{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:17:17Z","timestamp":1794003437049,"version":"4.8.0"},"reference-count":171,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bcp.2024.116399","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T13:57:30Z","timestamp":1719496650000},"page":"116399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers"],"prefix":"10.1016","volume":"226","author":[{"given":"Amirhossein","family":"Ahmadieh-Yazdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Afkhami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Hajizadeh-Tafti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Kuchakzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Sheykhhasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bcp.2024.116399_b0005","article-title":"Advances in the management of diabetes mellitus: a focus on personalized medicine","volume":"15","author":"Sugandh","year":"2023","journal-title":"Cureus."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S2213-8587(20)30381-8","article-title":"Management of diabetes and hyperglycaemia in the hospital","volume":"9","author":"Pasquel","year":"2021","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.bcp.2024.116399_b0015","article-title":"Based on clinical research matrix metalloprotease (MMP) inhibitors to promote diabetic wound healing","author":"Yadav","year":"2023","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bcp.2024.116399_b0020","article-title":"Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing? Pharmaceuticals","volume":"15","author":"Umar","year":"2022","journal-title":"(Basel, Switzerland)"},{"key":"10.1016\/j.bcp.2024.116399_b0025","article-title":"Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies","volume":"1\u201380","author":"Yadav","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030655","article-title":"Chronic Diabetic Wounds and Their Treatment with Skin Substitutes","volume":"10","author":"Holl","year":"2021","journal-title":"Cells."},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0035","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4239\/wjd.v13.i12.1066","article-title":"Mesenchymal stem cell-derived exosomes: The dawn of diabetic wound healing","volume":"13","author":"Wu","year":"2022","journal-title":"World J. Diabetes"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-0938-6","article-title":"Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research","volume":"9","author":"Lopes","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116399_b0045","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.biopha.2018.08.013","article-title":"Adipose-derived stem cells: effectiveness and advances in delivery in diabetic wound healing","volume":"107","author":"Gadelkarim","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2024.116399_b0050","article-title":"Tissue liquefaction liposuction for body contouring and autologous fat transfer: a retrospective review over 3 years","volume":"16","author":"Borab","year":"2016","journal-title":"Eplasty"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22802","article-title":"Exosomes from adipose-derived stem cells restore fibroblast function and accelerate diabetic wound healing","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon."},{"key":"10.1016\/j.bcp.2024.116399_b0060","article-title":"Exosomes: Biomarkers and Therapeutic Targets of Diabetic Vascular Complications","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"10","key":"10.1016\/j.bcp.2024.116399_b0065","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00109-023-02357-w","article-title":"The mechanisms of exosomes in diabetic foot ulcers healing: a detailed review","volume":"101","author":"Yu","year":"2023","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bcp.2024.116399_b0070","article-title":"Exosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complications","volume":"1229\u201353","author":"Ashrafizadeh","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bcp.2024.116399_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.756581","article-title":"The utility of exosomes in diagnosis and therapy of diabetes mellitus and associated complications","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"18","key":"10.1016\/j.bcp.2024.116399_b0080","doi-asserted-by":"crossref","first-page":"2100275","DOI":"10.1002\/advs.202100275","article-title":"Emerging targets in type 2 diabetes and diabetic complications","volume":"8","author":"Demir","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bcp.2024.116399_b0085","first-page":"495","article-title":"Global burden of diabetes mellitus: prevalence, pattern, and trends. Handbook of","author":"Arokiasamy","year":"2021","journal-title":"Global Health."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7748\/ns.2021.e11709","article-title":"Diabetes mellitus: an overview of the types, symptoms, complications and management","volume":"37","author":"Cloete","year":"2021","journal-title":"Nursing Standard (Royal College of Nursing (Great Britain): 1987"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/diabetology2020004","article-title":"Diabetes Mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management","volume":"2","author":"Alam","year":"2021","journal-title":"Diabetology."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0100","doi-asserted-by":"crossref","first-page":"ITC33","DOI":"10.7326\/AITC202203150","article-title":"Type 1 diabetes mellitus","volume":"175","author":"Syed","year":"2022","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0105","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1530\/EC-17-0347","article-title":"On type 1 diabetes mellitus pathogenesis","volume":"7","author":"Paschou","year":"2018","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.bcp.2024.116399_b0110","unstructured":"Organization WH. Classification of diabetes mellitus. 2019."