{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:25:17Z","timestamp":1772670317565,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222241"],"award-info":[{"award-number":["7222241"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bcp.2024.116490","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T16:53:19Z","timestamp":1723567999000},"page":"116490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson\u2019s disease"],"prefix":"10.1016","volume":"229","author":[{"given":"Xiaodan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aobo","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2024.116490_b0005","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: from transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0010","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.nurt.2008.05.001","article-title":"Therapeutics for Alzheimer\u2019s disease based on the metal hypothesis, (in Eng)","volume":"5","author":"Bush","year":"2008","journal-title":"Neurotherapeutics"},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116490_b0015","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-2999(01)00792-0","article-title":"Oxidative stress and c-Jun-amino-terminal kinase activation involved in apoptosis of primary astrocytes induced by disulfiram-Cu(2+) complex, (in Eng)","volume":"414","author":"Chen","year":"2001","journal-title":"Eur. J. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2024.116490_b0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12011-013-9665-0","article-title":"Biochemical, histological, and memory impairment effects of chronic copper toxicity: a model for non-Wilsonian brain copper toxicosis in Wistar rat, (in Eng)","volume":"153","author":"Pal","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bcp.2024.116490_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113369","article-title":"Copper induces microglia-mediated neuroinflammation through ROS\/NF-\u03baB pathway and mitophagy disorder, (in Eng)","volume":"168","author":"Zhou","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1474-4422(14)70190-5","article-title":"Wilson\u2019s disease and other neurological copper disorders","volume":"14","author":"Bandmann","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bcp.2024.116490_b0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pneurobio.2014.01.002","article-title":"Metabolism and functions of copper in brain","volume":"116","author":"Scheiber","year":"2014","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.bcp.2024.116490_b0040","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/hep.30911","article-title":"The prevalence of Wilson\u2019s disease: an update, (in Eng)","volume":"71","author":"Sandahl","year":"2020","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0045","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson disease","volume":"4","author":"Cz\u0142onkowska","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10","key":"10.1016\/j.bcp.2024.116490_b0050","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.parkreldis.2009.01.010","article-title":"Neuropsychiatric aspects of treated Wilson\u2019s disease","volume":"15","author":"Svetel","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.bcp.2024.116490_b0055","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5334\/tohm.435","article-title":"Advances in treatment of Wilson disease","volume":"8","author":"Aggarwal","year":"2018","journal-title":"Tremor Other Hyperkinet. Mov. (N Y)"},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1749-6632.2009.05109.x","article-title":"Neurologic Wilson\u2019s disease","volume":"1184","author":"Lorincz","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000115077","article-title":"Oral zinc sulphate as long-term treatment in Wilson\u2019s disease (hepatolenticular degeneration)","volume":"18","author":"Hoogenraad","year":"1979","journal-title":"Eur. Neurol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.braindev.2005.08.008","article-title":"Paradigm shift in treatment of Wilson\u2019s disease: zinc therapy now treatment of choice","volume":"28","author":"Hoogenraad","year":"2006","journal-title":"Brain Dev."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.lab.2005.01.007","article-title":"Treatment of Wilson\u2019s disease with zinc from the time of diagnosis in pediatric patients: a single-hospital, 10-year follow-up study","volume":"145","author":"Marcellini","year":"2005","journal-title":"J. Lab. Clin. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-019-0330-8","article-title":"Pineal gland dysfunction in Alzheimer\u2019s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis","volume":"14","author":"Song","year":"2019","journal-title":"Mol. Neurodegener."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0085","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-079X.2009.00664.x","article-title":"Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms","volume":"46","author":"Ersahin","year":"2009","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0090","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbr.2012.08.045","article-title":"Behavioural actions of two new 1-N substituted analogues of melatonin","volume":"236","author":"Bustamante-Garcia","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bcp.2024.116490_b0095","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-079X.2010.00828.x","article-title":"Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy","volume":"50","author":"Uberos","year":"2011","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-079X.1998.tb00361.x","article-title":"The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: an adsorptive voltammetric study, (in Eng)","volume":"24","author":"Limson","year":"1998","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/jpi.12196","article-title":"Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis, (in Eng)","volume":"58","author":"Galano","year":"2015","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.bcp.2024.116490_b0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1034\/j.1600-079X.2002.01859.x","article-title":"Melatonin protects against copper-mediated free radical damage, (in Eng)","volume":"32","author":"Parmar","year":"2002","journal-title":"J. Pineal Res."