{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:02:21Z","timestamp":1793646141714,"version":"4.5.1"},"reference-count":207,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172971"],"award-info":[{"award-number":["82172971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bcp.2024.116348","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T19:20:40Z","timestamp":1717788040000},"page":"116348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Insight into the structure, function and the tumor suppression effect of gasdermin E"],"prefix":"10.1016","volume":"226","author":[{"given":"Yuge","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0005","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2023.02.021","article-title":"Mitochondrial pores at the crossroad between cell death and inflammatory signaling","volume":"83","author":"Flores-Romero","year":"2023","journal-title":"Mol Cell"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0010","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s003350010138","article-title":"Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells","volume":"11","author":"Saeki","year":"2000","journal-title":"Mamm Genome"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0015","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41575-023-00743-w","article-title":"The gasdermin protein family: emerging roles in gastrointestinal health and disease","volume":"20","author":"Privitera","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0020","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.3390\/ijms22052412","article-title":"Genetics and Epigenetics in Asthma","volume":"22","author":"Ntontsi","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"46","key":"10.1016\/j.bcp.2024.116348_b0025","doi-asserted-by":"crossref","first-page":"13132","DOI":"10.1073\/pnas.1610433113","article-title":"GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation","volume":"113","author":"Das","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4168\/aair.2015.7.2.175","article-title":"The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis","volume":"7","author":"Zhao","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0035","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.0022-202X.2005.23623.x","article-title":"Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland","volume":"124","author":"Lunny","year":"2005","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jdermsci.2012.05.001","article-title":"Gsdma 3(I359N) is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis","volume":"67","author":"Kumar","year":"2012","journal-title":"J Dermatol Sci"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0045","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.3390\/ijms21113951","article-title":"DFNA5 (GSDME) c.991-15_991-13delTTC: Founder Mutation or Mutational Hotspot?","volume":"21","author":"Booth","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0050","doi-asserted-by":"crossref","first-page":"e12915","DOI":"10.1111\/cpr.12915","article-title":"Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis","volume":"53","author":"Wu","year":"2020","journal-title":"Cell Prolif"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0055","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/jmg.2003.015073","article-title":"DFNA5: hearing impairment exon instead of hearing impairment gene?","volume":"41","author":"Van Laer","year":"2004","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/genes13010149","article-title":"Novel Pathogenic Variants in PJVK, the Gene Encoding Pejvakin, in Subjects with Autosomal Recessive Non-Syndromic Hearing Impairment and Auditory Neuropathy Spectrum Disorder","volume":"13","author":"Dom\u00ednguez-Ruiz","year":"2022","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bcp.2024.116348_b0065","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat Commun"},{"issue":"7610","key":"10.1016\/j.bcp.2024.116348_b0070","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"7897","key":"10.1016\/j.bcp.2024.116348_b0075","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-021-04384-4","article-title":"Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis","volume":"602","author":"Deng","year":"2022","journal-title":"Nature"},{"issue":"6494","key":"10.1016\/j.bcp.2024.116348_b0080","doi-asserted-by":"crossref","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0085","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1038\/s41418-023-01211-3","article-title":"Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage","volume":"30","author":"Li","year":"2023","journal-title":"Cell Death Differ"},{"issue":"10","key":"10.1016\/j.bcp.2024.116348_b0090","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41556-020-0575-z","article-title":"PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis","volume":"22","author":"Hou","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0095","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41422-021-00506-9","article-title":"The metabolite \u03b1-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8","volume":"31","author":"Zhang","year":"2021","journal-title":"Cell Res"},{"issue":"7575","key":"10.1016\/j.bcp.2024.116348_b0100","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0105","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 inflammasome in cancer and metabolic diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat Immunol"},{"issue":"6418","key":"10.1016\/j.bcp.2024.116348_b0110","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.bcp.2024.116348_b0115","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1016\/j.celrep.2019.05.065","article-title":"Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation","volume":"27","author":"Burgener","year":"2019","journal-title":"Cell Rep"},{"issue":"7575","key":"10.1016\/j.bcp.2024.116348_b0120","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bcp.2024.116348_b0125","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res"},{"issue":"46","key":"10.1016\/j.bcp.2024.116348_b0130","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0135","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.bcp.2024.116348_b0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.661162","article-title":"Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation","volume":"12","author":"Fischer","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.bcp.2024.116348_b0145","doi-asserted-by":"crossref","first-page":"1178662","DOI":"10.3389\/fimmu.2023.1178662","article-title":"Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors","volume":"14","author":"Dai","year":"2023","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.bcp.2024.116348_b0150","doi-asserted-by":"crossref","first-page":"e102065","DOI":"10.15252\/embj.2019102065","article-title":"Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases","volume":"38","author":"Gram","year":"2019","journal-title":"Embo