{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:38:17Z","timestamp":1785839897687,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012574"],"award-info":[{"award-number":["2022A1515012574"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bcp.2025.116841","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T02:32:28Z","timestamp":1740709948000},"page":"116841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Phosducin inhibits the cell proliferation and promotes the antitumor effect of temozolomide in glioma"],"prefix":"10.1016","volume":"235","author":[{"given":"Shibin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songshan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2025.116841_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2019.101896","article-title":"Molecular targeted therapy of glioblastoma","volume":"80","author":"Le Rhun","year":"2019","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0010","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-022-01513-z","article-title":"Glioma targeted therapy: insight into future of molecular approaches","volume":"21","author":"Yang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010351","article-title":"Molecular Mechanisms of Treatment Resistance in Glioblastoma","volume":"22","author":"Ou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bcp.2025.116841_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126385","article-title":"Molecular Mechanisms of Drug Resistance in Glioblastoma","volume":"22","author":"Dymova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.116841_b0025","doi-asserted-by":"crossref","unstructured":"Q.T. Ostrom G. Cioffi K. Waite C. Kruchko J.S. Barnholtz-Sloan CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018, Neuro Oncol 23(12 Suppl 2) 2021 iii1-iii105.","DOI":"10.1093\/neuonc\/noab200"},{"issue":"7","key":"10.1016\/j.bcp.2025.116841_b0030","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and Other Primary Brain Malignancies in Adults: A Review","volume":"329","author":"Schaff","year":"2023","journal-title":"J. Am. Med. Assoc."},{"issue":"9","key":"10.1016\/j.bcp.2025.116841_b0035","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41590-019-0433-y","article-title":"Mechanisms of immunotherapy resistance: lessons from glioblastoma","volume":"20","author":"Jackson","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcp.2025.116841_b0040","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.semcancer.2018.07.006","article-title":"Comparison of glioblastoma (GBM) molecular classification methods","volume":"53","author":"Lee","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bcp.2025.116841_b0045","unstructured":"A.F. Tamimi, M. Juweid, Epidemiology and Outcome of Glioblastoma, in: S. De Vleeschouwer (Ed.), Glioblastoma, Brisbane (AU), 2017."},{"issue":"7","key":"10.1016\/j.bcp.2025.116841_b0050","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"issue":"6409","key":"10.1016\/j.bcp.2025.116841_b0055","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.aau1646","article-title":"RNA modifications modulate gene expression during development","volume":"361","author":"Frye","year":"2018","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.bcp.2025.116841_b0060","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"issue":"7397","key":"10.1016\/j.bcp.2025.116841_b0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2025.116841_b0070","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/ncomms2822","article-title":"FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA","volume":"4","author":"Fu","year":"2013","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ccell.2016.11.017","article-title":"FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase","volume":"31","author":"Li","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2025.116841_b0080","doi-asserted-by":"crossref","unstructured":"R. Su, L. Dong, C. Li, S. Nachtergaele, M. Wunderlich, Y. Qing, X. Deng, Y. Wang, X. Weng, C. Hu, M. Yu, J. Skibbe, Q. Dai, D. Zou, T. Wu, K. Yu, H. Weng, H. Huang, K. Ferchen, X. Qin, B. Zhang, J. Qi, A.T. Sasaki, D.R. Plas, J.E. Bradner, M. Wei, G. Marcucci, X. Jiang, J.C. Mulloy, J. Jin, C. He, J. Chen, R-2HG Exhibits Anti-tumor Activity by Targeting FTO\/m(6)A\/MYC\/CEBPA Signaling, Cell 172(1-2) (2018) 90-105 e23.","DOI":"10.1016\/j.cell.2017.11.031"},{"issue":"11","key":"10.1016\/j.bcp.2025.116841_b0085","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1016\/j.celrep.2017.02.059","article-title":"m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells","volume":"18","author":"Cui","year":"2017","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.bcp.2025.116841_b0090","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/s41388-022-02214-z","article-title":"M(6)A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression","volume":"41","author":"Lv","year":"2022","journal-title":"Oncogene"},{"issue":"18","key":"10.1016\/j.bcp.2025.116841_b0095","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1158\/0008-5472.CAN-20-0132","article-title":"FTO Inhibition Enhances the Antitumor Effect of Temozolomide by Targeting MYC-miR-155\/23a Cluster-MXI1 Feedback Circuit in Glioma","volume":"80","author":"Xiao","year":"2020","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/phrs.2000.0757","article-title":"The pharmacology of phosducin","volume":"43","author":"Schulz","year":"2001","journal-title":"Pharmacol. Res."},{"issue":"39","key":"10.1016\/j.bcp.2025.116841_b0105","doi-asserted-by":"crossref","first-page":"24050","DOI":"10.1016\/S0021-9258(19)51046-8","article-title":"The phosphorylation state of phosducin determines its ability to block transducin subunit interactions and inhibit transducin binding to activated rhodopsin","volume":"269","author":"Yoshida","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bcp.2025.116841_b0110","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.cellsig.2007.06.013","article-title":"Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding","volume":"19","author":"Willardson","year":"2007","journal-title":"Cell. Signal."