{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:18:23Z","timestamp":1792588703054,"version":"4.5.0"},"reference-count":112,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bcp.2023.115871","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:15:31Z","timestamp":1697775331000},"page":"115871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review"],"prefix":"10.1016","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-876X","authenticated-orcid":false,"given":"Sandra Maria","family":"Barbalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahum","family":"M\u00e9ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Fornari Laurindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2023.115871_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041180","article-title":"Adiponectin: structure, physiological functions, role in diseases, and effects of nutrition","volume":"13","author":"Khoramipour","year":"2021","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0010","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2174\/138955706777435689","article-title":"Adiponectin, structure, function and pathophysiological implications in non-alcoholic fatty liver disease","volume":"6","author":"M\u00e9ndez-S\u00e1nchez","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"issue":"51","key":"10.1016\/j.bcp.2023.115871_b0015","doi-asserted-by":"crossref","first-page":"32584","DOI":"10.1073\/pnas.1922169117","article-title":"Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice","volume":"117","author":"Li","year":"2020","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.smhs.2022.08.001","article-title":"Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2","volume":"5","author":"Liu","year":"2023","journal-title":"Sports Med Health Sci."},{"key":"10.1016\/j.bcp.2023.115871_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113302","article-title":"Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK\/GSK-3\u03b2","volume":"329","author":"Liu","year":"2020","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0030","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1161\/CIRCRESAHA.121.319976","article-title":"Targeting adiponectin receptor 1 phosphorylation against ischemic heart failure","volume":"131","author":"Zhu","year":"2022","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.bcp.2023.115871_b0035","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.3748\/wjg.v11.i12.1737","article-title":"Adiponectin as a protective factor in hepatic steatosis","volume":"11","author":"Mendez-Sanchez","year":"2005","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1665-2681(19)31890-3","article-title":"Hepatic expression of ghrelin and adiponectin and their receptors in patients with nonalcoholic fatty liver disease","volume":"7","author":"Uribe","year":"2008","journal-title":"Ann. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0045","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12931-021-01855-0","article-title":"Adiponectin ameliorates lung ischemia-reperfusion injury through SIRT1-PINK1 signaling-mediated mitophagy in type 2 diabetic rats","volume":"22","author":"Jiang","year":"2021","journal-title":"Respir. Res."},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0050","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5021\/ad.2019.31.2.186","article-title":"Adiponectin attenuates the inflammation in atopic dermatitis-like reconstructed human epidermis","volume":"31","author":"Seo","year":"2019","journal-title":"Ann. Dermatol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0055","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12882-021-02391-1","article-title":"Adiponectin protects obesity-related glomerulopathy by inhibiting ROS\/NF-\u03baB\/NLRP3 inflammation pathway","volume":"22","author":"Xu","year":"2021","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bcp.2023.115871_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119524","article-title":"The bifurcated role of adiponectin in colorectal cancer","volume":"278","author":"Chakraborty","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13046-021-02223-y","article-title":"Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming","volume":"41","author":"Pham","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105307","article-title":"Role of leptin and adiponectin in endometrial cancer","volume":"23","author":"S\u0142abuszewska-J\u00f3\u017awiak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108907","article-title":"Unraveling the role of adiponectin receptors in obesity-related breast cancer","volume":"24","author":"Naimo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115871_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00539","article-title":"Potential adiponectin receptor response modifier therapeutics","volume":"10","author":"Otvos","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065801","article-title":"Adiponectin enhances fatty acid signaling in human taste cells by increasing surface expression of CD36","volume":"24","author":"Lin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115871_b0090","series-title":"Handbook of Hormones (second Edition)","first-page":"577","article-title":"Subchapter 48B - Adiponectin","author":"Hirako","year":"2021"},{"key":"10.1016\/j.bcp.2023.115871_b0095","doi-asserted-by":"crossref","unstructured":"C. Hug, J. Wang, N.S. Ahmad, J.S. Bogan, T.