{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:45:55Z","timestamp":1791978355765,"version":"4.4.0"},"reference-count":226,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bcp.2024.116565","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T15:23:43Z","timestamp":1727969023000},"page":"116565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"P1","title":["Carnitine traffic and human fertility"],"prefix":"10.1016","volume":"230","author":[{"given":"Tiziano","family":"Mazza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariafrancesca","family":"Scalise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Console","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Galluccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Giangregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Tonazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Pochini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-6621","authenticated-orcid":false,"given":"Cesare","family":"Indiveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 3","key":"10.1016\/j.bcp.2024.116565_b0005","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/bj3610417","article-title":"Carnitine biosynthesis in mammals","volume":"361","author":"Vaz","year":"2002","journal-title":"Biochem. J"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0010","first-page":"85","article-title":"Molecular cloning and characterization of the cDNA encoding the rat liver gamma-butyrobetaine hydroxylase","volume":"1441","author":"Galland","year":"1999","journal-title":"BBA"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0015","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1038\/s41467-024-47466-3","article-title":"One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse","volume":"15","author":"Malatesta","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2024.116565_b0020","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1750-1172-7-68","article-title":"Systemic primary carnitine deficiency: an overview of clinical manifestations, diagnosis, and management","volume":"7","author":"Magoulas","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b0025","first-page":"2422","article-title":"Carnitine transport and fatty acid oxidation","volume":"1863","author":"Longo","year":"2016","journal-title":"BBA"},{"issue":"4\u20136","key":"10.1016\/j.bcp.2024.116565_b0030","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.mam.2011.10.008","article-title":"The mitochondrial carnitine\/acylcarnitine carrier: function, structure and physiopathology","volume":"32","author":"Indiveri","year":"2011","journal-title":"Mol. Aspects Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0035","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0002-9629(15)40569-5","article-title":"The role of the carnitine system in peroxisomal fatty acid oxidation","volume":"318","author":"Ramsay","year":"1999","journal-title":"Am. J. Med. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b0040","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1194\/jlr.R005959","article-title":"Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism","volume":"51","author":"Van Veldhoven","year":"2010","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bcp.2024.116565_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.583850","article-title":"Carnitine Traffic in Cells. Link with Cancer","volume":"8","author":"Console","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41387-018-0017-1","article-title":"Role of carnitine and its derivatives in the development and management of type 2 diabetes","volume":"8","author":"Bene","year":"2018","journal-title":"Nutr. Diabetes"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s44192-023-00056-z","article-title":"The neuropsychopharmacology of acetyl-L-carnitine (LAC): basic, translational and therapeutic implications","volume":"4","author":"Bigio","year":"2024","journal-title":"Discov Ment Health"},{"issue":"7","key":"10.1016\/j.bcp.2024.116565_b0060","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2741\/4459","article-title":"The neurobiology of acetyl-L-carnitine","volume":"21","author":"Traina","year":"2016","journal-title":"Front Biosci (landmark Ed)"},{"issue":"12","key":"10.1016\/j.bcp.2024.116565_b0065","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s12033-022-00522-z","article-title":"Overproduction, Purification, and Stability of the Functionally Active Human Carnitine Acetyl Transferase","volume":"64","author":"Giudice","year":"2022","journal-title":"Mol. Biotechnol."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b0070","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.devcel.2021.04.013","article-title":"Lipid metabolism in cancer: New perspectives and emerging mechanisms","volume":"56","author":"Broadfield","year":"2021","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/biom14040392","article-title":"Inflammation and Organic Cation Transporters Novel (OCTNs)","volume":"14","author":"Pochini","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2024.116565_b0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1196\/annals.1320.012","article-title":"Carnitines and its congeners: a metabolic pathway to the regulation of immune response and inflammation","volume":"1033","author":"Famularo","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116565_b0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mad.2012.01.007","article-title":"Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart","volume":"133","author":"Gomez","year":"2012","journal-title":"Mech. Ageing Dev."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0090","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/GIM.0b013e3181614289","article-title":"Acylcarnitine profile analysis","volume":"10","author":"Rinaldo","year":"2008","journal-title":"Genet. Med."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/pr.118.015578","article-title":"Organic Cation Transporters in Health and Disease","volume":"72","author":"Koepsell","year":"2020","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.c.30087","article-title":"Disorders of carnitine transport and the carnitine cycle","volume":"142C","author":"Longo","year":"2006","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"issue":"11","key":"10.1016\/j.bcp.2024.116565_b0105","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2165\/00003088-200342110-00002","article-title":"Pharmacokinetics of L-carnitine","volume":"42","author":"Evans","year":"2003","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00394-015-0838-9","article-title":"Effect of L-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians","volume":"55","author":"Novakova","year":"2016","journal-title":"Eur. J. Nutr."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ymgme.2015.09.004","article-title":"Disorders of carnitine biosynthesis and transport","volume":"116","author":"El-Hattab","year":"2015","journal-title":"Mol. Genet. Metab."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/iub.323","article-title":"Enzymology of the carnitine biosynthesis pathway","volume":"62","author":"Strijbis","year":"2010","journal-title":"IUBMB Life"},{"issue":"21","key":"10.1016\/j.bcp.2024.116565_b0125","doi-asserted-by":"crossref","first-page":"7974","DOI":"10.1073\/pnas.1120210109","article-title":"A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism","volume":"109","author":"Celestino-Soper","year":"2012","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0130","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1038\/tp.2012.143","article-title":"Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder","volume":"3","author":"Frye","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"46","key":"10.1016\/j.bcp.2024.116565_b0135","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210247119","article-title":"Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency","volume":"119","author":"Koleske","year":"2022","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2024.116565_b0140","series-title":"Carnitine Deficiency","author":"Dahash","year":"2024"},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0145","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology","volume":"103","author":"Yu","year":"2006","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0015-0282(02)04679-4","article-title":"Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial","volume":"79","author":"Lenzi","year":"2003","journal-title":"Fertil. Steril."