{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:28:44Z","timestamp":1792452524523,"version":"4.5.0"},"reference-count":149,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871180"],"award-info":[{"award-number":["31871180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91957113"],"award-info":[{"award-number":["91957113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2019JJ40410"],"award-info":[{"award-number":["2019JJ40410"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40794"],"award-info":[{"award-number":["2023JJ40794"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0803604"],"award-info":[{"award-number":["2020YFA0803604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0806102"],"award-info":[{"award-number":["2022YFA0806102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bcp.2024.116104","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T06:02:15Z","timestamp":1709186535000},"page":"116104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The role of novel adipokines and adipose-derived extracellular vesicles (ADEVs): Connections and interactions in liver diseases"],"prefix":"10.1016","volume":"222","author":[{"given":"Lijun","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2024.116104_b0005","unstructured":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128\u00b79 million children, adolescents, and adults, Lancet (London, England) 390(10113) (2017) 2627\u20132642."},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41569-020-00465-5","article-title":"Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging","volume":"18","author":"Ng","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41574-020-00462-1","article-title":"Global pandemics interconnected \u2013 obesity, impaired metabolic health and COVID-19","volume":"17","author":"Stefan","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0020","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4158\/EP12160.PS","article-title":"American Association of Clinical Endocrinologists' position statement on obesity and obesity medicine","volume":"18","author":"Mechanick","year":"2012","journal-title":"Endocr. Pract."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0030","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2024.116104_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2023.102089","article-title":"Adipose tissue-derived lipokines in metabolism","volume":"81","author":"Tsuji","year":"2023","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2024.116104_b0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/prca.201100052","article-title":"Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders","volume":"6","author":"Lehr","year":"2012","journal-title":"Proteomics Clin. Appl."},{"issue":"11","key":"10.1016\/j.bcp.2024.116104_b0045","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1096\/fj.00-0829hyp","article-title":"Rationale for the existence of additional adipostatic hormones","volume":"15","author":"Fruhbeck","year":"2001","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.bcp.2024.116104_b0050","doi-asserted-by":"crossref","first-page":"E691","DOI":"10.1152\/ajpendo.00297.2015","article-title":"Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism","volume":"309","author":"Rodriguez","year":"2015","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0055","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2024.116104_b0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.coph.2020.04.006","article-title":"Genetic variation, adipokines, and cardiometabolic disease","volume":"52","author":"Metz","year":"2020","journal-title":"Curr. Opin. Pharmacol."},{"issue":"21","key":"10.1016\/j.bcp.2024.116104_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218308","article-title":"Roles of adipokines in digestive diseases: markers of inflammation, metabolic alteration and disease progression","volume":"21","author":"Chang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0070","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/apha.12246","article-title":"Adipose tissue and its role in organ crosstalk","volume":"210","author":"Romacho","year":"2014","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.bcp.2024.116104_b0075","doi-asserted-by":"crossref","first-page":"1198984","DOI":"10.3389\/fendo.2023.1198984","article-title":"Effects of multi-organ crosstalk on the physiology and pathology of adipose tissue","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0085","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1053\/j.gastro.2019.12.054","article-title":"Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease","volume":"158","author":"Azzu","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0090","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/hep4.1479","article-title":"Pathogenesis of nonalcoholic steatohepatitis: an overview","volume":"4","author":"Parthasarathy","year":"2020","journal-title":"Hepatol. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3803\/EnM.2018.33.1.33","article-title":"Association of Adipokines with development and progression of nonalcoholic fatty liver disease","volume":"33","author":"Boutari","year":"2018","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"10.1016\/j.bcp.2024.116104_b0100","doi-asserted-by":"crossref","first-page":"101238","DOI":"10.1016\/j.plipres.2023.101238","article-title":"Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): recent advances","author":"Musso","year":"2023","journal-title":"Prog. Lipid Res."