{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:23:47Z","timestamp":1790022227782,"version":"4.0.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bcp.2024.116344","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T16:30:41Z","timestamp":1717777841000},"page":"116344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["A 14-amino acid cationic peptide Bolespleenin334-347 from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential"],"prefix":"10.1016","volume":"226","author":[{"given":"Yuqi","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Zhan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-9956","authenticated-orcid":false,"given":"Ke-Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bcp.2024.116344_b0005","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/cid\/ciw217","article-title":"Implementing an antibiotic stewardship program: guidelines by the infectious diseases society of america and the society for healthcare epidemiology of America","volume":"62","author":"Barlam","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bcp.2024.116344_b0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mib.2019.10.008","article-title":"Antibiotics: past, present and future","volume":"51","author":"Hutchings","year":"2019","journal-title":"Curr. Opin. Microbiol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116344_b0015","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/1040841X.2020.1813687","article-title":"Antimicrobial resistance: more than 70 years of war between humans and bacteria","volume":"46","author":"Nadeem","year":"2020","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0020","first-page":"199","article-title":"Staphylococcus aureus-associated skin and soft tissue infections: anatomical localization, epidemiology, therapy and potential prophylaxis","volume":"409","author":"Olaniyi","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116344_b0025","doi-asserted-by":"crossref","first-page":"E1045","DOI":"10.1093\/cid\/ciaa1717","article-title":"Staphylococcus aureus skin and soft tissue infection recurrence rates in outpatients: a retrospective database study at 3 US medical centers","volume":"73","author":"Vella","year":"2021","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.bcp.2024.116344_b0030","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1468-3083.2011.04416.x","article-title":"Bacterial skin and soft tissue infections: review of the epidemiology, microbiology, aetiopathogenesis and treatment: a collaboration between dermatologists and infectivologists","volume":"26","author":"Tognetti","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.bcp.2024.116344_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2024.01.004","article-title":"Infection prevention\u2014how can we prevent transmission of community-onset methicillin-resistant Staphylococcus aureus?","author":"Kao","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"issue":"3","key":"10.1016\/j.bcp.2024.116344_b0040","doi-asserted-by":"crossref","first-page":"616-+","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"David","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"issue":"7","key":"10.1016\/j.bcp.2024.116344_b0045","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1056\/NEJMoa055356","article-title":"aureus infections among patients in the emergency department","volume":"355","author":"Moran","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bcp.2024.116344_b0050","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1128\/CMR.00112-16","article-title":"Current and emerging topical antibacterials and antiseptics: agents, action, and resistance patterns","volume":"30","author":"Williamson","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.bcp.2024.116344_b0055","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijantimicag.2013.05.008","article-title":"Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model","volume":"42","author":"Lundberg","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"12","key":"10.1016\/j.bcp.2024.116344_b0060","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.disamonth.2008.09.002","article-title":"Antimicrobial agents in treatment of MRSA infections","volume":"54","author":"Johnson","year":"2008","journal-title":"Dis. Mon."},{"issue":"4","key":"10.1016\/j.bcp.2024.116344_b0065","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116344_b0070","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1007\/s10311-021-01274-z","article-title":"The impact of human vaccines on bacterial antimicrobial resistance a review","volume":"19","author":"Jansen","year":"2021","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.bcp.2024.116344_b0075","article-title":"Antibiotic use in agriculture: background and legislation","author":"Becker","year":"2010","journal-title":"Congress. Res. Ser."},{"key":"10.1016\/j.bcp.2024.116344_b0080","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1469-0691.2006.01527.x","article-title":"Impact of antibiotic restrictions: the ethical perspective","volume":"12","author":"Garau","year":"2006","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bcp.2024.116344_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118407","article-title":"Antimicrobial peptides - advances in development of therapeutic applications","volume":"260","author":"Luong","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2024.116344_b0090","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jcis.2018.10.103","article-title":"Membrane targeting cationic antimicrobial peptides","volume":"537","author":"Ciumac","year":"2019","journal-title":"J. Colloid Interface Sci."},{"issue":"5","key":"10.1016\/j.bcp.2024.116344_b0095","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01418-16","article-title":"Cathelicidin antimicrobial peptides with reduced activation of toll-like receptor signaling have potent bactericidal activity against colistin-resistant bacteria","volume":"7","author":"Kao","year":"2016","journal-title":"MBio"},{"issue":"4","key":"10.1016\/j.bcp.2024.116344_b0100","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000336619","article-title":"\u03b2-defensins: multifunctional modulators of infection, inflammation and more?","volume":"4","author":"Semple","year":"2012","journal-title":"J. Innate Immun."