},{"issue":"8","key":"10.1016\/j.bcp.2024.116490_b0115","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1021\/acs.jproteome.5b00434","article-title":"Divergent urinary metabolic phenotypes between major depressive disorder and bipolar disorder identified by a combined GC-MS and NMR spectroscopic metabonomic approach","volume":"14","author":"Chen","year":"2015","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0120","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev.pharmtox.48.113006.094715","article-title":"Metabolomics: a global biochemical approach to drug response and disease","volume":"48","author":"Kaddurah-Daouk","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116490_b0125","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1469-7580.2002.00064.x","article-title":"Astrocyte-endothelial interactions and blood-brain barrier permeability","volume":"200","author":"Abbott","year":"2002","journal-title":"J. Anat."},{"key":"10.1016\/j.bcp.2024.116490_b0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneumeth.2013.09.001","article-title":"Detecting brain structural changes as biomarker from magnetic resonance images using a local feature based SVM approach","volume":"221","author":"Chen","year":"2014","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.bcp.2024.116490_b0135","doi-asserted-by":"crossref","first-page":"e0119654","DOI":"10.1371\/journal.pone.0119654","article-title":"1H NMR-based metabolomics investigation of copper-laden rat: a model of Wilson\u2019s disease","volume":"10","author":"Xu","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13024-018-0304-2","article-title":"Recent advances and perspectives of metabolomics-based investigations in Parkinson\u2019s disease, (in Eng)","volume":"14","author":"Shao","year":"2019","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0145","first-page":"1333","article-title":"Mechanism of action of salvianolic acid B by module-based network analysis, (in Eng)","volume":"24","author":"Ren","year":"2014","journal-title":"Biomed. Mater. Eng."},{"key":"10.1016\/j.bcp.2024.116490_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120710","article-title":"Integrated strategy for accurately screening biomarkers based on metabolomics coupled with network pharmacology, (in Eng)","volume":"211","author":"Zhang","year":"2020","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0155","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.taap.2010.09.027","article-title":"Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with d-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis, (in Eng)","volume":"250","author":"Roy","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116490_b0160","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1042\/BSR20180800","article-title":"GanDouLing combined with Penicillamine improves cerebrovascular injury via PERK\/eIF2\u03b1\/CHOP endoplasmic reticulum stress pathway in the mouse model of Wilson\u2019s disease, (in Eng)","volume":"38","author":"Chen","year":"2018","journal-title":"Biosci. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2024.116490_b0165","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.21037\/apm-20-301","article-title":"Gandou decoction, a Chinese medicinal formula, in the treatment of hepatic injury by Wnt\/\u03b2-catenin pathway regulation in models of Wilson disease, (in Eng)","volume":"9","author":"Gao","year":"2020","journal-title":"Ann. Palliat. Med."},{"issue":"9559","key":"10.1016\/j.bcp.2024.116490_b0170","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(07)60196-2","article-title":"Wilson\u2019s disease, (in Eng)","volume":"369","author":"Ala","year":"2007","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.bcp.2024.116490_b0175","article-title":"Hepatoprotective effect of melatonin in toxic liver injury in rats (in Eng)","volume":"55","author":"Oleshchuk","year":"2019","journal-title":"Medicina (kaunas)"},{"issue":"4","key":"10.1016\/j.bcp.2024.116490_b0180","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1080\/01480545.2020.1858853","article-title":"Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat, (in Eng)","volume":"45","author":"Lamtai","year":"2022","journal-title":"Drug Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116490_b0185","doi-asserted-by":"crossref","first-page":"pp","DOI":"10.1111\/jpi.12399","article-title":"Melatonin prevents obesity through modulation of gut microbiota in mice, (in Eng)","volume":"62","author":"Xu","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bcp.2024.116490_b0190","article-title":"Gandou decoction decreases copper levels and alleviates hepatic injury in copper-laden hepatolenticular degeneration model rats","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116490_b0195","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.taap.2016.01.007","article-title":"Relationship of antioxidant and oxidative stress markers in different organs following copper toxicity in a rat model, (in Eng)","volume":"293","author":"Kumar","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/bdi.12962","article-title":"Regulatory effect of lithium on hippocampal blood-brain barrier integrity in a rat model of depressive-like behavior, (in Eng)","volume":"23","author":"Taler","year":"2021","journal-title":"Bipolar Disord."