Neurovirol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0610","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/QAD.0000000000001267","article-title":"Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques","volume":"31","author":"Gama","year":"2017","journal-title":"Aids."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0615","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s13365-017-0604-2","article-title":"HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency","volume":"24","author":"Llewellyn","year":"2018","journal-title":"Journal of neurovirology."},{"issue":"10","key":"10.1016\/j.bcp.2023.115679_b0620","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1073\/pnas.0500649102","article-title":"A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness","volume":"102","author":"Potash","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0625","doi-asserted-by":"crossref","first-page":"9428","DOI":"10.1038\/s41598-019-45878-6","article-title":"Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model","volume":"9","author":"Omeragic","year":"2019","journal-title":"Scientific Reports."},{"key":"10.1016\/j.bcp.2023.115679_b0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbih.2020.100054","article-title":"Prevention and treatment of HIV infection and cognitive disease in mice by innate immune responses","volume":"3","author":"Dong","year":"2020","journal-title":"Brain, Behavior, & Immunity - Health."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0635","doi-asserted-by":"crossref","first-page":"e1007061","DOI":"10.1371\/journal.ppat.1007061","article-title":"EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment","volume":"14","author":"Gu","year":"2018","journal-title":"PLoS Pathog."},{"issue":"517","key":"10.1016\/j.bcp.2023.115679_b0640","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax5516","article-title":"Reproducing human and cross-species drug toxicities using a Liver-Chip","volume":"11","author":"Jang","year":"2019","journal-title":"Sci Transl Med."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0645","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jacbts.2019.10.008","article-title":"Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?","volume":"4","author":"Van Norman","year":"2019","journal-title":"JACC Basic to translational science."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0650","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.tins.2006.06.002","article-title":"Viral infections in the developing and mature brain","volume":"29","author":"van den Pol","year":"2006","journal-title":"Trends Neurosci."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0655","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/15476278.2015.1011921","article-title":"Large-scale generation of human iPSC-derived neural stem cells\/early neural progenitor cells and their neuronal differentiation","volume":"10","author":"D'Aiuto","year":"2014","journal-title":"Organogenesis."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0660","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1002\/cpcb.51","article-title":"Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons","volume":"79","author":"Fernandopulle","year":"2018","journal-title":"Current protocols in cell biology."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0665","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.stemcr.2017.06.018","article-title":"An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells","volume":"9","author":"Tcw","year":"2017","journal-title":"Stem cell reports."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0670","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.stemcr.2021.11.007","article-title":"APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes","volume":"17","author":"de Leeuw","year":"2022","journal-title":"Stem cell reports."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0675","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13024-018-0297-x","article-title":"Development and validation of a simplified method to generate human microglia from pluripotent stem cells","volume":"13","author":"McQuade","year":"2018","journal-title":"Mol Neurodegener."},{"issue":"10","key":"10.1016\/j.bcp.2023.115679_b0680","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/nprot.2012.116","article-title":"Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks","volume":"7","author":"Shi","year":"2012","journal-title":"Nat Protoc."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0685","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nprot.2015.075","article-title":"Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells","volume":"10","author":"Douvaras","year":"2015","journal-title":"Nat Protoc."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0690","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13365-016-0499-3","article-title":"Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system","volume":"23","author":"Garcia-Mesa","year":"2017","journal-title":"Journal of neurovirology."},{"issue":"12","key":"10.1016\/j.bcp.2023.115679_b0695","doi-asserted-by":"crossref","first-page":"e1008249","DOI":"10.1371\/journal.ppat.1008249","article-title":"Cross-talk between microglia and neurons regulates HIV latency","volume":"15","author":"Alvarez-Carbonell","year":"2019","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0700","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12977-020-00544-y","article-title":"Comparative analysis of human microglial models for studies of HIV replication and pathogenesis","volume":"17","author":"Rai","year":"2020","journal-title":"Retrovirology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0705","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12985-020-01301-5","article-title":"Characterization of HIV-1 uncoating in human microglial cell lines","volume":"17","author":"Ingram","year":"2020","journal-title":"Virology journal."