j"},{"issue":"7799","key":"10.1016\/j.bcp.2024.116348_b0155","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating anti-tumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.bcp.2024.116348_b0160","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embj.201694696","article-title":"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death","volume":"35","author":"Sborgi","year":"2016","journal-title":"Embo j"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0165","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","article-title":"Innate immunity to intracellular LPS","volume":"20","author":"Rathinam","year":"2019","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a036400","article-title":"Mechanism and Regulation of Gasdermin-Mediated Cell Death","volume":"12","author":"Xia","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0175","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/cr.2015.124","article-title":"Gasdermin D: the long-awaited executioner of pyroptosis","volume":"25","author":"Man","year":"2015","journal-title":"Cell Res"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bj.2017.10.002","article-title":"Gasdermin: A new player to the inflammasome game","volume":"40","author":"Ramos-Junior","year":"2017","journal-title":"Biomed J"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0185","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13046-022-02533-9","article-title":"OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis","volume":"41","author":"Di","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0190","doi-asserted-by":"crossref","first-page":"717","DOI":"10.7150\/ijbs.64350","article-title":"Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway","volume":"18","author":"Liu","year":"2022","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.bcp.2024.116348_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.855828","article-title":"Gasdermin E: A Prospective Target for Therapy of Diseases","volume":"13","author":"Liao","year":"2022","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0200","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/00220345211073072","article-title":"GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer","volume":"101","author":"Wang","year":"2022","journal-title":"J Dent Res"},{"issue":"Pt 2","key":"10.1016\/j.bcp.2024.116348_b0205","article-title":"The pyroptotic role of Caspase-3\/GSDME signalling pathway among various cancer: A Review","volume":"242","author":"Bhat","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"7661","key":"10.1016\/j.bcp.2024.116348_b0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0215","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41419-020-2476-2","article-title":"Chemotherapy-induced pyroptosis is mediated by BAK\/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0220","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: Effectors of Pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/jhg.2009.114","article-title":"Evidence for a founder mutation causing DFNA5 hearing loss in East Asians","volume":"55","author":"Park","year":"2010","journal-title":"J Hum Genet"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0230","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0888-7543(03)00175-7","article-title":"A 3-nucleotide deletion in the polypyrimidine tract of intron 7 of the DFNA5 gene causes nonsyndromic hearing impairment in a Chinese family","volume":"82","author":"Yu","year":"2003","journal-title":"Genomics"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0235","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10038-007-0137-2","article-title":"A novel DFNA5 mutation does not cause hearing loss in an Iranian family","volume":"52","author":"Van Laer","year":"2007","journal-title":"J Hum Genet"},{"key":"10.1016\/j.bcp.2024.116348_b0240","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41420-020-00349-0","article-title":"The caspase-3\/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer","volume":"6","author":"Jiang","year":"2020","journal-title":"Cell Death Discov"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0245","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/hmg\/4.11.2159","article-title":"Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15","volume":"4","author":"van Camp","year":"1995","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0250","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000484798","article-title":"Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea","volume":"5","author":"Van Laer","year":"1997","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0255","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/2503","article-title":"Nonsyndromic hearing impairment is associated with a mutation in DFNA5","volume":"20","author":"Van Laer","year":"1998","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0260","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/ejhg.2011.63","article-title":"The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein","volume":"19","author":"Op de Beeck","year":"2011","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.bcp.2024.116348_b0265","article-title":"Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bcp.2024.116348_b0270","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fonc.2012.00077","article-title":"The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae","volume":"2","author":"Van Rossom","year":"2012","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0275","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41419-021-03431-2","article-title":"Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation","volume":"12","author":"Xia","year":"2021","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0280","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00210-019-01674-7","article-title":"The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers","volume":"392","author":"Li","year":"2019","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"7610","key":"10.1016\/j.bcp.2024.116348_b0285","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0290","doi-asserted-by":"crossref","first-page":"e0273921","DOI":"10.1128\/mbio.02739-21","article-title":"Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 