{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:03:50Z","timestamp":1790622230506,"version":"4.1.0"},"reference-count":204,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["SAF2017-85806-R"],"award-info":[{"award-number":["SAF2017-85806-R"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bcp.2024.116226","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T06:53:05Z","timestamp":1713855185000},"page":"116226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Control of articular degeneration by extracellular vesicles from stem\/stromal cells as a potential strategy for the treatment of osteoarthritis"],"prefix":"10.1016","volume":"228","author":[{"given":"Mar\u00eda","family":"Jos\u00e9 Alcaraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2024.116226_b0005","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2024.116226_b0010","unstructured":"Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol 2023;5:e508-e522."},{"key":"10.1016\/j.bcp.2024.116226_b0015","unstructured":"OARSI White paper. OA as a serious disease. oarsi org\/oarsi-white-paper-oa-serious-disease 2018."},{"key":"10.1016\/j.bcp.2024.116226_b0020","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/ijms17122146","article-title":"Insights on molecular mechanisms of chondrocytes death in osteoarthritis","volume":"17","author":"Charlier","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","article-title":"The bone-cartilage unit in osteoarthritis","volume":"7","author":"Lories","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bcp.2024.116226_b0030","doi-asserted-by":"crossref","unstructured":"Mobasheri A, Saarakkala S, Finnil\u00e4 M, Karsdal MA, Bay-Jensen AC, van Spil WE. Recent advances in understanding the phenotypes of osteoarthritis. F1000Res 2019;8:F1000Faculty Rev-2091.","DOI":"10.12688\/f1000research.20575.1"},{"key":"10.1016\/j.bcp.2024.116226_b0035","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.3390\/ijms24129939","article-title":"Clinical trials with mesenchymal stem cell therapies for osteoarthritis: challenges in the regeneration of articular cartilage","volume":"24","author":"Carneiro","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcell.2020.00107","article-title":"Mesenchymal stem cell derived extracellular vesicles in aging","volume":"8","author":"Boulestreau","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0045","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.ymthe.2020.04.020","article-title":"Comprehensive molecular profiles of functionally effective MSC-derived extracellular vesicles in immunomodulation","volume":"28","author":"Kim","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0050","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.21212","article-title":"Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source","volume":"52","author":"Sakaguchi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0055","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/bioengineering10020195","article-title":"Advances in mesenchymal stem cell therapy for osteoarthritis: from preclinical and clinical perspectives","volume":"10","author":"Lv","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.bcp.2024.116226_b0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"Van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0065","doi-asserted-by":"crossref","unstructured":"[13] Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina ZA, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borras FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MA, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Gorecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzas EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta CA, de CP, De Santana EF, De WO, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di VD, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekstrom K, El AS, Elie-Caille C, Erdbrugger U, Falcon-Perez JM, Fatima F, Fish JE, Flores-Bellver M, Forsonits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gamez-Valero A, Gardiner C, Gartner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Gorgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovacs AF, Kramer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lasser C, Laurent LC, Lavieu G, Lazaro-Ibanez E, Le LS, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstons K, Llorente A, Lombard CA, Lorenowicz MJ, Lorincz AM, Lotvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Jr., Meehan KL, Mertens I, Minciacchi VR, Moller A, Moller JM, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren HN, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Ostergaard O, Ostrowski M. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018;7:1535750.","DOI":"10.1080\/20013078.2018.1535750"},{"key":"10.1016\/j.bcp.2024.116226_b0070","doi-asserted-by":"crossref","unstructured":"Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di VD, Driedonks TAP, Erdbr\u00fcgger U, Falcon-Perez JM, Fu QL, Hill AF, Lenassi M, Lim SK, Mahoney MG, Mohanty S, M\u00f6ller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas AC, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges EM, Brucale M, Burger D, Carney RP, Cocucci E, Crescitelli R, Hanser E, Harris AL, Haughey NJ, Hendrix A, Ivanov AR, Jovanovic-Talisman T, Kruh-Garcia NA, Ku'ulei-Lyn F, V, Kyburz D, L\u00e4sser C, Lennon KM, L\u00f6tvall J, Maddox AL, Martens-Uzunova ES, Mizenko RR, Newman LA, Ridolfi A, Rohde E, Rojalin T, Rowland A, Saftics A, Sandau US, Saugstad JA, Shekari F, Swift S, Ter-Ovanesyan D, Tosar JP, Useckaite Z, Valle F, Varga Z, van der Pol E, van Herwijnen MJC, Wauben MHM, Wehman AM, Williams S, Zendrini A, Zimmerman AJ, Th\u00e9ry C, Witwer KW. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles 2024;13:e12404.","DOI":"10.1002\/jev2.12404"},{"key":"10.1016\/j.bcp.2024.116226_b0075","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41580-023-00576-0","article-title":"Context-specific regulation of extracellular vesicle biogenesis and cargo selection","volume":"24","author":"Dixson","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0080","doi-asserted-by":"crossref","first-page":"29828","DOI":"10.3402\/jev.v5.29828","article-title":"MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA","volume":"5","author":"Lai","year":"2016","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.bcp.2024.116226_b0085","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/biof.1576","article-title":"Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate-induced animal model of osteoarthritis","volume":"46","author":"Zavatti","year":"2020","journal-title":"Biofactors"},{"key":"10.1016\/j.bcp.2024.116226_b0090","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.3390\/ijms23105795","article-title":"Bone Marrow MSC Secretome Increases Equine Articular Chondrocyte Collagen Accumulation and Their Migratory Capacities","volume":"23","author":"Contentin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0095","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00018-022-04580-z","article-title":"Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA","volume":"79","author":"Morente-L\u00f3pez","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fcell.2020.00149","article-title":"Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications","volume":"8","author":"Gowen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010098","article-title":"Extracellular Vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases","volume":"9","author":"Alcaraz","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2024.116226_b0110","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0120","doi-asserted-by":"crossref","first-page":"1735249","DOI":"10.1080\/20013078.2020.1735249","article-title":"Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration","volume":"9","author":"Woo","year":"2020","journal-title":"J. Extracell Vesicles"},{"key":"10.1016\/j.bcp.2024.116226_b0125","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1177\/03635465221073991","article-title":"Exosomes derived from human urine-derived stem cells overexpressing miR-140-5p alleviate knee osteoarthritis through downregulation of VEGFA in a rat model","volume":"50","author":"Liu","year":"2022","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.bcp.2024.116226_b0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12951-021-01236-1","article-title":"Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages","volume":"20","author":"Li","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bcp.2024.116226_b0135","doi-asserted-by":"crossref","first-page":"1157498","DOI":"10.1155\/2022\/1157498","article-title":"Human umbilical cord mesenchymal stem cell-derived extracellular vesicles carrying MicroRNA-181c-5p Promote BMP2-induced repair of cartilage injury through inhibition of SMAD7 expression","volume":"2022","author":"Zhang","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bcp.2024.116226_b0140","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1080\/21655979.2021.1995580","article-title":"miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis","volume":"12","author":"Xia","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.bcp.2024.116226_b0145","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13075-020-02325-6","article-title":"Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3","volume":"22","author":"Chen","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0150","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.7150\/thno.31017","article-title":"Desktop-stereolithography 3D printing of a radially oriented extracellular matrix\/mesenchymal stem cell exosome bioink for osteochondral defect regeneration","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2024.116226_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.870193","article-title":"Human mesenchymal stromal cells release functional mitochondria in extracellular vesicles","volume":"10","author":"Thomas","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bcp.2024.116226_b0160","doi-asserted-by":"crossref","first-page":"25138","DOI":"10.18632\/aging.104110","article-title":"Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bcp.2024.116226_b0165","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13287-023-03368-7","article-title":"Mesenchymal stem\/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model","volume":"14","author":"Warmink","year":"2023","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0170","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1111\/jcmm.16860","article-title":"Therapeutic effects of bone marrow mesenchymal stem cells-derived exosomes on osteoarthritis","volume":"25","author":"Jin","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0175","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12951-021-00940-2","article-title":"Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3\/miR-124-3p\/MYH9 axis","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.bcp.2024.116226_b0180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13287-018-1004-0","article-title":"Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A","volume":"9","author":"Mao","year":"2018","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0185","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/art.42353","article-title":"Role of human mesenchymal stem cells and derived extracellular vesicles in reducing sensory neuron hyperexcitability and pain behaviors in murine osteoarthritis","volume":"75","author":"Ai","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bcp.2024.116226_b0190","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0195","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.actbio.2020.12.034","article-title":"Hypoxic pretreatment of small extracellular vesicles mediates cartilage repair in osteoarthritis by delivering miR-216a-5p","volume":"122","author":"Rong","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bcp.2024.116226_b0200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00441-020-03193-x","article-title":"Exosomal miR-9-5p secreted by bone marrow-derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1","volume":"381","author":"Jin","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bcp.2024.116226_b0205","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9972805","article-title":"BMSC-derived exosomes ameliorate osteoarthritis by inhibiting pyroptosis of cartilage via delivering miR-326 targeting HDAC3 and STAT1\/NF-kB p65 to chondrocytes","volume":"2021","author":"Xu","year":"2021","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bcp.2024.116226_b0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10863-023-09991-6","article-title":"Chondroprotective effects of bone marrow mesenchymal stem cell-derived exosomes in osteoarthritis","volume":"56","author":"Cheng","year":"2024","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.bcp.2024.116226_b0215","doi-asserted-by":"crossref","first-page":"e3510","DOI":"10.1002\/jgm.3510","article-title":"Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR-3473b\/phosphatase and tensin homolog axis","volume":"25","author":"Zhang","year":"2023","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bcp.2024.116226_b0220","doi-asserted-by":"crossref","first-page":"7734","DOI":"10.1111\/jcmm.16654","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-206 promotes osteoblast proliferation and differentiation in osteoarthritis by reducing Elf3","volume":"25","author":"Huang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0225","doi-asserted-by":"crossref","first-page":"16214","DOI":"10.1038\/s41598-017-15376-8","article-title":"Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis","volume":"7","author":"Cosenza","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0230","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/jor.24497","article-title":"BMSCs-derived exosomes ameliorate pain via abrogation of aberrant nerve invasion in subchondral bone in lumbar facet joint osteoarthritis","volume":"38","author":"Li","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bcp.2024.116226_b0235","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.2147\/IJN.S336062","article-title":"Comparison of curative effect of human umbilical cord-derived mesenchymal stem cells and their small extracellular vesicles in treating osteoarthritis","volume":"16","author":"Tang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bcp.2024.116226_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121952","article-title":"Wharton's