{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:00:13Z","timestamp":1790305213262,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2021D01D11"],"award-info":[{"award-number":["2021D01D11"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2022D01D14"],"award-info":[{"award-number":["2022D01D14"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160772"],"award-info":[{"award-number":["82160772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274313"],"award-info":[{"award-number":["82274313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304947"],"award-info":[{"award-number":["82304947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2023GHZD43"],"award-info":[{"award-number":["2023GHZD43"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bcp.2023.115968","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T02:08:49Z","timestamp":1702606129000},"page":"115968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Acteoside alleviates blood\u2013brain barrier damage induced by ischemic stroke through inhibiting microglia HMGB1\/TLR4\/NLRP3 signaling"],"prefix":"10.1016","volume":"220","author":[{"given":"Yucheng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bcp.2023.115968_b0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1474-4422(22)00519-1","article-title":"Thrombolysis for acute ischaemic stroke: current status and future perspectives","volume":"22","author":"Tsivgoulis","year":"2023","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/j.bcp.2023.115968_b0010","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and management of transient ischemic attack and acute ischemic stroke: a review","volume":"325","author":"Mendelson","year":"2021","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bcp.2023.115968_b0015","article-title":"Management of acute ischemic stroke","volume":"368","author":"Phipps","year":"2020","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0020","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bcp.2023.115968_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2023.115968_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107695","article-title":"Natural medicine in neuroprotection for ischemic stroke: challenges and prospective","volume":"216","author":"Tao","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2023.115968_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175717","article-title":"Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2\/HO-1 pathway in ischemic stroke","volume":"949","author":"Qiao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115968_b0040","doi-asserted-by":"crossref","first-page":"1552127","DOI":"10.1155\/2021\/1552127","article-title":"Curcumin ameliorates white matter injury after ischemic stroke by inhibiting microglia\/macrophage pyroptosis through NF-kappaB suppression and NLRP3 inflammasome inhibition","volume":"2021","author":"Ran","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12974-022-02501-2","article-title":"Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NFkappaB\/NLRP3 signaling pathway in cerebral ischemic mice","volume":"19","author":"Luo","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0050","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12974-020-01946-7","article-title":"Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.bcp.2023.115968_b0055","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-022-00943-7","article-title":"Inflammatory responses after ischemic stroke","volume":"44","author":"DeLong","year":"2022","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bcp.2023.115968_b0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood-brain barrier dysfunction and recovery after ischemic stroke","volume":"163\u2013164","author":"Jiang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bcp.2023.115968_b0065","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.addr.2021.01.015","article-title":"D, Targeting the blood-brain barrier for the delivery of stroke therapies","volume":"171","author":"D'Souza","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"10","key":"10.1016\/j.bcp.2023.115968_b0070","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","article-title":"Microglia: immune and non-immune functions","volume":"54","author":"Borst","year":"2021","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.bcp.2023.115968_b0075","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s12264-019-00388-3","article-title":"Dual functions of microglia in ischemic stroke","volume":"35","author":"Qin","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bcp.2023.115968_b0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2016.01.005","article-title":"The biphasic function of microglia in ischemic stroke","volume":"157","author":"Ma","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bcp.2023.115968_b0085","doi-asserted-by":"crossref","first-page":"1047550","DOI":"10.3389\/fimmu.2022.1047550","article-title":"The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: a review","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2023.115968_b0090","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s40122-021-00288-3","article-title":"Microglia in the pathophysiology of hemorrhagic stroke and the relationship between microglia and pain after stroke: a narrative review","volume":"10","author":"He","year":"2021","journal-title":"Pain Ther."},{"key":"10.1016\/j.bcp.2023.115968_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.980722","article-title":"Microglia-mediated neuroinflammation and neuroplasticity after stroke","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bcp.2023.115968_b0100","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bcp.2023.115968_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106230","article-title":"Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic\/reperfusion brain injury via JUNB\/JNK\/NF-kappaB and SOX5\/PI3K\/AKT pathways","volume":"180","author":"Cai","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2023.115968_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112563","article-title":"A review on the structure and pharmacological activity of phenylethanoid glycosides","volume":"209","author":"Tian","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2023.115968_b0115","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/med.21717","article-title":"Therapeutic potential of phenylethanoid glycosides: a systematic review","volume":"40","author":"Wu","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bcp.2023.115968_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116269","article-title":"Cistanche