-S. Tsao, H.F. Lodish, T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30\/adiponectin, Proceedings of the National Academy of Sciences 101(28) (2004) 10308-10313.","DOI":"10.1073\/pnas.0403382101"},{"key":"10.1016\/j.bcp.2023.115871_b0100","doi-asserted-by":"crossref","DOI":"10.1507\/endocrj.EJ23-0160","article-title":"Cardiovascular significance of adipose-derived adiponectin and liver-derived xanthine oxidoreductase in metabolic syndrome","author":"Fujishima","year":"2023","journal-title":"Endocr. J."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13098-017-0247-8","article-title":"Low serum adiponectin level is associated with metabolic syndrome and is an independent marker of peripheral arterial stiffness in hypertensive patients","volume":"9","author":"Chen","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bcp.2023.115871_b0110","article-title":"Serum adiponectin level and different kinds of cancer: a review of recent evidence","volume":"2012","author":"Izadi","year":"2012","journal-title":"ISRN Oncol."},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.55519\/JAMC-02-9491","article-title":"Relationship of serum adiponectin levels with glycaemic status in pregnant women","volume":"34","author":"Akhtar","year":"2022","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0120","doi-asserted-by":"crossref","first-page":"e75535","DOI":"10.1371\/journal.pone.0075535","article-title":"Adiponectin provides additional information to conventional cardiovascular risk factors for assessing the risk of atherosclerosis in both genders","volume":"8","author":"Yoon","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11883-017-0644-3","article-title":"The role of adipocytokines in coronary atherosclerosis","volume":"19","author":"Liberale","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0130","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/cells12101349","article-title":"Organokines in COVID-19: a systematic review","volume":"12","author":"Barbalho","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12020-009-9278-8","article-title":"Adiponectin action from head to toe","volume":"37","author":"Brochu-Gaudreau","year":"2010","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.bcp.2023.115871_b0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041219","article-title":"Multifaceted physiological roles of adiponectin in inflammation and diseases","volume":"21","author":"Choi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0145","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jcb.30252","article-title":"Contribution of organokines in the development of NAFLD\/NASH associated hepatocellular carcinoma","volume":"123","author":"Vachher","year":"2022","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2023.115871_b0150","doi-asserted-by":"crossref","first-page":"1119005","DOI":"10.3389\/fcvm.2023.1119005","article-title":"The regulatory role of metabolic organ-secreted factors in the nonalcoholic fatty liver disease and cardiovascular disease","volume":"10","author":"Qin","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.bcp.2023.115871_b0155","article-title":"Danthron ameliorates obesity and MAFLD through activating the interplay between PPAR\u03b1\/RXR\u03b1 heterodimer and adiponectin receptor 2","volume":"137","author":"Ma","year":"2021","journal-title":"Biomed. Pharmacother. = Biomedecine & Pharmacotherapie"},{"issue":"5","key":"10.1016\/j.bcp.2023.115871_b0160","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S2468-1253(22)00062-0","article-title":"Global multi-stakeholder endorsement of the MAFLD definition","volume":"7","author":"M\u00e9ndez-S\u00e1nchez","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12902-022-00980-1","article-title":"Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss","volume":"22","author":"Pouwels","year":"2022","journal-title":"BMC Endocr. Disord."