},{"issue":"1","key":"10.1016\/j.bcp.2024.116344_b0105","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1016\/j.cub.2015.11.017","article-title":"Antimicrobial peptides","volume":"26","author":"Zhang","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bcp.2024.116344_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2016.00194","article-title":"Antimicrobial peptides : an emerging category of therapeutic agents","volume":"6","author":"Mahlapuu","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00281","article-title":"Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds","volume":"9","author":"Pfalzgraff","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116344_b0120","article-title":"Antimicrobial peptides: a novel and promising arsenal against methicillin-resistant Staphylococcus aureus (MRSA) infections","author":"Odunitan","year":"2023","journal-title":"Pharm. Sci. Adv."},{"key":"10.1016\/j.bcp.2024.116344_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114135","article-title":"Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens","volume":"231","author":"Lin","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"24","key":"10.1016\/j.bcp.2024.116344_b0130","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2174\/1568026618666181022140348","article-title":"Antimicrobial activity of different antimicrobial peptides (AMPs) against clinical methicillin-resistant Staphylococcus aureus (MRSA)","volume":"18","author":"Ciandrini","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bcp.2024.116344_b0135","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-981-13-3588-4_15","article-title":"Clinical Application of AMPs","volume":"1117","author":"Costa","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"12","key":"10.1016\/j.bcp.2024.116344_b0140","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/nbt1211-1066b","article-title":"Antimicrobial peptides stage a comeback (vol 31, pg 379, 2013)","volume":"31","author":"Fox","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116344_b0145","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1039\/D0CS01026J","article-title":"Chemically modified and conjugated antimicrobial peptides against superbugs","volume":"50","author":"Li","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bcp.2024.116344_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2021.170666","article-title":"Chemical modifications to increase the therapeutic potential of antimicrobial peptides","volume":"146","author":"Han","year":"2021","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.bcp.2024.116344_b0155","doi-asserted-by":"crossref","DOI":"10.1039\/D3NP00031A","article-title":"Embracing the era of antimicrobial peptides with marine organisms","volume":"41","author":"Chen","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bcp.2024.116344_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2022.1112595","article-title":"Antimicrobial peptides from marine animals: sources, structures, mechanisms and the potential for drug development","volume":"9","author":"Wang","year":"2023","journal-title":"Front. Mar. Sci."},{"issue":"38","key":"10.1016\/j.bcp.2024.116344_b0165","doi-asserted-by":"crossref","first-page":"10319","DOI":"10.1016\/j.biomaterials.2013.09.037","article-title":"Use of the antimicrobial peptide Epinecidin-1 to protect against MRSA infection in mice with skin injuries","volume":"34","author":"Huang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2024.116344_b0170","article-title":"Therapeutic utility of the antimicrobial peptide Tilapia Piscidin 4 (TP4)","volume":"17","author":"Hazam","year":"2020","journal-title":"Aquacult. Rep."},{"key":"10.1016\/j.bcp.2024.116344_b0175","series-title":"Fishes of the World","author":"Nelson","year":"2016"},{"issue":"11","key":"10.1016\/j.bcp.2024.116344_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/md15110364","article-title":"High-throughput identification of antimicrobial peptides from amphibious mudskippers","volume":"15","author":"Yi","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bcp.2024.116344_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.752637","article-title":"The long-term effect of a nine amino-acid antimicrobial peptide AS-hepc3(48\u201356) Against Pseudomonas aeruginosa with no detectable resistance","volume":"11","author":"Zhu","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0190","article-title":"A truncated peptide Spgillcin177-189 derived from mud crab Scylla paramamosain exerting multiple antibacterial activities","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.572849","article-title":"The synergistic effect of mud crab antimicrobial peptides sphistin and Sph12-38 with antibiotics azithromycin and rifampicin enhances bactericidal activity against pseudomonas aeruginosa","volume":"10","author":"Liu","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0200","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3389\/fmicb.2020.01589","article-title":"A novel antimicrobial peptide Scyreprocin from mud crab Scylla paramamosain showing potent antifungal and anti-biofilm activity","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fmicb.2017.00051","article-title":"Comparative analysis of the bacterial membrane disruption effect of two natural plant antimicrobial peptides","volume":"8","author":"Farkas","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115917","article-title":"A novel antimicrobial peptide Scyreptin1-30 from Scylla paramamosain exhibiting potential therapy of Pseudomonas aeruginosa early infection in a mouse burn wound model","volume":"218","author":"Zhang","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116344_b0215","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1128\/AAC.49.8.3435-3441.2005","article-title":"Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes","volume":"49","author":"Kugelberg","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2024.116344_b0220","doi-asserted-by":"crossref","unstructured":"M. Krishnan, J. Choi, A. Jang, S. Choi, J. Yeon, M. Jang, Y. Lee, K. Son, S.Y. Shin, M.S. Jeong, Y. Kim, Molecular