tubulosa alleviates ischemic stroke-induced blood-brain barrier damage by modulating microglia-mediated neuroinflammation","volume":"309","author":"Liao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2023.115968_b0125","doi-asserted-by":"crossref","DOI":"10.1039\/D2FO03110H","article-title":"Microbiome-metabolomics analysis reveals the potential effect of verbascoside in alleviating cognitive impairment in db\/db mice","author":"Ran","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.bcp.2023.115968_b0130","article-title":"Combination of systems pharmacology and experimental evaluation to explore the mechanism of synergistic action of frankincense-myrrh in the treatment of cerebrovascular diseases","volume":"12","author":"Liao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2023.115968_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106720","article-title":"An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity","volume":"190","author":"Ji","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12974-021-02316-7","article-title":"Interleukin-10 improves stroke outcome by controlling the detrimental Interleukin-17A response","volume":"18","author":"Piepke","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.bcp.2023.115968_b0145","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1073\/pnas.1316925111","article-title":"JAK\/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation","volume":"111","author":"Lu","year":"2014","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.bcp.2023.115968_b0150","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1474-4422(19)30415-6","article-title":"Advances and challenges in stroke rehabilitation","volume":"19","author":"Stinear","year":"2020","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.bcp.2023.115968_b0155","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bcp.2023.115968_b0160","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/17474930221107500","article-title":"Treatment of posterior circulation stroke: acute management and secondary prevention","volume":"17","author":"Markus","year":"2022","journal-title":"Int. J. Stroke"},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0165","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/STROKEAHA.120.032020","article-title":"Which imaging approach should be used for stroke of unknown time of onset?","volume":"52","author":"Simonsen","year":"2021","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.bcp.2023.115968_b0170","doi-asserted-by":"crossref","first-page":"e1002","DOI":"10.1212\/WNL.0000000000013274","article-title":"Circulating interleukin-6 levels and incident ischemic stroke: a systematic review and meta-analysis of prospective studies","volume":"98","author":"Papadopoulos","year":"2022","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0175","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12974-022-02467-1","article-title":"Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bcp.2023.115968_b0180","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1161\/CIRCRESAHA.122.320877","article-title":"Interleukin-6 predicts carotid plaque severity vulnerability, and progression","volume":"131","author":"Kamtchum-Tatuene","year":"2022","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.bcp.2023.115968_b0185","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/med.21960","article-title":"Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: effects of cerebrolysin","volume":"43","author":"Rejdak","year":"2023","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bcp.2023.115968_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111828","article-title":"Recovery of post-stroke cognitive and motor deficiencies by Shuxuening injection via regulating hippocampal BDNF-mediated neurotrophin\/Trk signaling","volume":"141","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.bcp.2023.115968_b0195","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12975-018-0648-5","article-title":"The serum BDNF level offers minimum predictive value for motor function recovery after stroke","volume":"10","author":"Luo","year":"2019","journal-title":"Transl. Stroke Res."},{"issue":"3","key":"10.1016\/j.bcp.2023.115968_b0200","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a therapeutic target in inflammatory diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bcp.2023.115968_b0205","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fimmu.2020.00484","article-title":"Targeting inflammation driven by HMGB1","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"issue":"Pt B","key":"10.1016\/j.bcp.2023.115968_b0210","article-title":"Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1\/TLR4\/MYD88\/NF-kb signaling pathway in HUVEC cells","volume":"404","author":"Liu","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bcp.2023.115968_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154083","article-title":"Gegen Qinlian pills alleviate carrageenan-induced thrombosis in mice model by regulating the HMGB1\/NF-kappaB\/NLRP3 signaling","volume":"100","author":"Wei","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2023.115968_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112617","article-title":"Gestational exposure to PM(2.5) leads to cognitive dysfunction in mice offspring via promoting HMGB1-NLRP3 axis mediated hippocampal inflammation","volume":"223","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bcp.2023.115968_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113664","article-title":"HMGB1-NLRP3-P2X7R pathway participates in PM(2.5)-induced hippocampal neuron impairment by regulating microglia activation","volume":"239","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.bcp.2023.115968_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107623","article-title":"Sepsis-induced acute lung injury in young rats is relieved by calycosin through inactivating the HMGB1\/MyD88\/NF-kappaB pathway and NLRP3 inflammasome","volume":"96","author":"Chen","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2023.115968_b0235","doi-asserted-by":"crossref","first-page":"13431","DOI":"10.1002\/jcp.28022","article-title":"Inhibition of HMGB1 improves necrotizing enterocolitis by inhibiting NLRP3 via TLR4 and NF-kappaB signaling