},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0170","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1530\/EC-20-0490","article-title":"Pathophysiology of NASH in endocrine diseases","volume":"10","author":"Gariani","year":"2021","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.bcp.2023.115871_b0175","doi-asserted-by":"crossref","unstructured":"M.E. Rinella, J.V. Lazarus, V. Ratziu, S.M. Francque, A.J. Sanyal, F. Kanwal, D. Romero, M.F. Abdelmalek, Q.M. Anstee, J.P. Arab, M. Arrese, R. Bataller, U. Beuers, J. Boursier, E. Bugianesi, C. Byrne, G.E. Castro Narro, A. Chowdhury, H. Cortez-Pinto, D. Cryer, K. Cusi, M. El-Kassas, S. Klein, W. Eskridge, J. Fan, S. Gawrieh, C.D. Guy, S.A. Harrison, S.U. Kim, B. Koot, M. Korenjak, K. Kowdley, F. Lacaille, R. Loomba, R. Mitchell-Thain, T.R. Morgan, E. Powell, M. Roden, M. Romero-G\u00f3mez, M. Silva, S.P. Singh, S.C. Sookoian, C.W. Spearman, D. Tiniakos, L. Valenti, M.B. Vos, V.W. Wong, S. Xanthakos, Y. Yilmaz, Z. Younossi, A. Hobbs, M. Villota-Rivas, P.N. Newsome, A multi-society Delphi consensus statement on new fatty liver disease nomenclature, Hepatology (2023).","DOI":"10.1097\/HEP.0000000000000520"},{"issue":"4","key":"10.1016\/j.bcp.2023.115871_b0180","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ajcnut.2023.02.008","article-title":"Treatment of obesity and metabolic-associated fatty liver disease with a diet or orlistat: A randomized controlled trial","volume":"117","author":"Feng","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bcp.2023.115871_b0185","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221145650","article-title":"Screening for MAFLD: who, when and how?","volume":"14","author":"Pal","year":"2023","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2023.115871_b0190","doi-asserted-by":"crossref","unstructured":"Q. Zhang, K. Yu, Y. Cao, Y. Luo, Y. Liu, C.J.L.S. Zhao, miR-125b promotes the NF-\u03baB-mediated inflammatory response in NAFLD via directly targeting TNFAIP3, 270 (2021) 119071.","DOI":"10.1016\/j.lfs.2021.119071"},{"key":"10.1016\/j.bcp.2023.115871_b0195","article-title":"Hepatoprotective effect of bee bread in metabolic dysfunction-associated fatty liver disease (MAFLD)","volume":"10","author":"Zakaria","year":"2021","journal-title":"Rats: Impact on Oxidative Stress and Inflammation, Antioxidants"},{"issue":"9","key":"10.1016\/j.bcp.2023.115871_b0200","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/14656566.2023.2206953","article-title":"How far are we from an approved drug for nonalcoholic steatohepatitis?","volume":"24","author":"M\u00e9ndez-S\u00e1nchez","year":"2023","journal-title":"Expert Opin. Pharmacother."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0205","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.7326\/M21-2941","article-title":"First-line therapy for type 2 diabetes with sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists : a cost-effectiveness study","volume":"175","author":"Choi","year":"2022","journal-title":"Ann. Intern. Med."},{"issue":"5","key":"10.1016\/j.bcp.2023.115871_b0210","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease","volume":"77","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/biomedicines6020052","article-title":"Adiponectin signaling pathways in liver diseases","volume":"6","author":"Gamberi","year":"2018","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0220","doi-asserted-by":"crossref","first-page":"E22","DOI":"10.1152\/ajpendo.90731.2008","article-title":"APPL1: role in adiponectin signaling and beyond","volume":"296","author":"Deepa","year":"2009","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.bcp.2023.115871_b0225","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ncb1404","article-title":"APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function","volume":"8","author":"Mao","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0230","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10735-008-9198-6","article-title":"Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli","volume":"39","author":"Cammisotto","year":"2008","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.bcp.2023.115871_b0235","series-title":"Translational research in coronary artery disease","first-page":"33","article-title":"Chapter 4 - adiponectin: a mediator of obesity, insulin resistance, diabetes, and the metabolic syndrome","author":"Sharma","year":"2016"},{"issue":"7","key":"10.1016\/j.bcp.2023.115871_b0240","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1172\/JCI29126","article-title":"Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome","volume":"116","author":"Kadowaki","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"6941","key":"10.1016\/j.bcp.2023.115871_b0245","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature01705","article-title":"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects","volume":"423","author":"Yamauchi","year":"2003","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2023.115871_b0250","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010498","article-title":"Non-alcoholic steatohepatitis (NASH) and organokines: what is now and what will be in the future","volume":"23","author":"Santos","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0260","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4254\/wjh.v10.i10.708","article-title":"Adiponectin as a novel biomarker for liver fibrosis","volume":"10","author":"Udomsinprasert","year":"2018","journal-title":"World J. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0265","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12944-023-01847-7","article-title":"Adipose tissue dysfunction serum markers are associated with high density lipoprotein size and glycation in the early stages of type 2 diabetes","volume":"22","author":"Jorge-Galarza","year":"2023","journal-title":"Lipids Health Dis."},{"issue":"5","key":"10.1016\/j.bcp.2023.115871_b0270","article-title":"Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions","volume":"22","author":"de Oliveira Dos","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0275","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1159\/000481732","article-title":"Adiponectin and its receptors are differentially expressed in human tissues and cell lines of distinct origin","volume":"10","author":"Jasinski-Bergner","year":"2017","journal-title":"Obes. Facts"},{"issue":"41","key":"10.1016\/j.bcp.2023.115871_b0280","doi-asserted-by":"crossref","first-page":"40352","DOI":"10.1074\/jbc.M300365200","article-title":"Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin","volume":"278","author":"Waki","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0285","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jmcb\/mjw011","article-title":"Adiponectin, the past two decades","volume":"8","author":"Wang","year":"2016","journal-title":"J. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0290","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbrc.2010.06.020","article-title":"Access to gram scale amounts of functional globular adiponectin from E. coli inclusion bodies by alkaline-shock solubilization","volume":"398","author":"Heiker","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0295","doi-asserted-by":"crossref","first-page":"e0199256","DOI":"10.1371\/journal.pone.0199256","article-title":"Discovery of a novel potent peptide agonist to adiponectin receptor 1","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0300","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1472-6750-11-90","article-title":"Design and development of a peptide-based adiponectin receptor agonist for cancer treatment","volume":"11","author":"Otvos","year":"2011","journal-title":"BMC Biotech."},{"issue":"11","key":"10.1016\/j.bcp.2023.115871_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115569","article-title":"AdipoRon and other adiponectin receptor agonists as potential candidates in cancer treatments","volume":"22","author":"Nigro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108566","article-title":"Anti-inflammatory effects of adiponectin receptor agonist AdipoRon against intervertebral disc degeneration","volume":"24","author":"Ohnishi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115871_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114355","article-title":"AdipoRon mitigates tau pathology and restores mitochondrial dynamics via AMPK-related pathway in a mouse model of Alzheimer's disease","volume":"363","author":"Wang","year":"2023","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0320","doi-asserted-by":"crossref","first-page":"e5358","DOI":"10.1002\/bmc.5358","article-title":"Development, validation and application of a UHPLC-MS\/MS method for quantification of the adiponectin-derived active peptide ADP355 in rat plasma","volume":"36","author":"Li","year":"2022","journal-title":"Biomed. Chromatogr."