jelly mesenchymal stem cell-derived small extracellular vesicles as natural nanoparticles to attenuate cartilage injury via microRNA regulation","volume":"623","author":"Chen","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2024.116226_b0245","doi-asserted-by":"crossref","first-page":"976","DOI":"10.21037\/atm-22-3912","article-title":"Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis","volume":"10","author":"Li","year":"2022","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.bcp.2024.116226_b0250","doi-asserted-by":"crossref","first-page":"14975","DOI":"10.1038\/s41598-023-42349-x","article-title":"Umbilical cord mesenchymal stem cells relieve osteoarthritis in rats through immunoregulation and inhibition of chondrocyte apoptosis","volume":"13","author":"Pan","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0255","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13287-022-03005-9","article-title":"Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage","volume":"13","author":"Zhou","year":"2022","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0260","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s10495-022-01787-0","article-title":"Adipose mesenchymal stem cells-derived exosomes alleviate osteoarthritis by transporting microRNA -376c-3p and targeting the WNT-beta-catenin signaling axis","volume":"28","author":"Li","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2024.116226_b0265","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12951-023-02086-9","article-title":"Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis","volume":"21","author":"Zhao","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.bcp.2024.116226_b0270","doi-asserted-by":"crossref","first-page":"e12337","DOI":"10.1002\/jev2.12337","volume":"12","author":"Hanai","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bcp.2024.116226_b0275","article-title":"Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was beneficial for long-term treatment of osteoarthritis","volume":"23","author":"Yin","year":"2023","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.bcp.2024.116226_b0280","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1038\/s41598-022-07569-7","article-title":"Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures","volume":"12","author":"Kouroupis","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0285","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/cells12141824","article-title":"CD10-bound human mesenchymal stem\/stromal cell-derived small extracellular vesicles possess immunomodulatory cargo and maintain cartilage homeostasis under inflammatory conditions","volume":"12","author":"Kouroupis","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2024.116226_b0290","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2019.03.022","article-title":"miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis","volume":"206","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2024.116226_b0295","doi-asserted-by":"crossref","first-page":"e3379","DOI":"10.1002\/jgm.3379","article-title":"Synovial mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p ameliorate cartilage damage of osteoarthritis","volume":"23","author":"Lu","year":"2021","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bcp.2024.116226_b0300","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.omtn.2020.09.014","article-title":"Synovial Mesenchymal stem cell-derived EV-packaged miR-31 downregulates histone demethylase KDM2A to prevent knee osteoarthritis","volume":"22","author":"Wang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bcp.2024.116226_b0305","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13287-017-0510-9","article-title":"Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0310","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s10787-023-01142-y","article-title":"Synovial mesenchymal stem cell-derived exosomal microRNA-320c facilitates cartilage damage repair by targeting ADAM19-dependent Wnt signalling in osteoarthritis rats","volume":"31","author":"Kong","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bcp.2024.116226_b0315","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jot.2023.06.003","article-title":"MATN3 delivered by exosome from synovial mesenchymal stem cells relieves knee osteoarthritis: Evidence from in vitro and in vivo studies","volume":"41","author":"Long","year":"2023","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bcp.2024.116226_b0320","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/08923973.2022.2038192","article-title":"Synovial mesenchymal stem cell-derived extracellular vesicles alleviate chondrocyte damage during osteoarthritis through microRNA-130b-3p-mediated inhibition of the LRP12\/AKT\/Beta-catenin axis","volume":"44","author":"Zeng","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.bcp.2024.116226_b0325","article-title":"Extracellular vesicles from synovial fluid-derived mesenchymal stem cells confer chondroprotective effects on in vitro and in vivo osteoarthritic chondrocytes","volume":"3","author":"Liang","year":"2023","journal-title":"JCJP"},{"key":"10.1016\/j.bcp.2024.116226_b0330","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3892\/ijmm.2020.4840","article-title":"Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR-140-5p overexpressing human dental pulp stem cells","volume":"47","author":"Lin","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0335","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.3390\/ijms24054926","article-title":"Dental pulp stem cell-derived exosomes alleviate mice knee osteoarthritis by inhibiting TRPV4-mediated osteoclast activation","volume":"24","author":"Fu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0340","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13287-017-0632-0","article-title":"Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix","volume":"8","author":"Wang","year":"2017","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0345","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biomaterials.2019.02.006","article-title":"MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis","volume":"200","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2024.116226_b0350","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s13238-021-00860-9","article-title":"Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis","volume":"13","author":"Lei","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.bcp.2024.116226_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2022.151933","article-title":"TGFB1-modified MSC-derived exosome attenuates osteoarthritis by inhibiting PDGF-BB secretion and H-type vessel activity in the subchondral bone","volume":"124","author":"Wang","year":"2022","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bcp.2024.116226_b0360","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1097\/01.blo.0000143818.74887.b1","article-title":"Chondrocyte senescence, joint loading and osteoarthritis","author":"Martin","year":"2004","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bcp.2024.116226_b0365","doi-asserted-by":"crossref","first-page":"B172","DOI":"10.1093\/gerona\/56.4.B172","article-title":"Telomere