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0710","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/imm.13181","article-title":"HIV infection suppresses TLR3 activation-mediated antiviral immunity in microglia and macrophages","volume":"160","author":"Liu","year":"2020","journal-title":"Immunology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0715","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s13365-016-0472-1","article-title":"Development and characterization of a human microglia cell model of HIV-1 infection","volume":"23","author":"Rawat","year":"2017","journal-title":"J Neurovirol."},{"key":"10.1016\/j.bcp.2023.115679_b0720","doi-asserted-by":"crossref","unstructured":"Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017. 94 (2). 278-93.e9.","DOI":"10.1016\/j.neuron.2017.03.042"},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0725","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/glia.20372","article-title":"Characterization of human monocyte-derived microglia-like cells","volume":"54","author":"Leone","year":"2006","journal-title":"Glia."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0730","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.stemcr.2020.02.010","article-title":"Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection","volume":"14","author":"Ryan","year":"2020","journal-title":"Stem cell reports."},{"key":"10.1016\/j.bcp.2023.115679_b0735","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3389\/fncel.2019.00480","article-title":"Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner","volume":"13","author":"Bellmann","year":"2019","journal-title":"Frontiers in cellular neuroscience."},{"issue":"10","key":"10.1016\/j.bcp.2023.115679_b0740","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn.2017.107","article-title":"The use of brain organoids to investigate neural development and disease","volume":"18","author":"Di Lullo","year":"2017","journal-title":"Nature reviews Neuroscience."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0745","doi-asserted-by":"crossref","DOI":"10.1242\/dev.166074","article-title":"Brain organoids: advances, applications and challenges","volume":"146","author":"Qian","year":"2019","journal-title":"Development."},{"issue":"7652","key":"10.1016\/j.bcp.2023.115679_b0750","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature22047","article-title":"Cell diversity and network dynamics in photosensitive human brain organoids","volume":"545","author":"Quadrato","year":"2017","journal-title":"Nature."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0755","doi-asserted-by":"crossref","first-page":"362","DOI":"10.14573\/altex.1609122","article-title":"A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity","volume":"34","author":"Pamies","year":"2017","journal-title":"Altex."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0760","article-title":"Organoid and Spheroid Tumor Models","volume":"13","author":"Gunti","year":"2021","journal-title":"Techniques and Applications. Cancers."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0765","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1039\/C6LC01422D","article-title":"A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications","volume":"17","author":"Phan","year":"2017","journal-title":"Lab on a chip."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0770","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.3415","article-title":"Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture","volume":"12","author":"Pa\u015fca","year":"2015","journal-title":"Nature Methods."},{"issue":"7467","key":"10.1016\/j.bcp.2023.115679_b0775","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0780","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13036-017-0055-6","article-title":"Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels","volume":"11","author":"Zhu","year":"2017","journal-title":"Journal of Biological Engineering."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0785","doi-asserted-by":"crossref","first-page":"970","DOI":"10.5966\/sctm.2015-0305","article-title":"Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium","volume":"5","author":"Lindborg","year":"2016","journal-title":"Stem cells translational medicine."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0790","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmed.2017.02.007","article-title":"Disease Modeling in Stem Cell-Derived 3D Organoid Systems","volume":"23","author":"Dutta","year":"2017","journal-title":"Trends Mol Med."},{"key":"10.1016\/j.bcp.2023.115679_b0795","doi-asserted-by":"crossref","unstructured":"Faustino Martins JM, Fischer C, Urzi A, Vidal R, Kunz S, Ruffault PL, et al. Self-Organizing 3D Human Trunk Neuromuscular Organoids. Cell Stem Cell. 2020. 26 (2). 172-86.e6.","DOI":"10.1016\/j.stem.2019.12.007"},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2019.100001","article-title":"Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development","volume":"1","author":"Xiang","year":"2020","journal-title":"STAR protocols."},{"key":"10.1016\/j.bcp.2023.115679_b0805","doi-asserted-by":"crossref","unstructured":"Xiang Y, Tanaka Y, Cakir B, Patterson B, Kim KY, Sun P, et al. hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. Cell Stem Cell. 2019. 24 (3). 487-97.e7.","DOI":"10.1016\/j.stem.2018.12.015"},{"issue":"6500","key":"10.1016\/j.bcp.2023.115679_b0810","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz5626","article-title":"Human CNS barrier-forming organoids with cerebrospinal fluid production","volume":"369","author":"Pellegrini","year":"2020","journal-title":"Science."},{"key":"10.1016\/j.bcp.2023.115679_b0815","doi-asserted-by":"crossref","unstructured":"Pellegrini L, Albecka A, Mallery DL, Kellner MJ, Paul D, Carter AP, et al. SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids. Cell Stem Cell. 2020. 