},{"issue":"8","key":"10.1016\/j.bcp.2023.115871_b0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082833","article-title":"Adiponectin-based peptide (ADP355) inhibits transforming growth factor-\u03b21-induced fibrosis in keloids","volume":"21","author":"Darmawan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2023.115871_b0330","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bbrc.2020.09.035","article-title":"Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress","volume":"533","author":"Zhao","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.bcp.2023.115871_b0335","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1530\/ERC-20-0297","article-title":"Adiponectin receptor activation inhibits prostate cancer xenograft growth","volume":"27","author":"Philp","year":"2020","journal-title":"Endocr. Relat. Cancer"},{"issue":"7","key":"10.1016\/j.bcp.2023.115871_b0340","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/ATVBAHA.117.309630","article-title":"Activation of adiponectin receptor regulates proprotein convertase Subtilisin\/Kexin Type 9 expression and inhibits lesions in ApoE-deficient mice","volume":"37","author":"Sun","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2023.115871_b0345","doi-asserted-by":"crossref","first-page":"19445","DOI":"10.1038\/srep19445","article-title":"Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.bcp.2023.115871_b0350","doi-asserted-by":"crossref","first-page":"e110405","DOI":"10.1371\/journal.pone.0110405","article-title":"Adiponectin agonist ADP355 attenuates CCl4-induced liver fibrosis in mice","volume":"9","author":"Kumar","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bcp.2023.115871_b0355","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1096\/fj.14-253229","article-title":"Adiponectin modulates focal adhesion disassembly in activated hepatic stellate cells: implication for reversing hepatic fibrosis","volume":"28","author":"Kumar","year":"2014","journal-title":"FASEB J."},{"issue":"7477","key":"10.1016\/j.bcp.2023.115871_b0360","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature12656","article-title":"A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity","volume":"503","author":"Okada-Iwabu","year":"2013","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bcp.2023.115871_b0365","doi-asserted-by":"crossref","first-page":"625","DOI":"10.20517\/cdr.2022.34","article-title":"AdipoRon and Pancreatic Ductal Adenocarcinoma: a future perspective in overcoming chemotherapy-induced resistance?","volume":"5","author":"Sapio","year":"2022","journal-title":"Cancer Drug Resist"},{"issue":"11","key":"10.1016\/j.bcp.2023.115871_b0370","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.3390\/ijms22115569","article-title":"AdipoRon and other adiponectin receptor agonists as potential candidates in cancer treatments","volume":"22","author":"Nigro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2023.115871_b0375","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.837503","article-title":"Integrating gemcitabine-based therapy with adiporon enhances growth inhibition in human PDAC Cell Lines","volume":"13","author":"Ragone","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0380","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41419-022-04572-8","article-title":"Synthetic adiponectin-receptor agonist, AdipoRon, induces glycolytic dependence in pancreatic cancer cells","volume":"13","author":"Manley","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0385","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1038\/s41598-021-82617-2","article-title":"Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice","volume":"11","author":"Takenaga","year":"2021","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bcp.2023.115871_b0390","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41419-018-0851-z","article-title":"Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1\/ERK-dependent necroptosis","volume":"9","author":"Akimoto","year":"2018","journal-title":"Cell Death Dis."},{"issue":"49","key":"10.1016\/j.bcp.2023.115871_b0395","doi-asserted-by":"crossref","first-page":"85378","DOI":"10.18632\/oncotarget.19905","article-title":"Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth","volume":"8","author":"Messaggio","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0400","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/path.5874","article-title":"Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen-activated protein kinase","volume":"257","author":"Yan","year":"2022","journal-title":"J. Pathol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2023.115871_b0405","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11010-019-03586-9","article-title":"Adiponectin receptor agonist AdipoRon induces apoptotic cell death and suppresses proliferation in human ovarian cancer cells","volume":"461","author":"Ramzan","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2023.115871_b0410","doi-asserted-by":"crossref","first-page":"7262479","DOI":"10.1155\/2020\/7262479","article-title":"AdipoRon affects cell cycle progression and inhibits proliferation in human osteosarcoma cells","volume":"2020","author":"Sapio","year":"2020","journal-title":"J. Oncol."