Fragment","volume":"13","author":"Shi","year":"2022","journal-title":"MBio"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0295","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20150204","article-title":"Loss of conserved Gsdma3 self-regulation causes autophagy and cell death","volume":"468","author":"Shi","year":"2015","journal-title":"Biochem J"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188635","article-title":"The multifaceted roles of gasdermins in cancer biology and oncologic therapies","volume":"1876","author":"Sarri\u00f3","year":"2021","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"18 Pt B","key":"10.1016\/j.bcp.2024.116348_b0305","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/j.jmb.2018.07.002","article-title":"Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death","volume":"430","author":"Feng","year":"2018","journal-title":"J Mol Biol"},{"issue":"6417","key":"10.1016\/j.bcp.2024.116348_b0310","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aar7607","article-title":"ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation","volume":"362","author":"R\u00fchl","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0315","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.immuni.2020.02.012","article-title":"Mitochondrial GSDMD Pores DAMPen Pyroptosis","volume":"52","author":"Barnett","year":"2020","journal-title":"Immunity"},{"issue":"64","key":"10.1016\/j.bcp.2024.116348_b0320","doi-asserted-by":"crossref","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","article-title":"NLRP3 inflammasome activation triggers gasdermin D-independent inflammation","volume":"6","author":"Wang","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.bcp.2024.116348_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2023.127383","article-title":"Gasdermin D kills bacteria","volume":"272","author":"Salami","year":"2023","journal-title":"Microbiol Res"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0330","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41590-023-01526-w","article-title":"Molecular mechanisms of gasdermin D pore-forming activity","volume":"24","author":"Devant","year":"2023","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0335","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1038\/s41467-019-09753-2","article-title":"Caspase-1 initiates apoptosis in the absence of gasdermin D","volume":"10","author":"Tsuchiya","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.bcp.2024.116348_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109595","article-title":"Pyroptosis: A new frontier in cancer","volume":"121","author":"Fang","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0345","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0966-842X(00)01945-4","article-title":"Dismantling the Cryptococcus coat","volume":"9","author":"D'Souza","year":"2001","journal-title":"Trends Microbiol"},{"issue":"16","key":"10.1016\/j.bcp.2024.116348_b0350","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1016\/S0021-9258(17)38364-3","article-title":"Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process","volume":"261","author":"Friedlander","year":"1986","journal-title":"J Biol Chem"},{"issue":"6382","key":"10.1016\/j.bcp.2024.116348_b0355","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/358167a0","article-title":"Shigella flexneri induces apoptosis in infected macrophages","volume":"358","author":"Zychlinsky","year":"1992","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0360","doi-asserted-by":"crossref","first-page":"e05503","DOI":"10.1016\/j.heliyon.2020.e05503","article-title":"Pyroptotic cell death by exposure to 1-butanol in H9c2 cardiomyoblastoma cells","volume":"6","author":"Noritake","year":"2020","journal-title":"Heliyon"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0365","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0370","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.mib.2013.04.004","article-title":"Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection","volume":"16","author":"Aachoui","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bcp.2024.116348_b0375","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-immunol-073119-095439","article-title":"Caspases in Cell Death, Inflammation, and Pyroptosis","volume":"38","author":"Kesavardhana","year":"2020","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167378","article-title":"Apoptosis, Pyroptosis, and Necroptosis-Oh My! The Many Ways a Cell Can Die","volume":"434","author":"Ketelut-Carneiro","year":"2022","journal-title":"J Mol Biol"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0385","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0390","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13046-021-01959-x","article-title":"Pyroptosis: a new paradigm of cell death for fighting against cancer","volume":"40","author":"Tan","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.bcp.2024.116348_b0395","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.2147\/CMAR.S330232","article-title":"Role of Cytokines Released During Pyroptosis in Non-Small Cell Lung Cancer","volume":"13","author":"Huang","year":"2021","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.bcp.2024.116348_b0400","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fcimb.2020.00238","article-title":"The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)","volume":"10","author":"Samir","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0405","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation","volume":"10","author":"Rogers","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0410","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41423-018-0165-1","article-title":"Visualization of perforin\/gasdermin\/complement-formed pores in real cell membranes using atomic force microscopy","volume":"16","author":"Liu","year":"2019","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0415","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00018-021-04078-0","article-title":"Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis","volume":"79","author":"De Schutter","year":"2021","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0420","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0425","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41580-022-00564-w","article-title":"Pore-forming proteins as drivers of membrane permeabilization in cell death pathways","volume":"24","author":"Vandenabeele","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.bcp.2024.116348_b0430","first-page":"e21757","article-title":"Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis","volume":"35","author":"de