{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:55:58Z","timestamp":1781787358740,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bcp.2023.115859","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:40:19Z","timestamp":1697614819000},"page":"115859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-5728","authenticated-orcid":false,"given":"Shijian","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingchen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoxiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-110X","authenticated-orcid":false,"given":"Benjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2023.115859_b0005","doi-asserted-by":"crossref","unstructured":"K.D. Miller, L. Nogueira, T. Devasia, A.B. Mariotto, K.R. Yabroff, A. Jemal, J. Kramer, R.L. Siegel, Cancer treatment and survivorship statistics, 2022, CA: a cancer journal for clinicians (2022).","DOI":"10.3322\/caac.21731"},{"issue":"1","key":"10.1016\/j.bcp.2023.115859_b0010","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1038\/s41467-020-15546-9","article-title":"Pre-clinical modeling of cutaneous melanoma","volume":"11","author":"Rebecca","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2023.115859_b0015","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41392-021-00827-6","article-title":"Signal pathways of melanoma and targeted therapy","volume":"6","author":"Guo","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"23","key":"10.1016\/j.bcp.2023.115859_b0020","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1056\/NEJMra2034861","article-title":"Recent Advances in the Treatment of Melanoma","volume":"384","author":"Curti","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"10240","key":"10.1016\/j.bcp.2023.115859_b0025","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0140-6736(20)30934-X","article-title":"Atezolizumab, vemurafenib, and cobimetinib as first-line treatment for unresectable advanced BRAF mutation-positive melanoma (IMspire150): primary analysis of the randomised, double-blind, placebo-controlled, phase 3 trial","volume":"395","author":"Gutzmer","year":"2020","journal-title":"Lancet (London, England)"},{"issue":"14","key":"10.1016\/j.bcp.2023.115859_b0030","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMoa1709684","article-title":"Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma","volume":"377","author":"Wolchok","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.bcp.2023.115859_b0035","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/s41591-021-01331-8","article-title":"Evolution of delayed resistance to immunotherapy in a melanoma responder","volume":"27","author":"Liu","year":"2021","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bcp.2023.115859_b0040","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.apsb.2015.05.005","article-title":"The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb","volume":"5","author":"Wang","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.bcp.2023.115859_b0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13046-019-1361-2","article-title":"Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1","volume":"38","author":"Wang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res.: CR"},{"key":"10.1016\/j.bcp.2023.115859_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115368","article-title":"The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1\/NF-\u03baB and MAPK signaling pathways","volume":"294","author":"Sun","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2023.115859_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154406","article-title":"Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy","volume":"106","author":"Zhang","year":"2022","journal-title":"Phytomed.: Int. J. Phytotherapy Phytopharmacol."},{"key":"10.1016\/j.bcp.2023.115859_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125727","article-title":"Isoliquiritigenin triggers developmental toxicity and oxidative stress-mediated apoptosis in zebrafish embryos\/larvae via Nrf2-HO1\/JNK-ERK\/mitochondrion pathway","volume":"246","author":"Song","year":"2020","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.bcp.2023.115859_b0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13046-018-0844-x","article-title":"Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b\/LRIG1 signaling","volume":"37","author":"Xiang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res.: CR"},{"key":"10.1016\/j.bcp.2023.115859_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118598","article-title":"The dietary flavonoid isoliquiritigenin induced apoptosis and suppressed metastasis in melanoma cells: An in vitro and in vivo study","volume":"264","author":"Xiang","year":"2021","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.bcp.2023.115859_b0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrm.2016.166","article-title":"Variants of core histones and their roles in cell fate decisions, development and cancer","volume":"18","author":"Buschbeck","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"36","key":"10.1016\/j.bcp.2023.115859_b0080","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/onc.2012.442","article-title":"H2A.Z-dependent crosstalk between enhancer and promoter regulates cyclin D1 expression","volume":"32","author":"Dalvai","year":"2013","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.bcp.2023.115859_b0085","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s13402-022-00675-8","article-title":"GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer","volume":"45","author":"Han","year":"2022","journal-title":"Cell. Oncol. (Dordr.)"},{"key":"10.1016\/j.bcp.2023.115859_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.701736","article-title":"H2AFZ Is a Prognostic Biomarker Correlated to TP53 Mutation and Immune Infiltration in Hepatocellular Carcinoma","volume":"11","author":"Dong","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2023.115859_b0095","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbrc.2022.03.141","article-title":"Role of H2A.Z.1 in epithelial-mesenchymal transition and radiation resistance of lung adenocarcinoma in vitro","volume":"611","author":"Zheng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2023.115859_b0100","first-page":"9817576","article-title":"Isoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells","volume":"2019","author":"Chen","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.bcp.2023.115859_b0105","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/febs.16021","article-title":"Epithelial-to-mesenchymal-like transition events in melanoma","volume":"289","author":"Pedri","year":"2022","journal-title":"FEBS J."},{"issue":"11","key":"10.1016\/j.bcp.2023.115859_b0110","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1038\/s41388-021-01664-1","article-title":"H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma","volume":"40","author":"\u00c1vila-L\u00f3pez","year":"2021","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.bcp.2023.115859_b0115","doi-asserted-by":"crossref","first-page":"11412","DOI":"10.18632\/oncotarget.7194","article-title":"Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.bcp.2023.115859_b0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molcel.2015.05.009","article-title":"Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma","volume":"59","author":"Vardabasso","year":"2015","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.bcp.2023.115859_b0125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/jnci\/djp458","article-title":"E2F1 in melanoma progression and metastasis","volume":"102","author":"Alla","year":"2010","journal-title":"J. Natl Cancer Inst."},{"issue":"5","key":"10.1016\/j.bcp.2023.115859_b0130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41419-018-0566-1","article-title":"E2F1 inhibition mediates cell death of metastatic melanoma","volume":"9","author":"Rouaud","year":"2018","journal-title":"Cell Death Dis."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223004501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223004501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:06:55Z","timestamp":1731028015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223004501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":26,"alternative-id":["S0006295223004501"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115859","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoliquiritigenin suppresses the progression of malignant melanoma via targeting H2A.Z.1-E2F1 pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115859"}}