erosion and senescence in human articular cartilage chondrocytes","volume":"56","author":"Martin","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0370","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.joca.2012.05.009","article-title":"DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes","volume":"20","author":"Rose","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0375","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.joca.2009.09.008","article-title":"Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes","volume":"18","author":"Kim","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0380","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1038\/s41598-023-34825-1","article-title":"Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence","volume":"13","author":"Yagi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0385","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI119526","article-title":"Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints","volume":"100","author":"Lark","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2024.116226_b0390","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1136\/ard.59.6.455","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis","volume":"59","author":"Yoshihara","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0395","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/ard.56.9.542","article-title":"Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific","volume":"56","author":"Freemont","year":"1997","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0400","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.joca.2006.12.008","article-title":"Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages","volume":"15","author":"Plaas","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0405","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.21300","article-title":"Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions","volume":"52","author":"Roach","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0410","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.603598","article-title":"hBMSC-derived extracellular vesicles attenuate IL-1\u03b2-induced catabolic effects on OA-chondrocytes by regulating pro-inflammatory signaling pathways","volume":"8","author":"Li","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bcp.2024.116226_b0415","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1042\/BCJ20180675","article-title":"Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis","volume":"475","author":"Liu","year":"2018","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2024.116226_b0420","doi-asserted-by":"crossref","first-page":"1778883","DOI":"10.1080\/20013078.2020.1778883","article-title":"miR-23a-3p-abundant small extracellular vesicles released from Gelma\/nanoclay hydrogel for cartilage regeneration","volume":"9","author":"Hu","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bcp.2024.116226_b0425","doi-asserted-by":"crossref","first-page":"906","DOI":"10.7150\/thno.20746","article-title":"Mesenchymal Stromal\/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro","volume":"8","author":"Vonk","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2024.116226_b0430","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1177\/1947603513495889","article-title":"The Roles of Mechanical Stresses in the Pathogenesis of Osteoarthritis: Implications for Treatment of Joint Injuries","volume":"4","author":"Buckwalter","year":"2013","journal-title":"Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0435","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","article-title":"Redox and NF-kappaB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0440","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000489739","article-title":"Microvesicles from human adipose tissue-derived mesenchymal stem cells as a new protective strategy in osteoarthritic chondrocytes","volume":"47","author":"Tofi\u00f1o-Vian","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2024.116226_b0445","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22203\/eCM.v021a16","article-title":"Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis","volume":"21","author":"Goldring","year":"2011","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bcp.2024.116226_b0450","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1172\/JCI113823","article-title":"Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes","volume":"82","author":"Goldring","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2024.116226_b0455","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/322547a0","article-title":"Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage","volume":"322","author":"Saklatvala","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2024.116226_b0460","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/03008207.2016.1200566","article-title":"ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP\/p300-driven histone acetyltransferase activity","volume":"58","author":"Otero","year":"2017","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bcp.2024.116226_b0465","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1074\/jbc.M111.265744","article-title":"E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress","volume":"287","author":"Otero","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2024.116226_b0470","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jcb.27289","article-title":"Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells","volume":"120","author":"Sun","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2024.116226_b0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119544","article-title":"TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles","volume":"226","author":"Ruiz","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2024.116226_b0480","first-page":"1881","article-title":"Exosomes from adipose derived stem cells promote chondrogenesis and suppress inflammation by upregulating miR-145 and miR-221","volume":"21","author":"Zhao","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0485","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4155\/fmc-2021-0177","article-title":"Synovial mesenchymal stem cell-derived exosomal miR-320c enhances chondrogenesis by targeting ADAM19","volume":"14","author":"Kong","year":"2022","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bcp.2024.116226_b0490","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1002\/art.23043","article-title":"Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes","volume":"56","author":"Chockalingam","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0495","doi-asserted-by":"crossref","first-page":"e000061","DOI":"10.1136\/rmdopen-2015-000061","article-title":"Pathophysiology of osteoarthritis: canonical NF-kappaB\/IKKbeta-dependent and kinase-independent effects of IKKalpha in cartilage degradation and chondrocyte