},{"issue":"17","key":"10.1016\/j.bcp.2024.116399_b0115","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus","volume":"5","author":"McIntyre","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0125","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00695-20","article-title":"Living in your skin: microbes, molecules, and mechanisms","volume":"89","author":"Swaney","year":"2021","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mpsur.2020.01.010","article-title":"Classification and management of acute wounds and open fractures","volume":"38","author":"Milne","year":"2020","journal-title":"Surgery (Oxford)"},{"key":"10.1016\/j.bcp.2024.116399_b0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-981-32-9236-9_13","article-title":"Different Types of Wounds","author":"Vachhrajani","year":"2020","journal-title":"Sci. Wound Healing Dressing Mater."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0140","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0145","first-page":"159","article-title":"Chronic wounds: evaluation and management","volume":"101","author":"Bowers","year":"2020","journal-title":"Am. Fam. Physician"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic wounds","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0155","first-page":"298","article-title":"Venous ulcers: diagnosis and treatment","volume":"100","author":"Millan","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.bcp.2024.116399_b0160","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.2147\/CIA.S231896","article-title":"Atypical ulcers: diagnosis and management","author":"Janowska","year":"2019","journal-title":"Clin. Interv. Aging"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0165","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: a review","volume":"330","author":"Armstrong","year":"2023","journal-title":"J. Am. Med. Assoc."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0170","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jtv.2020.04.003","article-title":"Pressure ulcer\/injury classification today: An international perspective","volume":"29","author":"Kottner","year":"2020","journal-title":"J. Tissue Viability"},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0175","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/biom11050700","article-title":"Immunology of acute and chronic wound healing","volume":"11","author":"Raziyeva","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0180","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/stcltm\/szac081","article-title":"Adipose-Derived Stromal Cells for Chronic Wounds: Scientific Evidence and Roadmap Toward Clinical Practice","volume":"12","author":"Brembilla","year":"2023","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bcp.2024.116399_b0185","doi-asserted-by":"crossref","DOI":"10.1021\/acsptsci.3c00336","article-title":"Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts","author":"Mahmoud","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0190","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dci22-0043","article-title":"Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers","volume":"46","author":"McDermott","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bcp.2024.116399_b0195","doi-asserted-by":"crossref","DOI":"10.1177\/2632010X231205366","article-title":"Various Types of Wounds That Diabetic Patients Can Develop: A Narrative Review","volume":"16","author":"Jais","year":"2023","journal-title":"Clin. Pathol."},{"key":"10.1016\/j.bcp.2024.116399_b0200","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biopha.2018.07.157","article-title":"Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: an update on glucose toxicity","volume":"107","author":"Giri","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2024.116399_b0205","doi-asserted-by":"crossref","first-page":"44","DOI":"10.37757\/MR2021.V23.N3.8","article-title":"Wound chronicity, impaired immunity and infection in diabetic patients","volume":"24","author":"Rodr\u00edguez-Rodr\u00edguez","year":"2022","journal-title":"MEDICC Rev."},{"key":"10.1016\/j.bcp.2024.116399_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.989844","article-title":"Epigenetic basis of diabetic vasculopathy","volume":"13","author":"Bhamidipati","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116399_b0215","article-title":"Neuropeptide substance P: a promising regulator of wound healing in diabetic foot ulcers","volume":"115736","author":"Chen","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116399_b0220","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","article-title":"Wound healing, fibroblast heterogeneity, and fibrosis","volume":"29","author":"Talbott","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcp.2024.116399_b0225","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.573032","article-title":"Cellular senescence as the pathogenic hub of diabetes-related wound chronicity","volume":"11","author":"Berlanga-Acosta","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116399_b0230","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.redox.2015.06.019","article-title":"Redox regulation of FoxO transcription factors","volume":"6","author":"Klotz","year":"2015","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0235","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/wrr.12514","article-title":"Effect of systemic insulin treatment on diabetic wound healing","volume":"25","author":"Vatankhah","year":"2017","journal-title":"Wound Repair Regen."},{"issue":"3S","key":"10.1016\/j.bcp.2024.116399_b0240","doi-asserted-by":"crossref","first-page":"179S","DOI":"10.1097\/PRS.0000000000002686","article-title":"The role of pressure offloading on diabetic foot ulcer healing and prevention of recurrence","volume":"138","author":"Bus","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0245","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1016\/j.surge.2021.01.005","article-title":"Diabetic foot off loading and ulcer remission: Exploring surgical off-loading","volume":"19","author":"Ahluwalia","year":"2021","journal-title":"Surgeon"},{"key":"10.1016\/j.bcp.2024.116399_b0250","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/TCRM.S131193","article-title":"Evaluation of negative-pressure wound therapy for patients with diabetic foot ulcers: systematic review and meta-analysis","author":"Liu","year":"2017","journal-title":"Ther. Clin. Risk Manag."