},{"issue":"24","key":"10.1016\/j.bcp.2024.116104_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249368","article-title":"Unraveling the role of leptin in liver function and its relationship with liver diseases","volume":"21","author":"Mart\u00ednez-U\u00f1a","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2024.116104_b0110","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jacc.2020.11.069","article-title":"Leptin in leanness and obesity: JACC state-of-the-art review","volume":"77","author":"Perakakis","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0115","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.molmet.2017.04.011","article-title":"The glucoregulatory actions of leptin","volume":"6","author":"D'souza","year":"2017","journal-title":"Mol. Metabolism"},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9070762","article-title":"Role of leptin in non-alcoholic fatty liver disease","volume":"9","author":"Jim\u00e9nez-Cortegana","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0125","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1038\/s41467-019-10684-1","article-title":"Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis","volume":"10","author":"Hackl","year":"2019","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2024.116104_b0130","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cmet.2022.09.020","article-title":"Leptin increases hepatic triglyceride export via a vagal mechanism in humans","volume":"34","author":"Metz","year":"2022","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jhep.2013.02.007","article-title":"The liver diseases of lipodystrophy: the long-term effect of leptin treatment","volume":"59","author":"Safar Zadeh","year":"2013","journal-title":"J. Hepatol."},{"issue":"48","key":"10.1016\/j.bcp.2024.116104_b0140","doi-asserted-by":"crossref","first-page":"40441","DOI":"10.1074\/jbc.M112.384545","article-title":"Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and \u03b11-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin","volume":"287","author":"Miyamoto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2024.116104_b0145","doi-asserted-by":"crossref","unstructured":"W. Zhu, K. Cheng, P. Vanhoutte, K. Lam, A. Xu, Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention, Clin. Sci. (London, England: 1979) 114(5) (2008) 361\u2013374.","DOI":"10.1042\/CS20070347"},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11154-019-09510-2","article-title":"Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease","volume":"20","author":"Ishtiaq","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11154-013-9280-6","article-title":"Adiponectin signaling in the liver","volume":"15","author":"Combs","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bcp.2024.116104_b0160","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/ijpvm.IJPVM_193_20","article-title":"Adiponectin: role in physiology and pathophysiology","volume":"11","author":"Nguyen","year":"2020","journal-title":"Int. J. Prev. Med."},{"issue":"15","key":"10.1016\/j.bcp.2024.116104_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155242","article-title":"Data on adiponectin from 2010 to 2020: therapeutic target and prognostic factor for liver diseases?","volume":"21","author":"Heydari","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116104_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110785","article-title":"The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling","volume":"131","author":"Shabalala","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.bcp.2024.116104_b0175","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.2337\/db20-1073","article-title":"Adiponectin alleviates diet-induced inflammation in the liver by suppressing MCP-1 expression and macrophage infiltration","volume":"70","author":"Ryu","year":"2021","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0180","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1038\/s41467-020-19668-y","article-title":"AdipoR1\/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis","volume":"11","author":"Xu","year":"2020","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0185","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00109-015-1313-z","article-title":"Adiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells","volume":"93","author":"Dong","year":"2015","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0190","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1600-079X.2012.01023.x","article-title":"Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin","volume":"54","author":"Gonciarz","year":"2013","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2015.08.038","article-title":"Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis","volume":"64","author":"Armstrong","year":"2016","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0200","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/hep.31843","article-title":"Saroglitazar, a PPAR-\u03b1\/\u03b3 agonist, for treatment of NAFLD: a randomized controlled double-blind phase 2 trial","volume":"74","author":"Gawrieh","year":"2021","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"6","key":"10.1016\/j.bcp.2024.116104_b0205","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.2337\/dc19-1892","article-title":"Effects of novel dual GIP and GLP-1 receptor agonist tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes","volume":"43","author":"Hartman","year":"2020","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0210","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1463-1326.2009.01176.x","article-title":"The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease","volume":"12","author":"Polyzos","year":"2010","journal-title":"Diabetes Obes. Metab."},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0215","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4254\/wjh.v10.i10.708","article-title":"Adiponectin as a novel biomarker for liver fibrosis","volume":"10","author":"Udomsinprasert","year":"2018","journal-title":"World J. Hepatol."