{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:10:17Z","timestamp":1785762617480,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bcp.2024.116638","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T21:23:31Z","timestamp":1732051411000},"page":"116638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Recent discoveries of propyl gallate restore the antibacterial effect of tigecycline against tet(X4)-positive Escherichia coli"],"prefix":"10.1016","volume":"231","author":[{"given":"Zhiying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhe","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-187X","authenticated-orcid":false,"given":"Yonglin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2024.116638_b0005","unstructured":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis, Lancet 399(10325) (2022) 629-655."},{"issue":"2","key":"10.1016\/j.bcp.2024.116638_b0010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bcp.2024.116638_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100989","article-title":"Identification of TMexCD-TOprJ-producing carbapenem-resistant Gram-negative bacteria from hospital sewage","volume":"70","author":"Zhu","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bcp.2024.116638_b0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.sajb.2018.09.010","article-title":"Natural products as biofilm formation antagonists and regulators of quorum sensing functions: A comprehensive review update and future trends","volume":"120","author":"\u0106iri\u0107","year":"2019","journal-title":"S. Afr. J. Bot."},{"issue":"9","key":"10.1016\/j.bcp.2024.116638_b0025","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1473-3099(10)70143-2","article-title":"Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study","volume":"10","author":"Kumarasamy","year":"2010","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"10.1016\/j.bcp.2024.116638_b0030","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/AAC.45.4.1151-1161.2001","article-title":"Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae","volume":"45","author":"Yigit","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.bcp.2024.116638_b0035","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/s41564-019-0445-2","article-title":"Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans","volume":"4","author":"He","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0040","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1128\/jb.172.1.292-298.1990","article-title":"A tetracycline efflux gene on Bacteroides transposon Tn4400 does not contribute to tetracycline resistance","volume":"172","author":"Speer","year":"1990","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0045","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1128\/jb.171.1.148-153.1989","article-title":"Novel aerobic tetracycline resistance gene that chemically modifies tetracycline","volume":"171","author":"Speer","year":"1989","journal-title":"J. Bacteriol."},{"issue":"50","key":"10.1016\/j.bcp.2024.116638_b0050","doi-asserted-by":"crossref","first-page":"52346","DOI":"10.1074\/jbc.M409573200","article-title":"TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics","volume":"279","author":"Yang","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2024.116638_b0055","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/10600280211031390","article-title":"Antibiotic Approvals in the Last Decade: Are We Keeping Up With Resistance?","volume":"56","author":"Chahine","year":"2022","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.bcp.2024.116638_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103943","article-title":"A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)\/tet(X4)-positive bacteria","volume":"78","author":"Xu","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0065","doi-asserted-by":"crossref","first-page":"e0157821","DOI":"10.1128\/spectrum.01578-21","article-title":"Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria","volume":"10","author":"Deng","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0070","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s42003-020-0877-5","article-title":"Anti-HIV agent azidothymidine decreases Tet(X)-mediated bacterial resistance to tigecycline in Escherichia coli","volume":"3","author":"Liu","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2024.116638_b0075","series-title":"Microbial Biotechnology in Food and Health","first-page":"113","article-title":"5 - Microbial bioprocessing of health promoting food supplements","author":"Mishra","year":"2021"},{"issue":"10\u201311","key":"10.1016\/j.bcp.2024.116638_b0080","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0278-6915(86)90290-5","article-title":"Toxicology of gallates: a review and evaluation","volume":"24","author":"van der Heijden","year":"1986","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2024.116638_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135219","article-title":"Ezzati Nazhad Dolatabadi, Pharmacokinetic and toxicological overview of propyl gallate food additive","volume":"423","author":"Javaheri-Ghezeldizaj","year":"2023","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.bcp.2024.116638_b0090","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jat.4231","article-title":"Propyl gallate decreases the proliferation of Calu-6 and A549 lung cancer cells via affecting reactive oxygen species and glutathione levels","volume":"42","author":"Park","year":"2022","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2024.116638_b0095","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0006-2952(94)90115-5","article-title":"Propyl gallate as a hepatoprotector in vitro and in vivo","volume":"48","author":"Wu","year":"1994","journal-title":"Biochem. Pharmacol."