{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:46:12Z","timestamp":1764225972026,"version":"3.37.3"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.bcp.2024.116310","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:42:08Z","timestamp":1716360128000},"page":"116310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inhibition of the ATR-DNAPKcs-RB axis drives G1\/S-phase transition and sensitizes triple-negative breast cancer (TNBC) to DNA holliday junctions"],"prefix":"10.1016","volume":"225","author":[{"given":"Yue-miao","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-cun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-wen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-ying","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-ke","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-4089","authenticated-orcid":false,"given":"Qi-kun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2024.116310_b0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41568-022-00535-5","article-title":"Targeting DNA damage response pathways in cancer","volume":"23","author":"Groelly","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2024.116310_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114109","article-title":"Recent advances in DDR (DNA damage response) inhibitors for cancer therapy","volume":"230","author":"Cheng","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116310_b0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1101\/gad.349431.122","article-title":"DNA repair defects in cancer and therapeutic opportunities","volume":"36","author":"Hopkins","year":"2022","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcp.2024.116310_b0020","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrc3891","article-title":"Therapeutic opportunities within the DNA damage response","volume":"15","author":"Pearl","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2024.116310_b0025","doi-asserted-by":"crossref","first-page":"9752","DOI":"10.1021\/acs.jmedchem.0c00917","article-title":"Design, synthesis, and evaluation of new quinazolinone derivatives that inhibit bloom syndrome protein (BLM) helicase, trigger DNA damage at the telomere region, and synergize with PARP inhibitors","volume":"63","author":"Wang","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116310_b0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","article-title":"State-of-the-art strategies for targeting the DNA damage response in cancer","volume":"16","author":"Pili\u00e9","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bcp.2024.116310_b0035","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2011278118","article-title":"SETD2-mediated H3K14 trimethylation promotes ATR activation and stalled replication fork restart in response to DNA replication stress","volume":"118","author":"Zhu","year":"2021","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2024.116310_b0040","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.leukres.2017.08.007","article-title":"3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt","volume":"64","author":"Miyata","year":"2018","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2024.116310_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106162","article-title":"Cell cycle checkpoints and beyond: Exploiting the ATR\/CHK1\/WEE1 pathway for the treatment of PARP inhibitor-resistant cancer","volume":"178","author":"Gupta","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2024.116310_b0050","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/15384101.2017.1412147","article-title":"DNA-PK, ATM, and ATR: PIKKing on p53","volume":"17","author":"Ashley","year":"2018","journal-title":"Cell Cycle (georgetown, Tex)."},{"key":"10.1016\/j.bcp.2024.116310_b0055","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.aap9346","article-title":"An intrinsic S\/G(2) checkpoint enforced by ATR","volume":"361","author":"Saldivar","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bcp.2024.116310_b0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature09350","article-title":"Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint","volume":"467","author":"Liu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2024.116310_b0065","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4143\/crt.2020.080","article-title":"Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer","volume":"52","author":"Nam","year":"2020","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.bcp.2024.116310_b0070","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1158\/0008-5472.CAN-14-2650","article-title":"Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity","volume":"74","author":"Kawasumi","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2024.116310_b0075","doi-asserted-by":"crossref","first-page":"e1009717","DOI":"10.1371\/journal.pgen.1009717","article-title":"Distribution of Holliday junctions and repair forks during Escherichia coli DNA double-strand break repair","volume":"17","author":"Yasmin","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcp.2024.116310_b0080","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tibs.2014.07.003","article-title":"Holliday junction processing enzymes as guardians of genome stability","volume":"39","author":"Sarbajna","year":"2014","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.bcp.2024.116310_b0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41556-017-0011-1","article-title":"Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations","volume":"20","author":"Chan","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116310_b0090","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nature09790","article-title":"Aberrant chromosome morphology in human cells defective for Holliday junction resolution","volume":"471","author":"Wechsler","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2024.116310_b0095","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/gcc.22721","article-title":"The role of fork stalling and DNA structures in causing chromosome fragility","volume":"58","author":"Kaushal","year":"2019","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.bcp.2024.116310_b0100","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nature08868","article-title":"Double Holliday junctions are intermediates of DNA break repair","volume":"464","author":"Bzymek","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2024.116310_b0105","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrm2974","article-title":"Pathways of mammalian replication fork restart","volume":"11","author":"Petermann","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116310_b0110","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1002\/anie.200603760","article-title":"Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule","volume":"46","author":"Brogden","year":"2007","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bcp.2024.116310_b0115","doi-asserted-by":"crossref","first-page":"12636","DOI":"10.1093\/nar\/gkac1043","article-title":"Interactions of small molecules with DNA junctions","volume":"50","author":"McQuaid","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2024.116310_b0120","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.tig.2019.03.001","article-title":"Tools To Live By: Bacterial DNA Structures Illuminate Cancer","volume":"35","author":"Xia","year":"2019","journal-title":"Trends Genet."