Torre-Minguela","year":"2021","journal-title":"Faseb j"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0435","first-page":"603","article-title":"Gasdermins in Apoptosis: New players in an Old Game","volume":"92","author":"Rogers","year":"2019","journal-title":"Yale J Biol Med"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0440","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3390\/ijms21041456","article-title":"Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer","volume":"21","author":"Zheng","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.bcp.2024.116348_b0445","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/s41422-018-0090-y","article-title":"Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis","volume":"28","author":"Zhou","year":"2018","journal-title":"Cell Res"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0450","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/s41401-023-01094-7","article-title":"Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy","volume":"44","author":"Luo","year":"2023","journal-title":"Acta Pharmacol Sin"},{"issue":"23","key":"10.1016\/j.bcp.2024.116348_b0455","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1158\/1078-0432.CCR-18-1478","article-title":"Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death","volume":"24","author":"Lu","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0460","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.immuni.2021.04.012","article-title":"Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells","volume":"54","author":"Orzalli","year":"2021","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.bcp.2024.116348_b0465","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.apsb.2020.06.015","article-title":"Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis","volume":"10","author":"Zhang","year":"2020","journal-title":"Acta Pharm Sin B"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0470","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1021\/acs.jnatprod.5b00516","article-title":"Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells","volume":"78","author":"Zhou","year":"2015","journal-title":"J Nat Prod"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0475","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41581-022-00662-0","article-title":"Gasdermins and pyroptosis in the kidney","volume":"19","author":"Elias","year":"2023","journal-title":"Nat Rev Nephrol"},{"issue":"22","key":"10.1016\/j.bcp.2024.116348_b0480","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1016\/j.molcel.2021.09.003","article-title":"Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity","volume":"81","author":"Hou","year":"2021","journal-title":"Mol Cell"},{"key":"10.1016\/j.bcp.2024.116348_b0485","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3389\/fonc.2019.00971","article-title":"Induction of Pyroptosis and Its Implications in Cancer Management","volume":"9","author":"Wang","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.bcp.2024.116348_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101803","article-title":"Pyroptosis and the cellular consequences of gasdermin pores","volume":"69","author":"Huston","year":"2023","journal-title":"Semin Immunol"},{"issue":"28","key":"10.1016\/j.bcp.2024.116348_b0495","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101189118","article-title":"RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling","volume":"118","author":"Chen","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0500","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0505","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1158\/2159-8290.CD-20-0805","article-title":"Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy","volume":"11","author":"Rosenbaum","year":"2021","journal-title":"Cancer Discov"},{"issue":"18","key":"10.1016\/j.bcp.2024.116348_b0510","doi-asserted-by":"crossref","first-page":"8813","DOI":"10.7150\/thno.62521","article-title":"Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment","volume":"11","author":"Hsu","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0515","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1007\/s10753-021-01493-0","article-title":"Differential Expression and Copy Number Variation of Gasdermin (GSDM) Family Members, Pore-Forming Proteins in Pyroptosis, in Normal and Malignant Serous Ovarian Tissue","volume":"44","author":"Berkel","year":"2021","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0520","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3390\/ijms23010372","article-title":"Pyroptosis-Mediated Periodontal Disease","volume":"23","author":"Sordi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bcp.2024.116348_b0525","doi-asserted-by":"crossref","first-page":"1254150","DOI":"10.3389\/fimmu.2023.1254150","article-title":"The gasdermins: a pore-forming protein family expressed in the epidermis","volume":"14","author":"Slaufova","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0530","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3390\/ijms22010426","article-title":"Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity","volume":"22","author":"Tsuchiya","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bcp.2024.116348_b0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101833","article-title":"Gasdermins and cancers","volume":"70","author":"Hou","year":"2023","journal-title":"Semin Immunol"},{"issue":"7\u20139","key":"10.1016\/j.bcp.2024.116348_b0540","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1089\/ars.2023.0257","article-title":"Pyroptosis, Metabolism, and Oxidation in Tumorigenesis: Mechanisms and Therapeutic Implications","volume":"39","author":"Cao","year":"2023","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.bcp.2024.116348_b0545","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.canlet.2019.11.009","article-title":"Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy","volume":"470","author":"Lei","year":"2020","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0550","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0555","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00535-020-01666-y","article-title":"Recent advances in chemotherapy for pancreatic cancer: evidence from Japan and recommendations in guidelines","volume":"55","author":"Okusaka","year":"2020","journal-title":"J Gastroenterol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0560","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12943-019-1058-3","article-title":"Surgical stress and cancer progression: the