{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T19:50:27Z","timestamp":1774554627969,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bcp.2024.116618","type":"journal-article","created":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T17:48:40Z","timestamp":1731260920000},"page":"116618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P3","title":["3,3\u2032-Diindolylmethane promotes bone formation \u2013 A assessment in MC3T3-E1 cells and zebrafish"],"prefix":"10.1016","volume":"230","author":[{"given":"Ying","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianlian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongzhu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bcp.2024.116618_b0005","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.mcna.2020.06.004","article-title":"Osteoporosis in Older Adults","volume":"104","author":"Johnston","year":"2020","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.bcp.2024.116618_b0010","article-title":"T-Cell Mediated Inflammation in Postmenopausal Osteoporosis","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2024.116618_b0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbrc.2021.02.100","article-title":"Strontium gluconate potently promotes osteoblast development and restores bone formation in glucocorticoid-induced osteoporosis rats","volume":"554","author":"Dai","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"18","key":"10.1016\/j.bcp.2024.116618_b0020","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.2165\/0003495-200868180-00012","article-title":"Teriparatide: a review of its use in osteoporosis","volume":"68","author":"Blick","year":"2008","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.bcp.2024.116618_b0025","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/mnfr.201500867","article-title":"The bounty of nature for changing the cancer landscape","volume":"60","author":"Ahmad","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2024.116618_b0030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10555-013-9478-9","article-title":"Recent progress on nutraceutical research in prostate cancer","volume":"33","author":"Li","year":"2014","journal-title":"Cancer Metastasis Rev."},{"issue":"5","key":"10.1016\/j.bcp.2024.116618_b0035","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.7150\/ijbs.56833","article-title":"3,3'-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry","volume":"17","author":"Ye","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2024.116618_b0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.molimm.2020.11.013","article-title":"3,3'-Diindolylmethane alleviates acute atopic dermatitis by regulating T cell differentiation in a mouse model","volume":"130","author":"Wu","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bcp.2024.116618_b0045","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.fitote.2016.03.013","article-title":"Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice","volume":"110","author":"Zhang","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bcp.2024.116618_b0050","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3389\/fphar.2019.01344","article-title":"Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis","volume":"10","author":"He","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2024.116618_b0055","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.3892\/mmr.2015.3249","article-title":"Radix Dipsaci total saponins stimulate MC3T3-E1 cell differentiation via the bone morphogenetic protein-2\/MAPK\/Smad-dependent Runx2 pathway","volume":"11","author":"Niu","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"Pt 1","key":"10.1016\/j.bcp.2024.116618_b0060","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.fct.2017.08.037","article-title":"Inhibitory effects of 3,3'-diindolylmethane on epithelial-mesenchymal transition induced by endocrine disrupting chemicals in cellular and xenograft mouse models of breast cancer","volume":"109","author":"Lee","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2024.116618_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.999851","article-title":"3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116618_b0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jphs.2014.11.006","article-title":"3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice","volume":"127","author":"Yu","year":"2015","journal-title":"J. Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2024.116618_b0075","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bcp.2009.10.010","article-title":"3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis","volume":"79","author":"Dong","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2024.116618_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102722","article-title":"Alteration of STIM1\/Orai1-Mediated SOCE in Skeletal Muscle: Impact in Genetic Muscle Diseases and Beyond","volume":"10","author":"Conte","year":"2021","journal-title":"Cells"},{"issue":"sup1","key":"10.1016\/j.bcp.2024.116618_b0085","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/03008207.2017.1408601","article-title":"The ER Ca(2+) sensor STIM1 can activate osteoblast and odontoblast differentiation in mineralized tissues","volume":"59","author":"Chen","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bcp.2024.116618_b0090","article-title":"Melatonin Mediates Osteoblast Proliferation Through the STIM1\/ORAI1 Pathway","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"17","key":"10.1016\/j.bcp.2024.116618_b0095","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1093\/emboj\/cdf467","article-title":"An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes","volume":"21","author":"Vazquez","year":"2002","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bcp.2024.116618_b0100","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbrc.2020.04.048","article-title":"Intracellular Ca(2+) signaling mediates IGF-1-induced osteogenic differentiation in bone marrow mesenchymal stem cells","volume":"527","author":"Wu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2024.116618_b0105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s10020-022-00448-x","article-title":"Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways","volume":"28","author":"Cheng","year":"2022","journal-title":"Mol. Med."},{"issue":"5","key":"10.1016\/j.bcp.2024.116618_b0110","doi-asserted-by":"crossref","first-page":"C977","DOI":"10.1152\/ajpcell.00413.2021","article-title":"Calcium released by osteoclastic resorption stimulates autocrine\/paracrine activities in local osteogenic cells to promote coupled bone formation","volume":"322","author":"Ahmed","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"9","key":"10.1016\/j.bcp.2024.116618_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107217","article-title":"Elevation of extracellular Ca2+ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts","volume":"9","author":"Hu","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bcp.2024.116618_b0120","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrendo.2015.30","article-title":"The calcium-sensing receptor in bone\u2013mechanistic and therapeutic insights","volume":"11","author":"Goltzman","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bcp.2024.116618_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102091","article-title":"BAP1: Not just a BRCA1-associated protein","volume":"90","author":"Louie","year":"2020","journal-title":"Cancer Treat. Rev."},{"issue":"8","key":"10.1016\/j.bcp.2024.116618_b0130","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1158\/2159-8290.CD-19-1220","article-title":"Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer","volume":"10","author":"Carbone","year":"2020","journal-title":"Cancer Discov."