{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:09Z","timestamp":1791946029502,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bcp.2024.116404","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:45:28Z","timestamp":1719582328000},"page":"116404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Laurocapram, a transdermal enhancer, boosts cephalosporin\u2019s antibacterial activity against Methicillin-resistant Staphylococcus aureus"],"prefix":"10.1016","volume":"227","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarui","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhe","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-187X","authenticated-orcid":false,"given":"Yonglin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bcp.2024.116404_b0005","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1021\/acs.chemrev.0c01010","article-title":"beta-Lactams against the fortress of the gram-positive Staphylococcus aureus bacterium","volume":"121","author":"Fisher","year":"2021","journal-title":"Chem. Rev."},{"issue":"4","key":"10.1016\/j.bcp.2024.116404_b0010","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/CMR.00120-16","article-title":"The role of antibiotics in modulating virulence in Staphylococcus aureus","volume":"30","author":"Hodille","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"issue":"11","key":"10.1016\/j.bcp.2024.116404_b0015","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3201\/eid2111.150452","article-title":"USA300 methicillin-resistant Staphylococcus aureus, United States, 2000\u20132013","volume":"21","author":"Carrel","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bcp.2024.116404_b0020","doi-asserted-by":"crossref","unstructured":"P. Glaser, P. Martins-Simoes, A. Villain, M. Barbier, A. Tristan, C. Bouchier, L. Ma, M. Bes, F. Laurent, D. Guillemot, T. Wirth, F. Vandenesch, Demography and intercontinental spread of the USA300 community-acquired methicillin-resistant Staphylococcus aureus lineage, mBio 7(1) (2016) e02183-15.","DOI":"10.1128\/mBio.02183-15"},{"issue":"3","key":"10.1016\/j.bcp.2024.116404_b0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bcp.2024.116404_b0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06839-1","article-title":"Differential active site requirements for NDM-1 beta-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics","volume":"9","author":"Sun","year":"2018","journal-title":"Nat. Commun."},{"issue":"24","key":"10.1016\/j.bcp.2024.116404_b0035","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.1007\/s00253-022-12272-8","article-title":"Cephalosporins as key lead generation beta-lactam antibiotics","volume":"106","author":"Lin","year":"2022","journal-title":"Appl. Microbiol. Biot."},{"issue":"15","key":"10.1016\/j.bcp.2024.116404_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158088","article-title":"Molecular mechanisms of drug resistance in Staphylococcus aureus","volume":"23","author":"Mlynarczyk-Bonikowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2024.116404_b0045","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/s41598-018-37900-0","article-title":"Effect of chemical permeation enhancers on skin permeability: in silico screening using molecular dynamics simulations","volume":"9","author":"Gupta","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2024.116404_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13010066","article-title":"CPE-DB: an open database of chemical penetration enhancers","volume":"13","author":"Vasyuchenko","year":"2021","journal-title":"Pharmaceutics"},{"issue":"12","key":"10.1016\/j.bcp.2024.116404_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082581","article-title":"Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery","volume":"8","author":"Marepally","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bcp.2024.116404_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122818","article-title":"Improved topical drug delivery: role of permeation enhancers and advanced approaches","volume":"14","author":"Hmingthansanga","year":"2022","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.bcp.2024.116404_b0065","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/phar.2505","article-title":"A guide to therapeutic drug monitoring of beta-lactam antibiotics","volume":"41","author":"Fratoni","year":"2021","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bcp.2024.116404_b0070","doi-asserted-by":"crossref","unstructured":"R. Humphries, A.M. Bobenchik, J.A. Hindler, A.N. Schuetz, Overview of Changes to the Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial Susceptibility Testing, M100, 31st Edition, J Clin Microbiol 59(12) (2021) e0021321.","DOI":"10.1128\/JCM.00213-21"},{"issue":"6","key":"10.1016\/j.bcp.2024.116404_b0075","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/JCM.39.6.2206-2212.2001","article-title":"Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory","volume":"39","author":"Paterson","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bcp.2024.116404_b0080","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fcimb.2018.00418","article-title":"Baicalin Weakens Staphylococcus aureus pathogenicity by targeting sortase