{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:26:11Z","timestamp":1791462371770,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bcp.2024.116093","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T16:13:20Z","timestamp":1708791200000},"page":"116093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["CGRP attenuates pulmonary vascular remodeling by inhibiting the cGAS-STING-NF\u03baB pathway in pulmonary arterial hypertension"],"prefix":"10.1016","volume":"222","author":[{"given":"Xin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxia","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-6846","authenticated-orcid":false,"given":"Ren","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2024.116093_b0005","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bcp.2024.116093_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107576","article-title":"Pulmonary arterial hypertension specific therapy: the old and the new","volume":"214","author":"Zolty","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2024.116093_b0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","article-title":"Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension","volume":"115","author":"Rabinovitch","year":"2014","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.bcp.2024.116093_b0020","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1161\/HYPERTENSIONAHA.121.17809","article-title":"Resolvin E1 attenuates pulmonary hypertension by suppressing Wnt7a\/beta-catenin signaling","volume":"78","author":"Liu","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.bcp.2024.116093_b0025","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/cphy.c190027","article-title":"Mitochondria in the pulmonary vasculature in health and disease: oxygen-sensing","volume":"10","author":"Dasgupta","year":"2020","journal-title":"Metabolism, and Dynamics, Compr Physiol"},{"issue":"11","key":"10.1016\/j.bcp.2024.116093_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112338","article-title":"Perivascular inflammation in pulmonary arterial hypertension","volume":"9","author":"Hu","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bcp.2024.116093_b0035","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","article-title":"The cGAS-STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy","volume":"12","author":"Oduro","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.bcp.2024.116093_b0040","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.bcp.2024.116093_b0045","first-page":"117","article-title":"Activation of cGAS-STING pathway after hypoxia induced mitochondrial DNA release promotes proliferation of pulmonary artery smooth muscle cells","volume":"44","author":"Wei HN","year":"2022","journal-title":"Journal of the Army Medical University"},{"issue":"9288","key":"10.1016\/j.bcp.2024.116093_b0050","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(01)06250-X","article-title":"Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study","volume":"358","author":"Channick","year":"2001","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bcp.2024.116093_b0055","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/eurheartj\/ehq011","article-title":"Combination therapy with bosentan and sildenafil in eisenmenger syndrome: a randomized, placebo-controlled, double-blinded trial","volume":"31","author":"Iversen","year":"2010","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.bcp.2024.116093_b0060","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1183\/09031936.00114407","article-title":"Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension","volume":"32","author":"Schermuly","year":"2008","journal-title":"Eur. Respir. J."},{"issue":"26","key":"10.1016\/j.bcp.2024.116093_b0065","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1056\/NEJMoa1503184","article-title":"Selexipag for the treatment of pulmonary arterial hypertension","volume":"373","author":"Sitbon","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bcp.2024.116093_b0070","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.bcp.2024.116093_b0075","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/01.shk.0000183395.29014.7c","article-title":"Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia","volume":"24","author":"Gomes","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.bcp.2024.116093_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173205","article-title":"The effects of CGRP in vascular tissue - classical vasodilation, shadowed effects and systemic dilemmas","volume":"881","author":"Sohn","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116093_b0085","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3389\/fphys.2018.01167","article-title":"The regulation of pulmonary vascular tone by neuropeptides and the implications for pulmonary hypertension","volume":"9","author":"Lo","year":"2018","journal-title":"Front. Physiol."},{"issue":"25","key":"10.1016\/j.bcp.2024.116093_b0090","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/0024-3205(89)90004-0","article-title":"Effect of sensory neuropeptides on canine bronchial and pulmonary vessels in vitro","volume":"45","author":"McCormack","year":"1989","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116093_b0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/01902149209031681","article-title":"Dynamic aspects of regulatory lung peptides in chronic hypoxic pulmonary hypertension","volume":"18","author":"Keith","year":"1992","journal-title":"Exp. Lung Res."},{"issue":"8","key":"10.1016\/j.bcp.2024.116093_b0100","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.CIR.101.8.923","article-title":"In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse","volume":"101","author":"Champion","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bcp.2024.116093_b0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1476-5381.2011.01525.x","article-title":"Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?","volume":"166","author":"Barwell","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116093_b0110","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fphys.2019.00821","article-title":"Protective role of alpha-calcitonin gene-related peptide in cardiovascular diseases","volume":"10","author":"Kumar","year":"2019","journal-title":"Front. Physiol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116093_b0115","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1161\/HYPERTENSIONAHA.121.17809","article-title":"Resolvin E1 attenuates pulmonary hypertension by suppressing Wnt7a\/\u03b2-catenin signaling","volume":"78","author":"Liu","year":"2021","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.bcp.2024.116093_b0120","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1161\/HYPERTENSIONAHA.121.17868","article-title":"Caspase-4\/11-mediated pulmonary artery endothelial cell pyroptosis contributes to pulmonary arterial hypertension","volume":"79","author":"Wu","year":"2022","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.bcp.2024.116093_b0125","article-title":"Cinnamaldehyde supplementation reverts endothelial dysfunction in rat models of diet-induced obesity: role of NF-E2-related Factor-2","volume":"12","author":"Sena","year":"2022","journal-title":"Antioxidants (basel)"},{"issue":"9","key":"10.1016\/j.bcp.2024.116093_b0130","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41401-020-0359-9","article-title":"Cinnamaldehyde protects against rat intestinal ischemia\/reperfusion injuries by synergistic inhibition of NF-\u03baB and p53","volume":"41","author":"Almoiliqy","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"16","key":"10.1016\/j.bcp.2024.116093_b0135","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.3748\/wjg.v21.i16.4852","article-title":"Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by shugan decoction","volume":"21","author":"Shi","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bcp.2024.116093_b0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2016.11.020","article-title":"MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G(0)\/G(1) cell cycle arrest by targeting c-myc","volume":"170","author":"Zhang","year":"2017","journal-title":"Life Sci."