differentiation","volume":"1","author":"Olivotto","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.bcp.2024.116226_b0500","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4","article-title":"Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3","volume":"43","author":"Mengshol","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0505","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0945-053X(02)00007-0","article-title":"Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes","volume":"21","author":"Liacini","year":"2002","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0510","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41598-020-80032-7","article-title":"Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-kB dependent inflammatory\/catabolic environment of osteoarthritis","volume":"11","author":"Cavallo","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0515","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","article-title":"The NF-kappaB signalling pathway in osteoarthritis","volume":"45","author":"Rigoglou","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110315","article-title":"Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2","volume":"120","author":"Meng","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2024.116226_b0525","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13287-019-1341-7","article-title":"Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p\/mTOR","volume":"10","author":"Luo","year":"2019","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0530","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.berh.2018.03.004","article-title":"Wnt signaling as target for the treatment of osteoarthritis","volume":"31","author":"Stampella","year":"2017","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bcp.2024.116226_b0535","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/iep.12472","article-title":"Wnt signalling in the articular cartilage: A matter of balance","volume":"104","author":"Gill","year":"2023","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.bcp.2024.116226_b0540","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s40744-020-00205-8","article-title":"Review Article: Is Wnt Signaling an Attractive Target for the Treatment of Osteoarthritis?","volume":"7","author":"Lories","year":"2020","journal-title":"Rheumatol Ther"},{"key":"10.1016\/j.bcp.2024.116226_b0545","doi-asserted-by":"crossref","first-page":"9455152","DOI":"10.1155\/2022\/9455152","article-title":"miR-3960 from mesenchymal stem cell-derived extracellular vesicles inactivates SDC1\/Wnt\/beta-catenin axis to relieve chondrocyte injury in osteoarthritis by targeting PHLDA2","volume":"2022","author":"Ye","year":"2022","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bcp.2024.116226_b0550","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/JPR.S291472","article-title":"Exosome-Encapsulated microRNA-127-3p released from bone marrow-derived mesenchymal stem cells alleviates osteoarthritis through regulating CDH11-mediated Wnt\/Beta-catenin pathway","volume":"14","author":"Dong","year":"2021","journal-title":"J. Pain Res."},{"key":"10.1016\/j.bcp.2024.116226_b0555","doi-asserted-by":"crossref","first-page":"22039","DOI":"10.1074\/jbc.M601804200","article-title":"Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes","volume":"281","author":"Ryu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2024.116226_b0560","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.joca.2017.05.018","article-title":"Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes","volume":"25","author":"Huang","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0565","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1210\/me.2010-0037","article-title":"WNT5A regulates chondrocyte differentiation through differential use of the CaN\/NFAT and IKK\/NF-kappaB pathways","volume":"24","author":"Bradley","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116226_b0570","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.joca.2021.06.013","article-title":"An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA","volume":"30","author":"Batushansky","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0575","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11626-019-00330-x","article-title":"Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways","volume":"55","author":"Qi","year":"2019","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.bcp.2024.116226_b0580","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1007\/s12015-022-10436-7","article-title":"BMSCs-derived mitochondria improve osteoarthritis by ameliorating mitochondrial dysfunction and promoting mitochondrial biogenesis in chondrocytes","volume":"18","author":"Yu","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0585","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/ard.59.12.959","article-title":"Apoptosis in normal and osteoarthritic human articular cartilage","volume":"59","author":"Heraud","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0590","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.joca.2007.06.005","article-title":"Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis","volume":"16","author":"Lambrecht","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0595","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15384101.2021.2019411","article-title":"Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis","volume":"21","author":"Wen","year":"2022","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2024.116226_b0600","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1080\/15384101.2018.1526603","article-title":"MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1\/miR-206\/GIT1 axis in osteoarthritis","volume":"17","author":"Liu","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2024.116226_b0605","first-page":"5517648","article-title":"Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Containing Long Noncoding RNA NEAT1 Relieve Osteoarthritis","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2024.116226_b0610","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1186\/s13018-022-03437-2","article-title":"Exosomes derived from miR-338-3p-modified adipose stem cells inhibited inflammation injury of chondrocytes via targeting RUNX2 in osteoarthritis","volume":"17","author":"Li","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bcp.2024.116226_b0615","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/cbin.11657","article-title":"Exosomes from human umbilical cord mesenchymal stem cells inhibit ROS production and cell apoptosis in human articular chondrocytes via the miR-100-5p\/NOX4 axis","volume":"45","author":"Li","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bcp.2024.116226_b0620","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jot.2021.08.003","article-title":"Role of peroxiredoxin 6 in the chondroprotective effects of microvesicles from human adipose tissue-derived mesenchymal stem cells","volume":"30","author":"Guill\u00e9n","year":"2021","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bcp.2024.116226_b0625","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1089\/ars.2015.6336","article-title":"Peroxiredoxin 6 Is a Crucial Factor in the Initial Step of Mitochondrial Clearance and Is Upstream of the PINK1-Parkin Pathway","volume":"24","author":"Ma","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2024.116226_b0630","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10565-020-09559-9","article-title":"Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes","volume":"37","author":"Wang","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bcp.2024.116226_b0635","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12920-019-0649-6","article-title":"MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p\/FOXO1 axis","volume":"12","author":"Wang","year":"2019","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.bcp.2024.116226_b0640","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13578-017-0195-x","article-title":"The lncRNA MEG3 downregulation leads to osteoarthritis progression via miR-16\/SMAD7 axis","volume":"7","author":"Xu","year":"2017","journal-title":"Cell Biosci."