},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2024.116565_b0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/dom.14007","article-title":"An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines","volume":"22","author":"Selby","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bcp.2024.116565_b0160","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev-pharmtox-010617-052713","article-title":"The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease","volume":"58","author":"Nigam","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0165","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrd4626","article-title":"SLC transporters as therapeutic targets: emerging opportunities","volume":"14","author":"Lin","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0170","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1124\/pr.54.4.589","article-title":"Pivalate-generating prodrugs and carnitine homeostasis in man","volume":"54","author":"Brass","year":"2002","journal-title":"Pharmacol. Rev."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116565_b0175","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cbi.2008.10.052","article-title":"Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes","volume":"179","author":"Pochini","year":"2009","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/biom11040521","article-title":"The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs","volume":"11","author":"Tonazzi","year":"2021","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0185","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/cpt.2627","article-title":"New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium","volume":"112","author":"Giacomini","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0190","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/cpt.2644","article-title":"International Transporter, Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance","volume":"112","author":"Zamek-Gliszczynski","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116565_b0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0014-5793(99)00241-0","article-title":"Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice","volume":"446","author":"Toshimori","year":"1999","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and Management of Infertility: A Review","volume":"326","author":"Carson","year":"2021","journal-title":"J. Am. Med. Assoc."},{"issue":"10271","key":"10.1016\/j.bcp.2024.116565_b0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(20)32667-2","article-title":"Male infertility","volume":"397","author":"Agarwal","year":"2021","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.bcp.2024.116565_b0210","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.12968\/bjon.2016.25.18.S35","article-title":"Male infertility: an overview of causes and treatment options","volume":"25","author":"Leaver","year":"2016","journal-title":"Br. J. Nurs."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0215","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ucl.2013.08.006","article-title":"The epidemiology of male infertility","volume":"41","author":"Winters","year":"2014","journal-title":"Urol. Clin. North Am."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0220","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/biolre\/ioz084","article-title":"Genetics of human female infertilitydagger","volume":"101","author":"Yatsenko","year":"2019","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0225","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ajhg.2013.03.016","article-title":"Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia","volume":"92","author":"Dirami","year":"2013","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0230","first-page":"101","article-title":"Environmental and occupational exposures associated with male infertility","volume":"72","author":"Maric","year":"2021","journal-title":"Arh. Hig. Rada Toksikol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0235","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.fertnstert.2017.02.115","article-title":"Obesity, male infertility, and the sperm epigenome","volume":"107","author":"Craig","year":"2017","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0240","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/01.AOG.0000287293.25465.e1","article-title":"Diet and lifestyle in the prevention of ovulatory disorder infertility","volume":"110","author":"Chavarro","year":"2007","journal-title":"Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0245","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/cen.13003","article-title":"Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial","volume":"84","author":"Samimi","year":"2016","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0250","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.fertnstert.2018.08.015","article-title":"Male infertility as a window to health","volume":"110","author":"Choy","year":"2018","journal-title":"Fertil. Steril."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b0255","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1089\/jwh.2015.5194","article-title":"Understanding Fertility in Young Female Cancer Patients","volume":"24","author":"Waimey","year":"2015","journal-title":"J Womens Health (Larchmt)"},{"issue":"27","key":"10.1016\/j.bcp.2024.116565_b0260","doi-asserted-by":"crossref","first-page":"e29401","DOI":"10.1097\/MD.0000000000029401","article-title":"COVID-19 and male infertility: An overview of the disease","volume":"101","author":"Malki","year":"2022","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0265","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/13697137.2023.2246878","article-title":"COVID-19-related premature ovarian insufficiency: case report and literature review","volume":"26","author":"Pankiewicz","year":"2023","journal-title":"Climacteric"},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0270","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/cge.12896","article-title":"Genetics of mitochondrial dysfunction and infertility","volume":"91","author":"Demain","year":"2017","journal-title":"Clin. Genet."