},{"issue":"11","key":"10.1016\/j.bcp.2024.116490_b0205","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1038\/nprot.2007.376","article-title":"Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts","volume":"2","author":"Beckonert","year":"2007","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0210","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28031514","article-title":"Silymarin encapsulated liposomal formulation: an effective treatment modality against copper toxicity associated liver dysfunction and neurobehavioral abnormalities in Wistar rats","volume":"28","author":"Maryam","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2024.116490_b0215","article-title":"Oxidative stress and neurobehavioural changes in rats following copper exposure and their response to MiADMSA and d-penicillamine","volume":"3","author":"Quamar","year":"2019","journal-title":"Toxicol. Res. Appl."},{"issue":"4","key":"10.1016\/j.bcp.2024.116490_b0220","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s43188-020-00043-4","article-title":"Chronic copper exposure leads to hippocampus oxidative stress and impaired learning and memory in male and female rats","volume":"36","author":"Lamtai","year":"2020","journal-title":"Toxicol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0225","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijpharm.2016.08.040","article-title":"Delivery of Copper-chelating Trientine (TETA) to the central nervous system by surface modified liposomes, (in Eng)","volume":"512","author":"Tremmel","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0230","first-page":"197","article-title":"Chelation treatment of neurological Wilson\u2019s disease, (in Eng)","volume":"86","author":"Walshe","year":"1993","journal-title":"Q. J. Med."},{"issue":"5","key":"10.1016\/j.bcp.2024.116490_b0235","doi-asserted-by":"crossref","first-page":"e37709","DOI":"10.1371\/journal.pone.0037709","article-title":"Penicillamine increases free copper and enhances oxidative stress in the brain of toxic milk mice","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2024.116490_b0240","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbrc.2015.01.071","article-title":"Effects of tetrathiomolybdate and penicillamine on brain hydroxyl radical and free copper levels: a microdialysis study in vivo","volume":"458","author":"Zhang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0245","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"issue":"16","key":"10.1016\/j.bcp.2024.116490_b0250","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.lfs.2007.01.017","article-title":"Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson\u2019s disease, (in Eng)","volume":"80","author":"Levy","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2024.116490_b0255","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jep.2019.01.018","article-title":"Brain metabonomics study of the antidepressant-like effect of Xiaoyaosan on the CUMS-depression rats by (1)H NMR analysis","volume":"235","author":"Liu","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0260","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jnr.20749","article-title":"Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons, (in Eng)","volume":"83","author":"Santos","year":"2006","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0265","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/brain\/awac444","article-title":"MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy, (in Eng)","volume":"146","author":"Pujol","year":"2023","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.bcp.2024.116490_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108719","article-title":"Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration, (in Eng)","volume":"196","author":"Andersen","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2024.116490_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2023.110777","article-title":"Melatonin reduces radiation-induced ferroptosis in hippocampal neurons by activating the PKM2\/NRF2\/GPX4 signaling pathway","volume":"126","author":"Ren","year":"2023","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"22","key":"10.1016\/j.bcp.2024.116490_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212494","article-title":"Melatonin and pathological cell interactions: mitochondrial glucose processing in cancer cells","volume":"22","author":"Reiter","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0285","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.sjbs.2022.01.039","article-title":"Application of melatonin and PGPR alleviates thiamethoxam induced toxicity by regulating the TCA cycle in Brassica juncea L","volume":"29","author":"Jan","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2024.116490_b0290","doi-asserted-by":"crossref","first-page":"459","DOI":"10.5483\/BMBRep.2022.55.9.177","article-title":"Melatonin inhibits glycolysis in hepatocellular carcinoma cells by downregulating mitochondrial respiration and mTORC1 activity","volume":"55","author":"Lee","year":"2022","journal-title":"BMB Rep."},{"issue":"2","key":"10.1016\/j.bcp.2024.116490_b0295","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jcp.25488","article-title":"Can cholesterol metabolism modulation affect brain function and behavior?, (in Eng)","volume":"232","author":"Cartocci","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116490_b0300","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1034\/j.1600-079X.2001.280304.x","article-title":"Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats","volume":"28","author":"Hoyos","year":"2000","journal-title":"J. Pineal Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224004738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224004738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:16:13Z","timestamp":1741713373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224004738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":60,"alternative-id":["S0006295224004738"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116490","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116490"}}