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0255","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jtv.2019.04.001","article-title":"The efficacy of negative pressure wound therapy for diabetic foot ulcers: A systematised review","volume":"28","author":"Wynn","year":"2019","journal-title":"J. Tissue Viability"},{"issue":"24","key":"10.1016\/j.bcp.2024.116399_b0260","doi-asserted-by":"crossref","DOI":"10.7748\/ns.26.24.51.s55","article-title":"Debridement of diabetic foot wounds","volume":"26","author":"Haycocks","year":"2012","journal-title":"Nurs. Stand."},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0265","article-title":"A systematic review and meta-analysis of d\u00e9bridement methods for chronic diabetic foot ulcers","volume":"63","author":"Elraiyah","year":"2016","journal-title":"J. Vasc. Surg."},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0270","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1089\/wound.2021.0016","article-title":"Debridement of diabetic foot ulcers","volume":"11","author":"Dayya","year":"2022","journal-title":"Adv. Wound Care"},{"issue":"14","key":"10.1016\/j.bcp.2024.116399_b0275","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.3390\/polym14142764","article-title":"Current Advances in the Development of Hydrogel-Based Wound Dressings for Diabetic Foot Ulcer Treatment","volume":"14","author":"G\u00fciza-Arg\u00fcello","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.bcp.2024.116399_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2022.100320","article-title":"Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing","volume":"15","author":"Wang","year":"2022","journal-title":"Materials Today Bio."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0285","doi-asserted-by":"crossref","first-page":"2102466","DOI":"10.1002\/advs.202102466","article-title":"Emerging theranostic nanomaterials in diabetes and its complications","volume":"9","author":"Liu","year":"2022","journal-title":"Adv. Sci."},{"issue":"24","key":"10.1016\/j.bcp.2024.116399_b0290","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.3390\/cells11244094","article-title":"Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages","volume":"11","author":"Shi","year":"2022","journal-title":"Cells."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0295","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.3892\/mmr.2017.7707","article-title":"Metformin accelerates wound healing in type 2 diabetic db\/db mice","volume":"16","author":"Han","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bcp.2024.116399_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111586","article-title":"Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study","volume":"119","author":"Cam","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.bcp.2024.116399_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155398","article-title":"Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt\/mTOR activation","volume":"140","author":"Du","year":"2023","journal-title":"Metabolism"},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0310","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1042\/CS20150393","article-title":"Release of insulin from PLGA\u2013alginate dressing stimulates regenerative healing of burn wounds in rats","volume":"129","author":"Dhall","year":"2015","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0315","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1524-475X.2012.00792.x","article-title":"Topical insulin application improves healing by regulating the wound inflammatory response","volume":"20","author":"Chen","year":"2012","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bcp.2024.116399_b0320","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.avsg.2019.05.041","article-title":"Topical recombinant human epidermal growth factor for diabetic foot ulcers: A meta-analysis of randomized controlled clinical trials","volume":"62","author":"Yang","year":"2020","journal-title":"Ann. Vasc. Surg."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0325","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13047-017-0244-z","article-title":"Diabetic Foot Australia guideline on footwear for people with diabetes","volume":"11","author":"van Netten","year":"2018","journal-title":"J. Foot Ankle Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0330","doi-asserted-by":"crossref","first-page":"e00132","DOI":"10.1002\/edm2.132","article-title":"Footwear and insole design features for offloading the diabetic at risk foot\u2014A systematic review and meta-analyses","volume":"4","author":"Collings","year":"2021","journal-title":"Endocrinol., Diabetes Metabol."},{"key":"10.1016\/j.bcp.2024.116399_b0335","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkab018","article-title":"Consensus on the application of negative pressure wound therapy of diabetic foot wounds","volume":"9","author":"Ji","year":"2021","journal-title":"Burns Trauma."},{"key":"10.1016\/j.bcp.2024.116399_b0340","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00268-016-3782-9","article-title":"Handcrafted vacuum-assisted device for skin ulcers treatment versus traditional therapy, randomized controlled trial","volume":"41","author":"Gonzalez","year":"2017","journal-title":"World J. Surg."},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0345","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.athoracsur.2004.10.053","article-title":"Blood flow responses in the peristernal thoracic wall during vacuum-assisted closure therapy","volume":"79","author":"Wackenfors","year":"2005","journal-title":"Ann. Thorac. Surg."