{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:45:58Z","timestamp":1786445158390,"version":"build-2736575974"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012698","name":"University of Basilicata","doi-asserted-by":"publisher","award":["ARS01_01081"],"award-info":[{"award-number":["ARS01_01081"]}],"id":[{"id":"10.13039\/501100012698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bcp.2023.115728","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T10:55:32Z","timestamp":1690628132000},"page":"115728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Persulfidation of mitoKv7.4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"215","author":[{"given":"L.","family":"Testai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Montanaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Flori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pagnotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vellecco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gorica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ugolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Righetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Brancaleone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Piragine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ghelardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Calderone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2023.115728_b0005","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/med.21332","article-title":"Mitochondrial potassium channels as pharmacological target for cardioprotective drugs","volume":"35","author":"Testai","year":"2015","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2023.115728_b0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/cvr\/cvv281","article-title":"Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection","volume":"110","author":"Testai","year":"2016","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bcp.2023.115728_b0015","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3390\/antiox10060910","article-title":"Modulation of EndMT by hydrogen sulfide in the prevention of cardiovascular fibrosis","volume":"10","author":"Testai","year":"2021","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.bcp.2023.115728_b0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3390\/biom12040581","article-title":"Potential effects of natural <sub>2<\/sub>s-donors in hypertension management","volume":"12","author":"Piragine","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2023.115728_b0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jare.2020.02.017","article-title":"Structure-activity relationships study of isothiocyanates for H<sub>2<\/sub>S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent","volume":"27","author":"Citi","year":"2020","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bcp.2023.115728_b0030","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.2174\/0929867325666180212120504","article-title":"The role of hydrogen sulfide and H2S-donors in myocardial protection against ischemia\/reperfusion injury","volume":"25","author":"Citi","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bcp.2023.115728_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105125","article-title":"Role of hydrogen sulfide in cardiovascular ageing","volume":"160","author":"Testai","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2023.115728_b0040","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ejcts.2008.03.017","article-title":"Effects of hydrogen sulphide on ischaemia-reperfusion injury and ischaemic preconditioning in the isolated, perfused rat heart","volume":"34","author":"Bliks\u00f8en","year":"2008","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.bcp.2023.115728_b0045","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"issue":"3","key":"10.1016\/j.bcp.2023.115728_b0050","doi-asserted-by":"crossref","first-page":"H1330","DOI":"10.1152\/ajpheart.00244.2008","article-title":"Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning","volume":"295","author":"Yong","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2023.115728_b0055","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3892\/etm.2012.733","article-title":"Endogenous hydrogen sulfide mediates the cardioprotection induced by ischemic postconditioning in the early reperfusion phase","volume":"4","author":"Huang","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bcp.2023.115728_b0060","first-page":"275","article-title":"Hydrogen sulfide protects cardiomyocytes from myocardial ischemia-reperfusion injury by enhancing phosphorylation of apoptosis repressor with caspase recruitment domain, Tohoku","volume":"226","author":"Yao","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2023.115728_b0065","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biopha.2017.10.118","article-title":"Role of endogenous hydrogen sulfide in cardiac mitochondrial preservation during ischemia reperfusion injury","volume":"97","author":"Nandi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2023.115728_b0070","doi-asserted-by":"crossref","unstructured":"L. Testai, A. Marino, I. Piano, V. Brancaleone, K. Tomita, L. Di Cesare Mannelli, A. Martelli, V. Citi, M.C. Breschi, R. Levi, C. Gargini, M. Bucci, G. Cirino, C. Ghelardini, V. Calderone, The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia\/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress, Pharmacol. Res. 113(2016) 290\u2013299.","DOI":"10.1016\/j.phrs.2016.09.006"},{"key":"10.1016\/j.bcp.2023.115728_b0075","doi-asserted-by":"crossref","unstructured":"B.M. Pharoah, V.S. Khodade, A. Eremiev, E. Bao, T. Liu, B. O'Rourke, N. Paolocci, J.P. Toscano, Hydropersulfides (RSSH) Outperform post-conditioning and other reactive sulfur species in limiting ischemia-reperfusion injury in the isolated mouse heart, Antioxidants (Basel). 