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0275","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.fertnstert.2005.03.064","article-title":"Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia","volume":"84","author":"Balercia","year":"2005","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0280","first-page":"69","article-title":"Evaluation of L-Carnitine Potential in Improvement of Male Fertility","volume":"24","author":"Kooshesh","year":"2023","journal-title":"J Reprod Infertil"},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0285","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0290","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1210\/jc.2007-2616","article-title":"Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa","volume":"93","author":"Koppers","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"18","key":"10.1016\/j.bcp.2024.116565_b0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810574","article-title":"Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects","volume":"23","author":"Dutta","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0300","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","article-title":"Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems","volume":"65","author":"Tacar","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0305","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.biopsych.2013.03.018","article-title":"Meta-analysis of oxidative stress in schizophrenia","volume":"74","author":"Flatow","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bcp.2024.116565_b0310","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0315","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.mib.2009.06.018","article-title":"Role of reactive oxygen species in antibiotic action and resistance","volume":"12","author":"Dwyer","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0320","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.gco.0000193003.58158.4e","article-title":"The role of free radicals and antioxidants in reproduction","volume":"18","author":"Agarwal","year":"2006","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.bcp.2024.116565_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.cryobiol.2024.104884","article-title":"l-carnitine enhances the kinematics and protects the sperm membranes of chilled and frozen-thawed Peruvian Paso horse spermatozoa","volume":"115","author":"Palacios","year":"2024","journal-title":"Cryobiology"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0330","first-page":"76","article-title":"Effect of antioxidant supplementation containing L-carnitine on semen parameters: a prospective interventional study","volume":"25","author":"Nazari","year":"2021","journal-title":"JBRA Assist Reprod"},{"key":"10.1016\/j.bcp.2024.116565_b0335","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.theriogenology.2021.12.030","article-title":"Addition of l-carnitine to the freezing extender improves post-thaw sperm quality of Okinawan native Agu pig","volume":"188","author":"Tatemoto","year":"2022","journal-title":"Theriogenology"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0340","first-page":"610","article-title":"Omega-3 fatty acids and L-carnitine prevent meiotic oocyte damage induced by follicular fluid from infertile women with endometriosis: an experimental study","volume":"27","author":"Giorgi","year":"2023","journal-title":"JBRA Assist Reprod"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0345","article-title":"Carnitines as Mitochondrial Modulators of Oocyte and Embryo Bioenergetics","volume":"11","author":"Placidi","year":"2022","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2024.116565_b0350","article-title":"Carnitine Deficiency and Pregnancy","volume":"2015","author":"de Bruyn","year":"2015","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"10.1016\/j.bcp.2024.116565_b0355","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbacli.2017.07.003","article-title":"Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile","volume":"8","author":"Ku","year":"2017","journal-title":"BBA Clin."},{"key":"10.1016\/j.bcp.2024.116565_b0360","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: a review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0365","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1017\/S0029665110002016","article-title":"Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet","volume":"69","author":"O'Connor","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.bcp.2024.116565_b0370","doi-asserted-by":"crossref","unstructured":"A. Kaltsas, A. Zikopoulos, E. Moustakli, A. Zachariou, G. Tsirka, C. Tsiampali, N. Palapela, N. Sofikitis, F. Dimitriadis, The Silent Threat to Women's Fertility: Uncovering the Devastating Effects of Oxidative Stress, Antioxidants (Basel) 12(8) (2023).","DOI":"10.3390\/antiox12081490"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0375","article-title":"The Importance of Natural Antioxidants in Female Reproduction","volume":"12","author":"Vaskova","year":"2023","journal-title":"Antioxidants (basel)"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0380","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12906-022-03749-0","article-title":"The protective effect of L-carnitine on testosterone synthesis pathway, and spermatogenesis in monosodium glutamate-induced rats","volume":"22","author":"Koohpeyma","year":"2022","journal-title":"BMC Complement Med Ther"},{"issue":"1\u20133","key":"10.1016\/j.bcp.2024.116565_b0385","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsbmb.2009.12.005","article-title":"Central effects of estradiol in the regulation of food intake, body weight, and adiposity","volume":"122","author":"Brown","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0390","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12958-018-0323-4","article-title":"Role of L-carnitine in female infertility","volume":"16","author":"Agarwal","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116565_b0395","doi-asserted-by":"crossref","first-page":"1160440","DOI":"10.3389\/fphar.2023.1160440","article-title":"Mitochondrial CPT1A: Insights into structure, function, and basis for drug development","volume":"14","author":"Liang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0400","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1210\/jcem.86.8.7747","article-title":"Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial","volume":"86","author":"Benvenga","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0405","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s00018-002-8445-3","article-title":"Thyroid hormone controls carnitine status through modifications of gamma-butyrobetaine hydroxylase activity and gene expression","volume":"59","author":"Galland","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0410","doi-asserted-by":"crossref","first-page":"E637","DOI":"10.1152\/ajpendo.00508.2006","article-title":"A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans","volume":"292","author":"Stephens","year":"2007","journal-title":"Am. J. Phys. Endocrinol. Metab."},{"issue":"22","key":"10.1016\/j.bcp.2024.116565_b0415","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26226872","article-title":"The Effects of Streptozotocin-Induced Diabetes and Insulin Treatment on Carnitine Biosynthesis and Renal Excretion","volume":"26","author":"Upadhyay","year":"2021","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.bcp.2024.116565_b0420","doi-asserted-by":"crossref","first-page":"e0271062","DOI":"10.1371\/journal.pone.0271062","article-title":"Systematic in silico discovery of novel solute carrier-like proteins from proteomes","volume":"17","author":"Gyimesi","year":"2022","journal-title":"PLoS One"},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116565_b0425","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.mam.2012.10.010","article-title":"The SLC22 family with transporters of organic cations, anions and zwitterions","volume":"34","author":"Koepsell","year":"2013","journal-title":"Mol. Aspects Med."