},{"key":"10.1016\/j.bcp.2024.116226_b0645","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3892\/ijmm.2015.2114","article-title":"Integrin-beta1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression","volume":"35","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0650","article-title":"Exosomes isolated from bone marrow mesenchymal stem cells exert a protective effect on osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115488","article-title":"Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis","volume":"167","author":"Shen","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2024.116226_b0660","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41420-022-01282-0","article-title":"The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.bcp.2024.116226_b0665","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jot.2020.09.006","article-title":"Chondrocyte ferroptosis contribute to the progression of osteoarthritis","volume":"27","author":"Yao","year":"2021","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.bcp.2024.116226_b0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110566","article-title":"Exosomes derived from mesenchymal stem cells rescue cartilage injury in osteoarthritis through Ferroptosis by GOT1\/CCR2 expression","volume":"122","author":"Peng","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2024.116226_b0675","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI95147","article-title":"Senescent cells and osteoarthritis: a painful connection","volume":"128","author":"Jeon","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2024.116226_b0680","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bcp.2024.116226_b0685","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1474-9728.2002.00008.x","article-title":"The role of chondrocyte senescence in osteoarthritis","volume":"1","author":"Price","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2024.116226_b0690","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/1756-185X.12096","article-title":"Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis","volume":"19","author":"Gao","year":"2016","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0695","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2024.116226_b0700","doi-asserted-by":"crossref","first-page":"e125019","DOI":"10.1172\/jci.insight.125019","article-title":"Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers","volume":"4","author":"Jeon","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bcp.2024.116226_b0705","first-page":"13","article-title":"Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration","author":"Lei","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0710","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.27305","article-title":"Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis","volume":"62","author":"Carames","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0715","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.joca.2017.07.020","article-title":"Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes","volume":"26","author":"Ansari","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0720","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/art.34323","article-title":"Autophagy modulates osteoarthritis-related gene expression in human chondrocytes","volume":"64","author":"Sasaki","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"428","key":"10.1016\/j.bcp.2024.116226_b0725","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan0746","article-title":"FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis","volume":"10","author":"Matsuzaki","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bcp.2024.116226_b0730","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/annrheumdis-2011-200557","article-title":"Autophagy activation by rapamycin reduces severity of experimental osteoarthritis","volume":"71","author":"Carames","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0735","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1136\/annrheumdis-2013-204599","article-title":"Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis","volume":"74","author":"Zhang","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0740","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.joca.2016.09.017","article-title":"Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism","volume":"25","author":"Shen","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0745","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2353\/ajpath.2006.050981","article-title":"Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis","volume":"169","author":"van der","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bcp.2024.116226_b0750","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1086\/375556","article-title":"Genomewide scan for hand osteoarthritis: a novel mutation in matrilin-3","volume":"72","author":"Stef\u00e1nsson","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bcp.2024.116226_b0755","doi-asserted-by":"crossref","first-page":"R197","DOI":"10.1186\/ar4033","article-title":"Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression","volume":"14","author":"Jayasuriya","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0760","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/art.37951","article-title":"Identification of soluble 14-3-3\u03b5 as a novel subchondral bone mediator involved in cartilage degradation in osteoarthritis","volume":"65","author":"Priam","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0765","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bcp.2024.116226_b0770","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.joca.2022.10.002","article-title":"Changes of the subchondral bone microchannel network in early osteoarthritis","volume":"31","author":"Taheri","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0775","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/art.23159","article-title":"Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone","volume":"58","author":"Sanchez","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0780","article-title":"Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bcp.2024.116226_b0785","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3390\/biomedicines10071752","article-title":"Enhancement of Osteoblast Function through Extracellular Vesicles Derived from Adipose-Derived Stem