},{"issue":"2021","key":"10.1016\/j.bcp.2023.115871_b0415","first-page":"n71","article-title":"The PRISMA statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2020","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.bcp.2023.115871_b0420","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/XEB.0000000000000055","article-title":"Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach","volume":"13","author":"Aromataris","year":"2015","journal-title":"Int. J. Evid. Based Healthc."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0425","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jebm.12141","article-title":"The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review","volume":"8","author":"Zeng","year":"2015","journal-title":"J. Evid. Based Med."},{"key":"10.1016\/j.bcp.2023.115871_b0430","doi-asserted-by":"crossref","DOI":"10.3168\/jds.2022-22723","article-title":"AdipoRon alleviates fatty acid-induced lipid accumulation and mitochondrial dysfunction in bovine hepatocytes by promoting autophagy","author":"Zhao","year":"2023","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0435","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jcsm.13148","article-title":"AdipoRon enhances healthspan in middle-aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers","volume":"14","author":"Selvais","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.bcp.2023.115871_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.101708","article-title":"Protective effects of AdipoRon on the liver of Huoyan goose fed a high-fat diet","volume":"101","author":"Cao","year":"2022","journal-title":"Poult. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0445","article-title":"A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference","volume":"10","author":"Graffmann","year":"2021","journal-title":"Biol Open"},{"key":"10.1016\/j.bcp.2023.115871_b0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106157","article-title":"Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl(4) in mice","volume":"79","author":"Sha","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"20","key":"10.1016\/j.bcp.2023.115871_b0455","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1097\/CM9.0000000000000488","article-title":"Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice","volume":"132","author":"Xiao","year":"2019","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"13","key":"10.1016\/j.bcp.2023.115871_b0460","doi-asserted-by":"crossref","first-page":"e14152","DOI":"10.14814\/phy2.14152","article-title":"AdipoRon prevents myostatin-induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line","volume":"7","author":"Liu","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bcp.2023.115871_b0465","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejps.2016.08.017","article-title":"Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice","volume":"93","author":"Wang","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bcp.2023.115871_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100095","article-title":"PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions","volume":"62","author":"Onodera","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bcp.2023.115871_b0475","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2022.11.025","article-title":"Metabolic switch in cancer \u2013 Survival of the fittest","volume":"180","author":"Raskov","year":"2023","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"10.1016\/j.bcp.2023.115871_b0480","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.atherosclerosis.2014.01.051","article-title":"Modulation of adiponectin as a potential therapeutic strategy","volume":"233","author":"Lim","year":"2014","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0485","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.drudis.2022.02.015","article-title":"Small molecules and their impact in drug discovery: A perspective on the occasion of the 125th anniversary of the Bayer Chemical Research Laboratory","volume":"27","author":"Beck","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bcp.2023.115871_b0490","doi-asserted-by":"crossref","unstructured":"M.J. Watt, P.M. Miotto, W. De Nardo, M.K.J.E.r. Montgomery, The liver as an endocrine organ\u2014linking NAFLD and insulin resistance, 40(5) (2019) 1367\u20131393.","DOI":"10.1210\/er.2019-00034"},{"key":"10.1016\/j.bcp.2023.115871_b0495","doi-asserted-by":"crossref","unstructured":"J.P.M.d. Santos, M.C.d. Maio, M.A. Lemes, L.F. Laurindo, J.F.d.S. Haber, M.D. Bechara, P.S.d. Prado Jr, E.C. Rauen, F. Costa, B.C.d.A.J.I.J.o.M.S. Pereira, Non-alcoholic steatohepatitis (NASH) and organokines: What is now and what will be in the future, 23(1) (2022) 