mechanism underlying the TLR4 antagonistic and antiseptic activities of papiliocin, an insect innate immune response molecule, Proceedings of the National Academy of Sciences 119(10) (2022).","DOI":"10.1073\/pnas.2115669119"},{"issue":"D1","key":"10.1016\/j.bcp.2024.116344_b0225","doi-asserted-by":"crossref","first-page":"D894","DOI":"10.1093\/nar\/gkx1157","article-title":"aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance","volume":"46","author":"Rajput","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.bcp.2024.116344_b0230","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jinf.2020.10.016","article-title":"Developing new therapeutic approaches for treating infections caused by multi-drug resistant Acinetobacter baumannii: acinetobacter baumannii therapeutics","volume":"81","author":"Gallagher","year":"2020","journal-title":"J. Infect."},{"issue":"6","key":"10.1016\/j.bcp.2024.116344_b0235","article-title":"The human LL-37 peptide exerts antimicrobial activity against Legionella micdadei interacting with membrane phospholipids","volume":"1867","author":"Palusinska-Szysz","year":"2022","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids"},{"issue":"5","key":"10.1016\/j.bcp.2024.116344_b0240","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbamem.2015.11.004","article-title":"Gram-positive bacterial cell envelopes: the impact on the activity of antimicrobial peptides","volume":"1858","author":"Malanovic","year":"2016","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"issue":"5","key":"10.1016\/j.bcp.2024.116344_b0245","article-title":"Oxidative stress-generating antimicrobials, a novel strategy to overcome antibacterial resistance","volume":"9","author":"Mourenza","year":"2020","journal-title":"Antioxidants-Basel"},{"key":"10.1016\/j.bcp.2024.116344_b0250","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijbiomac.2022.06.043","article-title":"Plant antimicrobial peptides: an overview about classification, toxicity and clinical applications","volume":"214","author":"Lima","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"D1","key":"10.1016\/j.bcp.2024.116344_b0255","doi-asserted-by":"crossref","first-page":"D1087","DOI":"10.1093\/nar\/gkv1278","article-title":"APD3: the antimicrobial peptide database as a tool for research and education","volume":"44","author":"Wang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2024.116344_b0260","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6594","article-title":"Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes","volume":"5","author":"You","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2024.116344_b0265","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1006\/rwos.2001.0017","article-title":"Intertidal fishes","volume":"3","author":"Gibson","year":"2001","journal-title":"Encycl. Ocean Sci."},{"key":"10.1016\/j.bcp.2024.116344_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162875","article-title":"The diversification of the antimicrobial peptides from marine worms is driven by environmental conditions","volume":"879","author":"Bruno","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bcp.2024.116344_b0275","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fsi.2016.07.025","article-title":"Cloning and expression of two hepcidin genes in the mudskipper (Boleophthalmus pectinirostris) provides insights into their roles in male reproductive immunity","volume":"56","author":"Li","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"22","key":"10.1016\/j.bcp.2024.116344_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213707","article-title":"Expression of antimicrobic peptide piscidin1 in gills mast cells of giant mudskipper periophthalmodon schlosseri (Pallas, 1770)","volume":"23","author":"Alesci","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116344_b0285","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.plipres.2011.12.005","article-title":"Role of lipids in the interaction of antimicrobial peptides with membranes","volume":"51","author":"Teixeira","year":"2012","journal-title":"Prog. Lipid Res."},{"issue":"6","key":"10.1016\/j.bcp.2024.116344_b0290","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/acs.accounts.6b00074","article-title":"How membrane-active peptides get into lipid membranes","volume":"49","author":"Sani","year":"2016","journal-title":"Acc. Chem. Res."},{"issue":"24","key":"10.1016\/j.bcp.2024.116344_b0295","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1016\/j.febslet.2015.11.002","article-title":"Role of arginine and lysine in the antimicrobial mechanism of histone-derived antimicrobial peptides","volume":"589","author":"Cutrona","year":"2015","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bcp.2024.116344_b0300","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/1570180814666170213161341","article-title":"Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity","volume":"15","author":"Mollica","year":"2018","journal-title":"Lett. Drug Des. Discovery"},{"issue":"4","key":"10.1016\/j.bcp.2024.116344_b0305","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1002\/agt2.329","article-title":"The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency: special issue: emerging investigators","volume":"4","author":"Lin","year":"2023","journal-title":"Aggregate"},{"issue":"40","key":"10.1016\/j.bcp.2024.116344_b0310","doi-asserted-by":"crossref","first-page":"11906","DOI":"10.1021\/jp405418y","article-title":"The different interactions of lysine and arginine side chains with lipid membranes","volume":"117","author":"Li","year":"2013","journal-title":"J. Phys. Chem. B"},{"issue":"11","key":"10.1016\/j.bcp.2024.116344_b0315","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1021\/la200917y","article-title":"Physicochemical mechanism for the enhanced ability of lipid membrane penetration of