twisted tango","volume":"18","author":"Chen","year":"2019","journal-title":"Mol Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0565","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/ijms23010441","article-title":"Cancer Therapy-Induced Cardiotoxicity-A Metabolic Perspective on Pathogenesis, Diagnosis and Therapy","volume":"23","author":"Choksey","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bcp.2024.116348_b0570","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ctrv.2017.04.008","article-title":"Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer","volume":"57","author":"Galletti","year":"2017","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0575","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7150\/thno.22679","article-title":"Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance","volume":"8","author":"Zhou","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2024.116348_b0580","first-page":"24","article-title":"Biological effects and mechanisms of shortwave radiation: a review","volume":"4","author":"Yu","year":"2017","journal-title":"Mil Med Res"},{"issue":"7467","key":"10.1016\/j.bcp.2024.116348_b0585","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature12626","article-title":"Influence of tumour micro-environment heterogeneity on therapeutic response","volume":"501","author":"Junttila","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2024.116348_b0590","first-page":"451","article-title":"Collab or Cancel?","volume":"77","author":"Herrmann","year":"2023","journal-title":"Bacterial Influencers of Inflammasome Signaling, Annu Rev Microbiol"},{"issue":"13","key":"10.1016\/j.bcp.2024.116348_b0595","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.7150\/ijbs.86855","article-title":"Molecular mechanisms of pyroptosis and its role in anti-tumor immunity","volume":"19","author":"Huang","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"14","key":"10.1016\/j.bcp.2024.116348_b0600","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1182\/blood.2022017789","article-title":"A phase 2 clinical trial of combined BRAF\/MEK inhibition for BRAFV600E-mutated multiple myeloma","volume":"141","author":"Giesen","year":"2023","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0605","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1158\/2159-8290.CD-19-0672","article-title":"Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis","volume":"10","author":"Erkes","year":"2020","journal-title":"Cancer Discov"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0610","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41590-022-01386-w","article-title":"Human T(H)17 cells engage gasdermin E pores to release IL-1\u03b1 on NLRP3 inflammasome activation","volume":"24","author":"Chao","year":"2023","journal-title":"Nat Immunol"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0615","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1158\/0008-5472.CAN-22-1812","article-title":"USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer","volume":"83","author":"Ren","year":"2023","journal-title":"Cancer Res"},{"issue":"35","key":"10.1016\/j.bcp.2024.116348_b0620","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.3748\/wjg.v22.i35.7999","article-title":"Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer","volume":"22","author":"Huang","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"22","key":"10.1016\/j.bcp.2024.116348_b0625","doi-asserted-by":"crossref","first-page":"13431","DOI":"10.1111\/jcmm.15966","article-title":"Doxorubicin hydrochloride enhanced antitumour effect of CEA-regulated oncolytic virotherapy in live cancer cells and a mouse model","volume":"24","author":"Xiao","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0630","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0635","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.molmed.2021.02.004","article-title":"AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies","volume":"27","author":"Yang","year":"2021","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bcp.2024.116348_b0640","article-title":"AAV-mediated gene therapy: Advancing cardiovascular disease treatment","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"15\u201316","key":"10.1016\/j.bcp.2024.116348_b0645","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/hum.2020.024","article-title":"Oncolytic Adenovirus Expressing ST13 Increases Antitumor Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Against Pancreatic Ductal Adenocarcinoma","volume":"31","author":"Zhang","year":"2020","journal-title":"Hum Gene Ther"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0650","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2017.08.027","article-title":"Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy","volume":"170","author":"Ribas","year":"2017","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0655","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrg3742","article-title":"Engineering adeno-associated viruses for clinical gene therapy","volume":"15","author":"Kotterman","year":"2014","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.bcp.2024.116348_b0660","doi-asserted-by":"crossref","unstructured":"E. Liu, D. Marin, P. Banerjee, H.A. Macapinlac, P. Thompson, R. Basar, L. Nassif Kerbauy, B. Overman, P. Thall, M. Kaplan, V. Nandivada, I. Kaur, A. Nunez Cortes, K. Cao, M. Daher, C. Hosing, E.N. Cohen, P. Kebriaei, R. Mehta, S. Neelapu, Y. Nieto, M. Wang, W. Wierda, M. Keating, R. Champlin, E.J. Shpall, K. Rezvani, Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors, N Engl J Med 382(6) (2020) 545-553.","DOI":"10.1056\/NEJMoa1910607"},{"issue":"20","key":"10.1016\/j.bcp.2024.116348_b0665","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1158\/1078-0432.CCR-22-0622","article-title":"A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer","volume":"28","author":"Sun","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0670","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.3892\/mmr.2017.7784","article-title":"Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model","volume":"16","author":"Xiao","year":"2017","journal-title":"Mol Med Rep"},{"issue":"12","key":"10.1016\/j.bcp.2024.116348_b0675","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/biomedicines8120593","article-title":"Oncolytic Adenovirus CD55-Smad4 Suppresses Cell Proliferation, Metastasis, and Tumor Stemness in Colorectal Cancer by Regulating Wnt\/\u03b2-Catenin Signaling Pathway","volume":"8","author":"Xiao","year":"2020","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0680","doi-asserted-by":"crossref","first-page":"e23677","DOI":"10.1002\/jcla.23677","article-title":"Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL-24 