},{"issue":"15","key":"10.1016\/j.bcp.2024.116104_b0220","doi-asserted-by":"crossref","first-page":"12983","DOI":"10.1074\/jbc.M110.215889","article-title":"Thermogenic activation induces FGF21 expression and release in brown adipose tissue","volume":"286","author":"Hondares","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0225","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cmet.2016.01.006","article-title":"FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and Brown adipose tissues","volume":"23","author":"Schlein","year":"2016","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0230","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/cvr\/cvab076","article-title":"Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis","volume":"118","author":"Liu","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2024.116104_b0235","doi-asserted-by":"crossref","first-page":"11382","DOI":"10.1038\/srep11382","article-title":"FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance","volume":"5","author":"Bernardo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116104_b0240","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmet.2019.10.009","article-title":"Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster","volume":"31","author":"Lewis","year":"2020","journal-title":"Mol. Metabolism"},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0245","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.cmet.2013.03.019","article-title":"An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice","volume":"17","author":"Holland","year":"2013","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0250","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cmet.2013.04.005","article-title":"Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice","volume":"17","author":"Lin","year":"2013","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0255","doi-asserted-by":"crossref","first-page":"e15205","DOI":"10.14814\/phy2.15205","article-title":"Effects of exercise intensity on white adipose tissue browning and its regulatory signals in mice","volume":"10","author":"Tanimura","year":"2022","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bcp.2024.116104_b0260","doi-asserted-by":"crossref","first-page":"13479","DOI":"10.1038\/ncomms13479","article-title":"The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes","volume":"7","author":"Quesada-L\u00f3pez","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2024.116104_b0265","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ebiom.2016.01.031","article-title":"The ablation of mitochondrial protein phosphatase Pgam5 confers resistance against metabolic stress","volume":"5","author":"Sekine","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2024.116104_b0270","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bcp.2019.04.017","article-title":"Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue","volume":"164","author":"Hirai","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0275","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/nm.3713","article-title":"The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis","volume":"20","author":"Wang","year":"2014","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.bcp.2024.116104_b0280","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.molmet.2017.03.016","article-title":"Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders","volume":"6","author":"Chen","year":"2017","journal-title":"Mol. Metabolism"},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0285","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1172\/JCI96324","article-title":"Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression","volume":"127","author":"Guo","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2024.116104_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173350","article-title":"Neuregulin 4 alleviates hepatic steatosis via activating AMPK\/MTOR-mediated autophagy in aged mice fed a high fat diet","volume":"884","author":"Zhu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0295","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.cmet.2022.07.010","article-title":"Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment","volume":"34","author":"Zhang","year":"2022","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0300","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.metabol.2015.08.013","article-title":"A case-control study: association between serum neuregulin 4 level and non-alcoholic fatty liver disease","volume":"64","author":"Dai","year":"2015","journal-title":"Metab. Clin. Exp."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0305","doi-asserted-by":"crossref","first-page":"e12289","DOI":"10.1111\/cob.12289","article-title":"Decreased serum neuregulin 4 levels associated with non-alcoholic fatty liver disease in children with obesity","volume":"9","author":"Wang","year":"2019","journal-title":"Clin. Obesity"},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0310","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.2337\/db21-0064","article-title":"NRG4Mutations of contribute to the pathogenesis of nonalcoholic fatty liver disease and related metabolic disorders","volume":"70","author":"Li","year":"2021","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0315","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15092634","article-title":"Prognostic value of erythroblastic leukemia viral oncogene homolog 2 and neuregulin 4 in hepatocellular carcinoma","volume":"15","author":"Rou","year":"2023","journal-title":"Cancers"},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0320","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/bies.10136","article-title":"Secreted Frizzled-related proteins: searching for relationships and