11(2022):1010.","DOI":"10.3390\/antiox11051010"},{"key":"10.1016\/j.bcp.2023.115728_b0080","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.3390\/ijms21239100","article-title":"Garlic Derived diallyl trisulfide in experimental metabolic syndrome: metabolic effects and cardioprotective role","volume":"21","author":"Jeremic","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115728_b0085","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.bcp.2023.115728_b0090","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.bcp.2023.115728_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237643","article-title":"Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke","volume":"15","author":"Lei","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2023.115728_b0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1124\/jpet.121.001017","article-title":"Targeting mitochondrial large- onductance calcium-activated potassium channel by hydrogen sulfide via heme-binding site","volume":"381","author":"Walewska","year":"2022","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bcp.2023.115728_b0105","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3892\/ijmm.2016.2467","article-title":"ATP-sensitive K+ channels contribute to the protective effects of exogenous hydrogen sulfide against high glucose-induced injury in H9c2 cardiac cells","volume":"37","author":"Liang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2023.115728_b0110","doi-asserted-by":"crossref","unstructured":"S. Toldo, A. Das, E. Mezzaroma, V.Q. Chau, C, Marchetti, D, Durrant, A, Samidurai, B.W. Van Tassell, C. Yin, R.A. Ockaili, N. Vigneshwar, N.D Mukhopadhyay, R.C. Kukreja, A. Abbate, F.N. Salloum, Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice, Circ. Cardiovasc. Genet. 7(2014) 311\u2013320.","DOI":"10.1161\/CIRCGENETICS.113.000381"},{"key":"10.1016\/j.bcp.2023.115728_b0115","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3892\/mmr.2021.12157","article-title":"Hydrogen sulfide attenuates renal I\/R-induced activation of the inflammatory response and apoptosis via regulating Nrf2-mediated NLRP3 signaling pathway inhibition","volume":"24","author":"Su","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bcp.2023.115728_b0120","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jtcvs.2008.08.074","article-title":"Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia\/reperfusion injury","volume":"138","author":"Sodha","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"10","key":"10.1016\/j.bcp.2023.115728_b0125","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/ars.2009.2882","article-title":"Novel insights into hydrogen sulfide\u2013mediated cytoprotection","volume":"12","author":"Calvert","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"8","key":"10.1016\/j.bcp.2023.115728_b0130","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003551","article-title":"Nitrite therapy ameliorates myocardial dysfunction via H 2 S and nuclear factor\u2010erythroid 2\u2010related factor 2 (Nrf2)\u2010dependent signaling in chronic heart failure","volume":"5","author":"Donnarumma","year":"2016","journal-title":"JAHA"},{"key":"10.1016\/j.bcp.2023.115728_b0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yjmcc.2018.01.011","article-title":"Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK","volume":"116","author":"Shimizu","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2023.115728_b0140","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2012.03.121","article-title":"Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia\/reperfusion","volume":"421","author":"Sun","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2023.115728_b0145","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1055\/s-0034-1368591","article-title":"Hydrogen sulfide releasing capacity of natural isothiocyanates: is it a reliable explanation for the multiple biological effects of Brassicaceae?","volume":"80","author":"Citi","year":"2014","journal-title":"Planta Med."},{"key":"10.1016\/j.bcp.2023.115728_b0150","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/ars.2019.7888","article-title":"Organic isothiocyanates as hydrogen sulfide donors","volume":"32","author":"Martelli","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2023.115728_b0155","doi-asserted-by":"crossref","unstructured":"L. Testai, E. Pagnotta, E. Piragine, L. Flori, V. Citi, A. Martelli, L.D.C. Mannelli, C. Ghelardini, R. Matteo, S. Suriano, A. Troccoli, N. Pecchioni, V. Calderone, Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: Potential role of hydrogen sulfide, Phytother. Res. 36(2022) 2616\u20132627.","DOI":"10.1002\/ptr.7479"},{"key":"10.1016\/j.bcp.2023.115728_b0160","doi-asserted-by":"crossref","unstructured":"A. Martelli, E. Piragine, V. Citi, L. Testai, E. Pagnotta, L. Ugolini, L. Lazzeri, L. Di Cesare Mannelli, O.L. Manzo, M. Bucci, C. Ghelardini, M.C. Breschi, V. Calderone, Erucin exhibits vasorelaxing effects and antihypertensive activity by H(2) S-releasing properties, Br. J. Pharmacol. 