{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:57:47Z","timestamp":1770145067854,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"am","delay-in-days":334,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21672043"],"award-info":[{"award-number":["21672043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bcp.2023.115835","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:00:48Z","timestamp":1696003248000},"page":"115835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["GDU-952, a novel AhR agonist ameliorates skin barrier abnormalities and immune dysfunction in DNFB-induced atopic dermatitis in mice"],"prefix":"10.1016","volume":"217","author":[{"given":"Ye-Hao","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menggeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Heng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanpeng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yun","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Zhi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Meunier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-1584","authenticated-orcid":false,"given":"Hui-Xiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bcp.2023.115835_b0005","doi-asserted-by":"crossref","first-page":"e15901","DOI":"10.1111\/dth.15901","article-title":"Children atopic dermatitis: Diagnosis, mimics, overlaps, and therapeutic implication","volume":"35","author":"Napolitano","year":"2022","journal-title":"Dermatol. Ther."},{"issue":"9","key":"10.1016\/j.bcp.2023.115835_b0010","article-title":"The epidemiology and global burden of atopic dermatitis. A narrative review","volume":"11","author":"Hadi","year":"2021","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.bcp.2023.115835_b0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaip.2019.06.044","article-title":"Update on atopic dermatitis: diagnosis, severity assessment, and treatment selection","volume":"8","author":"Fishbein","year":"2020","journal-title":"J. Allergy. Clin. Immunol. Pract."},{"issue":"10","key":"10.1016\/j.bcp.2023.115835_b0020","first-page":"590","article-title":"Atopic dermatitis: diagnosis and treatment","volume":"101","author":"Frazier","year":"2020","journal-title":"Am. Fam. Physician."},{"issue":"1","key":"10.1016\/j.bcp.2023.115835_b0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.alit.2021.10.004","article-title":"Innovation in the treatment of atopic dermatitis: Emerging topical and oral Janus kinase inhibitors","volume":"71","author":"Nakashima","year":"2022","journal-title":"Allergol. Int."},{"issue":"21","key":"10.1016\/j.bcp.2023.115835_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20215424","article-title":"Aryl hydrocarbon receptor in atopic dermatitis and psoriasis","volume":"20","author":"Furue","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2023.115835_b0035","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2174\/138920011795016818","article-title":"Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art","volume":"12","author":"Stejskalova","year":"2011","journal-title":"Curr. Drug. Metab."},{"issue":"11","key":"10.1016\/j.bcp.2023.115835_b0040","doi-asserted-by":"crossref","first-page":"e79819","DOI":"10.1371\/journal.pone.0079819","article-title":"Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo","volume":"8","author":"Duarte","year":"2013","journal-title":"PLoS One"},{"key":"#cr-split#-10.1016\/j.bcp.2023.115835_b0045.1","doi-asserted-by":"crossref","unstructured":"G.H. Perdew, C. Esser, M. Snyder, D.H. Sherr, E.H. van den Bogaard, K. McGovern, P.M. Fernandez-Salguero, X. Coumoul, A.D. Patterson, The Ah receptor from toxicity to therapeutics: report from the 5th AHR Meeting at Penn State University, USA, June 2022, Int. J. Mol. Sci. 24","DOI":"10.3390\/ijms24065550"},{"key":"#cr-split#-10.1016\/j.bcp.2023.115835_b0045.2","doi-asserted-by":"crossref","unstructured":"(6) (2023), https:\/\/doi.org\/10.3390\/ijms24065550.","DOI":"10.3390\/ijms24065550"},{"issue":"21","key":"10.1016\/j.bcp.2023.115835_b0050","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1111\/febs.14956","article-title":"AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1","volume":"286","author":"Ye","year":"2019","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.bcp.2023.115835_b0055","first-page":"4","article-title":"Crisaborole 2% ointment (eucrisa) for atopic dermatitis","volume":"24","author":"Woo","year":"2019","journal-title":"Skin Therapy. Lett."},{"issue":"11","key":"10.1016\/j.bcp.2023.115835_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113176","article-title":"Role of AHR ligands in skin homeostasis and cutaneous inflammation","volume":"10","author":"Fernandez-Gallego","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bcp.2023.115835_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010288","article-title":"Targeting AhR as a novel therapeutic modality against inflammatory diseases","volume":"23","author":"Cannon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2023.115835_b0070","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jid.2017.05.004","article-title":"Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans","volume":"137","author":"Smith","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"10.1016\/j.bcp.2023.115835_b0075","doi-asserted-by":"crossref","first-page":"956","DOI":"10.36849\/JDD.2020.5214","article-title":"Topical agents currently in phase II or phase III trials for atopic dermatitis","volume":"19","author":"Uppal","year":"2020","journal-title":"J. Drugs. Dermatol."