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0430","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1007\/s11033-022-07491-1","article-title":"Bacterial over-expression of functionally active human CT2 (SLC22A16) carnitine transporter","volume":"49","author":"Galluccio","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0435","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051791","article-title":"Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs","volume":"21","author":"Engelhart","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0440","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-5793(97)01441-5","article-title":"Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1","volume":"419","author":"Tamai","year":"1997","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0445","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.bbamem.2011.12.014","article-title":"The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease","volume":"1818","author":"Pochini","year":"2012","journal-title":"BBA"},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0450","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020914","article-title":"OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions","volume":"23","author":"Pochini","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0455","first-page":"768","article-title":"Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations","volume":"289","author":"Yabuuchi","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"14","key":"10.1016\/j.bcp.2024.116565_b0460","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1073\/pnas.0408624102","article-title":"Discovery of the ergothioneine transporter","volume":"102","author":"Grundemann","year":"2005","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0465","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41421-024-00664-1","article-title":"Structural insights into human organic cation transporter 1 transport and inhibition","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Discov"},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2023.184263","article-title":"OCTN1 (SLC22A4) displays two different transport pathways for organic cations or zwitterions","volume":"1866","author":"Pochini","year":"2024","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0475","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1124\/dmd.119.086959","article-title":"The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis","volume":"47","author":"Harwood","year":"2019","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0480","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11064-017-2350-5","article-title":"Carnitine\/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells","volume":"43","author":"Ishimoto","year":"2018","journal-title":"Neurochem. Res."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0485","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/ng1339","article-title":"Functional variants of OCTN cation transporter genes are associated with Crohn disease","volume":"36","author":"Peltekova","year":"2004","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.bcp.2024.116565_b0490","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1124\/dmd.120.000067","article-title":"Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics","volume":"48","author":"Anoshchenko","year":"2020","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0495","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/toxsci\/kfu259","article-title":"Functional and molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition","volume":"144","author":"Galluccio","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2024.116565_b0500","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2009.11.042","article-title":"The role of peroxisome proliferator-activated receptor alpha in transcriptional regulation of novel organic cation transporters","volume":"628","author":"Eder","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0505","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1248\/bpb.32.982","article-title":"Regulatory role of testosterone in organic cation transport: in vivo and in vitro studies","volume":"32","author":"Meetam","year":"2009","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0510","first-page":"1000","article-title":"OCTN2VT, a splice variant of OCTN2, does not transport carnitine because of the retention in the endoplasmic reticulum caused by insertion of 24 amino acids in the first extracellular loop of OCTN2","volume":"1773","author":"Maekawa","year":"2007","journal-title":"BBA"},{"issue":"32","key":"10.1016\/j.bcp.2024.116565_b0515","doi-asserted-by":"crossref","first-page":"20378","DOI":"10.1074\/jbc.273.32.20378","article-title":"Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2","volume":"273","author":"Tamai","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"47","key":"10.1016\/j.bcp.2024.116565_b0520","doi-asserted-by":"crossref","first-page":"33388","DOI":"10.1074\/jbc.274.47.33388","article-title":"Mutations in novel organic cation transporter (OCTN2), an organic cation\/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function","volume":"274","author":"Seth","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2024.116565_b0525","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015175","article-title":"Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine\/organic cation transporter novel 2 (OCTN2)","volume":"296","author":"Zhang","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0530","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbamem.2003.12.001","article-title":"Reconstitution into liposomes and functional characterization of the carnitine transporter from renal cell plasma membrane","volume":"1661","author":"Pochini","year":"2004","journal-title":"BBA"},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0535","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/1087057113493006","article-title":"OCTN cation transporters in health and disease: role as drug targets and assay development","volume":"18","author":"Pochini","year":"2013","journal-title":"J. Biomol. Screen."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0540","doi-asserted-by":"crossref","first-page":"F459","DOI":"10.1152\/ajprenal.90340.2008","article-title":"Role of N-glycosylation in trafficking of apical membrane proteins in epithelia","volume":"296","author":"Vagin","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0545","first-page":"312","article-title":"Glycosylation of the OCTN2 carnitine transporter: study of natural mutations identified in patients with primary carnitine deficiency","volume":"1812","author":"Filippo","year":"2011","journal-title":"BBA"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0550","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010294","article-title":"L-Carnitine Functionalization to Increase Skeletal Muscle Tropism of PLGA Nanoparticles","volume":"24","author":"Andreana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2024.116565_b0555","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1002\/jps.22557","article-title":"Synthesis and in vitro characterization of drug conjugates of l-carnitine as potential prodrugs that target human Octn2","volume":"100","author":"Diao","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bcp.2024.116565_b0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153757","article-title":"Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice","volume":"503","author":"Chen","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2024.116565_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114185","article-title":"L-carnitine modified nanoparticles target the OCTN2 transporter to improve the oral absorption of jujuboside B","volume":"196","author":"Li","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0570","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12951-024-02402-x","article-title":"OCTN2- and ATB(0,+)-targeted nanoemulsions for improving ocular drug delivery","volume":"22","author":"Tang","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0575","doi-asserted-by":"crossref","first-page":"G1046","DOI":"10.1152\/ajpgi.00233.2007","article-title":"Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+)","volume":"293","author":"Srinivas","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0580","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.crohns.2012.08.011","article-title":"Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health","volume":"7","author":"Shekhawat","year":"2013","journal-title":"J. Crohns Colitis"},{"issue":"39","key":"10.1016\/j.bcp.2024.116565_b0585","first-page":"36262","article-title":"Molecular identification of a novel carnitine transporter specific to human testis","volume":"277","author":"Enomoto","year":"2002","journal-title":"Insights into the Mechanism of Carnitine Recognition, J Biol Chem"},{"issue":"11","key":"10.1016\/j.bcp.2024.116565_b0590","doi-asserted-by":"crossref","first-page":"e0140569","DOI":"10.1371\/journal.pone.0140569","article-title":"Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0595","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ymgme.2011.05.001","article-title":"Expanded molecular features of carnitine acyl-carnitine translocase (CACT) deficiency by comprehensive molecular analysis","volume":"103","author":"Wang","year":"2011","journal-title":"Mol. Genet. Metab."