498.","DOI":"10.3390\/ijms23010498"},{"issue":"3","key":"10.1016\/j.bcp.2023.115871_b0500","doi-asserted-by":"crossref","first-page":"e3502","DOI":"10.1002\/dmrr.3502","article-title":"Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors","volume":"38","author":"Silveira Rossi","year":"2022","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bcp.2023.115871_b0505","doi-asserted-by":"crossref","unstructured":"A.R. de Oliveira dos Santos, B. de Oliveira Zanuso, V.F.B. Miola, S.M. Barbalho, P.C. Santos Bueno, U.A.P. Flato, C.R.P. Detregiachi, D.V. Buchaim, R.L. Buchaim, R.J.J.I.J.o.M.S. Tofano, Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions, 22(5) (2021) 2639.","DOI":"10.3390\/ijms22052639"},{"issue":"3","key":"10.1016\/j.bcp.2023.115871_b0510","doi-asserted-by":"crossref","first-page":"e0008","DOI":"10.1097\/HC9.0000000000000008","article-title":"Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium","volume":"7","author":"Pydyn","year":"2023","journal-title":"Hepatol. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2023.115871_b0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4254\/wjh.v10.i1.1","article-title":"Role of inflammatory response in liver diseases: therapeutic strategies","volume":"10","author":"Del Campo","year":"2018","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.bcp.2023.115871_b0520","doi-asserted-by":"crossref","unstructured":"L. Dai, Q. Wang, P. Wang, S. Zhang, L. Tai, X. Xu, G. Sun, M. Duan, H. Yuan, Z.J.E.J.o.M.C. Feng, Discovery of novel AdipoRon analogues as potent anti-inflammatory agents against nonalcoholic steatohepatitis, 244 (2022) 114800.","DOI":"10.1016\/j.ejmech.2022.114800"},{"key":"10.1016\/j.bcp.2023.115871_b0525","doi-asserted-by":"crossref","unstructured":"I.D. Vachliotis, S.A. Polyzos, The Role of Tumor Necrosis Factor-Alpha in the Pathogenesis and Treatment of Nonalcoholic Fatty Liver Disease, Current obesity reports (2023).","DOI":"10.1007\/s13679-023-00519-y"},{"issue":"3","key":"10.1016\/j.bcp.2023.115871_b0530","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxres\/tfad028","article-title":"Hepatoprotective effect of avicularin on lead-induced steatosis, oxidative stress, and inflammation in mice associated with the MAPK\/HSP60\/NLRP3 and SREBP1c pathway","volume":"12","author":"Qiu","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.bcp.2023.115871_b0535","doi-asserted-by":"crossref","first-page":"1161537","DOI":"10.3389\/fnut.2023.1161537","article-title":"Assessment of Auricularia cornea var. Li. polysaccharides potential to improve hepatic, antioxidation and intestinal microecology in rats with non-alcoholic fatty liver disease","volume":"10","author":"Zhou","year":"2023","journal-title":"Front. Nutr."},{"issue":"6","key":"10.1016\/j.bcp.2023.115871_b0540","doi-asserted-by":"crossref","DOI":"10.3390\/md21060360","article-title":"Antioxidant peptides from monkfish swim bladders: ameliorating NAFLD in vitro by suppressing lipid accumulation and oxidative stress via regulating AMPK\/Nrf2 pathway","volume":"21","author":"Wu","year":"2023","journal-title":"Mar. Drugs"},{"issue":"9","key":"10.1016\/j.bcp.2023.115871_b0545","article-title":"Quinoa ameliorates hepatic steatosis, oxidative stress, inflammation and regulates the gut microbiota in nonalcoholic fatty liver disease rats","volume":"12","author":"Zhong","year":"2023","journal-title":"Foods (Basel Switzerland)"},{"key":"10.1016\/j.bcp.2023.115871_b0550","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.3c00822","article-title":"Discovery of NAFLD-improving agents by promoting the degradation of keap1","author":"Qi","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2023.115871_b0555","doi-asserted-by":"crossref","unstructured":"S.S. Chambel, A. Santos-Gon\u00e7alves, T.L.J.B.r.i. Duarte, The dual role of Nrf2 in nonalcoholic fatty liver disease: regulation of antioxidant defenses and hepatic lipid metabolism, 2015 (2015).","DOI":"10.1155\/2015\/597134"},{"issue":"4","key":"10.1016\/j.bcp.2023.115871_b0560","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/ten.tec.2023.0008","article-title":"The safety of adiponectin receptor agonist AdipoRon in a rabbit model of arthrofibrosis","volume":"29","author":"Salmons","year":"2023","journal-title":"Tissue Eng. Part C Methods"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223004628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223004628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T20:07:31Z","timestamp":1731010051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223004628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":112,"alternative-id":["S0006295223004628"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115871","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115871","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115871"}}