177(2020) 824\u2013835.","DOI":"10.1111\/bph.14645"},{"key":"10.1016\/j.bcp.2023.115728_b0165","doi-asserted-by":"crossref","unstructured":"V. Citi, E. Piragine, E. Pagnotta, L. Ugolini, L. Di Cesare Mannelli, L. Testai, C. Ghelardini, L. Lazzeri, V. Calderone, A. Martelli, Anticancer properties of erucin, an H<sub>2<\/sub> S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1), Phytother. Res. 33(2019) 845\u2013855.","DOI":"10.1002\/ptr.6278"},{"key":"10.1016\/j.bcp.2023.115728_b0170","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0003-9861(90)90346-Z","article-title":"An improved method for the purification of myrosinase and its physicochemical characterization","volume":"280","author":"Pessina","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2023.115728_b0175","doi-asserted-by":"crossref","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bcp.2023.115728_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113273","article-title":"Refining rodent models of spinal cord injury","volume":"328","author":"Lilley","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bcp.2023.115728_b0185","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1124\/mol.117.109645","article-title":"Hydrogen sulfide preserves endothelial nitric oxide synthase function by inhibiting proline-rich kinase 2: implications for cardiomyocyte survival and cardioprotection","volume":"92","author":"Bibli","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115728_b0190","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1159\/000503755","article-title":"Protective effects of allicin on ISO-induced rat model of myocardial infarction via JNK signaling pathway","volume":"105","author":"Xu","year":"2020","journal-title":"Pharmacology"},{"key":"10.1016\/j.bcp.2023.115728_b0195","doi-asserted-by":"crossref","first-page":"19643","DOI":"10.18632\/aging.203375","article-title":"The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca<sup>2+<\/sup> overload-induced cardiomyocyte apoptosis via the PI3K\/GRK2\/PLC-\u03b3\/IP3R signaling pathway","volume":"13","author":"Gao","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bcp.2023.115728_b0200","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12872-021-01918-6","article-title":"Allicin attenuates myocardial apoptosis, inflammation and mitochondrial injury during hypoxia-reoxygenation: an in vitro study","volume":"21","author":"Deng","year":"2021","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.bcp.2023.115728_b0205","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1089\/ars.2020.8217","article-title":"Diet and hydrogen sulfide production in mammals","volume":"34","author":"Rose","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2023.115728_b0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jare.2020.05.015","article-title":"Role of hydrogen sulfide in endothelial dysfunction: pathophysiology and therapeutic approaches","volume":"27","author":"Citi","year":"2020","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bcp.2023.115728_b0215","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/ptr.6923","article-title":"Pharmacological modulation of the hydrogen sulfide (H<sub>2<\/sub> S) system by dietary H<sub>2<\/sub> S-donors: A novel promising strategy in the prevention and treatment of type 2 diabetes mellitus","volume":"35","author":"Piragine","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bcp.2023.115728_b0220","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1021\/acs.jafc.0c02358","article-title":"Moringin and its structural analogues as slow H<sub>2<\/sub>S donors: their mechanisms and bioactivity","volume":"68","author":"Lu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2023.115728_b0225","doi-asserted-by":"crossref","unstructured":"A. Martelli, E. Piragine, E. Gorica, V. Citi, L. Testai, E. Pagnotta, L. Lazzeri, N. Pecchioni, V. Ciccone, R. Montanaro, L. Di Cesare Mannelli, C. Ghelardini, V. Brancaleone, L. Morbidelli, V. Calderone, The H<sub>2<\/sub>S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells, Antioxidants (Basel). 10(2021) 961.","DOI":"10.3390\/antiox10060961"},{"key":"10.1016\/j.bcp.2023.115728_b0230","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/SHK.0b013e318180ff89","article-title":"Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I\/R","volume":"31","author":"Sivarajah","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.bcp.2023.115728_b0235","doi-asserted-by":"crossref","unstructured":"G. Meng, J. Zhu, Y. Xiao, Z. Huang, Y. Zhang, X. Tang, L. Xie, Y. Chen, Y. Shao, A. Ferro, R. Wang, P.K. Moore, Y. Ji, Hydrogen sulfide donor GYY4137 protects against myocardial fibrosis, Oxid. Med. Cell. Longev. 