B","volume":"8","author":"Wang","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116404_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9030161","article-title":"Isoalantolactone enhances the antimicrobial activity of penicillin G against Staphylococcus aureus by inactivating beta-lactamase during protein translation","volume":"9","author":"Zhou","year":"2020","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.bcp.2024.116404_b0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12941-018-0257-x","article-title":"Continued in vitro cefazolin susceptibility in methicillin-susceptible Staphylococcus aureus","volume":"17","author":"Gern","year":"2018","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.bcp.2024.116404_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2019.04.001","article-title":"Synergistic antibacterial mechanism of Bi2Te3 nanoparticles combined with the ineffective beta-lactam antibiotic cefotaxime against methicillin-resistant Staphylococcus aureus","volume":"196","author":"Liu","year":"2019","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2024.116404_b0110","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01912-19","article-title":"Subinhibitory concentrations of mupirocin stimulate Staphylococcus aureus biofilm formation by Upregulating cidA","volume":"64","author":"Jin","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2024.116404_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130117","article-title":"Preparation and photodynamic bactericidal effects of curcumin-beta-cyclodextrin complex","volume":"361","author":"Lai","year":"2021","journal-title":"Food Chem."},{"issue":"11","key":"10.1016\/j.bcp.2024.116404_b0120","article-title":"Antibacterial activity of squaric amide derivative SA2 against methicillin-resistant Staphylococcus aureus","volume":"11","author":"Yu","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.bcp.2024.116404_b0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.msec.2019.04.031","article-title":"Antibacterial activity of a novel Forsythia suspensa fruit mediated green silver nanoparticles against food-borne pathogens and mechanisms investigation","volume":"102","author":"Du","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"51","key":"10.1016\/j.bcp.2024.116404_b0130","doi-asserted-by":"crossref","first-page":"16201","DOI":"10.1021\/acs.jafc.2c06615","article-title":"Naringenin microsphere as a novel adjuvant reverses colistin resistance via various strategies against multidrug-resistant Klebsiella pneumoniae infection","volume":"70","author":"Sheng","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2024.116404_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153946","article-title":"Nordihydroguaiaretic acid reverses the antibacterial activity of colistin against MCR-1-positive bacteria in vivo\/in vitro by inhibiting MCR-1 activity and injuring the bacterial cell membrane","volume":"98","author":"Song","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2024.116404_b0140","article-title":"Antimicrobial activities of lavandulylated flavonoids in Sophora flavences against methicillin-resistant Staphylococcus aureus via membrane disruption","author":"Weng","year":"2023","journal-title":"J. Adv. Res."},{"issue":"5","key":"10.1016\/j.bcp.2024.116404_b0145","doi-asserted-by":"crossref","first-page":"894","DOI":"10.24272\/j.issn.2095-8137.2023.084","article-title":"Dihydroartemisinin inhibits plasmid transfer in drug-resistant Escherichia coli via limiting energy supply","volume":"44","author":"Wang","year":"2023","journal-title":"Zool. Res."},{"key":"10.1016\/j.bcp.2024.116404_b0150","doi-asserted-by":"crossref","first-page":"1133685","DOI":"10.3389\/fphar.2023.1133685","article-title":"Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming","volume":"14","author":"Fan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116404_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103943","article-title":"A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)\/tet(X4)-positive bacteria","volume":"78","author":"Xu","year":"2022","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.bcp.2024.116404_b0160","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00950-22","article-title":"Hibifolin, a natural sortase A inhibitor, attenuates the pathogenicity of Staphylococcus aureus and enhances the antibacterial activity of cefotaxime","volume":"10","author":"Song","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.bcp.2024.116404_b0165","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2940746","article-title":"Gentiopicroside ameliorates oxidative stress and lipid accumulation through nuclear factor erythroid 2-related factor 2 activation","volume":"2020","author":"Jin","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2024.116404_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127071","article-title":"Natural flavone hispidulin protects mice from Staphylococcus aureus pneumonia by inhibition of alpha-hemolysin production via targeting AgrA(C)","volume":"261","author":"Ren","year":"2022","journal-title":"Microbiol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116404_b0175","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/21505594.2022.2051313","article-title":"Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection","volume":"13","author":"Jing","year":"2022","journal-title":"Virulence"},{"issue":"10","key":"10.1016\/j.bcp.2024.116404_b0180","doi-asserted-by":"crossref","first-page":"16625","DOI":"10.1021\/acsnano.1c06460","article-title":"Lung-targeting lysostaphin microspheres for methicillin-resistant Staphylococcus aureus pneumonia treatment and prevention","volume":"15","author":"Lin","year":"2021","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.bcp.2024.116404_b0185","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1128\/AAC.02083-15","article-title":"Neomycin sulfate improves the antimicrobial activity of mupirocin-based antibacterial ointments","volume":"60","author":"Blanchard","year":"2016","journal-title":"Antimicrob. Agents Ch."