},{"issue":"7548","key":"10.1016\/j.bcp.2024.116093_b0145","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2024.116093_b0150","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/bph.15650","article-title":"Rodent models of hypertension","volume":"179","author":"Jama","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116093_b0155","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.freeradbiomed.2020.12.452","article-title":"Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer","volume":"170","author":"Wu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2024.116093_b0160","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00109-015-1263-5","article-title":"Mitochondrial dynamics in pulmonary arterial hypertension","volume":"93","author":"Ryan","year":"2015","journal-title":"J. Mol. Med. (Berl)"},{"issue":"3","key":"10.1016\/j.bcp.2024.116093_b0165","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.00041.2003","article-title":"Molecular regulation of vascular smooth muscle cell differentiation in development and disease","volume":"84","author":"Owens","year":"2004","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.bcp.2024.116093_b0170","first-page":"H613","article-title":"Metabolism of vascular smooth muscle cells in vascular diseases","volume":"319","author":"Shi","year":"2020","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"7","key":"10.1016\/j.bcp.2024.116093_b0175","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/ATVBAHA.119.312787","article-title":"Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation","volume":"39","author":"Petsophonsakul","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116093_b0180","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.redox.2013.10.011","article-title":"Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation","volume":"1","author":"Salabei","year":"2013","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116093_b0185","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jacbts.2022.03.006","article-title":"Targeting myocardial mitochondria-STING-polyamine Axis prevents cardiac hypertrophy in chronic kidney disease","volume":"7","author":"Han","year":"2022","journal-title":"JACC Basic Transl Sci"},{"issue":"21","key":"10.1016\/j.bcp.2024.116093_b0190","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.7150\/thno.47651","article-title":"HDAC3 inhibition ameliorates ischemia\/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway","volume":"10","author":"Liao","year":"2020","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.bcp.2024.116093_b0195","doi-asserted-by":"crossref","first-page":"2002738","DOI":"10.1002\/advs.202002738","article-title":"Mitochondrial damage-induced innate immune activation in vascular smooth muscle cells promotes chronic kidney disease-associated plaque vulnerability","volume":"8","author":"Bi","year":"2021","journal-title":"Adv Sci (weinh)"},{"issue":"6227","key":"10.1016\/j.bcp.2024.116093_b0200","doi-asserted-by":"crossref","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.bcp.2024.116093_b0205","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2174\/0929867323666160210125416","article-title":"An overview of non-neural sources of calcitonin gene-related peptide","volume":"23","author":"Hu","year":"2016","journal-title":"Curr. Med. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2024.116093_b0210","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1042\/cs0700389","article-title":"Human calcitonin gene related peptide: a potent endogenous vasodilator in man","volume":"70","author":"Struthers","year":"1986","journal-title":"Clin. Sci. (Lond.)"},{"issue":"11","key":"10.1016\/j.bcp.2024.116093_b0215","doi-asserted-by":"crossref","first-page":"e0188008","DOI":"10.1371\/journal.pone.0188008","article-title":"TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons","volume":"12","author":"Eberhardt","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2024.116093_b0220","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fphys.2018.01249","article-title":"The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects","volume":"9","author":"Kee","year":"2018","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116093_b0225","doi-asserted-by":"crossref","DOI":"10.3390\/cells8040287","article-title":"Mitochondrial biogenesis and mitochondrial reactive oxygen species (ROS): a complex relationship regulated by the CAMP\/PKA signaling pathway","volume":"8","author":"Bouchez","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.bcp.2024.116093_b0230","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/onc.2012.50","article-title":"Oncogenic K-ras expression is associated with derangement of the CAMP\/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration","volume":"32","author":"Palorini","year":"2013","journal-title":"Oncogene"},{"issue":"Pt 7","key":"10.1016\/j.bcp.2024.116093_b0235","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1113\/jphysiol.2010.202838","article-title":"Mitochondrial production of reactive oxygen species contributes to the \u03b2-adrenergic stimulation of mouse cardiomycytes","volume":"589","author":"Andersson","year":"2011","journal-title":"J. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2024.116093_b0240","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2012.01.015","article-title":"Inhibitory effect of calcitonin gene-related peptide on hypoxia-induced rat pulmonary artery smooth muscle cells proliferation: role of ERK1\/2 and p27","volume":"679","author":"Li","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2024.116093_b0245","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1139\/cjpp-2015-0602","article-title":"Calcitonin gene-related peptide down-regulates bleomycin-induced pulmonary fibrosis","volume":"94","author":"Li","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224000765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224000765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T19:57:22Z","timestamp":1711137442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224000765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":49,"alternative-id":["S0006295224000765"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116093","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CGRP attenuates pulmonary vascular remodeling by inhibiting the cGAS-STING-NF\u03baB pathway in pulmonary arterial hypertension","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116093"}}