},{"issue":"12","key":"10.1016\/j.bcp.2025.116841_b0115","first-page":"3597","article-title":"Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice","volume":"119","author":"Beetz","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.bcp.2025.116841_b0120","doi-asserted-by":"crossref","first-page":"10145","DOI":"10.1073\/pnas.93.19.10145","article-title":"Phosducin is a ubiquitous G-protein regulator","volume":"93","author":"Danner","year":"1996","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0125","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/MNH.0b013e3283432e05","article-title":"The identification of phosducin as a novel candidate gene for hypertension and its role in sympathetic activation","volume":"20","author":"Broeckel","year":"2011","journal-title":"Curr Opin Nephrol Hy"},{"issue":"4","key":"10.1016\/j.bcp.2025.116841_b0130","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nn1423","article-title":"G protein \u03b2\u03b3 directly regulates SNARE protein fusion machinery for secretory granule exocytosis","volume":"8","author":"Blackmer","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0135","first-page":"114","article-title":"Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells","volume":"47","author":"Piotrowska","year":"2015","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bcp.2025.116841_b0140","doi-asserted-by":"crossref","unstructured":"D.S. McGehee, M. Aldersberg, K.P. Liu, S. Hsuing, M.J. Heath, H. Tamir, Mechanism of extracellular Ca2+ receptor-stimulated hormone release from sheep thyroid parafollicular cells, J Physiol 502 (Pt 1)(Pt 1) (1997) 31-44.","DOI":"10.1111\/j.1469-7793.1997.031bl.x"},{"issue":"11","key":"10.1016\/j.bcp.2025.116841_b0145","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1074\/jbc.271.11.6441","article-title":"Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor","volume":"271","author":"Tamir","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0150","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cell.2010.12.029","article-title":"RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction","volume":"144","author":"Kaeser","year":"2011","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bcp.2025.116841_b0155","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41419-021-04016-9","article-title":"The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging","volume":"12","author":"Jiang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0160","first-page":"25","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"The Gene Ontology Consortium, Nat Genet"},{"key":"10.1016\/j.bcp.2025.116841_b0165","doi-asserted-by":"crossref","unstructured":"M. Kanehisa, S. Goto, M. Furumichi, M. Tanabe, M. Hirakawa, KEGG for representation and analysis of molecular networks involving diseases and drugs, Nucleic Acids Res 38(Database issue) (2010) D355-60.","DOI":"10.1093\/nar\/gkp896"},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0170","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-019-1004-4","article-title":"RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3","volume":"18","author":"Niu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.bcp.2025.116841_b0175","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0378-1119(90)90090-E","article-title":"Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland","volume":"91","author":"Abe","year":"1990","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0185","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1006\/bbrc.2000.2414","article-title":"The carboxyl terminal domain of phosducin functions as a transcriptional activator","volume":"270","author":"Zhu","year":"2000","journal-title":"Biochem Bioph Res Co"},{"issue":"12","key":"10.1016\/j.bcp.2025.116841_b0190","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1073\/pnas.112075699","article-title":"Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex","volume":"99","author":"McLaughlin","year":"2002","journal-title":"PNAS"},{"issue":"20","key":"10.1016\/j.bcp.2025.116841_b0195","doi-asserted-by":"crossref","first-page":"20042","DOI":"10.1074\/jbc.M409233200","article-title":"Phosducin-like protein regulates G-protein \u03b2\u03b3 folding by interaction with tailless complex polypeptide-1\u03b1 -: Dephosphorylation or splicing of PhLP turns the switch toward regulation of G\u03b2\u03b3 folding","volume":"280","author":"Humrich","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2025.116841_b0200","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.numecd.2011.08.004","article-title":"Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity","volume":"23","author":"Palatini","year":"2013","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.bcp.2025.116841_b0205","article-title":"Phosducin-like 3 is a novel prognostic and onco-immunological biomarker in glioma: A multi-omics analysis with experimental verification","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0210","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1172\/JCI62856","article-title":"Alkylpurine-DNA-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients (vol 122, pg 253, 2012)","volume":"122","author":"Agnihotri","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"25","key":"10.1016\/j.bcp.2025.116841_b0215","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1200\/JCO.2007.11.5964","article-title":"Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity","volume":"26","author":"Hegi","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcp.2025.116841_b0220","doi-asserted-by":"crossref","unstructured":"J.B. Wang, D.F. Dong, M.D. Wang, K. Gao, IDH1 overexpression induced chemotherapy resistance and IDH1 mutation enhanced chemotherapy sensitivity in Glioma cells in vitro and in vivo, Asian Pac J Cancer P 15(1) (2014) 427-432.","DOI":"10.7314\/APJCP.2014.15.1.427"},{"issue":"1","key":"10.1016\/j.bcp.2025.116841_b0225","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-022-00804-3","article-title":"Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation","volume":"29","author":"Tsai","year":"2022","journal-title":"J. Biomed. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.116841_b0230","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1158\/2159-8290.CD-20-0331","article-title":"The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells","volume":"11","author":"Dixit","year":"2021","journal-title":"Cancer Discov."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:21:33Z","timestamp":1762096893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":46,"alternative-id":["S0006295225001030"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116841","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosducin inhibits the cell proliferation and promotes the antitumor effect of temozolomide in glioma","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116841"}}