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2024.116565_b0600","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000134684","article-title":"Assignment of the carnitine\/acylcarnitine translocase gene (CACT) to human chromosome band 3p21.31 by in situ hybridization","volume":"79","author":"Viggiano","year":"1997","journal-title":"Cytogenet. Cell Genet."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0605","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1086\/301628","article-title":"Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient","volume":"61","author":"Huizing","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bcp.2024.116565_b0610","doi-asserted-by":"crossref","DOI":"10.1038\/s44318-024-00150-0","article-title":"Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism","author":"Cimadamore-Werthein","year":"2024","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0615","doi-asserted-by":"crossref","DOI":"10.3390\/biom13060993","article-title":"Inhibition of the Mitochondrial Carnitine\/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications","volume":"13","author":"Giangregorio","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2024.116565_b0620","doi-asserted-by":"crossref","first-page":"1377090","DOI":"10.3389\/fendo.2024.1377090","article-title":"Role of hydrogen sulfide in the male reproductive system","volume":"15","author":"Song","year":"2024","journal-title":"Front Endocrinol (lausanne)"},{"key":"10.1016\/j.bcp.2024.116565_b0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176265","article-title":"Regulatory effects of hydrogen sulfide on the female reproductive system","volume":"963","author":"Sun","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0630","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2133\/dmpk.DMPK-11-NT-053","article-title":"Carnitine precursor gamma-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2","volume":"26","author":"Nakanishi","year":"2011","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0635","doi-asserted-by":"crossref","first-page":"G681","DOI":"10.1152\/ajpgi.00238.2009","article-title":"Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats","volume":"297","author":"Fujita","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bcp.2024.116565_b0640","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.594464","article-title":"Amino Acid Transporter SLC6A14 (ATB(0,+)) - A Target in Combined Anti-cancer Therapy","volume":"8","author":"Nalecz","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"34","key":"10.1016\/j.bcp.2024.116565_b0645","doi-asserted-by":"crossref","first-page":"23740","DOI":"10.1074\/jbc.274.34.23740","article-title":"Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)","volume":"274","author":"Sloan","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0650","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1124\/jpet.103.057109","article-title":"Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery","volume":"308","author":"Hatanaka","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.bcp.2024.116565_b0655","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1023\/B:PHAM.0000033019.49737.28","article-title":"Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+)","volume":"21","author":"Umapathy","year":"2004","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0660","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygyno.2005.08.016","article-title":"Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix","volume":"100","author":"Gupta","year":"2006","journal-title":"Gynecol. Oncol."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0665","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201700012","article-title":"Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis","volume":"39","author":"Beaudet","year":"2017","journal-title":"Bioessays"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0670","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1080\/10717544.2017.1377316","article-title":"Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB(0,+) to deliver chemotherapeutic agents for colon cancer therapy","volume":"24","author":"Kou","year":"2017","journal-title":"Drug Deliv."},{"issue":"3\u20134","key":"10.1016\/j.bcp.2024.116565_b0675","first-page":"145","article-title":"Four Single Nucleotide Polymorphisms in INSR, SLC6A14, TAS2R38, and OR2W3 Genes in Association with Idiopathic Infertility in Persian Men","volume":"61","author":"Siasi","year":"2016","journal-title":"J. Reprod. Med."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0680","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2478\/bjmg-2014-0075","article-title":"Study of Three Single Nucleotide Polymorphisms in the SLC6A14 Gene in Association with Male Infertility","volume":"17","author":"Noveski","year":"2014","journal-title":"Balkan J Med Genet"},{"key":"10.1016\/j.bcp.2024.116565_b0685","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40104-017-0185-1","article-title":"Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity","volume":"8","author":"Franca","year":"2017","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116565_b0690","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.mam.2012.11.003","article-title":"Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications","volume":"34","author":"Smith","year":"2013","journal-title":"Mol. Aspects Med."},{"issue":"7\u20138","key":"10.1016\/j.bcp.2024.116565_b0695","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1080\/00498250701875254","article-title":"Peptide transporters and their roles in physiological processes and drug disposition","volume":"38","author":"Rubio-Aliaga","year":"2008","journal-title":"Xenobiotica"},{"issue":"12","key":"10.1016\/j.bcp.2024.116565_b0700","doi-asserted-by":"crossref","first-page":"15734","DOI":"10.1096\/fj.202001497R","article-title":"Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies","volume":"34","author":"Yee","year":"2020","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0705","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.bcp.2005.06.014","article-title":"Regulation of testis-specific carnitine transporter (octn3) gene by proximal cis-acting elements Sp1 in mice","volume":"70","author":"Maeda","year":"2005","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2024.116565_b0710","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1007\/s00204-017-2008-8","article-title":"Multiple drug transporters mediate the placental transport of sulpiride","volume":"91","author":"Bai","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0715","doi-asserted-by":"crossref","first-page":"165","DOI":"10.5534\/wjmh.210021","article-title":"Consequences