2015(2015) 691070.","DOI":"10.1155\/2015\/691070"},{"key":"10.1016\/j.bcp.2023.115728_b0240","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1002\/jcp.30214","article-title":"Hydrogen sulfide restores sevoflurane postconditioning mediated cardioprotection in diabetic rats: Role of SIRT1\/Nrf2 signaling-modulated mitochondrial dysfunction and oxidative stress","volume":"36","author":"Zhang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2023.115728_b0245","first-page":"1299","article-title":"Protective effect of a hydrogen sulfide donor on balloon injury-induced restenosis via the Nrf2\/HIF-1\u03b1 signaling pathway","volume":"43","author":"Ling","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2023.115728_b0250","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.109.199919","article-title":"Hydrogen sulfide mediates cardioprotection through Nrf2 signaling","volume":"105","author":"Calvert","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2023.115728_b0255","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3892\/ijmm.2016.2467","article-title":"ATP-sensitive K+ channels contribute to the protective effects of exogenous hydrogen sulfide against high glucose-induced injury in H9c2 cardiac cells","volume":"37","author":"Liang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2023.115728_b0260","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.bcp.2013.03.018","article-title":"The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia\/reperfusion injury","volume":"85","author":"Testai","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115728_b0265","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri2470","article-title":"Annexin A1 and glucocorticoids as effectors of the resolution of inflammation","volume":"9","author":"Perretti","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2023.115728_b0270","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.4049\/jimmunol.1003145","article-title":"Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2\/lipoxin A4 receptor and operative in the inflamed microvasculature","volume":"186","author":"Brancaleone","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2023.115728_b0275","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1182\/blood-2013-04-496661","article-title":"A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation","volume":"122","author":"Brancaleone","year":"2013","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bcp.2023.115728_b0280","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.4049\/jimmunol.1000119","article-title":"A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration","volume":"185","author":"Williams","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2023.115728_b0285","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/320077a0","article-title":"Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity","volume":"320","author":"Wallner","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2023.115728_b0290","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.bjp.0704054","article-title":"Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation","volume":"133","author":"Solito","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115728_b0295","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-5793(03)00570-2","article-title":"Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells","volume":"546","author":"Debret","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2023.115728_b0300","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bcp.2009.07.017","article-title":"Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel","volume":"79","author":"Calderone","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115728_b0305","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.niox.2015.05.001","article-title":"Mitochondria- targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice","volume":"49","author":"Ikeda","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bcp.2023.115728_b0310","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H\u2082S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2023.115728_b0315","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3389\/fphar.2017.00608","article-title":"H2S-induced sulfhydration: biological function and detection methodology","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2023.115728_b0320","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/CIRCULATIONAHA.120.051877","article-title":"Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function","volume":"143","author":"Bibli","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2023.115728_b0325","doi-asserted-by":"crossref","first-page":"106108","DOI":"10.1016\/j.phrs.2022.106108","article-title":"Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.","volume":"177","author":"Vellecco","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2023.115728_b0330","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.phrs.2016.08.023","article-title":"S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics","volume":"113","author":"Modis","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2023.115728_b0335","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/bph.14700","article-title":"Anomalous K<sub>v<\/sub> 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H<sub>2<\/sub> S and persulfidation in skeletal muscle","volume":"177","author":"Vellecco","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115728_b0340","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phrs.2012.12.005","article-title":"Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels","volume":"70","author":"Martelli","year":"2013","journal-title":"Pharmacol. Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223003192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223003192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:20:45Z","timestamp":1762096845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223003192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":68,"alternative-id":["S0006295223003192"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115728","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persulfidation of mitoKv7.4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115728"}}