},{"issue":"35","key":"10.1016\/j.bcp.2024.116638_b0100","doi-asserted-by":"crossref","first-page":"11829","DOI":"10.1021\/bi0506066","article-title":"Tigecycline Is Modified by the Flavin-Dependent Monooxygenase TetX","volume":"44","author":"Moore","year":"2005","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.bcp.2024.116638_b0105","doi-asserted-by":"crossref","first-page":"e14264","DOI":"10.1111\/jfbc.14264","article-title":"Health benefits of polyphenols: A concise review","volume":"46","author":"Rana","year":"2022","journal-title":"J. Food Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics1010001","article-title":"Classification Framework and Chemical Biology of Tetracycline-Structure-Based Drugs","volume":"1","author":"Fuoco","year":"2012","journal-title":"Antibiotics (basel)"},{"key":"10.1016\/j.bcp.2024.116638_b0115","doi-asserted-by":"crossref","unstructured":"I. Chopra, M. Roberts, Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance, Microbiol Mol Biol Rev 65(2) (2001) 232-60 ; second page, table of contents.","DOI":"10.1128\/MMBR.65.2.232-260.2001"},{"key":"10.1016\/j.bcp.2024.116638_b0120","doi-asserted-by":"crossref","unstructured":"Y. Amangelsin Y. Semenova M. Dadar M. Aljofan G. Bj\u00f8rklund The Impact of Tetracycline Pollution on the Aquatic Environment and Removal Strategies 12 2023 Antibiotics (Basel).","DOI":"10.3390\/antibiotics12030440"},{"issue":"7","key":"10.1016\/j.bcp.2024.116638_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12070903","article-title":"Characterization of an Escherichia coli Isolate Coharboring the Virulence Gene astA and Tigecycline Resistance Gene tet(X4) from a Dead Piglet","volume":"12","author":"Wang","year":"2023","journal-title":"Pathogens"},{"issue":"4","key":"10.1016\/j.bcp.2024.116638_b0130","doi-asserted-by":"crossref","first-page":"e02015","DOI":"10.1128\/spectrum.02015-22","article-title":"Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China","volume":"10","author":"Ma","year":"2022","journal-title":"Microbiol. Spectrum"},{"issue":"7","key":"10.1016\/j.bcp.2024.116638_b0135","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1021\/es103672x","article-title":"Occurrence, abundance, and diversity of tetracycline resistance genes in 15 sewage treatment plants across China and other global locations","volume":"45","author":"Zhang","year":"2011","journal-title":"Environ. Sci. Tech."},{"key":"10.1016\/j.bcp.2024.116638_b0140","article-title":"IncHI1 plasmids mediated the tet(X4) gene spread in Enterobacteriaceae in porcine","volume":"14","author":"Ma","year":"2023","journal-title":"Front. Microbiol."},{"issue":"12","key":"10.1016\/j.bcp.2024.116638_b0145","doi-asserted-by":"crossref","first-page":"1902227","DOI":"10.1002\/advs.201902227","article-title":"Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria","volume":"7","author":"Liu","year":"2020","journal-title":"Adv Sci (weinh)"},{"issue":"19","key":"10.1016\/j.bcp.2024.116638_b0150","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1021\/acs.jmedchem.8b01781","article-title":"Antibiotic Adjuvants: Make Antibiotics Great Again!","volume":"62","author":"Douafer","year":"2019","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0155","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01172-20","article-title":"Activity of Tigecycline or Colistin in Combination with Zidovudine against Escherichia coli Harboring tet(X) and mcr-1","volume":"65","author":"Zhou","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.bcp.2024.116638_b0160","first-page":"1621","article-title":"Synergistic effect of \u03b2-thujaplicin and tigecycline against tet(X4)-positive Escherichia coli in vitro","volume":"39","author":"Zhang","year":"2023","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0165","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s42003-021-02854-z","article-title":"Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine","volume":"4","author":"Liu","year":"2021","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2024.116638_b0170","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1080\/22221751.2020.1803769","article-title":"Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris","volume":"9","author":"Cheng","year":"2020","journal-title":"Emerg Microbes Infect"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224006385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295224006385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T08:38:55Z","timestamp":1733906335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295224006385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"alternative-id":["S0006295224006385"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116638","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent discoveries of propyl gallate restore the antibacterial effect of tigecycline against tet(X4)-positive Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2024.116638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116638"}}