27 (6). 951-61.e5.","DOI":"10.1016\/j.stem.2020.10.001"},{"issue":"6287","key":"10.1016\/j.bcp.2023.115679_b0820","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus impairs growth in human neurospheres and brain organoids","volume":"352","author":"Garcez","year":"2016","journal-title":"Science."},{"key":"10.1016\/j.bcp.2023.115679_b0825","article-title":"Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases","volume":"12","author":"Su","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.bcp.2023.115679_b0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102086","article-title":"Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson's disease: Midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment","volume":"204","author":"Kim","year":"2021","journal-title":"Progress in neurobiology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0835","doi-asserted-by":"crossref","first-page":"19565","DOI":"10.1038\/s41598-019-56021-w","article-title":"Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds","volume":"9","author":"Song","year":"2019","journal-title":"Scientific Reports."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0840","doi-asserted-by":"crossref","first-page":"45091","DOI":"10.1038\/srep45091","article-title":"Derivation of Functional Human Astrocytes from Cerebral Organoids","volume":"7","author":"Dezonne","year":"2017","journal-title":"Scientific Reports."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0845","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.nbd.2011.10.005","article-title":"HIV-1 Tat neurotoxicity: a model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes","volume":"45","author":"Agrawal","year":"2012","journal-title":"Neurobiol Dis."},{"issue":"10","key":"10.1016\/j.bcp.2023.115679_b0850","doi-asserted-by":"crossref","first-page":"e25994","DOI":"10.1371\/journal.pone.0025994","article-title":"HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K+ Currents","volume":"6","author":"Chen","year":"2011","journal-title":"PLOS ONE."},{"key":"10.1016\/j.bcp.2023.115679_b0855","doi-asserted-by":"crossref","unstructured":"Bartalska K, H\u00fcbschmann V, Korkut-Demirba\u015f M, Cubero RJA, Venturino A, R\u00f6ssler K, et al. A systematic characterization of microglia-like cell occurrence during retinal organoid differentiation. iScience. 2022. 25 (7). 104580.","DOI":"10.1016\/j.isci.2022.104580"},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0860","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tcb.2019.11.004","article-title":"Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease","volume":"30","author":"Marton","year":"2020","journal-title":"Trends in cell biology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0865","doi-asserted-by":"crossref","first-page":"15209","DOI":"10.1038\/s41598-020-72214-0","article-title":"Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia","volume":"10","author":"Dos Reis","year":"2020","journal-title":"Sci Rep."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0870","doi-asserted-by":"crossref","DOI":"10.3390\/v14040829","article-title":"Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids","volume":"14","author":"Gumbs","year":"2022","journal-title":"Viruses."},{"key":"10.1016\/j.bcp.2023.115679_b0875","doi-asserted-by":"crossref","unstructured":"Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, et al. Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell. 2020. 26 (5). 766-81.e9.","DOI":"10.1016\/j.stem.2020.02.002"},{"issue":"11","key":"10.1016\/j.bcp.2023.115679_b0880","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/s41593-021-00923-4","article-title":"Human ALS\/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology","volume":"24","author":"Szeb\u00e9nyi","year":"2021","journal-title":"Nature Neuroscience."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0885","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41593-019-0350-2","article-title":"Cerebral organoids at the air\u2013liquid interface generate diverse nerve tracts with functional output","volume":"22","author":"Giandomenico","year":"2019","journal-title":"Nature Neuroscience."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0890","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1038\/s41467-021-24775-5","article-title":"Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids","volume":"12","author":"Cho","year":"2021","journal-title":"Nat Commun."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0895","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell."},{"key":"10.1016\/j.bcp.2023.115679_b0900","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fbioe.2019.00400","article-title":"Neural Lineage Differentiation From Pluripotent Stem Cells to Mimic Human Brain Tissues","volume":"7","author":"Hong","year":"2019","journal-title":"Frontiers in bioengineering and biotechnology."},{"key":"10.1016\/j.bcp.2023.115679_b0905","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fphar.2018.00006","article-title":"Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning","volume":"9","author":"Langhans","year":"2018","journal-title":"Front Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0910","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s43586-022-00174-y","volume":"2","author":"Zhao","year":"2022","journal-title":"Organoids. Nature Reviews Methods Primers."},{"key":"10.1016\/j.bcp.2023.115679_b0915","article-title":"Advances in development and application of human organoids. 3","author":"Shankaran","year":"2021116257","journal-title":"Biotech."},{"issue":"7751","key":"10.1016\/j.bcp.2023.115679_b0920","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41586-019-1027-4","article-title":"HIV-1 remission following CCR5\u039432\/\u039432 haematopoietic stem-cell transplantation","volume":"568","author":"Gupta","year":"2019","journal-title":"Nature."