polyarginine","volume":"27","author":"Takechi","year":"2011","journal-title":"Langmuir"},{"issue":"3","key":"10.1016\/j.bcp.2024.116344_b0320","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrmicro2095","article-title":"Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations","volume":"7","author":"Melo","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116344_b0325","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jmedchem.6b01243","article-title":"Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria","volume":"60","author":"Dharmaraja","year":"2017","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2024.116344_b0330","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/1574-6976.12026","article-title":"Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy, and beyond","volume":"37","author":"Vatansever","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2024.116344_b0335","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tim.2004.11.010","article-title":"Survival strategies of infectious biofilms","volume":"13","author":"Fux","year":"2005","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0340","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1042\/BJ20141251","article-title":"Mechanisms of biofilm inhibition and degradation by antimicrobial peptides","volume":"468","author":"Segev-Zarko","year":"2015","journal-title":"Biochem. J"},{"issue":"6","key":"10.1016\/j.bcp.2024.116344_b0345","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10061239","article-title":"Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria","volume":"10","author":"Sionov","year":"2022","journal-title":"Microorganisms"},{"issue":"3\u20134","key":"10.1016\/j.bcp.2024.116344_b0350","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/1098-2299(200007\/08)50:3\/4<440::AID-DDR27>3.0.CO;2-4","article-title":"Peptide-based antibiotics: a potential answer to raging antimicrobial resistance","volume":"50","author":"Mor","year":"2000","journal-title":"Drug Dev. Res."},{"issue":"12","key":"10.1016\/j.bcp.2024.116344_b0355","doi-asserted-by":"crossref","DOI":"10.3390\/ma11122468","article-title":"Action of antimicrobial peptides against bacterial biofilms","volume":"11","author":"Yasir","year":"2018","journal-title":"Materials"},{"issue":"1","key":"10.1016\/j.bcp.2024.116344_b0360","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-023-02886-x","article-title":"In vitro and in vivo antibiofilm activity of the synthetic antimicrobial peptide WLBU2 against multiple drug resistant Pseudomonas aeruginosa strains","volume":"23","author":"Masihzadeh","year":"2023","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.bcp.2024.116344_b0365","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.3389\/fmicb.2020.01532","article-title":"Antimicrobial peptide cec4 eradicates the bacteria of clinical carbapenem-resistant acinetobacter baumannii biofilm","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116344_b0370","doi-asserted-by":"crossref","DOI":"10.3390\/biom8010004","article-title":"Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo","volume":"8","author":"Kumar","year":"2018","journal-title":"Biomolecules"},{"issue":"13","key":"10.1016\/j.bcp.2024.116344_b0375","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1021\/acs.jmedchem.9b00657","article-title":"Positive charge patterning and hydrophobicity of membrane-active antimicrobial peptides as determinants of activity toxicity, and pharmacokinetic stability","volume":"62","author":"Stone","year":"2019","journal-title":"J. Med. Chem."},{"issue":"13","key":"10.1016\/j.bcp.2024.116344_b0380","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1039\/D0CS00729C","article-title":"The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions","volume":"50","author":"Gan","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.bcp.2024.116344_b0385","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0092-8674(00)81099-5","article-title":"Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid","volume":"85","author":"Smith","year":"1996","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bcp.2024.116344_b0390","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.etap.2013.06.009","article-title":"Melittin: a lytic peptide with anticancer properties","volume":"36","author":"Gajski","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116344_b0395","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00195","article-title":"Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?","volume":"3","author":"Brender","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2024.116344_b0400","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1086\/519470","article-title":"Limitations of vancomycin in the management of resistant staphylococcal infections","volume":"45","author":"Kollef","year":"2007","journal-title":"Clin. Infect. Dis."},{"issue":"5","key":"10.1016\/j.bcp.2024.116344_b0405","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/biof.1225","article-title":"Unique features of human cathelicidin LL-37","volume":"41","author":"Bandurska","year":"2015","journal-title":"Biofactors"},{"issue":"12","key":"10.1016\/j.bcp.2024.116344_b0410","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/593185","article-title":"Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized controlled, double-blinded, multicenter trial of pexiganan cream","volume":"47","author":"Lipsky","year":"2008","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2024.116344_b0415","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrd3591","article-title":"Designing antimicrobial peptides: form follows function","volume":"11","author":"Fjell","year":"2012","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T20:10:42Z","timestamp":1728331842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224003277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":83,"alternative-id":["S0006295224003277"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116344","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A 14-amino acid cationic peptide Bolespleenin334-347 from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116344"}}