},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0350","doi-asserted-by":"crossref","DOI":"10.1097\/PRS.0b013e31829f4ad9","article-title":"Does a Zone of Increased Perfusion Exist around Negative-Pressure Dressings?","volume":"132","author":"Kairinos","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"issue":"8","key":"10.1016\/j.bcp.2024.116399_b0355","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.ASW.0000483038.18331.a4","article-title":"Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet","volume":"29","author":"Jung","year":"2016","journal-title":"Adv. Skin Wound Care"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0360","doi-asserted-by":"crossref","first-page":"160","DOI":"10.12968\/jowc.2016.25.3.160","article-title":"Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT","volume":"25","author":"Bellingeri","year":"2016","journal-title":"J. Wound Care"},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0365","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.3390\/jcm9124032","article-title":"Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound-Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): An Open-Label Randomized Controlled Trial","volume":"9","author":"L\u00e1zaro-Mart\u00ednez","year":"2020","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0370","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/2000656X.2019.1673170","article-title":"Clinical experience with surgical debridement and simultaneous meshed skin grafts in treating biofilm-associated infection: an exploratory retrospective pilot study","volume":"54","author":"Namgoong","year":"2020","journal-title":"J. Plast. Surg. Hand Surg."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0375","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/iwj.12734","article-title":"Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model","volume":"14","author":"Davis","year":"2017","journal-title":"Int. Wound J."},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0380","first-page":"409","article-title":"Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide","volume":"88","author":"Mancini","year":"2017","journal-title":"Acta Bio Medica: Atenei Parmensis."},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0385","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/jac\/dkx391","article-title":"Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo","volume":"73","author":"Johani","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"issue":"10","key":"10.1016\/j.bcp.2024.116399_b0390","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2217\/cer-2020-0058","article-title":"Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds","volume":"9","author":"Bain","year":"2020","journal-title":"J. Comp. Eff. Res."},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0395","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1039\/D0BM01747G","article-title":"Advances of hydrogel dressings in diabetic wounds","volume":"9","author":"Wang","year":"2021","journal-title":"Biomater. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0400","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1524-475X.2009.00538.x","article-title":"Development of a new chitosan hydrogel for wound dressing","volume":"17","author":"Ribeiro","year":"2009","journal-title":"Wound Repair Regen."},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0405","first-page":"16319","article-title":"Collagen hydrogel dressing for wound healing and angiogenesis in diabetic rat models","volume":"10","author":"Lei","year":"2017","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.bcp.2024.116399_b0410","doi-asserted-by":"crossref","unstructured":"Sharmeen S, Rahman MS, Islam MM, Islam MS, Shahruzzaman M, Mallik AK, et al. Application of polysaccharides in enzyme immobilization. Functional Polysaccharides for Biomedical Applications: Elsevier; 2019. p. 357-95.","DOI":"10.1016\/B978-0-08-102555-0.00011-X"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0415","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/1534734615580018","article-title":"Alginate and DNA gels are suitable delivery systems for diabetic wound healing","volume":"14","author":"Tellechea","year":"2015","journal-title":"Int. J. Low. Extrem. Wounds"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0420","first-page":"487","article-title":"Hydrocolloid dressing improves wound healing by increasing M2 macrophage polarization in mice with diabetes","volume":"82","author":"Takeuchi","year":"2020","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.bcp.2024.116399_b0425","doi-asserted-by":"crossref","unstructured":"Heidari F, Seyedebrahimi R, Yang P, Farsani M-E, Ababzadeh S, Kalhor N, et al. Exosomes in viral infection: Effects for pathogenesis and treatment strategies. 2023;47(12):2597--608.","DOI":"10.32604\/biocell.2023.043351"},{"key":"10.1016\/j.bcp.2024.116399_b0430","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11154-019-09492-1","article-title":"Role of growth factors and cytokines in diabetic foot ulcer healing: a detailed review","volume":"20","author":"Zubair","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0435","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.transci.2004.01.004","article-title":"Platelet gel for healing cutaneous chronic wounds","volume":"30","author":"Crovetti","year":"2004","journal-title":"Transfus. Apher. Sci."},{"issue":"21","key":"10.1016\/j.bcp.2024.116399_b0440","doi-asserted-by":"crossref","first-page":"12607","DOI":"10.1074\/jbc.270.21.12607","article-title":"Regulation of vascular endothelial growth factor expression in cultured keratinocytes.: implications for normal and impaired wound healing","volume":"270","author":"Frank","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0445","doi-asserted-by":"crossref","first-page":"9351","DOI":"10.1016\/j.actbio.2013.07.030","article-title":"Dual growth factor releasing multi-functional nanofibers for wound healing","volume":"9","author":"Xie","year":"2013","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0450","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/jsre.1996.0090","article-title":"Transforming growth factor-\u03b2 and insulin-like growth factor-I in relation to diabetes-induced impairment of wound healing","volume":"61","author":"Bitar","year":"1996","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bcp.2024.116399_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116035","article-title":"Enhancing angiogenesis: Innovative drug delivery systems to facilitate diabetic wound healing","volume":"170","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0460","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jdiacomp.2005.08.007","article-title":"Expression of matrix metalloproteinases and growth factors in diabetic foot wounds treated with a protease absorbent dressing","volume":"20","author":"Lobmann","year":"2006","journal-title":"J. Diabetes Complications"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0465","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jss.2007.02.044","article-title":"Research of PDGF-BB gel on the wound healing of diabetic rats and its pharmacodynamics","volume":"145","author":"Li","year":"2008","journal-title":"J. Surg. Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0470","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1084\/jem.172.1.245","article-title":"Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db\/db mice","volume":"172","author":"Tsuboi","year":"1990","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0475","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.mehy.2015.06.017","article-title":"Chronic and non-healing wounds: The story of vascular endothelial growth factor","volume":"85","author":"Zhou","year":"2015","journal-title":"Med. Hypotheses"},{"issue":"7","key":"10.1016\/j.bcp.2024.116399_b0480","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3390\/biomedicines10071507","article-title":"Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer","volume":"10","author":"El Hage","year":"2022","journal-title":"Biomedicines."},{"issue":"7","key":"10.1016\/j.bcp.2024.116399_b0485","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2174\/1574888X14666190411121528","article-title":"Human adipose-derived stem cells with great therapeutic potential","volume":"14","author":"Sheykhhasan","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0490","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3390\/ijms18050981","article-title":"Melatonin and vitamin D interfere with the adipogenic fate of adipose-derived stem cells","volume":"18","author":"Basoli","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0495","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2174\/22123946MTA5vOTEa1","article-title":"Therapeutic Applications of Mesenchymal Stem Cells: A Comprehensive Review","volume":"16","author":"Samadi","year":"2021","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116399_b0500","doi-asserted-by":"crossref","DOI":"10.18502\/ijml.v7i3.4134","article-title":"Vitamin E and selenium facilitate the osteogenesis and adipogenesis of the human adipose tissue-derived mesenchymal stem\/stromal cells","author":"Javadi","year":"2020","journal-title":"Int. J. Med. Labor."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0505","doi-asserted-by":"crossref","first-page":"26","DOI":"10.46582\/jsrm.0601005","article-title":"Establishment and molecular characterization of mesenchymal stem cell lines derived from human visceral & subcutaneous adipose tissues","volume":"6","author":"Potdar","year":"2010","journal-title":"J. Stem Cells Regenerat. Med."},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0510","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3727\/096368916X693833","article-title":"Are adipose-derived stem cells from liver falciform ligaments another possible source of mesenchymal stem cells?","volume":"26","author":"Lee","year":"2017","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1310-1","article-title":"Current understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases","volume":"10","author":"Hu","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0520","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.3892\/mmr.2017.6967","article-title":"Effects of age on biological and functional characterization of adipose-derived stem cells from patients with end-stage liver disease","volume":"16","author":"Jin","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0525","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.rvsc.2013.12.011","article-title":"Sequential sub-passage decreases the differentiation potential of canine adipose-derived mesenchymal stem cells","volume":"96","author":"Lee","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.bcp.2024.116399_b0530","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10561-014-9451-z","article-title":"Effects of continuous passage on immunomodulatory properties of human adipose-derived stem cells","volume":"16","author":"Wang","year":"2015","journal-title":"Cell Tissue Bank."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0535","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2174\/1574888X11666160429122133","article-title":"Cell surface markers on adipose-derived stem cells: a systematic review","volume":"12","author":"Mildmay-White","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.bcp.2024.116399_b0540","doi-asserted-by":"crossref","unstructured":"Surya P, Tomar S, Pandey R, Pathak S, Sharma P, Kumari M, et al. Stem cells as therapeutics and their implications in cytokine storm in COVID-19. Stem Cells: Elsevier; 2024. p. 243-53.","DOI":"10.1016\/B978-0-323-95545-4.00015-3"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0545","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/jcm8020249","article-title":"Regenerative and transplantation medicine: cellular therapy using adipose tissue-derived mesenchymal stromal cells for type 1 diabetes mellitus","volume":"8","author":"Takahashi","year":"2019","journal-title":"J. Clin. Med."