},{"issue":"15","key":"10.1016\/j.bcp.2024.116404_b0190","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100749","article-title":"Plant natural flavonoids against multidrug resistant pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116404_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26020329","article-title":"Antioxidant and antimicrobial activity of ethanol-water extract of fireweed (Epilobium angustifolium L.)","volume":"26","author":"Nowak","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2024.116404_b0200","doi-asserted-by":"crossref","first-page":"7977433","DOI":"10.1155\/2022\/7977433","article-title":"Vitexin mitigates Staphylococcus aureus-induced mastitis via regulation of ROS\/ER stress\/NF-kappaB\/MAPK pathway","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2024.116404_b0205","doi-asserted-by":"crossref","first-page":"1171339","DOI":"10.3389\/fmicb.2023.1171339","article-title":"Transcriptomic analyses reveal the potential antibacterial mechanism of citral against Staphylococcus aureus","volume":"14","author":"Liao","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bcp.2024.116404_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111933","article-title":"Staphyloxanthin inhibitory potential of thymol impairs antioxidant fitness, enhances neutrophil mediated killing and alters membrane fluidity of methicillin resistant Staphylococcus aureus","volume":"141","author":"Valliammai","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.bcp.2024.116404_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14070464","article-title":"Exploring the role of Staphylococcus aureus in inflammatory diseases","volume":"14","author":"Chen","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.bcp.2024.116404_b0220","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fcimb.2019.00193","article-title":"Drug repurposing to fight colistin and carbapenem-resistant bacteria","volume":"9","author":"Peyclit","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116404_b0225","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1038\/s41467-021-23659-y","article-title":"Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bcp.2024.116404_b0230","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02727-16","article-title":"High-level resistance of Staphylococcus aureus to beta-lactam antibiotics mediated by penicillin-binding protein 4 (PBP4)","volume":"61","author":"Hamilton","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.bcp.2024.116404_b0235","article-title":"Bacterial targets of antibiotics in methicillin-resistant Staphylococcus aureus","volume":"10","author":"Lade","year":"2021","journal-title":"Antibiotics (Basel)"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2024.116404_b0240","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijpharm.2006.07.022","article-title":"Investigation into the potential of low-frequency ultrasound facilitated topical delivery of Cyclosporin A","volume":"326","author":"Liu","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2024.116404_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118800","article-title":"Transdermal enhancement strategy of ketoprofen and teriflunomide: The effect of enhanced drug-drug intermolecular interaction by permeation enhancer on drug release of compound transdermal patch","volume":"572","author":"Liu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2024.116404_b0250","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1600-0609.1993.tb01898.x","article-title":"Teicoplanin in gram-positive infection: microbiological aspects","volume":"54","author":"Spencer","year":"1993","journal-title":"Eur. J. Haematol. Suppl."},{"issue":"3","key":"10.1016\/j.bcp.2024.116404_b0255","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0924-8579(95)00004-R","article-title":"A critical review of the in-vitro activity of teicoplanin","volume":"5","author":"Spencer","year":"1995","journal-title":"Int. J. Antimicrob. Agents"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224003873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T16:43:56Z","timestamp":1723653836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224003873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":49,"alternative-id":["S0006295224003873"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116404","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Laurocapram, a transdermal enhancer, boosts cephalosporin\u2019s antibacterial activity against Methicillin-resistant Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116404"}}