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b0925","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-023-02213-x","article-title":"In-depth virological and immunological characterization of HIV-1 cure after CCR5\u039432\/\u039432 allogeneic hematopoietic stem cell transplantation","volume":"29","author":"Jensen","year":"2023","journal-title":"Nature Medicine."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0930","doi-asserted-by":"crossref","first-page":"e340","DOI":"10.1016\/S2352-3018(20)30069-2","article-title":"Evidence for HIV-1 cure after CCR5\u039432\/\u039432 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report","volume":"7","author":"Gupta","year":"2020","journal-title":"The lancet HIV."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b0935","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2174\/1381612822666151221150733","article-title":"Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier","volume":"22","author":"Hersh","year":"2016","journal-title":"Curr Pharm Des."},{"key":"10.1016\/j.bcp.2023.115679_b0940","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.virol.2014.02.021","article-title":"HIV cure research: advances and prospects","volume":"454\u2013455","author":"Passaes","year":"2014","journal-title":"Virology."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b0945","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/JLB.5VMR0122-046RRR","article-title":"Shock and kill within the CNS: A promising HIV eradication approach?","volume":"112","author":"N\u00fchn","year":"2022","journal-title":"J Leukoc Biol."},{"issue":"7","key":"10.1016\/j.bcp.2023.115679_b0950","doi-asserted-by":"crossref","first-page":"e1005063","DOI":"10.1371\/journal.ppat.1005063","article-title":"An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression","volume":"11","author":"Darcis","year":"2015","journal-title":"PLoS Pathogens."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0955","doi-asserted-by":"crossref","first-page":"12442","DOI":"10.1038\/srep12442","article-title":"Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-\u0138B-dependent mechanism","volume":"5","author":"D\u00edaz","year":"2015","journal-title":"Scientific Reports."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0960","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1074\/jbc.M114.605428","article-title":"Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1","volume":"290","author":"Campbell","year":"2015","journal-title":"J Biol Chem."},{"issue":"4","key":"10.1016\/j.bcp.2023.115679_b0965","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s13365-015-0413-4","article-title":"Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells","volume":"22","author":"Gray","year":"2016","journal-title":"J Neurovirol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0970","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-021-01584-2","article-title":"Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy","volume":"18","author":"Saeb","year":"2021","journal-title":"Virology journal."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b0975","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s13365-014-0304-0","article-title":"Cell-cell contact viral transfer contributes to HIV infection and persistence in astrocytes","volume":"21","author":"Luo","year":"2015","journal-title":"J Neurovirol."},{"issue":"7534","key":"10.1016\/j.bcp.2023.115679_b0980","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature14053","article-title":"Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations","volume":"517","author":"Deng","year":"2015","journal-title":"Nature."},{"issue":"6","key":"10.1016\/j.bcp.2023.115679_b0985","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02638-19","article-title":"TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function","volume":"10","author":"Campbell","year":"2019","journal-title":"mBio."},{"issue":"8","key":"10.1016\/j.bcp.2023.115679_b0990","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1089\/aid.2015.0313","article-title":"Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers","volume":"32","author":"Ganesh","year":"2016","journal-title":"AIDS Res Hum Retroviruses."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b0995","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020617","article-title":"HIV Latency and Nanomedicine Strategies for Anti-HIV Treatment and Eradication","volume":"11","author":"Andre","year":"2023","journal-title":"Biomedicines."},{"issue":"9","key":"10.1016\/j.bcp.2023.115679_b1000","doi-asserted-by":"crossref","first-page":"e1005142","DOI":"10.1371\/journal.ppat.1005142","article-title":"The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo","volume":"11","author":"S\u00f8gaard","year":"2015","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b1005","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/QAD.0000000000003121","article-title":"Preserved central nervous system functioning after use of romidepsin as a latency-reversing agent in an HIV cure strategy","volume":"36","author":"Mu\u00f1oz-Moreno","year":"2022","journal-title":"Aids."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b1010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-017-1019-y","article-title":"Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion","volume":"14","author":"Proust","year":"2017","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.bcp.2023.115679_b1015","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1097\/QAD.0000000000002264","article-title":"Perspective on potential impact of HIV central nervous system latency on eradication","volume":"33","author":"Chan","year":"2019","journal-title":"Aids."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b1020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2012.05.016","article-title":"An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription","volume":"12","author":"Mousseau","year":"2012","journal-title":"Cell host & microbe."