patterns","volume":"24","author":"Jones","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.bcp.2024.116104_b0325","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1242\/jcs.026096","article-title":"Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease","volume":"121","author":"Bovolenta","year":"2008","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0330","doi-asserted-by":"crossref","first-page":"E503","DOI":"10.1210\/jc.2012-3416","article-title":"Characterization of the Wnt inhibitors secreted frizzled-related proteins (SFRPs) in human adipose tissue","volume":"98","author":"Ehrlund","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0335","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1016\/j.bbadis.2019.07.008","article-title":"The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver","volume":"1865","author":"H\u00f6rbelt","year":"2019","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0340","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/21623945.2020.1792614","article-title":"Effects of SFRP4 overexpression on the production of adipokines in transgenic mice","volume":"9","author":"Zhang","year":"2020","journal-title":"Adipocyte"},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0345","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0350","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1210\/en.2007-0175","article-title":"Chemerin is a novel adipokine associated with obesity and metabolic syndrome","volume":"148","author":"Bozaoglu","year":"2007","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0355","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1530\/JOE-14-0069","article-title":"Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice","volume":"222","author":"Rourke","year":"2014","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0360","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1084\/jem.20071601","article-title":"Synthetic chemerin-derived peptides suppress inflammation through ChemR23","volume":"205","author":"Cash","year":"2008","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0365","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1210\/en.2009-1098","article-title":"Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes","volume":"151","author":"Ernst","year":"2010","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bcp.2024.116104_b0370","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1210\/jc.2009-2374","article-title":"Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery","volume":"95","author":"Sell","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0375","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/00365520903443852","article-title":"Serum chemerin and vaspin in non-alcoholic fatty liver disease","volume":"45","author":"Kukla","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0380","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1530\/EJE-13-0112","article-title":"Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease","volume":"169","author":"D\u00f6cke","year":"2013","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0385","doi-asserted-by":"crossref","first-page":"9242","DOI":"10.1038\/s41598-018-27543-6","article-title":"Low circulating chemerin levels correlate with hepatic dysfunction and increased mortality in decompensated liver cirrhosis","volume":"8","author":"Horn","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0390","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.yexmp.2015.01.010","article-title":"Reduced serum chemerin in patients with more severe liver cirrhosis","volume":"98","author":"Eisinger","year":"2015","journal-title":"Exp. Mol. Pathol."},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0395","doi-asserted-by":"crossref","first-page":"11294","DOI":"10.3390\/ijms150711294","article-title":"Impact of serum chemerin levels on liver functional reserves and platelet counts in patients with hepatocellular carcinoma","volume":"15","author":"Imai","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0400","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1530\/JOE-18-0174","article-title":"Chemerin: a multifaceted adipokine involved in metabolic disorders","volume":"238","author":"Helfer","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116104_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170422","article-title":"Chemerin\/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway","volume":"135","author":"An","year":"2021","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0410","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.yexmp.2015.02.005","article-title":"Resolvin E1 and chemerin C15 peptide do not improve rodent non-alcoholic steatohepatitis","volume":"98","author":"Pohl","year":"2015","journal-title":"Exp. Mol. Pathol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0415","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1373\/clinchem.2006.075614","article-title":"Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans","volume":"53","author":"Wang","year":"2007","journal-title":"Clin. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0420","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.2337\/db07-0007","article-title":"The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance","volume":"56","author":"Yan","year":"2007","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0425","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2337\/db09-1541","article-title":"Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity","volume":"59","author":"Law","year":"2010","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0430","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s11033-013-2977-5","article-title":"Serum lipocalin-2, cathepsin S and chemerin levels and nonalcoholic fatty liver disease","volume":"41","author":"Ye","year":"2014","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0435","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0032-1331696","article-title":"Liver lipocalin 2 expression in severely obese women with non alcoholic fatty liver disease","volume":"121","author":"Auguet","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bcp.2024.116104_b0440","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-230X-13-120","article-title":"The FLS (fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis","volume":"13","author":"Semba","year":"2013","journal-title":"BMC Gastroenterol."