},{"issue":"11","key":"10.1016\/j.bcp.2024.116399_b0550","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.3390\/ijms24119356","article-title":"The Potential of MSC-Based Cell-Free Therapy in Wound Healing\u2014A Thorough Literature Review","volume":"24","author":"Ma","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0555","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/jcm8020249","article-title":"Regenerative and Transplantation Medicine: Cellular Therapy Using Adipose Tissue-Derived Mesenchymal Stromal Cells for Type 1 Diabetes Mellitus","volume":"8","author":"Takahashi","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bcp.2024.116399_b0560","doi-asserted-by":"crossref","unstructured":"Mundra V, Gerling IC, Mahato RI. Mesenchymal stem cell-based therapy. Mol Pharm. 2013 Jan 7;10(1):77-89. doi: 10.1021\/mp3005148. Epub 2012 Dec 24. PMID: 23215004; PMCID: PMC3549356.","DOI":"10.1021\/mp3005148"},{"issue":"654","key":"10.1016\/j.bcp.2024.116399_b0565","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gene.2018.02.008","article-title":"Role of adipose tissue derived stem cells differentiated into insulin producing cells in the treatment of type I diabetes mellitus","volume":"15","author":"Amer","year":"2018","journal-title":"Gene"},{"issue":"8","key":"10.1016\/j.bcp.2024.116399_b0570","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/stem.127","article-title":"Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice","volume":"27","author":"Kang","year":"2009","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0575","doi-asserted-by":"crossref","first-page":"e20615","DOI":"10.1371\/journal.pone.0020615","article-title":"Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice","volume":"6","author":"Chandra","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0580","doi-asserted-by":"crossref","first-page":"e1445948","DOI":"10.1080\/19382014.2018.1445948","article-title":"An engineered cell sheet composed of human islets and human fibroblast, bone marrow-derived mesenchymal stem cells, or adipose-derived mesenchymal stem cells: An in vitro comparison study","volume":"10","author":"Imamura","year":"2018","journal-title":"Islets"},{"issue":"5","key":"10.1016\/j.bcp.2024.116399_b0585","doi-asserted-by":"crossref","first-page":"e00632","DOI":"10.1016\/j.heliyon.2018.e00632","article-title":"Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells","volume":"4","author":"Tanaka","year":"2018","journal-title":"Heliyon."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0590","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/antiox12010058","article-title":"N, N'-Diphenyl-1,4-phenylenediamine Antioxidant's Potential Role in Enhancing the Pancreatic Antioxidant, Immunomodulatory, and Anti-Apoptotic Therapeutic Capabilities of Adipose-Derived Stem Cells in Type I Diabetic Rats","volume":"12","author":"Shaaban","year":"2022","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.bcp.2024.116399_b0595","doi-asserted-by":"crossref","unstructured":"Wang M, Song L, Strange C, Dong X, Wang H. Therapeutic Effects of Adipose Stem Cells from Diabetic Mice for the Treatment of Type 2 Diabetes. Mol Ther. 2018 Aug 1;26(8):1921-1930. doi: 10.1016\/j.ymthe.2018.06.013. Epub 2018 Jun 19. PMID: 30005867; PMCID: PMC6094391.","DOI":"10.1016\/j.ymthe.2018.06.013"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0600","doi-asserted-by":"crossref","first-page":"268","DOI":"10.15283\/ijsc20028","article-title":"Adipose Tissue-Derived Stem Cells from Type 2 Diabetics Reveal Conservative Alterations in Multidimensional Characteristics","volume":"13","author":"Wang","year":"2020","journal-title":"Int. J. Stem Cells"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0605","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.3390\/ijms24021472","article-title":"Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic Impact","volume":"24","author":"Mrozikiewicz-Rakowska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2024.116399_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108531","article-title":"Adipose-derived stem cells promote diabetic wound healing via the recruitment and differentiation of endothelial progenitor cells into endothelial cells mediated by the VEGF-PLC\u03b3-ERK pathway","volume":"692","author":"Chen","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0615","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s10020-021-00406-z","article-title":"ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to improve wound healing of diabetic foot ulcers","volume":"27","author":"Zhou","year":"2021","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0620","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s13287-021-02454-y","article-title":"Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway","volume":"12","author":"Ebrahim","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bcp.2024.116399_b0625","doi-asserted-by":"crossref","unstructured":"Ma H, Siu W-S, Koon C-M, Wu X-X, Li X, Cheng W, et al. The Application of Adipose Tissue-Derived Mesenchymal Stem Cells (ADMSCs) and a Twin-Herb Formula to the Rodent Wound Healing Model: Use Alone or Together? 2023;24(2):1372.","DOI":"10.3390\/ijms24021372"},{"key":"10.1016\/j.bcp.2024.116399_b0630","doi-asserted-by":"crossref","unstructured":"Kou Z, Li B, Aierken A, Tan N, Li C, Han M, et al. Mesenchymal Stem Cells Pretreated with Collagen Promote Skin Wound-Healing. 2023;24(10):8688.","DOI":"10.3390\/ijms24108688"},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0635","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.3390\/ijms21041306","article-title":"Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing","volume":"21","author":"Mazini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0640","doi-asserted-by":"crossref","DOI":"10.5812\/jssc.102152","article-title":"Mesenchymal Stem Cells and Their Derived Conditioned Media as Crucial Cell Candidates for Wound Healing: A Letter","volume":"6","author":"Kalhor","year":"2019","journal-title":"J. Skin Stem Cell"},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0645","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1002\/med.21789","article-title":"Adipose-derived stromal cells for nonhealing wounds: Emerging opportunities and challenges","volume":"41","author":"Deptu\u0142a","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"11","key":"10.1016\/j.bcp.2024.116399_b0650","doi-asserted-by":"crossref","first-page":"1094693","DOI":"10.3389\/fchem.2023.1094693","article-title":"Review: Research progress of adipose-derived stem cells in the treatment of chronic wounds","volume":"13","author":"Hao","year":"2023","journal-title":"Front. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2024.116399_b0655","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4252\/wjsc.v12.i7.659","article-title":"Role of stem cell therapies in treating chronic wounds: A systematic review","volume":"12","author":"Raghuram","year":"2020","journal-title":"World J Stem Cells."},{"issue":"7","key":"10.1016\/j.bcp.2024.116399_b0660","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/ijms20071671","article-title":"The effect of conditioned media of stem cells derived from lipoma and adipose tissue on macrophages\u2019 response and wound healing in indirect co-culture system in vitro","volume":"20","author":"Stojanovi\u0107","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0665","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/wrr.13033","article-title":"Stem cell-mediated angiogenesis in skin tissue engineering and wound healing","volume":"30","author":"Azari","year":"2022","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bcp.2024.116399_b0670","series-title":"Recent Trends in Nanomedicine and Tissue Engineering","first-page":"343","article-title":"Therapeutic Angiogenesis in Cardiovascular Diseases, Tissue Engineering, and Wound Healing","author":"Rakhimol","year":"2022"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0675","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3727\/096368910X520065","article-title":"Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis","volume":"20","author":"Nie","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bcp.2024.116399_b0680","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0685","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/term.2390","article-title":"Combination therapy of autologous adipose mesenchymal stem cell-enriched, high-density lipoaspirate and topical timolol for healing chronic wounds","volume":"12","author":"Larsen","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.bcp.2024.116399_b0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2019.105564","article-title":"Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P\/SK1\/S1PR1 signaling and promoting macrophage M2 polarization","volume":"114","author":"Deng","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6478","key":"10.1016\/j.bcp.2024.116399_b0695","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0700","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41556-023-01277-8","article-title":"Extracellular vesicles, genetic programmers","volume":"26","author":"Raposo","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcp.2024.116399_b0705","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113224","article-title":"Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease","volume":"152","author":"Sheykhhasan","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2024.116399_b0710","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5516078","article-title":"Exosomes of mesenchymal stem cells as a proper vehicle for transfecting miR-145 into the breast cancer cell line and its effect on metastasis","volume":"2021","author":"Sheykhhasan","year":"2021","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0715","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/2211738511666230523114311","article-title":"A Comprehensive Review on Exosome: Recent Progress and Outlook","volume":"12","author":"Agarwal","year":"2024","journal-title":"Pharmaceut. Nanotechnol."},{"key":"10.1016\/j.bcp.2024.116399_b0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytogfr.2023.08.006","article-title":"Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication","author":"Fyfe","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"issue":"10","key":"10.1016\/j.bcp.2024.116399_b0725","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3390\/cells12101416","article-title":"Current Strategies for Exosome Cargo Loading and Targeting Delivery","volume":"12","author":"Zeng","year":"2023","journal-title":"Cells."},{"key":"10.1016\/j.bcp.2024.116399_b0730","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1007\/s12035-021-02324-x","article-title":"Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment","volume":"58","author":"Fayazi","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bcp.2024.116399_b0735","first-page":"7","article-title":"Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration","author":"Hu","year":"2019","journal-title":"Burns & Trauma."},{"issue":"29","key":"10.1016\/j.bcp.2024.116399_b0740","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1039\/D2TB01044E","article-title":"Advances in hydrogels for stem cell therapy: regulation mechanisms and tissue engineering applications","volume":"10","author":"Liu","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"8","key":"10.1016\/j.bcp.2024.116399_b0745","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1080\/00325481.2020.1771047","article-title":"Beta-cell failure in type 2 diabetes: mechanisms, markers, and clinical implications","volume":"132","author":"Wysham","year":"2020","journal-title":"Postgrad. Med."