gene in liver cancer cells","volume":"35","author":"Wang","year":"2021","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0685","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41467-023-36550-9","article-title":"A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis","volume":"14","author":"Wang","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0690","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1021\/acsami.2c17579","article-title":"Carrier-Free Nanoplatform via Evoking Pyroptosis and Immune Response against Breast Cancer","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl Mater Interfaces"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0695","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1021\/acs.nanolett.3c01008","article-title":"Nanodrug Augmenting Antitumor Immunity for Enhanced TNBC Therapy via Pyroptosis and cGAS-STING Activation","volume":"23","author":"Zhong","year":"2023","journal-title":"Nano Lett"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0700","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12935-022-02483-4","article-title":"A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins","volume":"22","author":"Mu","year":"2022","journal-title":"Cancer Cell Int"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0705","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41419-021-03454-9","article-title":"Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3\/GSDME in triple-negative breast cancer cells","volume":"12","author":"An","year":"2021","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.bcp.2024.116348_b0710","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/cbin.11395","article-title":"BIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis","volume":"44","author":"Deng","year":"2020","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.bcp.2024.116348_b0715","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2021.02.043","article-title":"GW4064 enhances the chemosensitivity of colorectal cancer to oxaliplatin by inducing pyroptosis","volume":"548","author":"Guo","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2024.116348_b0720","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-5793(01)02304-3","article-title":"DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells","volume":"494","author":"Lage","year":"2001","journal-title":"FEBS Lett"},{"issue":"16","key":"10.1016\/j.bcp.2024.116348_b0725","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1111\/jcmm.17827","article-title":"AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer","volume":"27","author":"Chen","year":"2023","journal-title":"J Cell Mol Med"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0730","doi-asserted-by":"crossref","first-page":"537","DOI":"10.7150\/ijbs.89080","article-title":"Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME\/IL12\/CD4Tem Axis","volume":"20","author":"Xuzhang","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0735","doi-asserted-by":"crossref","first-page":"e0282244","DOI":"10.1371\/journal.pone.0282244","article-title":"Promoting GSDME expression through DNA demethylation to increase chemosensitivity of breast cancer MCF-7 \/ Taxol cells","volume":"18","author":"Gong","year":"2023","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0740","doi-asserted-by":"crossref","first-page":"e727","DOI":"10.1002\/ctm2.727","article-title":"The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer","volume":"12","author":"Zhao","year":"2022","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.bcp.2024.116348_b0745","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.670081","article-title":"Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells","volume":"12","author":"Yan","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bcp.2024.116348_b0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115002","article-title":"Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519","volume":"164","author":"Kara\u015b","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0755","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41419-022-05528-8","article-title":"The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bcp.2024.116348_b0760","article-title":"Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast Cancer","volume":"12","author":"Xu","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.bcp.2024.116348_b0765","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121941","article-title":"IMB5036 overcomes resistance to multiple chemotherapeutic drugs in human cancer cells through pyroptosis by targeting the KH-type splicing regulatory protein","volume":"328","author":"Zhao","year":"2023","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0770","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13020-022-00671-y","article-title":"Nitidine chloride induces caspase 3\/GSDME-dependent pyroptosis by inhibting PI3K\/Akt pathway in lung cancer","volume":"17","author":"Yu","year":"2022","journal-title":"Chin Med"},{"issue":"3\u20134","key":"10.1016\/j.bcp.2024.116348_b0775","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s10495-019-01515-1","article-title":"Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3\/GSDME activation","volume":"24","author":"Zhang","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2024.116348_b0780","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.959938","article-title":"Myricetin activates the Caspase-3\/GSDME pathway via ER stress induction of pyroptosis in lung cancer cells","volume":"13","author":"Han","year":"2022","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b0785","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-019-1441-4","article-title":"Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells","volume":"10","author":"Yu","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bcp.2024.116348_b0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154142","article-title":"The natural compound from Garcinia bracteata mainly induces GSDME-mediated pyroptosis in esophageal cancer cells","volume":"102","author":"Tan","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2022.101678","article-title":"Anaplastic thyroid cancer: An update","volume":"37","author":"Rao","year":"2023","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.bcp.2024.116348_b0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154528","article-title":"Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway","volume":"108","author":"Hu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2024.116348_b0805","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109704","article-title":"Dihydroartemisinin