Cells","volume":"10","author":"Ho","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bcp.2024.116226_b0790","doi-asserted-by":"crossref","first-page":"7197598","DOI":"10.1155\/2017\/7197598","article-title":"Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts","volume":"2017","author":"Tofi\u00f1o-Vian","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2024.116226_b0795","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00776-008-1227-5","article-title":"Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone","volume":"13","author":"Sakao","year":"2008","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0800","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1210\/endo.138.6.5192","article-title":"Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation","volume":"138","author":"Tai","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2024.116226_b0805","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI121561","article-title":"Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain","volume":"129","author":"Zhu","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2024.116226_b0810","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.joca.2023.06.005","article-title":"Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis","volume":"31","author":"De Roover","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0815","doi-asserted-by":"crossref","first-page":"12872","DOI":"10.4238\/2015.October.21.7","article-title":"Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Fan","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.bcp.2024.116226_b0820","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3899\/jrheum.130541","article-title":"Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study","volume":"41","author":"Guermazi","year":"2014","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bcp.2024.116226_b0825","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/art.11422","article-title":"Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation","volume":"50","author":"van Lent","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bcp.2024.116226_b0830","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/rheumatology\/kex308","article-title":"Divergent roles of immune cells and their mediators in pain","volume":"57","author":"Raoof","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bcp.2024.116226_b0835","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.joca.2014.05.021","article-title":"Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state","volume":"22","author":"Fahy","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0840","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0845","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678757","article-title":"Synovial macrophages in osteoarthritis: the key to understanding pathogenesis?","volume":"12","author":"Thomson","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2024.116226_b0850","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/stcltm\/szac075","article-title":"Cellular and molecular targets of extracellular vesicles from mesenchymal stem\/stromal cells in rheumatoid arthritis","volume":"11","author":"Alcaraz","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0855","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13287-019-1215-z","article-title":"Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes","volume":"10","author":"Ragni","year":"2019","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0860","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/annrheumdis-2021-221091","article-title":"METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression","volume":"81","author":"Chen","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bcp.2024.116226_b0865","doi-asserted-by":"crossref","first-page":"1198198","DOI":"10.3389\/fimmu.2023.1198198","article-title":"Immunomodulatory potential of mesenchymal stromal cell-derived extracellular vesicles in chondrocyte inflammation","volume":"14","author":"Ossendorff","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2024.116226_b0870","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1162263","article-title":"Engineered extracellular vesicles as therapeutics of degenerative orthopedic diseases","volume":"11","author":"Wei","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bcp.2024.116226_b0875","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40824-023-00468-6","article-title":"Recent advances in extracellular vesicle engineering and its applications to regenerative medicine","volume":"27","author":"Rhim","year":"2023","journal-title":"Biomater Res"},{"key":"10.1016\/j.bcp.2024.116226_b0880","doi-asserted-by":"crossref","first-page":"15178","DOI":"10.3390\/ijms242015178","article-title":"Exosome-Laden Scaffolds for Treatment of Post-Traumatic Cartilage Injury and Osteoarthritis of the Knee: A Systematic Review","volume":"24","author":"Xavier","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0885","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/membranes12020225","article-title":"Hypoxia-Preconditioned Extracellular Vesicles from Mesenchymal Stem Cells Improve Cartilage Repair in Osteoarthritis","volume":"12","author":"Zhang","year":"2022","journal-title":"Membranes (Basel)"},{"key":"10.1016\/j.bcp.2024.116226_b0890","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s10020-023-00709-3","article-title":"Hypoxia-treated adipose mesenchymal stem cell-derived exosomes attenuate lumbar facet joint osteoarthritis","volume":"29","author":"Zhao","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0895","doi-asserted-by":"crossref","first-page":"13414","DOI":"10.3390\/ijms241713414","article-title":"Exosomes derived from hypoxia-cultured human adipose stem cells alleviate articular chondrocyte inflammaging and post-traumatic osteoarthritis progression","volume":"24","author":"Chang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0900","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00441-023-03819-w","article-title":"Higher ratios of chondrocyte to mesenchymal stem cells elevate the therapeutic effects of extracellular vesicles harvested from chondrocyte\/mesenchymal stem cell co-culture on osteoarthritis in a rat model","volume":"394","author":"Hosseinzadeh","year":"2023","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bcp.2024.116226_b0905","doi-asserted-by":"crossref","first-page":"19827","DOI":"10.1038\/s41598-022-22592-4","article-title":"Co-aggregation of MSC\/chondrocyte in a dynamic 3D culture elevates the therapeutic effect of secreted extracellular vesicles on osteoarthritis in a rat model","volume":"12","author":"Esmaeili","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116226_b0910","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/cells8040369","article-title":"Insights into inflammatory priming of adipose-derived mesenchymal stem cells: validation of extracellular vesicles-embedded miRNA reference genes as a crucial step for donor selection","volume":"8","author":"Ragni","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2024.116226_b0915","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13287-021-02507-2","article-title":"Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model","volume":"12","author":"Duan","year":"2021","journal-title":"Stem. Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116226_b0920","doi-asserted-by":"crossref","first-page":"1041592","DOI":"10.3389\/fimmu.2022.1041592","article-title":"Cytokine-primed umbilical cord mesenchymal stem cells enhanced therapeutic effects of extracellular vesicles on osteoarthritic chondrocytes","volume":"13","author":"Nguyen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2024.116226_b0925","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814169","article-title":"Pro-inflammatory cytokine priming and purification method modulate the impact of exosomes derived from equine bone marrow mesenchymal stromal cells on equine articular chondrocytes","volume":"24","author":"Jammes","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b0930","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00441-020-03319-1","article-title":"TGF-B1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6","volume":"384","author":"Wang","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bcp.2024.116226_b0935","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.1111\/jcmm.15714","article-title":"Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124\/NF-kB and miR-143\/ROCK1\/TLR9 signalling pathways","volume":"24","author":"Qiu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2024.116226_b0940","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/dna.2023.0341","article-title":"Exosomes derived from quercetin-treated bone marrow derived mesenchymal stem cells inhibit the progression of osteoarthritis through delivering miR-124-3p to chondrocytes","volume":"43","author":"Dong","year":"2024","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bcp.2024.116226_b0945","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/jfb14040203","article-title":"Tropoelastin-pretreated exosomes from adipose-derived stem cells improve the synthesis of cartilage matrix and alleviate osteoarthritis","volume":"14","author":"Meng","year":"2023","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.bcp.2024.116226_b0950","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2217\/nnm-2019-0208","article-title":"Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair","volume":"15","author":"Liu","year":"2020","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.bcp.2024.116226_b0955","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13075-022-02778-x","article-title":"PTH (1\u201334) enhances the therapeutic effect of bone marrow mesenchymal stem cell-derived exosomes by inhibiting proinflammatory cytokines expression on OA chondrocyte repair in vitro","volume":"24","author":"Shao","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.bcp.2024.116226_b0960","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107824","article-title":"Low-intensity pulsed ultrasound promotes osteoarthritic cartilage regeneration by BMSC-derived exosomes via modulating the NF-kB signaling pathway","volume":"97","author":"Liao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2024.116226_b0965","doi-asserted-by":"crossref","DOI":"10.1177\/19476035221093060","article-title":"Low-intensity pulsed ultrasound enhances the efficacy of bone marrow-derived MSCS in osteoarthritis cartilage repair by regulating autophagy-mediated exosome release","volume":"13","author":"Xia","year":"2022","journal-title":"Cartilage"},{"key":"10.1016\/j.bcp.2024.116226_b0970","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s11658-023-00422-3","article-title":"Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles","volume":"28","author":"Li","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bcp.2024.116226_b0975","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2024.116226_b0980","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104978","article-title":"Human bone mesenchymal stem cells-derived exosomal miRNA-361-5p alleviates osteoarthritis by downregulating DDX20 and inactivating the NF-kB signaling pathway","volume":"113","author":"Tao","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bcp.2024.116226_b0985","first-page":"169","article-title":"Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223\/NLRP3\/pyroptosis axis: Toward a precision therapy","volume":"30","author":"Liu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bcp.2024.116226_b0990","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.actbio.2021.04.003","article-title":"Controlled release of MSC-derived small extracellular vesicles by an injectable Diels-Alder crosslinked hyaluronic acid\/PEG hydrogel for osteoarthritis improvement","volume":"128","author":"Yang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bcp.2024.116226_b0995","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13770-022-00509-6","article-title":"Combinatorial Effect of Mesenchymal Stem Cells and Extracellular Vesicles in a Hydrogel on Cartilage Regeneration","volume":"20","author":"Cho","year":"2023","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.bcp.2024.116226_b1000","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s12951-021-01086-x","article-title":"Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis","volume":"19","author":"Li","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.bcp.2024.116226_b1005","doi-asserted-by":"crossref","first-page":"e12160","DOI":"10.1002\/jev2.12160","article-title":"Reversing the surface charge of MSC-derived small extracellular vesicles by \u03b5PL-PEG-DSPE for enhanced osteoarthritis treatment","volume":"10","author":"Feng","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.bcp.2024.116226_b1010","doi-asserted-by":"crossref","first-page":"e2300315","DOI":"10.1002\/adhm.202300315","article-title":"Treatment with mesenchymal stem cell-derived nanovesicle-containing gelatin methacryloyl hydrogels alleviates osteoarthritis by modulating chondrogenesis and macrophage polarization","volume":"12","author":"Pang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bcp.2024.116226_b1015","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.3390\/ijms21124382","article-title":"Molecular and functional phenotypes of human bone marrow-derived mesenchymal stromal cells depend on harvesting techniques","volume":"21","author":"Walter","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116226_b1020","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jcyt.2022.11.006","article-title":"Impact of storage conditions and duration on function of native and cargo-loaded mesenchymal stromal cell extracellular vesicles","volume":"25","author":"Levy","year":"2023","journal-title":"Cytotherapy"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224002090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224002090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T05:17:45Z","timestamp":1731475065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224002090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":204,"alternative-id":["S0006295224002090"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116226","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Control of articular degeneration by extracellular vesicles from stem\/stromal cells as a potential strategy for the treatment of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116226"}}