of Anabolic-Androgenic Steroid Abuse in Males","volume":"40","author":"Corona","year":"2022","journal-title":"Sexual and Reproductive Perspective, World J Mens Health"},{"issue":"7","key":"10.1016\/j.bcp.2024.116565_b0720","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s11606-021-06751-3","article-title":"Harm Reduction in Male Patients Actively Using Anabolic Androgenic Steroids (AAS) and Performance-Enhancing Drugs (PEDs): a Review","volume":"36","author":"Bonnecaze","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.bcp.2024.116565_b0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116300","article-title":"Effects and mechanisms of endocrine disruptor bisphenol AF on male reproductive health: A mini review","volume":"276","author":"Xue","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0730","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12958-023-01098-2","article-title":"Psychoactive drugs and male fertility: impacts and mechanisms","volume":"21","author":"Hamed","year":"2023","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116565_b0735","doi-asserted-by":"crossref","first-page":"1012463","DOI":"10.3389\/fgwh.2022.1012463","article-title":"Recent advances in understanding adverse effects associated with drugs targeting the serotonin receptor, 5-HT GPCR","volume":"3","author":"Jamu","year":"2022","journal-title":"Front Glob Womens Health"},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b0740","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.3390\/cimb44100333","article-title":"Therapeutic Use and Chronic Abuse of CNS Stimulants and Anabolic Drugs","volume":"44","author":"Colita","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0745","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/PRA.0000000000000353","article-title":"The Association Between Psychotropic Drug Use and Fertility Problems Among Male Subjects","volume":"25","author":"Solomon","year":"2019","journal-title":"J. Psychiatr. Pract."},{"key":"10.1016\/j.bcp.2024.116565_b0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2023.104064","article-title":"Immune checkpoint inhibitors as a threat to reproductive function: A systematic review","volume":"188","author":"Tuerxun","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"9","key":"10.1016\/j.bcp.2024.116565_b0755","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11934-018-0819-7","article-title":"Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers","volume":"19","author":"Sood","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"10.1016\/j.bcp.2024.116565_b0760","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-3-319-69535-8_12","article-title":"Immunosuppressants and Male Reproduction","volume":"1034","author":"Drobnis","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.bcp.2024.116565_b0765","doi-asserted-by":"crossref","first-page":"e23371","DOI":"10.1002\/jbt.23371","article-title":"Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies","volume":"37","author":"Bhardwaj","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0770","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1530\/RAF-22-0020","article-title":"Potential ovarian toxicity and infertility risk following targeted anti-cancer therapies","volume":"3","author":"Rosario","year":"2022","journal-title":"Reprod Fertil"},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0775","article-title":"The Role of ROS as a Double-Edged Sword in (In)Fertility","volume":"14","author":"Mendes","year":"2022","journal-title":"The Impact of Cancer Treatment, Cancers (basel)"},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0780","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dmz027","article-title":"Ovarian damage from chemotherapy and current approaches to its protection","volume":"25","author":"Spears","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.bcp.2024.116565_b0785","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-3-319-69535-8_10","article-title":"Antimicrobials and Male Reproduction","volume":"1034","author":"Drobnis","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"11","key":"10.1016\/j.bcp.2024.116565_b0790","first-page":"CD003053","article-title":"Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility","volume":"11","author":"Morley","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"25","key":"10.1016\/j.bcp.2024.116565_b0795","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.2174\/1381612821666150710150041","article-title":"Impact of Metformin on Male Reproduction","volume":"21","author":"Ferreira","year":"2015","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0800","first-page":"627","article-title":"The Effects of Toxic Heavy Metals Lead","volume":"26","author":"Manouchehri","year":"2022","journal-title":"Cadmium and Copper on the Epidemiology of Male and Female Infertility, JBRA Assist Reprod"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0805","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ajog.2022.05.056","article-title":"Impact of cannabinoids on pregnancy, reproductive health, and offspring outcomes","volume":"227","author":"Lo","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.bcp.2024.116565_b0810","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s10815-015-0553-8","article-title":"Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility","volume":"32","author":"du Plessis","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0815","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/andr.12366","article-title":"The impact of drugs on male fertility: a review","volume":"5","author":"Semet","year":"2017","journal-title":"Andrology"},{"issue":"7","key":"10.1016\/j.bcp.2024.116565_b0820","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrurol.2015.145","article-title":"Adverse effects of common medications on male fertility","volume":"12","author":"Samplaski","year":"2015","journal-title":"Nat. Rev. Urol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0825","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s10534-011-9479-5","article-title":"Effects of heavy metal cations on the mitochondrial ornithine\/citrulline transporter reconstituted in liposomes","volume":"24","author":"Tonazzi","year":"2011","journal-title":"Biometals"},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b0830","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/15376516.2012.719166","article-title":"Inhibition of the OCTN2 carnitine transporter by HgCl2 and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity","volume":"23","author":"Pochini","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0835","doi-asserted-by":"crossref","first-page":"e22970","DOI":"10.1002\/jbt.22970","article-title":"Natural products against cisplatin-induced male reproductive toxicity: A comprehensive review","volume":"36","author":"Rahimi","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bcp.2024.116565_b0840","doi-asserted-by":"crossref","first-page":"e923592","DOI":"10.12659\/AOT.923592","article-title":"Infertility in Female and Male Solid Organ Recipients - From Diagnosis to Treatment: An Up-To-Date Review of the Literature","volume":"25","author":"Szymusik","year":"2020","journal-title":"Ann. Transplant."