},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0445","first-page":"1513","article-title":"Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver","volume":"1842","author":"Asimakopoulou","year":"2014","journal-title":"BBA"},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0450","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jhep.2016.05.041","article-title":"Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2","volume":"65","author":"Ye","year":"2016","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0455","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12974-020-01876-4","article-title":"Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis","volume":"17","author":"Mondal","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bcp.2024.116104_b0460","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molmet.2019.09.009","article-title":"Sex-specific metabolic functions of adipose lipocalin-2","volume":"30","author":"Chella Krishnan","year":"2019","journal-title":"Mol. Metabolism"},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0465","first-page":"660","article-title":"Protective effects of lipocalin-2 (LCN2) in acute liver injury suggest a novel function in liver homeostasis","volume":"1832","author":"Borkham-Kamphorst","year":"2013","journal-title":"BBA"},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0470","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/liv.12634","article-title":"The role of lipocalin-2 in liver regeneration","volume":"35","author":"Kienzl-Wagner","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.bcp.2024.116104_b0475","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cellsig.2019.01.001","article-title":"Liver parenchymal cells lacking Lipocalin 2 (LCN2) are prone to endoplasmic reticulum stress and unfolded protein response","volume":"55","author":"Borkham-Kamphorst","year":"2019","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0480","doi-asserted-by":"crossref","first-page":"15558","DOI":"10.1038\/s41598-020-72172-7","article-title":"Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bcp.2024.116104_b0485","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/SLA.0000000000000427","article-title":"The roles of lipocalin-2 in small-for-size fatty liver graft injury","volume":"260","author":"Cheng","year":"2014","journal-title":"Ann. Surg."},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0490","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1177\/39.9.1918940","article-title":"Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues","volume":"39","author":"Tada","year":"1991","journal-title":"J. Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0495","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0500","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2337\/dc12-0940","volume":"36","author":"Yang","year":"2013","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0505","doi-asserted-by":"crossref","first-page":"5062","DOI":"10.1210\/jc.2009-0764","article-title":"Circulating and adipose tissue gene expression of zinc-alpha2-glycoprotein in obesity: its relationship with adipokine and lipolytic gene markers in subcutaneous and visceral fat","volume":"94","author":"Ceperuelo-Mallafr\u00e9","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2024.116104_b0510","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fendo.2020.00154","article-title":"Low serum ZAG levels correlate with determinants of the metabolic syndrome in Chinese subjects","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0515","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/JOE-09-0299","article-title":"Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob\/ob mice and by tumour necrosis factor-alpha in adipocytes","volume":"204","author":"Mracek","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116104_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110669","article-title":"Zinc-\u03b12-glycoprotein promotes browning of white adipose tissue in cold-exposed male mice","volume":"501","author":"Fan","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116104_b0525","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mce.2016.06.003","article-title":"Zinc alpha2 glycoprotein alleviates palmitic acid-induced intracellular lipid accumulation in hepatocytes","volume":"439","author":"Xiao","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116104_b0530","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41366-018-0151-9","article-title":"Zinc alpha2 glycoprotein protects against obesity-induced hepatic steatosis","volume":"42","author":"Xiao","year":"2018","journal-title":"Int. J. Obes. (2005)"},{"key":"10.1016\/j.bcp.2024.116104_b0535","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1479-5876-10-106","article-title":"Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis","volume":"10","author":"Huang","year":"2012","journal-title":"J. Transl. Med."