},{"issue":"6101","key":"10.1016\/j.bcp.2024.116618_b0135","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.1221711","article-title":"Loss of the tumor suppressor BAP1 causes myeloid transformation","volume":"337","author":"Dey","year":"2012","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bcp.2024.116618_b0140","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.celrep.2016.05.096","article-title":"NeuCode Proteomics Reveals Bap1 Regulation of Metabolism","volume":"16","author":"Baughman","year":"2016","journal-title":"Cell Rep."},{"issue":"7659","key":"10.1016\/j.bcp.2024.116618_b0145","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature22798","article-title":"BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation","volume":"546","author":"Bononi","year":"2017","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2024.116618_b0150","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1089\/adt.2007.089","article-title":"Detection of high- and low-affinity antibodies against a human monoclonal antibody using various technology platforms","volume":"5","author":"Liang","year":"2007","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.bcp.2024.116618_b0155","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57264","article-title":"How to measure and evaluate binding affinities","volume":"9","author":"Jarmoskaite","year":"2020","journal-title":"Elife"},{"issue":"10","key":"10.1016\/j.bcp.2024.116618_b0160","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.tibs.2019.04.004","article-title":"Drug-Target Association Kinetics in Drug Discovery","volume":"44","author":"Ap","year":"2019","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.bcp.2024.116618_b0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.nut.2017.12.003","article-title":"Dietary flavonoid kaempferol inhibits glucocorticoid-induced bone loss by promoting osteoblast survival","volume":"53","author":"Adhikary","year":"2018","journal-title":"Nutrition"},{"issue":"1","key":"10.1016\/j.bcp.2024.116618_b0170","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1021\/acs.jafc.2c05954","article-title":"Avicularin Alleviates Osteoporosis in Ovariectomized Mice by Inhibiting Osteoclastogenesis through NF-\u03baB Pathway Inhibition","volume":"71","author":"Zhuang","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.bcp.2024.116618_b0175","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1021\/acs.jafc.2c07005","article-title":"Vitexin Regulates Angiogenesis and Osteogenesis in Ovariectomy-Induced Osteoporosis of Rats via the VDR\/PI3K\/AKT\/eNOS Signaling Pathway","volume":"71","author":"Liu","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.bcp.2024.116618_b0180","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.clinbiochem.2012.03.021","article-title":"An overview of the regulation of bone remodelling at the cellular level","volume":"45","author":"Kular","year":"2012","journal-title":"Clin. Biochem."},{"issue":"9","key":"10.1016\/j.bcp.2024.116618_b0185","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1359\/jbmr.2001.16.9.1575","article-title":"Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers","volume":"16","author":"Hauge","year":"2001","journal-title":"J. Bone Miner. Res."},{"issue":"9393","key":"10.1016\/j.bcp.2024.116618_b0190","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(03)14636-3","article-title":"Rickets","volume":"362","author":"Wharton","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2024.116618_b0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2015.12.004","article-title":"Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism","volume":"49","author":"Santa Maria","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2024.116618_b0200","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fonc.2020.00293","article-title":"Calcium Homeostasis: A Potential Vicious Cycle of Bone Metastasis in Breast Cancers","volume":"10","author":"Yang","year":"2020","journal-title":"Front. Oncol."},{"issue":"576","key":"10.1016\/j.bcp.2024.116618_b0205","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaw4847","article-title":"TRPM7 channels mediate spontaneous Ca(2+) fluctuations in growth plate chondrocytes that promote bone development","volume":"12","author":"Qian","year":"2019","journal-title":"Sci. Signal."},{"issue":"4","key":"10.1016\/j.bcp.2024.116618_b0210","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bbrc.2016.04.068","article-title":"Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells","volume":"473","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2024.116618_b0215","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1177\/0022034515608128","article-title":"The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells","volume":"94","author":"Sohn","year":"2015","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.bcp.2024.116618_b0220","doi-asserted-by":"crossref","first-page":"13252","DOI":"10.1038\/s41598-018-31621-0","article-title":"Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry","volume":"8","author":"Sampieri","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2024.116618_b0225","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035253","article-title":"The Endoplasmic Reticulum-Plasma Membrane Junction: A Hub for Agonist Regulation of Ca(2+) Entry","volume":"12","author":"Ong","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"11","key":"10.1016\/j.bcp.2024.116618_b0230","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1158\/0008-5472.CAN-20-3430","article-title":"Roles of the BAP1 Tumor Suppressor in Cell Metabolism","volume":"81","author":"Han","year":"2021","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2024.116618_b0235","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1074\/jbc.M114.611186","article-title":"The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release","volume":"290","author":"Hedgepeth","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2024.116618_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2015.12.009","article-title":"Effects of bioactive fatty acid amide derivatives in zebrafish scale model of bone metabolism and disease","volume":"104","author":"Carnovali","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2024.116618_b0245","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2019.11.016","article-title":"NF-\u03baB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration","volume":"52","author":"Mishra","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bcp.2024.116618_b0250","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jot.2015.07.002","article-title":"Tanshinol stimulates bone formation and attenuates dexamethasone-induced inhibition of osteogenesis in larval zebrafish","volume":"4","author":"Luo","year":"2016","journal-title":"J Orthop Translat"},{"issue":"30","key":"10.1016\/j.bcp.2024.116618_b0255","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1074\/jbc.RA119.007813","article-title":"Deficiency in the membrane protein Tmbim3a\/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish","volume":"294","author":"Chen","year":"2019","journal-title":"J. Biol. Chem."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522400618X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522400618X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T01:01:40Z","timestamp":1732928500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522400618X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":51,"alternative-id":["S000629522400618X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116618","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3,3\u2032-Diindolylmethane promotes bone formation \u2013 A assessment in MC3T3-E1 cells and zebrafish","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116618"}}