mediating PKM2-caspase-8\/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma","volume":"350","author":"Jiang","year":"2021","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0810","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1186\/s12885-021-08692-w","article-title":"Prognostic role of DFNA5 in head and neck squamous cell carcinoma revealed by systematic expression analysis","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0815","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41392-020-00274-9","article-title":"GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration","volume":"5","author":"Peng","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"25","key":"10.1016\/j.bcp.2024.116348_b0820","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1038\/sj.onc.1211021","article-title":"Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma","volume":"27","author":"Kim","year":"2008","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0825","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/cam4.2103","article-title":"Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer","volume":"8","author":"Ibrahim","year":"2019","journal-title":"Cancer Med"},{"issue":"16","key":"10.1016\/j.bcp.2024.116348_b0830","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJM199804163381601","article-title":"Ten-year risk of false positive screening mammograms and clinical breast examinations","volume":"338","author":"Elmore","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0835","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbrc.2008.03.026","article-title":"Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer","volume":"370","author":"Kim","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0840","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41467-023-35917-2","article-title":"Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity","volume":"14","author":"Lin","year":"2023","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0845","doi-asserted-by":"crossref","first-page":"e0172707","DOI":"10.1371\/journal.pone.0172707","article-title":"Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells","volume":"12","author":"Moussette","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0850","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/annrheumdis-2017-212454","article-title":"Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk","volume":"77","author":"Moreno-Moral","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b0855","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ppul.21424","article-title":"Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR","volume":"46","author":"Yu","year":"2011","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0860","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jaci.2011.03.015","article-title":"Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion","volume":"127","author":"Lluis","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.bcp.2024.116348_b0865","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/j.cell.2021.04.036","article-title":"Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions","volume":"184","author":"Hansen","year":"2021","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0870","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0875","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cell.2021.12.024","article-title":"GSDMB is increased in IBD and regulates epithelial restitution\/repair independent of pyroptosis","volume":"185","author":"Rana","year":"2022","journal-title":"Cell"},{"issue":"82","key":"10.1016\/j.bcp.2024.116348_b0880","doi-asserted-by":"crossref","first-page":"eadg3196","DOI":"10.1126\/sciimmunol.adg3196","article-title":"Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis","volume":"8","author":"Kong","year":"2023","journal-title":"Sci Immunol"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0885","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41418-023-01143-y","article-title":"Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells","volume":"30","author":"Oltra","year":"2023","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0890","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tcb.2022.06.006","article-title":"The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies","volume":"33","author":"Ivanov","year":"2023","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.bcp.2024.116348_b0895","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.2147\/CMAR.S246948","article-title":"Role of GSDMB in Pyroptosis and Cancer","volume":"12","author":"Li","year":"2020","journal-title":"Cancer Manag Res"},{"issue":"16","key":"10.1016\/j.bcp.2024.116348_b0900","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.devcel.2022.07.006","article-title":"N(6)-adenomethylation of GsdmC is essential for Lgr5(+) stem cell survival to maintain normal colonic epithelial morphogenesis","volume":"57","author":"Du","year":"2022","journal-title":"Dev Cell"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0905","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12967-022-03632-z","article-title":"System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma","volume":"20","author":"Yan","year":"2022","journal-title":"J Transl Med"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0910","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.immuni.2022.03.009","article-title":"Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C","volume":"55","author":"Zhao","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2024.116348_b0915","doi-asserted-by":"crossref","first-page":"14265","DOI":"10.1038\/ncomms14265","article-title":"Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation","volume":"8","author":"Bjornsdottir","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.bcp.2024.116348_b0920","first-page":"e166841","article-title":"Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models","author":"Wang","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bcp.2024.116348_b0925","article-title":"Sevoflurane Aggravates the Progress of Alzheimer's Disease Through NLRP3\/Caspase-1\/Gasdermin D Pathway","volume":"9","author":"Tian","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bcp.2024.116348_b0930","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trsl.2023.09.007","article-title":"Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction","volume":"264","author":"Zhuang","year":"2023","journal-title":"Transl