},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0540","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00125-019-05014-5","article-title":"Extracellular vesicles in metabolic disease","volume":"62","author":"Akbar","year":"2019","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0545","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0550","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12672-023-00704-4","article-title":"Adipocyte-derived extracellular vesicles: bridging the communications between obesity and tumor microenvironment","volume":"14","author":"Zhou","year":"2023","journal-title":"Discover. Oncology"},{"key":"10.1016\/j.bcp.2024.116104_b0555","doi-asserted-by":"crossref","first-page":"30087","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials \u2013 an ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bcp.2024.116104_b0560","article-title":"Adipose extracellular vesicles in intercellular and inter-organ crosstalk in metabolic health and diseases","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.bcp.2024.116104_b0565","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1002\/oby.20847","article-title":"Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells","volume":"22","author":"Kranendonk","year":"2014","journal-title":"Obesity (Silver Spring, Md.)"},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0570","doi-asserted-by":"crossref","first-page":"e12561","DOI":"10.1111\/jpi.12561","article-title":"Reduced delivery of epididymal adipocyte-derived exosomal resistin is essential for melatonin ameliorating hepatic steatosis in mice","volume":"66","author":"Rong","year":"2019","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bcp.2024.116104_b0575","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.freeradbiomed.2020.12.011","article-title":"ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice","volume":"163","author":"Gu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"18","key":"10.1016\/j.bcp.2024.116104_b0580","doi-asserted-by":"crossref","first-page":"8197","DOI":"10.7150\/thno.43968","article-title":"Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2024.116104_b0585","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-8722-6-37","article-title":"Long non-coding RNA: a new player in cancer","volume":"6","author":"Zhang","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2024.116104_b0590","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13045-014-0086-0","article-title":"Circulating miRNAs in cancer: from detection to therapy","volume":"7","author":"Wang","year":"2014","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2024.116104_b0595","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ebiom.2018.07.015","article-title":"Extracellular vesicles secreted by human adipose-derived stem cells (hASCs) improve survival rate of rats with acute liver failure by releasing lncRNA H19","volume":"34","author":"Jin","year":"2018","journal-title":"EBioMedicine"},{"issue":"7642","key":"10.1016\/j.bcp.2024.116104_b0600","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0605","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bbrc.2020.05.090","article-title":"Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes","volume":"530","author":"Kariba","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0610","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13105-019-00692-6","article-title":"Adipose-derived exosomes deliver miR-23a\/b to regulate tumor growth in hepatocellular cancer by targeting the VHL\/HIF axis","volume":"75","author":"Liu","year":"2019","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2024.116104_b0615","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13045-015-0220-7","article-title":"Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma","volume":"8","author":"Lou","year":"2015","journal-title":"J. Hematol. Oncol."},{"issue":"11","key":"10.1016\/j.bcp.2024.116104_b0620","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1111\/jcmm.13208","article-title":"MiR-122 modification enhances the therapeutic efficacy of adipose tissue-derived mesenchymal stem cells against liver fibrosis","volume":"21","author":"Lou","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0625","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13046-019-1512-5","article-title":"MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway","volume":"39","author":"Lou","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.bcp.2024.116104_b0630","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121560","article-title":"Extracellular vesicles-encapsulated MicroRNA-125b produced in genetically modified mesenchymal stromal cells inhibits hepatocellular carcinoma cell proliferation","volume":"8","author":"Baldari","year":"2019","journal-title":"Cells"},{"issue":"36","key":"10.1016\/j.bcp.2024.116104_b0635","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.3748\/wjg.v23.i36.6549","article-title":"Treatment options for alcoholic and non-alcoholic fatty liver disease: a review","volume":"23","author":"Singh","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0640","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.cmet.2013.04.012","article-title":"Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production","volume":"17","author":"Cao","year":"2013","journal-title":"Cell Metab."},{"issue":"51","key":"10.1016\/j.bcp.2024.116104_b0645","doi-asserted-by":"crossref","first-page":"39691","DOI":"10.1074\/jbc.M110.180695","article-title":"C1q\/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output","volume":"285","author":"Peterson","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0650","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/jcp.30982","article-title":"Adipokine gremlin-1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy-mediated signaling","volume":"238","author":"Choi","year":"2023","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116104_b0655","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2337\/db19-0701","article-title":"The novel adipokine gremlin 1 antagonizes insulin action and is increased in type 2 diabetes and NAFLD\/NASH","volume":"69","author":"Hedjazifar","year":"2020","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0660","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.cmet.2021.07.010","article-title":"Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis","volume":"33","author":"Jiang","year":"2021","journal-title":"Cell Metab."