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0845","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.chest.2021.07.024","article-title":"Fertility and Pregnancy in Cystic Fibrosis","volume":"160","author":"Shteinberg","year":"2021","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0850","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12958-020-0567-7","article-title":"Smoke, alcohol and drug addiction and female fertility","volume":"18","author":"de Angelis","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0855","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2019.101369","article-title":"Infertility in women with systemic autoimmune diseases","volume":"33","author":"Khizroeva","year":"2019","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0860","doi-asserted-by":"crossref","DOI":"10.3390\/nu14081591","article-title":"Inflammatory Bowel Disease and Reproductive Health: From Fertility to Pregnancy-A Narrative Review","volume":"14","author":"Ronchetti","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0865","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/MEG.0000000000001074","article-title":"Sexual and reproductive issues and inflammatory bowel disease: a neglected topic in men","volume":"30","author":"Allocca","year":"2018","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0870","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4292\/wjgpt.v7.i3.361","article-title":"Infertility in men with inflammatory bowel disease","volume":"7","author":"Shin","year":"2016","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"10.1016\/j.bcp.2024.116565_b0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107563","article-title":"Reproductive health in patients with epilepsy","volume":"113","author":"Markoula","year":"2020","journal-title":"Epilepsy Behav."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0880","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s12032-023-01954-6","article-title":"Lee, Chemotherapy: how to reduce its adverse effects while maintaining the potency?","volume":"40","author":"Brianna","year":"2023","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bcp.2024.116565_b0885","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112040","article-title":"Effects of chemotherapeutic agents on male germ cells and possible ameliorating impact of antioxidants","volume":"142","author":"Ghafouri-Fard","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0890","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1530\/RAF-20-0037","article-title":"l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility","volume":"1","author":"Khaw","year":"2020","journal-title":"Reprod Fertil"},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0895","doi-asserted-by":"crossref","first-page":"e13586","DOI":"10.1111\/and.13586","article-title":"Role of genetics and epigenetics in male infertility","volume":"53","author":"Gunes","year":"2021","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0900","first-page":"185","article-title":"Male Infertility","volume":"19","author":"Agharezaee","year":"2018","journal-title":"Precision Medicine and Systems Proteomics, J Reprod Infertil"},{"key":"10.1016\/j.bcp.2024.116565_b0905","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2024.119757","article-title":"Seminal plasma proteomics as putative biomarkers for male infertility diagnosis","volume":"561","author":"Parvin","year":"2024","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0910","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bbrc.2005.05.174","article-title":"Characterization of the organic cation transporter SLC22A16: a doxorubicin importer","volume":"333","author":"Okabe","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0915","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1158\/0008-5472.CAN-16-2548","article-title":"OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues","volume":"77","author":"Drenberg","year":"2017","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0920","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1530\/REP-06-0173","article-title":"Transport of carnitine and acetylcarnitine by carnitine\/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa","volume":"134","author":"Kobayashi","year":"2007","journal-title":"Reproduction"},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b0925","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11080396","article-title":"OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro","volume":"11","author":"Salomon","year":"2019","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0930","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/j.ajpath.2011.02.020","article-title":"Selective regulation of cardiac organic cation transporter novel type 2 (OCTN2) in dilated cardiomyopathy","volume":"178","author":"Grube","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0935","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25010014","article-title":"SLC22A5 (OCTN2) Carnitine Transporter-Indispensable for Cell Metabolism, a Jekyll and Hyde of Human Cancer","volume":"25","author":"Juraszek","year":"2019","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b0940","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1208\/s12248-014-9649-9","article-title":"The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family","volume":"16","author":"Dos Santos Pereira","year":"2014","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0945","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1189\/jlb.1A0616-254R","article-title":"Human macrophage differentiation induces OCTN2-mediated L-carnitine transport through stimulation of mTOR-STAT3 axis","volume":"101","author":"Ingoglia","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"9","key":"10.1016\/j.bcp.2024.116565_b0950","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1124\/dmd.121.000702","article-title":"Emerging Roles of the Human Solute Carrier 22 Family","volume":"50","author":"Yee","year":"2021","journal-title":"Drug Metab. Dispos."},{"issue":"9","key":"10.1016\/j.bcp.2024.116565_b0955","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1074\/jbc.M109.046151","article-title":"The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5","volume":"285","author":"Aouida","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b0960","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/toxsci\/kfs330","article-title":"Role of organic cation\/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria","volume":"132","author":"Shitara","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2024.116565_b0965","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3109\/00498254.2015.1129080","article-title":"The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs)","volume":"46","author":"Zheng","year":"2016","journal-title":"Xenobiotica"},{"issue":"11","key":"10.1016\/j.bcp.2024.116565_b0970","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1124\/dmd.114.059097","article-title":"Selective inhibition of human solute carrier transporters by multikinase inhibitors","volume":"42","author":"Johnston","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b0975","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1074\/jbc.275.3.1699","article-title":"beta-lactam antibiotics as substrates for OCTN2, an organic cation\/carnitine transporter","volume":"275","author":"Ganapathy","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.bcp.2024.116565_b0980","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1158\/1078-0432.CCR-10-1239","article-title":"Cisplatin-induced downregulation of OCTN2 affects carnitine wasting","volume":"16","author":"Lancaster","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b0985","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00280-015-2723-x","article-title":"Organic cation transporter OCT6 mediates cisplatin uptake and resistance to cisplatin in lung cancer","volume":"75","author":"Kunii","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b0990","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1158\/1535-7163.MCT-11-0980","article-title":"Inhibition of OCTN2-mediated transport of carnitine by etoposide","volume":"11","author":"Hu","year":"2012","journal-title":"Mol. Cancer Ther."