pathways","volume":"234","author":"Yu","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0240","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12974-021-02274-0","article-title":"HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury","volume":"18","author":"Tan","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bcp.2023.115968_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105967","article-title":"Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-kappaB activated pyroptosis pathways","volume":"174","author":"Tao","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2023.115968_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105748","article-title":"Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4\/NLRP3\/GSDMD-dependent pyroptosis","volume":"170","author":"Yuan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2023.115968_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101534","article-title":"Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway","volume":"32","author":"Jia","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2023.115968_b0260","doi-asserted-by":"crossref","first-page":"8704016","DOI":"10.1155\/2022\/8704016","article-title":"Inhibition of PFKFB preserves intestinal barrier function in sepsis by inhibiting NLRP3\/GSDMD","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"64","key":"10.1016\/j.bcp.2023.115968_b0265","doi-asserted-by":"crossref","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","article-title":"NLRP3 inflammasome activation triggers gasdermin D-independent inflammation","volume":"6","author":"Wang","year":"2021","journal-title":"Sci. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2023.115968_b0270","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/awab003","article-title":"Microglial activation and blood-brain barrier permeability in cerebral small vessel disease","volume":"144","author":"Walsh","year":"2021","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.bcp.2023.115968_b0275","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/glia.24146","article-title":"Astrocytic p75(NTR) expression provoked by ischemic stroke exacerbates the blood-brain barrier disruption","volume":"70","author":"Qin","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.bcp.2023.115968_b0280","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2018.02.035","article-title":"Autophagy- and MMP-2\/9-mediated reduction and redistribution of ZO-1 contribute to hyperglycemia-increased blood-brain barrier permeability during early reperfusion in stroke","volume":"377","author":"Zhang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bcp.2023.115968_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105650","article-title":"Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation","volume":"169","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2023.115968_b0290","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fneur.2013.00032","article-title":"Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke","volume":"4","author":"Lakhan","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bcp.2023.115968_b0295","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fncel.2016.00056","article-title":"Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke","volume":"10","author":"Turner","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bcp.2023.115968_b0300","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fneur.2020.00473","article-title":"Matrix metalloproteinase-9 relationship with infarct growth and hemorrhagic transformation in the era of thrombectomy","volume":"11","author":"Mechtouff","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bcp.2023.115968_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120132","article-title":"Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease","volume":"287","author":"Safar","year":"2021","journal-title":"Life Sci."},{"issue":"1_suppl","key":"10.1016\/j.bcp.2023.115968_b0310","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1177\/0271678X20932870","article-title":"Transcriptomic characterization of microglia activation in a rat model of ischemic stroke","volume":"40","author":"Deng","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"10","key":"10.1016\/j.bcp.2023.115968_b0315","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.3390\/ijms18102135","article-title":"Microglia and monocytes\/macrophages polarization reveal novel therapeutic mechanism against stroke","volume":"18","author":"Kanazawa","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0320","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12974-021-02197-w","article-title":"Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response","volume":"18","author":"Todd","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bcp.2023.115968_b0325","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1038\/s41467-021-27248-x","article-title":"Stroke subtype-dependent synapse elimination by reactive gliosis in mice","volume":"12","author":"Shi","year":"2021","journal-title":"Nat. Commun."},{"issue":"20","key":"10.1016\/j.bcp.2023.115968_b0330","doi-asserted-by":"crossref","first-page":"e131355","DOI":"10.1172\/jci.insight.131355","article-title":"STAT6\/Arg1 promotes microglia\/macrophage efferocytosis and inflammation resolution in stroke mice","volume":"4","author":"Cai","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bcp.2023.115968_b0335","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.biopha.2018.05.143","article-title":"Treatment targets for M2 microglia polarization in ischemic stroke","volume":"105","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bcp.2023.115968_b0340","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s11481-019-09903-9","article-title":"Calycosin preserves BDNF\/TrkB signaling and reduces post-stroke neurological injury after cerebral ischemia by reducing accumulation of hypertrophic and TNF-alpha-containing microglia in rats","volume":"15","author":"Hsu","year":"2020","journal-title":"J. Neuroimmune Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223005610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295223005610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T13:47:50Z","timestamp":1757771270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295223005610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":68,"alternative-id":["S0006295223005610"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115968","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acteoside alleviates blood\u2013brain barrier damage induced by ischemic stroke through inhibiting microglia HMGB1\/TLR4\/NLRP3 signaling","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2023.115968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115968"}}