},{"issue":"24","key":"10.1016\/j.bcp.2024.116104_b0665","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148545","article-title":"LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance","volume":"131","author":"He","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2024.116104_b0670","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejphar.2012.11.016","article-title":"Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells","volume":"698","author":"Zhang","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116104_b0675","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.26167","article-title":"Resistin reduces mitochondria and induces hepatic steatosis in mice by the protein kinase C\/protein kinase G\/p65\/PPAR gamma coactivator 1 alpha pathway","volume":"57","author":"Zhou","year":"2013","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"11","key":"10.1016\/j.bcp.2024.116104_b0680","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.2337\/db12-0232","article-title":"Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78\/MTJ-1 complex","volume":"61","author":"Nakatsuka","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0685","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13105-021-00852-7","article-title":"Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway","volume":"78","author":"Abdolahi","year":"2022","journal-title":"J. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.bcp.2024.116104_b0690","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1111\/jgh.15465","article-title":"Visfatin exacerbates hepatic inflammation and fibrosis in a methionine-choline-deficient diet mouse model","volume":"36","author":"Heo","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"19","key":"10.1016\/j.bcp.2024.116104_b0695","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910541","article-title":"A distinctive NAFLD signature in adipose tissue from women with severe obesity","volume":"22","author":"Osorio-Conles","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.bcp.2024.116104_b0700","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1210\/jc.2012-4297","article-title":"Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease","volume":"98","author":"Yoo","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0705","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4314\/ahs.v16i1.32","article-title":"Biochemical parameters response to weight loss in patients with non-alcoholic steatohepatitis","volume":"16","author":"Abd El-Kader","year":"2016","journal-title":"Afr. Health Sci."},{"issue":"8","key":"10.1016\/j.bcp.2024.116104_b0710","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.cgh.2006.05.005","article-title":"Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement","volume":"4","author":"Lutchman","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116104_b0715","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-2036.2010.04405.x","article-title":"Pioglitazone in the treatment of NASH: the role of adiponectin","volume":"32","author":"Gastaldelli","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2024.116104_b0720","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.gastro.2008.03.078","article-title":"Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) trial","volume":"135","author":"Ratziu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2024.116104_b0725","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1475-2840-11-61","article-title":"Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis: effects beyond glucose lowering?","volume":"11","author":"Shargorodsky","year":"2012","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bcp.2024.116104_b0730","doi-asserted-by":"crossref","unstructured":"X. Guo, C. Wang, T. Yang, W. Ma, J. Zhai, T. Zhao, T. Xu, J. Li, H. Liu, A. Sinclair, D. Li, Concentrated fish oil ameliorates non-alcoholic fatty liver disease by regulating fibroblast growth factor 21-adiponectin axis, Nutrition (Burbank, Los Angeles County, Calif.) (2022) 111659.","DOI":"10.1016\/j.nut.2022.111659"},{"issue":"5","key":"10.1016\/j.bcp.2024.116104_b0735","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jhep.2006.01.025","article-title":"Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis","volume":"44","author":"Zografos","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bcp.2024.116104_b0740","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cyto.2016.03.003","article-title":"Expression of fibroblast growth factor 21 in patients with biliary atresia","volume":"83","author":"Li","year":"2016","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.bcp.2024.116104_b0745","doi-asserted-by":"crossref","first-page":"E199","DOI":"10.1152\/ajpendo.00291.2005","article-title":"Elevated resistin levels in cirrhosis are associated with the proinflammatory state and altered hepatic glucose metabolism but not with insulin resistance","volume":"291","author":"Bahr","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522400087X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522400087X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T19:59:29Z","timestamp":1711137569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522400087X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":149,"alternative-id":["S000629522400087X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116104","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of novel adipokines and adipose-derived extracellular vesicles (ADEVs): Connections and interactions in liver diseases","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116104"}}