},{"key":"10.1016\/j.bcp.2024.116310_b0125","article-title":"DNA Holliday junction: history, regulation and bioactivity","volume":"23","author":"Song","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116310_b0130","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.jmedchem.7b00099","article-title":"New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription","volume":"60","author":"Liu","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116310_b0135","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1021\/acs.jmedchem.7b00421","article-title":"Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2\/G-Quadruplex Interaction","volume":"60","author":"Wang","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116310_b0140","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1534\/genetics.119.302193","article-title":"ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans","volume":"212","author":"Li","year":"2019","journal-title":"Genetics"},{"key":"10.1016\/j.bcp.2024.116310_b0145","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1021\/jm301859s","article-title":"Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity","volume":"56","author":"Foote","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116310_b0150","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1158\/0008-5472.CAN-21-2997","article-title":"ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib","volume":"82","author":"Wilson","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2024.116310_b0155","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1038\/s41467-021-27057-2","article-title":"ATR inhibition enables complete tumour regression in ALK-driven NB mouse models","volume":"12","author":"Szydzik","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2024.116310_b0160","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nsmb.2076","article-title":"A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations","volume":"18","author":"Toledo","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bcp.2024.116310_b0165","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1038\/cddis.2012.181","article-title":"Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation","volume":"3","author":"Fokas","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2024.116310_b0170","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1158\/0008-5472.CAN-13-0110","article-title":"ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status","volume":"73","author":"Huntoon","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2024.116310_b0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1158\/0008-5472.CAN-18-1733","article-title":"Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-\u03baB","volume":"79","author":"Aasland","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2024.116310_b0180","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ncb1969","article-title":"NEK11 regulates CDC25A degradation and the IR-induced G2\/M checkpoint","volume":"11","author":"Melixetian","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116310_b0185","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1016\/j.celrep.2017.09.007","article-title":"Controlling Depth of Cellular Quiescence by an Rb-E2F Network Switch","volume":"20","author":"Kwon","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2024.116310_b0190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/ncb1711","article-title":"A bistable Rb-E2F switch underlies the restriction point","volume":"10","author":"Yao","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116310_b0195","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/cr.2017.158","article-title":"Cryo-EM structure of human ATR-ATRIP complex","volume":"28","author":"Rao","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2024.116310_b0200","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41586-021-04274-9","article-title":"Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs","volume":"601","author":"Liang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2024.116310_b0205","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ccell.2015.06.004","article-title":"DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis","volume":"28","author":"Goodwin","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2024.116310_b0210","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.trecan.2018.09.007","article-title":"Synthetically Lethal Interactions of ATM, ATR, and DNA-PKcs","volume":"4","author":"Kantidze","year":"2018","journal-title":"Trends Cancer."},{"key":"10.1016\/j.bcp.2024.116310_b0215","doi-asserted-by":"crossref","first-page":"14597","DOI":"10.1038\/s41598-019-51071-6","article-title":"DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells","volume":"9","author":"Mladenov","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116310_b0220","doi-asserted-by":"crossref","first-page":"e3072","DOI":"10.21769\/BioProtoc.3072","article-title":"mRNA Stability Assay Using transcription inhibition by Actinomycin D in Mouse Pluripotent Stem Cells","volume":"8","author":"Ratnadiwakara","year":"2018","journal-title":"Bio-Protocol."},{"key":"10.1016\/j.bcp.2024.116310_b0225","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1158\/1078-0432.CCR-22-0568","article-title":"Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance","volume":"28","author":"Serra","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2024.116310_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114767","article-title":"VE-822, a novel DNA Holliday junction stabilizer, inhibits homologous recombination repair and triggers DNA damage response in osteogenic sarcomas","volume":"193","author":"Yin","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116310_b0235","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/acs.jmedchem.9b00083","article-title":"Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM\/DNA Interactions and Regulate the Homologous Recombination Repair","volume":"62","author":"Yin","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116310_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107492","article-title":"Role of Rad51 and DNA repair in cancer: A molecular perspective","volume":"208","author":"Laurini","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2024.116310_b0245","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.634789","article-title":"Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?","volume":"12","author":"Kaur","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.bcp.2024.116310_b0250","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1101\/gad.238303.114","article-title":"Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe","volume":"28","author":"Sarbajna","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcp.2024.116310_b0255","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2024.116310_b0260","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1158\/0008-5472.CAN-03-3207","article-title":"ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation","volume":"64","author":"Stiff","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2024.116310_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2021.08.004","article-title":"A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells","volume":"29","author":"Xu","year":"2022","journal-title":"Cell Chem. Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224002934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224002934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T03:40:17Z","timestamp":1718854817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224002934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":53,"alternative-id":["S0006295224002934"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116310","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of the ATR-DNAPKcs-RB axis drives G1\/S-phase transition and sensitizes triple-negative breast cancer (TNBC) to DNA holliday junctions","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116310"}}