},{"issue":"41","key":"10.1016\/j.bcp.2023.115835_b0080","doi-asserted-by":"crossref","first-page":"E6145","DOI":"10.1073\/pnas.1607843113","article-title":"Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor","volume":"113","author":"Kaye","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"issue":"3","key":"10.1016\/j.bcp.2023.115835_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031773","article-title":"Carboxamide derivatives are potential therapeutic AHR ligands for restoring IL-4 mediated repression of epidermal differentiation proteins","volume":"23","author":"Rikken","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115835_b0090","doi-asserted-by":"crossref","unstructured":"S.R.M. Ibrahim, A.M. Omar, A.A. Bagalagel, R.M. Diri, A.O. Noor, D.M. Almasri, S.G.A. Mohamed, G.A. Mohamed, Thiophenes-naturally occurring plant metabolites: biological activities and in silico evaluation of their potential as cathepsin D inhibitors, Plants (Basel). 11 (4) (2022), https:\/\/doi.org\/10.3390\/plants11040539.","DOI":"10.3390\/plants11040539"},{"issue":"7","key":"10.1016\/j.bcp.2023.115835_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/ph14070692","article-title":"Thiophene-based compounds with potential anti-inflammatory activity","volume":"14","author":"da Cruz","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"2","key":"10.1016\/j.bcp.2023.115835_b0100","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1389557520666201202113333","article-title":"Diverse thiophenes as scaffolds in anti-cancer drug development: A concise review","volume":"21","author":"Bhilare","year":"2021","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1016\/j.bcp.2023.115835_b0105","unstructured":"H. Chen, S. Chu, Y. Li, Y. Liang, Z. Ye, B. Ruan, New five-membered heterocyclic substituted styrene derivatives as well as preparation method and application thereof (2022) CN202210705821.X."},{"issue":"4","key":"10.1016\/j.bcp.2023.115835_b0110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.exer.2007.06.013","article-title":"Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells","volume":"85","author":"Yang","year":"2007","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.bcp.2023.115835_b0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000323299","article-title":"The role of cytokines\/chemokines in the pathogenesis of atopic dermatitis","volume":"41","author":"Yamanaka","year":"2011","journal-title":"Curr. Probl. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115835_b0120","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.coi.2009.09.006","article-title":"Mast cells in atopic dermatitis","volume":"21","author":"Kawakami","year":"2009","journal-title":"Curr. Opin. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2023.115835_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-alpha) in autoimmune disease and current TNF-alpha inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2023.115835_b0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115835_b0135","first-page":"13","article-title":"The role of cytokines in atopic dermatitis: a breakthrough in immunopathogenesis and treatment","volume":"31","author":"Alsabbagh","year":"2022","journal-title":"Acta. Dermatovenerol. Alp. Pannonica. Adriat."},{"issue":"2","key":"10.1016\/j.bcp.2023.115835_b0140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1081-1206(10)60170-6","article-title":"Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis","volume":"103","author":"Ito","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.bcp.2023.115835_b0145","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T cells and human disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bcp.2023.115835_b0150","doi-asserted-by":"crossref","first-page":"1820182","DOI":"10.1155\/2019\/1820182","article-title":"Correlation of blood FoxP3+ regulatory T cells and disease activity of atopic dermatitis","volume":"2019","author":"Li","year":"2019","journal-title":"J. Immunol. Res."},{"issue":"4","key":"10.1016\/j.bcp.2023.115835_b0155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s001050050573","article-title":"Th1 cells, Th2 cells and atopic dermatitis","volume":"48","author":"Bohm","year":"1997","journal-title":"Hautarzt"},{"issue":"5","key":"10.1016\/j.bcp.2023.115835_b0160","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1365-2133.2009.09035.x","article-title":"Regulatory T cells in atopic dermatitis: epidermal dendritic cell clusters may contribute to their local expansion","volume":"160","author":"Szegedi","year":"2009","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.bcp.2023.115835_b0165","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"De Benedetto","year":"2011","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223004264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223004264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:35:47Z","timestamp":1736346947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223004264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":34,"alternative-id":["S0006295223004264"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115835","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GDU-952, a novel AhR agonist ameliorates skin barrier abnormalities and immune dysfunction in DNFB-induced atopic dermatitis in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115835"}}