},{"issue":"9911","key":"10.1016\/j.bcp.2024.116399_b0750","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2024.116399_b0755","doi-asserted-by":"crossref","first-page":"1027686","DOI":"10.3389\/fendo.2022.1027686","article-title":"The roles of mesenchymal stem cell-derived exosomes in diabetes mellitus and its related complications","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"11","key":"10.1016\/j.bcp.2024.116399_b0760","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1002\/jcb.27260","article-title":"Immunomodulatory effects of mesenchymal stem cell\u2013derived exosomes on experimental type-1 autoimmune diabetes","volume":"119","author":"Nojehdehi","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2024.116399_b0765","article-title":"Immune Cell-Derived Exosomes in Inflammatory Disease and Inflammatory Tumor Microenvironment: A Review","volume":"301\u201312","author":"Zhang","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bcp.2024.116399_b0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115958","article-title":"Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus","volume":"170","author":"Luo","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0775","first-page":"385","article-title":"Islet transplantation in type 1 diabetes: ongoing challenges, refined procedures, and long-term outcome The review of diabetic studies","volume":"9","author":"Shapiro","year":"2012","journal-title":"RDS"},{"key":"10.1016\/j.bcp.2024.116399_b0780","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00125-007-0670-8","article-title":"Vascular endothelial growth factor as a survival factor for human islets: effect of immunosuppressive drugs","volume":"50","author":"Cross","year":"2007","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0785","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.2337\/db13-0859","article-title":"Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice","volume":"63","author":"Rahman","year":"2014","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.bcp.2024.116399_b0790","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1039\/C9NR08234D","article-title":"Wound dressings functionalized with silver nanoparticles: Promises and pitfalls","volume":"12","author":"Kalantari","year":"2020","journal-title":"Nanoscale"},{"issue":"9498","key":"10.1016\/j.bcp.2024.116399_b0795","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bcp.2024.116399_b0800","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/bjd.13954","article-title":"Cellular and molecular mechanisms of repair in acute and chronic wound healing","volume":"173","author":"Martin","year":"2015","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0805","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1002\/jcb.28376","article-title":"Adipose mesenchymal stem cell-derived exosomes promote cell proliferation, migration, and inhibit cell apoptosis via Wnt\/\u03b2-catenin signaling in cutaneous wound healing","volume":"120","author":"Ma","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0810","first-page":"124","article-title":"Effects of adipose-derived stem cell released exosomes on wound healing in diabetic mice. Zhongguo xiu fu Chong Jian wai ke za zhi= Zhongguo Xiufu Chongjian Waike Zazhi=","volume":"34","author":"Wang","year":"2020","journal-title":"Chin. J. Reparat. Reconstruct. Surgery"},{"issue":"12","key":"10.1016\/j.bcp.2024.116399_b0815","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1111\/jocd.15394","article-title":"Decellularized human amniotic membrane engraftment in combination with adipose-derived stem cells transplantation, synergistically improved diabetic wound healing","volume":"21","author":"Davoodi","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"issue":"10","key":"10.1016\/j.bcp.2024.116399_b0820","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s00403-023-02709-z","article-title":"Exosomes derived from human adipose mesenchymal stem cells loaded bioengineered three-dimensional amniotic membrane-scaffold-accelerated diabetic wound healing","volume":"315","author":"Khalatbary","year":"2023","journal-title":"Arch. Dermatol. Res."},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0825","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3892\/ijmm.2024.5347","article-title":"Low-intensity pulsed ultrasound accelerates diabetic wound healing by ADSC-derived exosomes via promoting the uptake of exosomes and enhancing angiogenesis","volume":"53","author":"Zhong","year":"2024","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0830","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s10103-024-03974-8","article-title":"Photobiomodulation and conditioned medium of adipose-derived stem cells for enhancing wound healing in rats with diabetes: an investigation on the proliferation phase","volume":"39","author":"Pourhashemi","year":"2024","journal-title":"Lasers Med. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2024.116399_b0835","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s13770-021-00383-8","article-title":"Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1\u03b1 Signaling Pathway","volume":"18","author":"Liu","year":"2021","journal-title":"Tissue Eng. Regenerative Med."},{"key":"10.1016\/j.bcp.2024.116399_b0840","doi-asserted-by":"crossref","unstructured":"Ge L, Wang K, Lin H, Tao E, Xia W, Wang F, et al. Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction. 2023;11.","DOI":"10.3389\/fbioe.2023.1129538"},{"issue":"3","key":"10.1016\/j.bcp.2024.116399_b0845","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s12015-022-10487-w","article-title":"Production and Biological Effects of Extracellular Vesicles from Adipose-Derived Stem Cells Were Markedly Increased by Low-Intensity Ultrasound Stimulation for Promoting Diabetic Wound Healing","volume":"19","author":"Zheng","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2024.116399_b0850","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/s13018-023-04165-x","article-title":"Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p\/HIPK2","volume":"18","author":"Huang","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.bcp.2024.116399_b0855","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.reth.2024.01.005","article-title":"circ-Amotl1 in extracellular vesicles derived from ADSCs improves wound healing by upregulating SPARC translation","volume":"25","author":"Wu","year":"2024","journal-title":"Regenerative Therapy"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T20:12:41Z","timestamp":1728331961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224003824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":171,"alternative-id":["S0006295224003824"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116399","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116399"}}