},{"issue":"12","key":"10.1016\/j.bcp.2024.116565_b0995","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1124\/dmd.117.077248","article-title":"Colistin is substrate of the carnitine\/organic cation transporter 2 (OCTN2, SLC22A5)","volume":"45","author":"Visentin","year":"2017","journal-title":"Drug Metab. Dispos."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b1000","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1161\/CIRCULATIONAHA.105.586107","article-title":"Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5)","volume":"113","author":"Grube","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b1005","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/mol.59.2.358","article-title":"Molecular and physiological evidence for multifunctionality of carnitine\/organic cation transporter OCTN2","volume":"59","author":"Ohashi","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2024.116565_b1010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110627","article-title":"Inhibition of multiple uptake transporters in cardiomyocytes\/mitochondria alleviates doxorubicin-induced cardiotoxicity","volume":"382","author":"Yi","year":"2023","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.bcp.2024.116565_b1015","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00199-19","article-title":"Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine","volume":"63","author":"Zeng","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b1020","doi-asserted-by":"crossref","first-page":"6260","DOI":"10.1128\/AAC.00986-16","article-title":"Multiple Drug Transporters Are Involved in Renal Secretion of Entecavir","volume":"60","author":"Yang","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b1025","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/1873-3468.14269","article-title":"The ergothioneine transporter (ETT): substrates and locations, an inventory","volume":"596","author":"Grundemann","year":"2022","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b1030","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.clpt.6100271","article-title":"Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin","volume":"83","author":"Urban","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b1035","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ajps.2020.02.002","article-title":"Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability","volume":"15","author":"Wang","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.bcp.2024.116565_b1040","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1007\/s11064-020-03118-8","article-title":"Homostachydrine is a Xenobiotic Substrate of OCTN1\/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice","volume":"45","author":"Nishiyama","year":"2020","journal-title":"Neurochem. Res."},{"issue":"10","key":"10.1016\/j.bcp.2024.116565_b1045","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1158\/1078-0432.CCR-07-4913","article-title":"Interaction of imatinib with human organic ion carriers","volume":"14","author":"Hu","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b1050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1021\/mp900206j","article-title":"Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation\/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption","volume":"7","author":"Nakamura","year":"2010","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b1055","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1124\/dmd.108.023929","article-title":"The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate","volume":"37","author":"Grigat","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b1060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.dmpk.2016.08.005","article-title":"Species specificity profiling of rat and human organic cation\/carnitine transporter Slc22a5\/SLC22A5 (Octn2\/OCTN2)","volume":"32","author":"Szabo","year":"2017","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b1065","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1124\/jpet.111.181297","article-title":"Oxaliplatin transport mediated by organic cation\/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons","volume":"338","author":"Jong","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b1070","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3892\/br.2016.772","article-title":"Organic cation transporter 6 directly confers resistance to anticancer platinum drugs","volume":"5","author":"Oguri","year":"2016","journal-title":"Biomed Rep"},{"issue":"4","key":"10.1016\/j.bcp.2024.116565_b1075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/humu.20085","article-title":"Molecular and functional analysis of SLC25A20 mutations causing carnitine-acylcarnitine translocase deficiency","volume":"24","author":"Iacobazzi","year":"2004","journal-title":"Hum. Mutat."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2024.116565_b1080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1469-7793.2001.0297f.x","article-title":"Na+- and Cl\u2013coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes","volume":"532","author":"Nakanishi","year":"2001","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116565_b1085","doi-asserted-by":"crossref","first-page":"e0304512","DOI":"10.1371\/journal.pone.0304512","article-title":"Atomistic description of the OCTN1 recognition mechanism via in silico methods","volume":"19","author":"Ben Mariem","year":"2024","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bcp.2024.116565_b1090","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s11064-010-0131-5","article-title":"High affinity carnitine transporters from OCTN family in neural cells","volume":"35","author":"Januszewicz","year":"2010","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116565_b1095","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/s41598-017-01438-4","article-title":"Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts","volume":"7","author":"Harrach","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2024.116565_b1100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.18433\/jpps30865","article-title":"Pharmacokinetics and Toxicokinetics Roles of Membrane Transporters at Kidney Level","volume":"23","author":"Veiga-Matos","year":"2020","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2024.116565_b1105","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/mol.106.024158","article-title":"Organic cation\/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse","volume":"70","author":"Kato","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b1110","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3892\/ijo.2015.3029","article-title":"Acetylcarnitine potentiates the anticarcinogenic effects of butyrate on SW480 colon cancer cells","volume":"47","author":"Elimrani","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"7873","key":"10.1016\/j.bcp.2024.116565_b1115","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/j.bcp.2024.116565_b1120","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"10.1016\/j.bcp.2024.116565_b1125","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2024.116565_b1130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224005653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224005653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T03:04:37Z","timestamp":1732849477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224005653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":226,"alternative-id":["S0006295224005653"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116565","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carnitine traffic and human fertility","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116565"}}