Res"},{"issue":"2","key":"10.1016\/j.bcp.2024.116348_b0935","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41419-022-04553-x","article-title":"E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis","volume":"13","author":"Shi","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bcp.2024.116348_b0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112771","article-title":"Ubiquitinated gasdermin D mediates arsenic-induced pyroptosis and hepatic insulin resistance in rat liver","volume":"160","author":"Zhu","year":"2022","journal-title":"Food Chem Toxicol"},{"issue":"20","key":"10.1016\/j.bcp.2024.116348_b0945","doi-asserted-by":"crossref","first-page":"e2204031","DOI":"10.1002\/smll.202204031","article-title":"Efficient Delivery of GSDMD-N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy","volume":"19","author":"Xing","year":"2023","journal-title":"Small"},{"issue":"11","key":"10.1016\/j.bcp.2024.116348_b0950","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cell.2023.04.025","article-title":"A 360\u00b0 view of the inflammasome: Mechanisms of activation, cell death, and diseases","volume":"186","author":"Barnett","year":"2023","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bcp.2024.116348_b0955","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41422-023-00848-6","article-title":"Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P","volume":"33","author":"Ai","year":"2023","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b0960","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40164-023-00428-9","article-title":"Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer","volume":"12","author":"Wu","year":"2023","journal-title":"Exp Hematol Oncol"},{"key":"10.1016\/j.bcp.2024.116348_b0965","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13148-018-0479-y","article-title":"Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer, Clin","volume":"10","author":"Croes","year":"2018","journal-title":"Epigenetics"},{"issue":"5","key":"10.1016\/j.bcp.2024.116348_b0970","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.trecan.2020.12.002","article-title":"GSDME: A Potential Ally in Cancer Detection and Treatment","volume":"7","author":"Ibrahim","year":"2021","journal-title":"Trends Cancer"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0975","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s13402-023-00860-3","article-title":"Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer","volume":"46","author":"Tian","year":"2023","journal-title":"Cell Oncol (dordr)"},{"key":"10.1016\/j.bcp.2024.116348_b0980","doi-asserted-by":"crossref","first-page":"1097772","DOI":"10.3389\/fonc.2023.1097772","article-title":"Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-\u03baB\/NLRP3\/GSDMD and GSDME signaling pathway","volume":"13","author":"Ding","year":"2023","journal-title":"Front Oncol"},{"issue":"6","key":"10.1016\/j.bcp.2024.116348_b0985","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.18632\/aging.203973","article-title":"GSDMs are potential therapeutic targets and prognostic biomarkers in clear cell renal cell carcinoma","volume":"14","author":"Yao","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"16","key":"10.1016\/j.bcp.2024.116348_b0990","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1073\/pnas.1821844116","article-title":"Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage","volume":"116","author":"Defourny","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.bcp.2024.116348_b0995","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.cell.2015.10.060","article-title":"Peroxisomes Get Loud: A Redox Antidote to Hearing Loss","volume":"163","author":"Mardones","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b1000","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1399-0004.2011.01741.x","article-title":"High frequency of autosomal-recessive DFNB59 hearing loss in an isolated Arab population in Israel","volume":"82","author":"Borck","year":"2012","journal-title":"Clin Genet"},{"issue":"7","key":"10.1016\/j.bcp.2024.116348_b1005","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ng1829","article-title":"Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy","volume":"38","author":"Delmaghani","year":"2006","journal-title":"Nat Genet"},{"issue":"20","key":"10.1016\/j.bcp.2024.116348_b1010","doi-asserted-by":"crossref","first-page":"e152941","DOI":"10.1172\/jci.insight.152941","article-title":"Gene therapy with a synthetic adeno-associated viral vector improves audiovestibular phenotypes in Pjvk-mutant mice","volume":"7","author":"Lu","year":"2022","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.bcp.2024.116348_b1015","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jcp.29197","article-title":"Dioscin inhibits the growth of human osteosarcoma by inducing G2\/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo","volume":"235","author":"Ding","year":"2020","journal-title":"J Cell Physiol"},{"issue":"10","key":"10.1016\/j.bcp.2024.116348_b1020","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/15384101.2020.1743911","article-title":"Metformin activates AMPK\/SIRT1\/NF-\u03baB pathway and induces mitochondrial dysfunction to drive caspase3\/GSDME-mediated cancer cell pyroptosis","volume":"19","author":"Zheng","year":"2020","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2024.116348_b1025","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.860546","article-title":"Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis","volume":"13","author":"Xia","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.bcp.2024.116348_b1030","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s12967-023-04481-0","article-title":"Antileukemic effect of venetoclax and hypomethylating agents via caspase-3\/GSDME-mediated pyroptosis","volume":"21","author":"Ye","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.bcp.2024.116348_b1035","article-title":"Aloe-emodin induces mitochondrial dysfunction and pyroptosis by activation of the caspase-9\/3\/Gasdermin E Axis in HeLa Cells","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharmacol"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:11:17Z","timestamp":1728346277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224003319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":207,"alternative-id":["S0006295224003319"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116348","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insight into the structure, function and the tumor suppression effect of gasdermin E","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116348"}}