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b1025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12977-015-0159-3","article-title":"Long lasting control of viral rebound with a new drug ABX464 targeting Rev\u2013mediated viral RNA biogenesis","volume":"12","author":"Campos","year":"2015","journal-title":"Retrovirology."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b1030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11481-018-9798-1","article-title":"The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells","volume":"14","author":"Alvarez-Carbonell","year":"2019","journal-title":"Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b1035","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/QAD.0b013e3283437d2f","article-title":"Eradication of HIV from the brain: reasons for pause","volume":"25","author":"Nath","year":"2011","journal-title":"AIDS (London, England)."},{"issue":"5","key":"10.1016\/j.bcp.2023.115679_b1040","doi-asserted-by":"crossref","first-page":"e02424","DOI":"10.1128\/mBio.02424-20","article-title":"Antibody neutralization of HIV-1 crossing the blood-brain barrier","volume":"11","author":"Lorin","year":"2020","journal-title":"Mbio."},{"key":"10.1016\/j.bcp.2023.115679_b1045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4690-10-136","article-title":"Dual-acting stapled peptides target both HIV-1 entry and assembly","volume":"10","author":"Zhang","year":"2013","journal-title":"Retrovirology."},{"key":"10.1016\/j.bcp.2023.115679_b1050","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.3389\/fimmu.2018.02861","article-title":"Therapeutic targeting of HIV reservoirs: how to give T cells a new direction","volume":"9","author":"Yang","year":"2018","journal-title":"Frontiers in immunology."},{"issue":"10","key":"10.1016\/j.bcp.2023.115679_b1055","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41577-018-0042-2","article-title":"CAR T cells for infection, autoimmunity and allotransplantation","volume":"18","author":"Maldini","year":"2018","journal-title":"Nat Rev Immunol."},{"key":"10.1016\/j.bcp.2023.115679_b1060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.873701","article-title":"Evolving Strategies to Eliminate the CD4 T Cells HIV Viral Reservoir via CAR T Cell Immunotherapy","volume":"13","author":"York","year":"2022","journal-title":"Frontiers in Immunology."},{"key":"10.1016\/j.bcp.2023.115679_b1065","first-page":"10","article-title":"Engineering CAR T Cells to Target the HIV Reservoir. Frontiers in Cellular and Infection","author":"Mu","year":"2020","journal-title":"Microbiology."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b1070","doi-asserted-by":"crossref","first-page":"e1006891","DOI":"10.1371\/journal.ppat.1006891","article-title":"Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV\/AIDS","volume":"14","author":"Zhen","year":"2018","journal-title":"PLoS pathogens."},{"issue":"19","key":"10.1016\/j.bcp.2023.115679_b1075","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150211","article-title":"Broadly neutralizing antibody-derived CAR T cells reduce viral reservoir in individuals infected with HIV-1","volume":"131","author":"Liu","year":"2021","journal-title":"J Clin Invest."},{"key":"10.1016\/j.bcp.2023.115679_b1080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00361","article-title":"Advances in Developing CAR T-Cell Therapy for HIV Cure","volume":"11","author":"Qi","year":"2020","journal-title":"Frontiers in Immunology."},{"issue":"3","key":"10.1016\/j.bcp.2023.115679_b1085","article-title":"CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral","volume":"12","author":"Binda","year":"2020","journal-title":"DNA."},{"key":"10.1016\/j.bcp.2023.115679_b1090","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.omtn.2020.07.016","article-title":"Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-\u03baB Binding Sites","volume":"21","author":"Chung","year":"2020","journal-title":"Molecular Therapy - Nucleic Acids."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b1095","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/s41467-019-10366-y","article-title":"Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice","volume":"10","author":"Dash","year":"2019","journal-title":"Nature Communications."},{"issue":"2","key":"10.1016\/j.bcp.2023.115679_b1100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/glia.23254","article-title":"Synthetic AAV\/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes","volume":"66","author":"Kunze","year":"2018","journal-title":"Glia."},{"issue":"1","key":"10.1016\/j.bcp.2023.115679_b1105","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1038\/s41598-019-40222-4","article-title":"Magnetically guided non-invasive CRISPR-Cas9\/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection","volume":"9","author":"Kaushik","year":"2019","journal-title":"Scientific Reports."},{"key":"10.1016\/j.bcp.2023.115679_b1110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114893","article-title":"Suicide gene therapy in cancer and HIV-1 infection: An alternative to conventional treatments","volume":"197","author":"Saeb","year":"2022","journal-title":"Biochemical Pharmacology."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223002708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223002708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:50:13Z","timestamp":1757771413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223002708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":222,"alternative-id":["S0006295223002708"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115679","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting and eradicating latent CNS reservoirs of HIV-1: Original strategies and new models","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115679","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115679"}}